The network for 'negative regulation of cellular macromolecule biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cellular macromolecule biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process.

NameDescriptionProbabilityFunc Analog Organism
RPD3Rpd3p0.999
GLC7Glc7p0.997
HHF1Hhf1p0.993
HHT1Hht1p0.993
SIR2Sir2p0.993
SPT16Spt16p0.991
SIN3Sin3p0.989
RAP1Rap1p0.983
RPN4Rpn4p0.972
RLF2Rlf2p0.956
YTA7Yta7p0.950
CYC8Cyc8p0.948
PHO23Pho23p0.943
CTI6Cti6p0.937
RCO1Rco1p0.935
ORC5Orc5p0.930
SIR4Sir4p0.926
ORC2Orc2p0.924
RXT2Rxt2p0.923
GLN3Gln3p0.920
SIN4Sin4p0.919
HDA1Hda1p0.917
GAL11Gal11p0.900
ISW2Isw2p0.897
CTF18Ctf18p0.895
HTA2Hta2p0.887
RIF1Rif1p0.883
ASF1Asf1p0.882
HOG1Hog1p0.878
CKA2Cka2p0.862
YAK1Yak1p0.862
SAS2Sas2p0.850
SIR3Sir3p0.840
HTB1Htb1p0.838
SWI4Swi4p0.832
RSC2Rsc2p0.808
HTZ1Htz1p0.807
AFT1Aft1p0.807
SNT1Snt1p0.800
BRE2Bre2p0.794
BRE1Bre1p0.791
SSN3Ssn3p0.768
SSD1Ssd1p0.763
SET1Set1p0.746
UME1Ume1p0.738
SDS3Sds3p0.732
SET2Set2p0.721
ADR1Adr1p0.716
MED2Med2p0.710
HTA1Hta1p0.698
SNF1Snf1p0.698
DED1Ded1p0.695
BDF1Bdf1p0.684
EAF3Eaf3p0.679
NMD2Nmd2p0.674
HTB2Htb2p0.672
PGD1Pgd1p0.667
RGR1Rgr1p0.666
HAT1Hat1p0.657
CSE2Cse2p0.654
HMO1Hmo1p0.652
SUM1Sum1p0.632
SCH9Sch9p0.628
DHH1Dhh1p0.628
LGE1Lge1p0.618
IFH1Ifh1p0.611
SAS4Sas4p0.610
ROX3Rox3p0.610
PAP2Pap2p0.584
SPT21Spt21p0.584
HHF2Hhf2p0.575
ORC1Orc1p0.572
NRG1Nrg1p0.571
HDA3Hda3p0.570
IZH4Izh4p0.567
SPP1Spp1p0.559
UBP8Ubp8p0.555
DCP2Dcp2p0.553
SRM1Srm1p0.548
PHO4Pho4p0.546
PHO85Pho85p0.537
NUT1Nut1p0.532
PRT1Prt1p0.531
VPS36Vps36p0.531
HST1Hst1p0.531
YRA1Yra1p0.528
HCM1Hcm1p0.527
HHO1Hho1p0.525
RLM1Rlm1p0.521
FUS3Fus3p0.520
FKH2Fkh2p0.518
CDC6Cdc6p0.517
RSC4Rsc4p0.511
SPT10Spt10p0.509
REG1Reg1p0.508
MSN2Msn2p0.505
SET3Set3p0.500
NTO1Nto1p0.495
SAS5Sas5p0.492
HAA1Haa1p0.491
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.963
elt-6Protein ELT-60.945
pha-4Protein PHA-40.887
hlh-2Protein HLH-20.781
egl-13Protein EGL-130.559
nhr-2Protein NHR-20.557
inx-3Protein INX-30.448
his-1Protein HIS-10.439
nhr-67Protein NHR-670.408
his-64Protein HIS-640.375
wrm-1Protein WRM-10.361
egl-27Protein EGL-270.346
mab-5Protein MAB-50.283
his-16Protein HIS-160.276
his-31Protein HIS-310.262
his-5Protein HIS-50.255
let-502Protein LET-5020.254
egl-46Protein EGL-460.252
mcm-7Protein MCM-70.250
eor-1Protein EOR-10.224
daf-14Protein DAF-140.221
unc-62Protein UNC-620.211
F55F8.9Protein F55F8.90.203
lin-53Protein LIN-530.197
hda-1Protein HDA-10.191
tbx-8Protein TBX-80.188
CELE_F54D5.5Protein F54D5.50.187
nhr-46Protein NHR-460.186
fkh-2Protein FKH-20.181
eftu-2Protein EFTU-20.177
daf-12Protein DAF-120.174
F39B2.1Protein F39B2.10.173
ceh-27Protein CEH-270.172
hlh-1Protein HLH-10.172
attf-2Protein ATTF-20.170
his-3Protein HIS-30.168
T28F4.1Protein T28F4.10.163
mes-4Protein MES-40.160
CELE_C24H12.5Protein C24H12.50.153
unc-73Protein UNC-730.148
his-62Protein HIS-620.147
his-51Protein HIS-510.146
spr-5Protein SPR-50.146
his-68Protein HIS-680.145
his-61Protein HIS-610.145
pry-1Protein PRY-10.145
lin-40Protein LIN-400.143
his-50Protein HIS-500.142
hlh-30Protein HLH-300.140
his-38Protein HIS-380.137
rad-26Protein RAD-260.133
nhr-25Protein NHR-250.133
lin-66Protein LIN-660.131
mix-1Protein MIX-10.128
cnd-1Protein CND-10.124
hbl-1Protein HBL-10.120
hil-2Protein HIL-20.119
npp-3Protein NPP-30.118
C27F2.8Protein C27F2.80.118
klp-16Protein KLP-160.117
his-29Protein HIS-290.117
his-42Protein HIS-420.117
his-4Protein HIS-40.114
hum-6Protein HUM-60.111
hcp-3Protein HCP-30.110
cnt-2Protein CNT-20.110
his-46Protein HIS-460.109
his-47Protein HIS-470.108
T09B4.5Protein T09B4.50.108
csn-4Protein CSN-40.107
lin-35Protein LIN-350.105
nhr-34Protein NHR-340.105
qua-1Protein QUA-10.104
snr-2Protein SNR-20.104
kle-2Protein KLE-20.103
daf-4Protein DAF-40.103
mig-38Protein MIG-380.101
egl-44Protein EGL-440.100
F26B1.2Protein F26B1.20.097
zip-7Protein ZIP-70.093
daf-1Protein DAF-10.093
lmn-1Protein LMN-10.092
eef-1A.1Protein EEF-1A.10.091
ulp-2Protein ULP-20.089
Y54E5A.7Protein Y54E5A.70.088
acs-4Protein ACS-40.088
eya-1Protein EYA-10.087
sma-6Protein SMA-60.087
atn-1Protein ATN-10.086
Y45G5AM.9Protein Y45G5AM.90.086
his-24Protein HIS-240.086
B0464.2Protein B0464.20.086
lsy-22Protein LSY-220.084
his-52Protein HIS-520.083
tam-1Protein TAM-10.083
hmg-4Protein HMG-40.083
ima-2Protein IMA-20.082
mex-5Protein MEX-50.082
tag-260Protein TAG-2600.082
Y82E9BR.13Protein Y82E9BR.130.081
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
notch1anotch homolog 1a0.911
gata6GATA-binding protein 60.739
gli1GLI-Kruppel family member 10.737
dlx2adistal-less homeobox gene 2a0.684
chdchordin0.670
foxa3forkhead box A30.651
robo3roundabout homolog 30.651
wnt5bwingless-type MMTV integration site family, member 5b0.632
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.570
bmp2bbone morphogenetic protein 2b0.529
fgf3fibroblast growth factor 30.510
prox1prospero-related homeobox gene 10.492
tfap2atranscription factor AP-2 alpha0.474
vsx2visual system homeobox 20.437
snai1bsnail homolog 1b (Drosophila)0.408
hp1bp3heterochromatin protein 1, binding protein 30.402
dlcdeltaC0.389
lhx1aLIM homeobox 1a0.387
mbnl2muscleblind-like 2 (Drosophila)0.377
her11hairy-related 110.373
tp53tumor protein p530.369
eng2aengrailed 2a0.369
pou3f3aPOU class 3 homeobox 3a0.356
mab21l2mab-21-like 20.347
gro1groucho 10.337
spry4sprouty (Drosophila) homolog 40.310
nkx2.5NK2 transcription factor related 50.309
bocbrother of CDO0.279
sox19aSRY-box containing gene 19a0.277
dnmt7DNA (cytosine-5-)-methyltransferase 70.273
sox9bSRY-box containing gene 9b0.271
hnf1baHNF1 homeobox Ba0.271
egr1early growth response 10.266
emx1empty spiracles homeobox 10.266
pax2apaired box gene 2a0.262
whsc1Wolf-Hirschhorn syndrome candidate 10.262
her1hairy-related 10.261
her6hairy-related 60.245
nkx1.2laNK1 transcription factor related 2-like,a0.245
sall1asal-like 1a (Drosophila)0.241
kctd15apotassium channel tetramerisation domain containing 15a0.238
per2period homolog 2 (Drosophila)0.235
ndr2nodal-related 20.234
dctdopachrome tautomerase0.234
nova2neuro-oncological ventral antigen 20.228
etv2ets variant gene 20.224
fstafollistatin a0.223
hmgb1ahigh-mobility group box 1a0.218
hoxb1bhomeo box B1b0.217
kdrlkinase insert domain receptor like0.216
ripply1ripply10.215
tcf7transcription factor 7 (T-cell specific, HMG-box)0.212
foxi1forkhead box I10.211
hmx1H6 homeo box 10.209
otx1borthodenticle homolog 1b0.202
prdm14PR domain containing 140.198
otx2orthodenticle homolog 20.194
aldh1a2aldehyde dehydrogenase 1 family, member A20.194
igf1rbinsulin-like growth factor 1b receptor0.193
vcanaversican a0.188
gbx2gastrulation brain homeo box 20.184
grem2gremlin 2, cysteine knot superfamily0.177
smc3structural maintenance of chromosomes 30.170
sesn1sestrin 10.166
mespamesoderm posterior a0.163
junbjun B proto-oncogene0.159
twist3twist30.159
cdh5cadherin 50.157
fgf19fibroblast growth factor 190.156
wnt1wingless-type MMTV integration site family, member 10.154
nkx2.3NK2 transcription factor related 30.154
jag2jagged 20.153
nr2e1nuclear receptor subfamily 2, group E, member 10.152
foxa2forkhead box A20.152
tfebtranscription factor EB0.152
tll1tolloid-like 10.152
prdm5PR domain containing 50.151
axin2axin 2 (conductin, axil)0.148
lhx1bLIM homeobox 1b0.147
bmp4bone morphogenetic protein 40.147
plekhg4pleckstrin homology domain containing, family G (with RhoGef domain) member 40.146
fezf2FEZ family zinc finger 20.144
cmybtranscription factor cmyb0.144
neo1neogenin 10.141
sox1aSRY-box containing gene 1a0.141
wnt2bbwingless-type MMTV integration site family, member 2Bb0.137
tpm4tropomyosin 40.136
runx1runt-related transcription factor 10.133
pea3ETS-domain transcription factor pea30.132
sox9aSRY-box containing gene 9a0.131
fgfr1afibroblast growth factor receptor 1a0.131
fzd7afrizzled homolog 7a0.129
ncor1nuclear receptor co-repressor 10.128
alcambactivated leukocyte cell adhesion molecule b0.127
ventventral expressed homeobox0.126
vax1ventral anterior homeobox 10.125
cry1acryptochrome 1a0.124
tcf12transcription factor 120.123
pou3f2POU class 3 homeobox 20.123
smyhc1slow myosin heavy chain 10.121
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp0.999
CTCFCG8591 gene product from transcript CG8591-RA0.999
Snr1Snf5-related 10.999
IswiImitation SWI0.999
Sir2CG5216 gene product from transcript CG5216-RA0.998
CtBPC-terminal Binding Protein0.997
NNotch0.997
shnschnurri0.996
PcPolycomb0.995
atoatonal0.992
nmonemo0.991
enengrailed0.986
JIL-1CG6297 gene product from transcript CG6297-RA0.985
gppgrappa0.984
lwrlesswright0.981
gsbgooseberry0.977
escextra sexcombs0.972
grogroucho0.968
smt3CG4494 gene product from transcript CG4494-RA0.967
InRInsulin-like receptor0.966
tlltailless0.965
panpangolin0.964
ScmSex comb on midleg0.961
Pp1-87BProtein phosphatase 1 at 87B0.961
D1D1 chromosomal protein0.954
knknot0.953
slmbsupernumerary limbs0.952
Acf1ATP-dependent chromatin assembly factor large subunit0.950
lolalongitudinals lacking0.948
ash1absent, small, or homeotic discs 10.947
hephemipterous0.947
Su(z)12CG8013 gene product from transcript CG8013-RA0.946
cicubitus interruptus0.943
tkvthickveins0.942
Spt5CG7626 gene product from transcript CG7626-RA0.941
dcodiscs overgrown0.939
UbxUltrabithorax0.939
TrlTrithorax-like0.938
PclPolycomblike0.935
osaCG7467 gene product from transcript CG7467-RD0.935
araaraucan0.932
HLHm7E(spl) region transcript m70.932
howheld out wings0.931
cnccap-n-collar0.930
Nf-YCNuclear factor Y-box C0.926
pbproboscipedia0.926
bowlbrother of odd with entrails limited0.923
polybromoCG11375 gene product from transcript CG11375-RA0.921
edechinoid0.920
tintinman0.918
SmrSmrter0.918
saxsaxophone0.913
salmspalt major0.908
Rpd3CG7471 gene product from transcript CG7471-RA0.907
foxoforkhead box, sub-group O0.907
pr-set7CG3307 gene product from transcript CG3307-RC0.906
prdpaired0.904
MoeMoesin0.902
Fmr1CG6203 gene product from transcript CG6203-RC0.901
E(spl)Enhancer of split0.899
eyaeyes absent0.897
hthhomothorax0.895
mammastermind0.895
nubnubbin0.894
Hel25EHelicase at 25E0.890
ykiyorkie0.887
mormoira0.886
E(var)3-9Enhancer of variegation 3-90.883
lidlittle imaginal discs0.879
kaykayak0.878
tuptailup0.875
stwlstonewall0.874
His2AvHistone H2A variant0.870
kiskismet0.860
frufruitless0.857
mirrmirror0.857
Su(var)3-7Suppressor of variegation 3-70.851
E2f2E2F transcription factor 20.845
vasvasa0.840
barrbarren0.837
fufused0.833
PcafCG4107 gene product from transcript CG4107-RA0.832
OptixCG18455 gene product from transcript CG18455-RA0.832
Jarid2CG3654 gene product from transcript CG3654-RD0.831
CycBCyclin B0.831
e(y)3enhancer of yellow 30.831
EcREcdysone receptor0.827
stisticky0.823
crmcramped0.823
eygeyegone0.818
kluklumpfuss0.816
dppdecapentaplegic0.816
rinrasputin0.814
psqpipsqueak0.812
bratbrain tumor0.808
rprreaper0.805
ssspineless0.802
hhairy0.797
Su(z)2Suppressor of zeste 20.787
CSN8COP9 complex homolog subunit 80.784
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Junbjun B proto-oncogene0.911
JunJun oncogene0.904
FosFBJ osteosarcoma oncogene0.809
Dusp1dual specificity phosphatase 10.795
Btg2BTG family, member 20.694
Smad7SMAD family member 70.614
Tgfbr2transforming growth factor, beta receptor II0.593
Egr1early growth response 10.579
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.575
Nfibnuclear factor I/B0.574
Trim28tripartite motif-containing 280.572
Nononon-POU domain containing, octamer-binding0.572
Ier2immediate early response 20.540
Nedd4neural precursor cell expressed, developmentally down-regulated 40.478
Nfianuclear factor I/A0.429
Fgfr1Fibroblast growth factor receptor 10.419
Klf2Kruppel-like factor 2 (lung)0.410
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.395
Socs3suppressor of cytokine signaling 30.389
Pcnaproliferating cell nuclear antigen0.376
Id1inhibitor of DNA binding 10.361
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.353
Pds5bPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.351
Kdm6blysine (K)-specific demethylase 6B0.339
Foxi2forkhead box I20.328
Tcfe2atranscription factor E2a0.321
Hnrnpkheterogeneous nuclear ribonucleoprotein K0.320
Shox2short stature homeobox 20.292
Siah1aseven in absentia 1A0.287
Ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.283
Neurog1neurogenin 10.274
Nr2f6nuclear receptor subfamily 2, group F, member 60.271
Nek9NIMA (never in mitosis gene a)- related kinase 90.269
MGC112830similar to transcription factor0.267
Nfixnuclear factor I/X (CCAAT-binding transcription factor)0.260
Stat5bsignal transducer and activator of transcription 5B0.260
Foxe3forkhead box E30.258
Pde4bphosphodiesterase 4B, cAMP specific0.244
Myh9myosin, heavy chain 9, non-muscle0.244
Nr4a1nuclear receptor subfamily 4, group A, member 10.240
Arntaryl hydrocarbon receptor nuclear translocator0.239
Iappislet amyloid polypeptide0.237
Hoxb7homeo box B70.237
Mycmyelocytomatosis oncogene0.233
Eif1ayeukaryotic translation initiation factor 1A, Y-linked0.232
Cgaglycoprotein hormones, alpha polypeptide0.231
Brd3bromodomain containing 30.230
Hoxd3homeo box D30.227
S100a8S100 calcium binding protein A80.226
Casp2caspase 20.226
Hes1hairy and enhancer of split 1 (Drosophila)0.226
Lzts2leucine zipper, putative tumor suppressor 20.225
Cand1cullin-associated and neddylation-dissociated 10.225
Eif4heukaryotic translation initiation factor 4H0.223
Hnrpdheterogeneous nuclear ribonucleoprotein D0.213
Hoxc4homeo box C40.211
Abcb4ATP-binding cassette, subfamily B (MDR/TAP), member 40.208
Msmbmicroseminoprotein, beta0.208
Dccdeleted in colorectal carcinoma0.206
Pou3f2POU class 3 homeobox 20.203
Hdac2histone deacetylase 20.203
Kcnt1potassium channel, subfamily T, member 10.200
Jak1Janus kinase 10.195
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.193
Arf6ADP-ribosylation factor 60.192
Gse1genetic suppressor element 10.190
Sf1splicing factor 10.189
Ascl1achaete-scute complex homolog 1 (Drosophila)0.186
Plagl1pleiomorphic adenoma gene-like 10.185
Csrnp1cysteine-serine-rich nuclear protein 10.185
Klf6Kruppel-like factor 60.185
Barhl1BarH-like homeobox 10.183
St8sia2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.182
Hmgb1high mobility group box 10.182
Baiap2BAI1-associated protein 20.182
Sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.177
DbpD site of albumin promoter (albumin D-box) binding protein0.177
Eef2eukaryotic translation elongation factor 20.176
Ptmaprothymosin alpha0.175
Slc12a1solute carrier family 12 (sodium/potassium/chloride transporters), member 10.171
Ptges3prostaglandin E synthase 3 (cytosolic)0.170
Dctn4dynactin 40.169
Zfp36l2zinc finger protein 36, C3H type-like 20.168
Kcnh1potassium voltage-gated channel, subfamily H (eag-related), member 10.167
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.167
Usf2upstream transcription factor 2, c-fos interacting0.167
Irs3insulin receptor substrate 30.167
Atp6v1g3ATPase, H+ transporting, lysosomal V1 subunit G30.166
Anp32eacidic (leucine-rich) nuclear phosphoprotein 32 family, member E0.166
Nr1d2nuclear receptor subfamily 1, group D, member 20.165
Znf76zinc finger protein 76 (expressed in testis)0.162
Klf9Kruppel-like factor 90.161
Ptpn1protein tyrosine phosphatase, non-receptor type 10.161
Slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.159
Ubtfupstream binding transcription factor, RNA polymerase I0.157
Rnps1ribonucleic acid binding protein S10.157
Actr3ARP3 actin-related protein 3 homolog (yeast)0.156
Dcaf15DDB1 and CUL4 associated factor 150.156
Cd40lgCD40 ligand0.156
Ppp2cbprotein phosphatase 2, catalytic subunit, beta isoform0.155