The network for 'negative regulation of transcription involved in g1 s transition of mitotic cell cycle' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of transcription involved in g1 s transition of mitotic cell cycle

Any process that stop, prevents or decreases transcription as part of the G1/S transition of the mitotic cell cycle.

NameDescriptionProbabilityFunc Analog Organism
YLR455Whypothetical protein0.090
CLN1Cln1p0.076
HIR2Hir2p0.055
MSA2Msa2p0.051
FKH1Fkh1p0.048
HIR1Hir1p0.043
HHO1Hho1p0.042
KIN4Kin4p0.041
STB1Stb1p0.040
TOF2Tof2p0.040
CLB1Clb1p0.037
YOX1Yox1p0.036
CDC6Cdc6p0.027
MSI1Msi1p0.026
CLB6Clb6p0.026
FKH2Fkh2p0.024
ARG8Arg8p0.023
SRD1Srd1p0.022
ARP10Arp10p0.021
TOS6Tos6p0.021
NDD1Ndd1p0.021
NRM1Nrm1p0.020
VAC17Vac17p0.020
YMR144Whypothetical protein0.019
YAR068Whypothetical protein0.019
SUR7Sur7p0.018
YLR264C-Ahypothetical protein0.018
LEU2Leu2p0.018
MOT3Mot3p0.018
SPS4Sps4p0.018
YLR162Whypothetical protein0.017
CAC2Cac2p0.017
YNL058Chypothetical protein0.017
YOL038C-Ahypothetical protein0.017
YOR390Whypothetical protein0.016
MER1Mer1p0.016
BNA4Bna4p0.016
RSC6Rsc6p0.015
YLR042Chypothetical protein0.015
FMT1Fmt1p0.015
CUP1-1Cup1-1p0.015
ATP6Atp6p0.015
YAR066Whypothetical protein0.014
SWC7Swc7p0.014
HXT3Hxt3p0.014
SPL2Spl2p0.014
YPR096Chypothetical protein0.013
GIC1Gic1p0.013
YIL151Chypothetical protein0.013
URA3Ura3p0.013
NUP157Nup157p0.013
YKR075Chypothetical protein0.013
YKR045Chypothetical protein0.013
YOL013W-Ahypothetical protein0.013
YPR157Whypothetical protein0.013
RRN5Rrn5p0.013
IRC8Irc8p0.012
AUA1Aua1p0.012
HHT2Hht2p0.012
PTR2Ptr2p0.012
CPD1Cpd1p0.012
YBR013Chypothetical protein0.012
HOHop0.012
LRO1Lro1p0.012
BSC1Bsc1p0.012
OPT2Opt2p0.012
ADH2Adh2p0.012
YJL181Whypothetical protein0.012
HPF1Hpf1p0.011
GAL80Gal80p0.011
BRN1Brn1p0.011
TBF1Tbf1p0.011
SUM1Sum1p0.011
TOS2Tos2p0.011
UPS3Ups3p0.011
CAB3Cab3p0.011
MF(ALPHA)2Mf(alpha)2p0.011
YIR035Chypothetical protein0.011
YLR040Chypothetical protein0.011
SCM4Scm4p0.010
RRN7Rrn7p0.010
SPC98Spc98p0.010
YLR419Whypothetical protein0.010
ZPS1Zps1p0.010
IFH1Ifh1p0.010
CHA1Cha1p0.010
CRP1Crp1p0.010
COS12Cos12p0.010
DIC1Dic1p0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RB1retinoblastoma 11.000
E2F1E2F transcription factor 11.000
RBL1retinoblastoma-like 1 (p107)0.995
TFDP1transcription factor Dp-10.995
CDK2cyclin-dependent kinase 20.993
MYBL2v-myb myeloblastosis viral oncogene homolog (avian)-like 20.951
E2F4E2F transcription factor 4, p107/p130-binding0.941
RBL2retinoblastoma-like 2 (p130)0.928
E2F3E2F transcription factor 30.837
TFDP2transcription factor Dp-2 (E2F dimerization partner 2)0.811
LIN9lin-9 homolog (C. elegans)0.721
RBBP8retinoblastoma binding protein 80.680
E2F2E2F transcription factor 20.680
UHRF2ubiquitin-like with PHD and ring finger domains 20.568
CUX1cut-like homeobox 10.461
CCNE1cyclin E10.192
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.177
AHRaryl hydrocarbon receptor0.171
PKMYT1protein kinase, membrane associated tyrosine/threonine 10.171
KAT2BK(lysine) acetyltransferase 2B0.169
LIN54lin-54 homolog (C. elegans)0.160
CDT1chromatin licensing and DNA replication factor 10.158
MDM4Mdm4 p53 binding protein homolog (mouse)0.155
CHEK2CHK2 checkpoint homolog (S. pombe)0.143
PURApurine-rich element binding protein A0.133
CHEK1CHK1 checkpoint homolog (S. pombe)0.116
MAPK14mitogen-activated protein kinase 140.112
HDAC1histone deacetylase 10.112
MDM2Mdm2 p53 binding protein homolog (mouse)0.103
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.096
CCND1cyclin D10.087
CDK6cyclin-dependent kinase 60.057
NCOA6nuclear receptor coactivator 60.055
CDC25Acell division cycle 25 homolog A (S. pombe)0.055
CDC45cell division cycle 45 homolog (S. cerevisiae)0.049
ORC1origin recognition complex, subunit 10.046
MCPH1microcephalin 10.039
E2F6E2F transcription factor 60.030
FRKfyn-related kinase0.028
HCFC1host cell factor C1 (VP16-accessory protein)0.025
CDC6cell division cycle 6 homolog (S. cerevisiae)0.023
PRMT2protein arginine methyltransferase 20.022
TAF1TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa0.022
BTG3BTG family, member 30.020
HBP1HMG-box transcription factor 10.020
RAD54LRAD54-like (S. cerevisiae)0.019
ASF1BASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.018
RECQL4RecQ protein-like 40.016
DYRK1Bdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B0.016
RNF40ring finger protein 400.015
CDC25Ccell division cycle 25 homolog C (S. pombe)0.011
BRCA1breast cancer 1, early onset0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Rb1retinoblastoma 11.000
Trp53transformation related protein 531.000
Cdkn1bcyclin-dependent kinase inhibitor 1B0.999
Ptenphosphatase and tensin homolog0.999
Ctnnb1catenin (cadherin associated protein), beta 10.992
Brca1breast cancer 10.901
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.899
Ptch1patched homolog 10.706
Apcadenomatosis polyposis coli0.691
Mdm2transformed mouse 3T3 cell double minute 20.682
Kitkit oncogene0.526
E2f1E2F transcription factor 10.506
Nf1neurofibromatosis 10.432
Itgb1integrin beta 1 (fibronectin receptor beta)0.421
Rbl1retinoblastoma-like 1 (p107)0.396
Notch1Notch gene homolog 1 (Drosophila)0.372
Kif22kinesin family member 220.310
Hif1ahypoxia inducible factor 1, alpha subunit0.279
Chd7chromodomain helicase DNA binding protein 70.278
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.275
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.275
Kitlkit ligand0.242
Zeb1zinc finger E-box binding homeobox 10.242
Psen1presenilin 10.238
Msh2mutS homolog 2 (E. coli)0.233
Rbl2retinoblastoma-like 20.231
Fgfr2fibroblast growth factor receptor 20.230
Brca2breast cancer 20.216
Cenpfcentromere protein F0.192
Foxo3forkhead box O30.174
BrafBraf transforming gene0.147
Aurkbaurora kinase B0.140
Meox2mesenchyme homeobox 20.117
Foxc1forkhead box C10.111
Thbs1thrombospondin 10.110
Bmpr1abone morphogenetic protein receptor, type 1A0.108
Cdca5cell division cycle associated 50.105
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.095
Fgfr3fibroblast growth factor receptor 30.091
Apaf1apoptotic peptidase activating factor 10.087
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.087
Ptpn11protein tyrosine phosphatase, non-receptor type 110.084
Shhsonic hedgehog0.084
Cdkn2dcyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)0.081
Ccdc99coiled-coil domain containing 990.080
Hprthypoxanthine guanine phosphoribosyl transferase0.074
Plk1polo-like kinase 1 (Drosophila)0.071
Sox2SRY-box containing gene 20.067
Xpaxeroderma pigmentosum, complementation group A0.065
Col1a1collagen, type I, alpha 10.064
Nr3c1nuclear receptor subfamily 3, group C, member 10.063
Cep55centrosomal protein 550.063
Tcf19transcription factor 190.062
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.062
Nf2neurofibromatosis 20.056
Sox11SRY-box containing gene 110.056
Vangl2vang-like 2 (van gogh, Drosophila)0.053
Tsc1tuberous sclerosis 10.052
Dtldenticleless homolog (Drosophila)0.052
Ncaphnon-SMC condensin I complex, subunit H0.050
Gja1gap junction protein, alpha 10.048
Melkmaternal embryonic leucine zipper kinase0.047
Stk11serine/threonine kinase 110.046
Ppp1cbprotein phosphatase 1, catalytic subunit, beta isoform0.045
Atf2activating transcription factor 20.044
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.043
Casp3caspase 30.040
Dlg1discs, large homolog 1 (Drosophila)0.039
Ckap2lcytoskeleton associated protein 2-like0.039
Prc1protein regulator of cytokinesis 10.038
Foxg1forkhead box G10.038
Mki67antigen identified by monoclonal antibody Ki 670.037
Ncapgnon-SMC condensin I complex, subunit G0.036
Pax6paired box gene 60.035
Tpx2TPX2, microtubule-associated protein homolog (Xenopus laevis)0.033
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.033
Lrr1leucine rich repeat protein 10.033
Kif4kinesin family member 40.032
E2f8E2F transcription factor 80.031
Jag1jagged 10.031
StilScl/Tal1 interrupting locus0.029
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.029
Ccna2cyclin A20.028
Mybl2myeloblastosis oncogene-like 20.027
TtkTtk protein kinase0.027
Sox4SRY-box containing gene 40.026
Emx1empty spiracles homolog 1 (Drosophila)0.026
Sox9SRY-box containing gene 90.025
Sgol1shugoshin-like 1 (S. pombe)0.025
Men1multiple endocrine neoplasia 10.025
Parp1poly (ADP-ribose) polymerase family, member 10.025
Notch2Notch gene homolog 2 (Drosophila)0.025
Lig1ligase I, DNA, ATP-dependent0.025
Birc5baculoviral IAP repeat-containing 50.024
Psapprosaposin0.024
Ccnd1cyclin D10.023
Cdt1chromatin licensing and DNA replication factor 10.023
Ckap2cytoskeleton associated protein 20.021
Cdkn2acyclin-dependent kinase inhibitor 2A0.021
Ube2cubiquitin-conjugating enzyme E2C0.021
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism