The network for 'cotranslational protein targeting to membrane' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cotranslational protein targeting to membrane

The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria.

NameDescriptionProbabilityFunc Analog Organism
SEC63Sec63p0.997
KAR2Kar2p0.911
SEC62Sec62p0.766
STI1Sti1p0.625
SBH1Sbh1p0.472
JEM1Jem1p0.343
SSS1Sss1p0.321
SEC72Sec72p0.294
ERO1Ero1p0.248
SCJ1Scj1p0.234
SSA1Ssa1p0.234
SRP14Srp14p0.232
SEC61Sec61p0.195
SSA3Ssa3p0.170
SSA2Ssa2p0.165
SSA4Ssa4p0.094
OST4Ost4p0.089
SSE1Sse1p0.078
SRP54Srp54p0.077
MPD1Mpd1p0.063
SRP21Srp21p0.061
RPS29BRps29bp0.059
SIL1Sil1p0.055
SEC65Sec65p0.054
WBP1Wbp1p0.046
YLR264C-Ahypothetical protein0.046
LHS1Lhs1p0.043
NOP10Nop10p0.040
SRD1Srd1p0.036
CPR6Cpr6p0.035
LEU2Leu2p0.035
BTN2Btn2p0.034
SGT2Sgt2p0.034
YDL085C-Ahypothetical protein0.031
YOL038C-Ahypothetical protein0.031
YLR162Whypothetical protein0.030
BFR1Bfr1p0.029
YAR068Whypothetical protein0.029
CUP1-1Cup1-1p0.028
MER1Mer1p0.025
SAR1Sar1p0.025
URA6Ura6p0.025
ARP10Arp10p0.024
YLR126Chypothetical protein0.023
URA3Ura3p0.023
SWC7Swc7p0.023
HOHop0.023
ARG8Arg8p0.022
RPL41ARpl41ap0.022
YIR035Chypothetical protein0.021
ERP2Erp2p0.021
PMT1Pmt1p0.021
SPL2Spl2p0.020
YBR013Chypothetical protein0.020
ATP6Atp6p0.020
ERD2Erd2p0.020
YAR066Whypothetical protein0.020
TSC3Tsc3p0.020
YLR042Chypothetical protein0.020
TYE7Tye7p0.019
EGD1Egd1p0.019
HXT3Hxt3p0.019
EGD2Egd2p0.019
ALG12Alg12p0.019
OYE2Oye2p0.019
FAS2Fas2p0.018
PRP8Prp8p0.018
AUA1Aua1p0.018
BSC1Bsc1p0.018
YNL010Whypothetical protein0.018
YPR157Whypothetical protein0.018
PTR2Ptr2p0.017
NAT5Nat5p0.017
HPF1Hpf1p0.017
PRS2Prs2p0.017
LRO1Lro1p0.017
GYL1Gyl1p0.017
ZPS1Zps1p0.017
RPL40ARpl40ap0.017
OST5Ost5p0.017
OPT2Opt2p0.017
TDH1Tdh1p0.017
FMT1Fmt1p0.016
CAM1Cam1p0.016
YOL013W-Ahypothetical protein0.016
MF(ALPHA)2Mf(alpha)2p0.016
ALT2Alt2p0.016
GLN1Gln1p0.015
CRP1Crp1p0.015
GND1Gnd1p0.015
CPD1Cpd1p0.015
SIS1Sis1p0.015
DIF1Dif1p0.015
YDL157Chypothetical protein0.015
NRG2Nrg2p0.014
YMR122W-Ahypothetical protein0.014
UPS3Ups3p0.014
ADH2Adh2p0.014
YAL037C-Ahypothetical protein0.014
YMR130Whypothetical protein0.014
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HSPA1Bheat shock 70kDa protein 1B0.982
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.975
HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 10.808
HSPA1Aheat shock 70kDa protein 1A0.633
CANXcalnexin0.591
BAG1BCL2-associated athanogene0.522
BAG3BCL2-associated athanogene 30.484
DNAJB1DnaJ (Hsp40) homolog, subfamily B, member 10.429
HSPH1heat shock 105kDa/110kDa protein 10.274
DNAJA1DnaJ (Hsp40) homolog, subfamily A, member 10.257
STIP1stress-induced-phosphoprotein 10.146
PPIDpeptidylprolyl isomerase D0.088
HSPD1heat shock 60kDa protein 1 (chaperonin)0.073
BAG2BCL2-associated athanogene 20.060
CHORDC1cysteine and histidine-rich domain (CHORD) containing 10.059
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.052
PPP5Cprotein phosphatase 5, catalytic subunit0.043
DNAJB11DnaJ (Hsp40) homolog, subfamily B, member 110.040
HSPA8heat shock 70kDa protein 80.038
STUB1STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase0.032
HSPB1heat shock 27kDa protein 10.024
DNAJB6DnaJ (Hsp40) homolog, subfamily B, member 60.023
TRADDTNFRSF1A-associated via death domain0.016
HSPA5heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)0.014
HSPA1Lheat shock 70kDa protein 1-like0.011
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Hsp90b1heat shock protein 90, beta (Grp94), member 10.213
Pdia3protein disulfide isomerase associated 30.132
Dnajc3DnaJ (Hsp40) homolog, subfamily C, member 30.060
Dnajb11DnaJ (Hsp40) homolog, subfamily B, member 110.057
Manfmesencephalic astrocyte-derived neurotrophic factor0.047
Creld2cysteine-rich with EGF-like domains 20.036
Spcs3signal peptidase complex subunit 3 homolog (S. cerevisiae)0.024
Sdf2l1stromal cell-derived factor 2-like 10.024
Hspa5heat shock protein 50.023
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.021
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.017
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.017
Iqcb1IQ calmodulin-binding motif containing 10.015
Pdia6protein disulfide isomerase associated 60.015
Surf4surfeit gene 40.013
Rpn1ribophorin I0.011
Hsph1heat shock 105kDa/110kDa protein 10.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism