The network for 'adaptation of signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

adaptation of signaling pathway

The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.

NameDescriptionProbabilityFunc Analog Organism
FAR3Far3p0.997
RRI1Rri1p0.994
CMP2Cmp2p0.983
CSN9Csn9p0.949
CSI1Csi1p0.947
PCI8Pci8p0.844
FAR10Far10p0.655
FAR7Far7p0.542
SKP1Skp1p0.409
CNA1Cna1p0.387
RRI2Rri2p0.381
STE18Ste18p0.373
STE2Ste2p0.355
KDX1Kdx1p0.263
CLN1Cln1p0.221
MSG5Msg5p0.203
STE5Ste5p0.201
CNB1Cnb1p0.177
RCN1Rcn1p0.152
VPS38Vps38p0.115
ROG3Rog3p0.106
VPS64Vps64p0.101
ITT1Itt1p0.093
TFB1Tfb1p0.092
THP3Thp3p0.092
SIA1Sia1p0.088
CRH1Crh1p0.085
TFB4Tfb4p0.083
ATG13Atg13p0.074
FAR11Far11p0.071
IML2Iml2p0.070
GFA1Gfa1p0.065
YJR084Whypothetical protein0.064
FAR8Far8p0.064
KRE1Kre1p0.062
KSS1Kss1p0.061
BAR1Bar1p0.060
FLC1Flc1p0.053
CCL1Ccl1p0.053
RLM1Rlm1p0.050
MPT5Mpt5p0.049
ROD1Rod1p0.045
YPL014Whypothetical protein0.043
MTL1Mtl1p0.043
CRP1Crp1p0.043
ECM38Ecm38p0.041
FUS3Fus3p0.040
YHR177Whypothetical protein0.039
RGC1Rgc1p0.038
DDR48Ddr48p0.038
SRD1Srd1p0.037
CMD1Cmd1p0.037
SRL3Srl3p0.037
FUS1Fus1p0.036
YHR097Chypothetical protein0.034
ART10Art10p0.034
YHR140Whypothetical protein0.034
YLR264C-Ahypothetical protein0.034
GLG1Glg1p0.032
YOL038C-Ahypothetical protein0.031
MDH2Mdh2p0.030
ACH1Ach1p0.030
RGD2Rgd2p0.030
LEU2Leu2p0.030
YLR162Whypothetical protein0.030
STE13Ste13p0.030
CSI2Csi2p0.028
YJL107Chypothetical protein0.027
ARP10Arp10p0.027
URA3Ura3p0.027
BCK2Bck2p0.026
RRP36Rrp36p0.026
STE7Ste7p0.025
AIM9Aim9p0.025
SSH4Ssh4p0.025
YDL121Chypothetical protein0.025
YLR042Chypothetical protein0.025
SNU56Snu56p0.025
YPS3Yps3p0.024
YNL035Chypothetical protein0.023
YIR007Whypothetical protein0.023
CLN3Cln3p0.023
MER1Mer1p0.023
YIR035Chypothetical protein0.022
YPR157Whypothetical protein0.022
YAR068Whypothetical protein0.021
PHM6Phm6p0.020
YDL124Whypothetical protein0.020
ZPS1Zps1p0.020
ATP6Atp6p0.020
YPL067Chypothetical protein0.020
CUP1-1Cup1-1p0.020
YIL151Chypothetical protein0.020
TOS2Tos2p0.019
CMK2Cmk2p0.019
YER158Chypothetical protein0.019
RCK1Rck1p0.019
HXT3Hxt3p0.019
YDR476Chypothetical protein0.018
GIS3Gis3p0.018
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
odr-3Protein ODR-30.122
vab-3Protein VAB-30.016
rgs-3Protein RGS-30.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
trpltrp-like0.350
inaDinactivation no afterpotential D0.348
trptransient receptor potential0.330
ninaCneither inactivation nor afterpotential C0.274
Arr2Arrestin 20.214
ninaEneither inactivation nor afterpotential E0.166
rdgCretinal degeneration C0.078
Galpha49BG protein alpha49B0.061
Rh3Rhodopsin 30.031
norpAno receptor potential A0.031
Rh5Rhodopsin 50.030
Gbeta76CG protein beta-subunit 76C0.025
chpchaoptic0.023
rdgAretinal degeneration A0.023
tadrtorn and diminished rhabdomeres0.022
ninaBneither inactivation nor afterpotential B0.019
inaCinactivation no afterpotential C0.015
retinophilinCG10233 gene product from transcript CG10233-RA0.015
Rh6Rhodopsin 60.014
CG13792CG13792 gene product from transcript CG13792-RA0.012
Pph13PvuII-PstI homology 130.011
ninaAneither inactivation nor afterpotential A0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MPDZmultiple PDZ domain protein0.699
HDAC6histone deacetylase 60.546
ARRB1arrestin, beta 10.542
CFL1cofilin 1 (non-muscle)0.229
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.221
ZNF496zinc finger protein 4960.160
ACTBactin, beta0.128
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.114
ADORA2Aadenosine A2a receptor0.103
NCF1neutrophil cytosolic factor 10.102
ARRB2arrestin, beta 20.100
PRKCAprotein kinase C, alpha0.090
MAP3K5mitogen-activated protein kinase kinase kinase 50.079
MAPK10mitogen-activated protein kinase 100.072
GIT1G protein-coupled receptor kinase interacting ArfGAP 10.062
GNMTglycine N-methyltransferase0.045
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.037
CYBAcytochrome b-245, alpha polypeptide0.035
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.033
BLOC1S2biogenesis of lysosomal organelles complex-1, subunit 20.033
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.028
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha0.024
CTTNcortactin0.021
PRKCDprotein kinase C, delta0.021
GNAQguanine nucleotide binding protein (G protein), q polypeptide0.021
ERCC8excision repair cross-complementing rodent repair deficiency, complementation group 80.021
RAB5CRAB5C, member RAS oncogene family0.017
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.015
ACTG1actin, gamma 10.015
MAP2K4mitogen-activated protein kinase kinase 40.014
PDE6Gphosphodiesterase 6G, cGMP-specific, rod, gamma0.012
TRIM9tripartite motif containing 90.011
RHOrhodopsin0.011
HIST2H2ABhistone cluster 2, H2ab0.011
DGKZdiacylglycerol kinase, zeta0.011
RICTORRPTOR independent companion of MTOR, complex 20.010
MDM2Mdm2 p53 binding protein homolog (mouse)0.010
ARRDC3arrestin domain containing 30.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Prph2peripherin 20.088
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.080
Slc14a2solute carrier family 14 (urea transporter), member 20.057
Pde1bphosphodiesterase 1B, calmodulin-dependent0.055
Pomcproopiomelanocortin0.054
Impg2interphotoreceptor matrix proteoglycan 20.042
Dsppdentin sialophosphoprotein0.041
Trhrthyrotropin releasing hormone receptor0.038
Acrv1acrosomal vesicle protein 10.035
MrgprfMAS-related GPR, member F0.033
Git1G protein-coupled receptor kinase interacting ArfGAP 10.028
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.028
Rftn2raftlin family member 20.027
Csf1colony stimulating factor 1 (macrophage)0.027
Chrna2cholinergic receptor, nicotinic, alpha 2 (neuronal)0.025
Dccdeleted in colorectal carcinoma0.025
Grpgastrin releasing peptide0.024
Znf483zinc finger protein 4830.023
Adora2aadenosine A2a receptor0.020
Camk2n2calcium/calmodulin-dependent protein kinase II inhibitor 20.020
Cnga4cyclic nucleotide gated channel alpha 40.019
Hoxc4homeo box C40.019
Kcnab2potassium voltage-gated channel, shaker-related subfamily, beta member 20.018
Apba2amyloid beta (A4) precursor protein-binding, family A, member 20.018
P2rx3purinergic receptor P2X, ligand-gated ion channel, 30.018
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.017
Fgf7fibroblast growth factor 70.017
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.017
N5DNA binding protein N50.016
B3gat1beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)0.016
Ednraendothelin receptor type A0.015
Htr2a5-hydroxytryptamine (serotonin) receptor 2A0.015
Slc29a2solute carrier family 29 (nucleoside transporters), member 20.015
Cacna1ecalcium channel, voltage-dependent, R type, alpha 1E subunit0.015
Pitx3paired-like homeodomain 30.014
Pla2g2cphospholipase A2, group IIC0.014
Adora1adenosine A1 receptor0.014
Fgfr2fibroblast growth factor receptor 20.014
Slc17a7solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 70.014
LOC296235similar to Cystatin S precursor (LM protein)0.014
Chrna7cholinergic receptor, nicotinic, alpha 70.014
Grk1G protein-coupled receptor kinase 10.014
Kcnq2potassium voltage-gated channel, KQT-like subfamily, member 20.014
Pou2f2POU class 2 homeobox 20.014
Hand1heart and neural crest derivatives expressed 10.014
St18suppression of tumorigenicity 180.014
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.013
Syt6synaptotagmin VI0.013
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.013
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.013
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.013
Tacr1tachykinin receptor 10.012
Prm3protamine 30.012
Hcn4hyperpolarization activated cyclic nucleotide-gated potassium channel 40.012
Syngap1synaptic Ras GTPase activating protein 1 homolog (rat)0.012
Pnma1paraneoplastic antigen MA10.012
Ctsjcathepsin J0.012
Bsnbassoon0.012
Phkg1phosphorylase kinase, gamma 10.012
Epha8Eph receptor A80.012
Il8rainterleukin 8 receptor, alpha0.012
UncxUNC homeobox0.012
Hoxa1homeo box A10.012
RGD1565057similar to hypothetical protein FLJ328710.012
Hsd3b5hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 50.011
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.011
Sftpbsurfactant protein B0.011
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.011
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.011
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.011
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.010
Zfp382zinc finger protein 3820.010
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.010
Kcnh5potassium voltage-gated channel, subfamily H (eag-related), member 50.010
Cd80Cd80 molecule0.010
Tubtubby homolog (mouse)0.010
Lipelipase, hormone sensitive0.010
Tgfbr2transforming growth factor, beta receptor II0.010