The network for 'protein targeting to er' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein targeting to er

The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane.

NameDescriptionProbabilityFunc Analog Organism
SEC63Sec63p1.000
SEC62Sec62p0.999
SGT2Sgt2p0.999
SRP54Srp54p0.995
SPC1Spc1p0.988
SEC65Sec65p0.988
SRP72Srp72p0.988
KAR2Kar2p0.988
GET3Get3p0.984
SSS1Sss1p0.982
SBH1Sbh1p0.976
SRP21Srp21p0.975
SRP14Srp14p0.974
SPC2Spc2p0.969
SIS1Sis1p0.954
SEC11Sec11p0.874
SRP68Srp68p0.872
SEC66Sec66p0.856
SEC61Sec61p0.839
STI1Sti1p0.710
SSA2Ssa2p0.645
SSH1Ssh1p0.640
ERP2Erp2p0.633
SEC72Sec72p0.597
GET1Get1p0.539
SIL1Sil1p0.528
LHS1Lhs1p0.497
BTN2Btn2p0.468
SPC3Spc3p0.445
SCJ1Scj1p0.432
SSA3Ssa3p0.398
YDJ1Ydj1p0.366
JEM1Jem1p0.323
EGD2Egd2p0.286
SSA4Ssa4p0.286
ERO1Ero1p0.281
CAF130Caf130p0.235
LCL2Lcl2p0.227
OST4Ost4p0.151
MDY2Mdy2p0.137
EGD1Egd1p0.123
HTA2Hta2p0.121
ERJ5Erj5p0.119
BFR1Bfr1p0.098
ERD2Erd2p0.083
YRB1Yrb1p0.074
UBA2Uba2p0.068
CUR1Cur1p0.066
SBH2Sbh2p0.061
LIF1Lif1p0.061
FES1Fes1p0.060
YLR126Chypothetical protein0.059
GET4Get4p0.057
UBC4Ubc4p0.056
YLR264C-Ahypothetical protein0.053
CPR6Cpr6p0.053
NUP82Nup82p0.053
WBP1Wbp1p0.052
NMT1Nmt1p0.048
YKL063Chypothetical protein0.047
PRP45Prp45p0.046
OST2Ost2p0.045
RPL15BRpl15bp0.044
SWC7Swc7p0.044
RPI1Rpi1p0.044
SRD1Srd1p0.039
BTT1Btt1p0.039
PRS2Prs2p0.038
YOL038C-Ahypothetical protein0.038
YJR011Chypothetical protein0.038
LEU2Leu2p0.037
MPD1Mpd1p0.036
SSE1Sse1p0.036
CUP1-1Cup1-1p0.036
APA1Apa1p0.036
SEC20Sec20p0.035
OTU1Otu1p0.034
NOP10Nop10p0.034
YAR068Whypothetical protein0.034
EMC4Emc4p0.034
YBL029Whypothetical protein0.033
ILS1Ils1p0.033
SES1Ses1p0.032
CUE4Cue4p0.031
AHA1Aha1p0.031
SFB2Sfb2p0.031
GNA1Gna1p0.030
GND1Gnd1p0.029
YNL155Whypothetical protein0.029
YLR162Whypothetical protein0.029
SLY1Sly1p0.029
URA6Ura6p0.028
CRP1Crp1p0.028
MER1Mer1p0.028
FRS2Frs2p0.028
ARP10Arp10p0.027
RPS29BRps29bp0.027
HUT1Hut1p0.027
YMR130Whypothetical protein0.027
PMT1Pmt1p0.026
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.225
HSPA1Bheat shock 70kDa protein 1B0.160
HSPA1Aheat shock 70kDa protein 1A0.114
PTPN23protein tyrosine phosphatase, non-receptor type 230.076
HSPA5heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)0.023
BAG3BCL2-associated athanogene 30.016
DNAJB11DnaJ (Hsp40) homolog, subfamily B, member 110.015
HSPA8heat shock 70kDa protein 80.014
CANXcalnexin0.014
DNAJB1DnaJ (Hsp40) homolog, subfamily B, member 10.013
BAG1BCL2-associated athanogene0.013
RPL36ALribosomal protein L36a-like0.012
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Hsp90b1heat shock protein 90, beta (Grp94), member 10.673
Creld2cysteine-rich with EGF-like domains 20.331
Hspd1heat shock protein 1 (chaperonin)0.263
Dnajb11DnaJ (Hsp40) homolog, subfamily B, member 110.256
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.239
Iqcb1IQ calmodulin-binding motif containing 10.236
Rpgrip1lRpgrip1-like0.183
Hsph1heat shock 105kDa/110kDa protein 10.167
Pdia6protein disulfide isomerase associated 60.163
Manfmesencephalic astrocyte-derived neurotrophic factor0.122
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.121
Pdia3protein disulfide isomerase associated 30.095
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.093
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.073
Surf4surfeit gene 40.064
Nphp1nephronophthisis 1 (juvenile) homolog (human)0.063
Hspa5heat shock protein 50.061
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.060
Ssr1signal sequence receptor, alpha0.057
Invsinversin0.053
Dnajc3DnaJ (Hsp40) homolog, subfamily C, member 30.050
P4hbprolyl 4-hydroxylase, beta polypeptide0.048
Hspa8heat shock protein 80.044
Arcn1archain 10.037
Sdf2l1stromal cell-derived factor 2-like 10.036
Rrbp1ribosome binding protein 10.033
Chordc1cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 10.032
Xbp1X-box binding protein 10.032
Clasp1CLIP associating protein 10.031
Prkcshprotein kinase C substrate 80K-H0.031
Dync1h1dynein cytoplasmic 1 heavy chain 10.028
Pdia4protein disulfide isomerase associated 40.028
Ahi1Abelson helper integration site 10.026
Spna2spectrin alpha 20.021
Atp2a2ATPase, Ca++ transporting, cardiac muscle, slow twitch 20.021
Ptbp2polypyrimidine tract binding protein 20.020
Calucalumenin0.019
Lman1lectin, mannose-binding, 10.019
Kpna1karyopherin (importin) alpha 10.018
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.018
Ntf3neurotrophin 30.018
Uso1USO1 homolog, vesicle docking protein (yeast)0.018
Spcs2signal peptidase complex subunit 2 homolog (S. cerevisiae)0.018
Lrrc59leucine rich repeat containing 590.017
Mks1Meckel syndrome, type 10.017
Erp44endoplasmic reticulum protein 440.017
Gorasp2golgi reassembly stacking protein 20.017
Spnb2spectrin beta 20.016
Canxcalnexin0.016
Hyou1hypoxia up-regulated 10.016
Ssr3signal sequence receptor, gamma0.016
Ufd1lubiquitin fusion degradation 1 like0.014
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.014
Slc35b1solute carrier family 35, member B10.013
Rpn2ribophorin II0.013
Tctn1tectonic family member 10.013
Sel1lsel-1 suppressor of lin-12-like (C. elegans)0.013
Edem1ER degradation enhancer, mannosidase alpha-like 10.013
Bdnfbrain derived neurotrophic factor0.012
Calrcalreticulin0.012
Nus1nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)0.012
P4ha1procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide0.012
Dnajc5DnaJ (Hsp40) homolog, subfamily C, member 50.012
Rpn1ribophorin I0.012
Uba5ubiquitin-like modifier activating enzyme 50.012
Serp1stress-associated endoplasmic reticulum protein 10.012
Csnk1g2casein kinase 1, gamma 20.011
Clasp2CLIP associating protein 20.011
Vcpvalosin containing protein0.011
OgtO-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)0.011
Csde1cold shock domain containing E1, RNA binding0.011
Spcs3signal peptidase complex subunit 3 homolog (S. cerevisiae)0.011
Hspa1bheat shock protein 1B0.011
Actg1actin, gamma, cytoplasmic 10.011
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.011
Mtmr1myotubularin related protein 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism