The network for 'macromolecule deacylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

macromolecule deacylation

The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a macromolecule.

NameDescriptionProbabilityFunc Analog Organism
SIN3Sin3p0.993
HOS2Hos2p0.928
SNT1Snt1p0.916
SIF2Sif2p0.887
RCO1Rco1p0.882
SET3Set3p0.842
SET2Set2p0.824
HDA2Hda2p0.735
HOS4Hos4p0.670
UME1Ume1p0.640
HDA1Hda1p0.636
RPD3Rpd3p0.521
CTI6Cti6p0.407
CPR1Cpr1p0.287
SDS3Sds3p0.257
HST1Hst1p0.222
SUM1Sum1p0.198
WWM1Wwm1p0.197
IRC8Irc8p0.146
HDA3Hda3p0.142
YML079Whypothetical protein0.141
ZDS1Zds1p0.112
PHO80Pho80p0.103
UME6Ume6p0.098
CDC4Cdc4p0.090
IZH4Izh4p0.083
PHO23Pho23p0.077
MMS1Mms1p0.064
ASH1Ash1p0.061
YCL021W-Ahypothetical protein0.056
SWR1Swr1p0.053
SSK1Ssk1p0.050
TOF2Tof2p0.049
BDF1Bdf1p0.049
UBX2Ubx2p0.043
CNB1Cnb1p0.042
GZF3Gzf3p0.041
SIR3Sir3p0.040
DOT5Dot5p0.039
HOT1Hot1p0.036
YPL014Whypothetical protein0.036
EST2Est2p0.033
AMD1Amd1p0.033
HHO1Hho1p0.032
COF1Cof1p0.032
MTR10Mtr10p0.031
HST3Hst3p0.031
OPT2Opt2p0.031
SRD1Srd1p0.030
DOT6Dot6p0.030
YLR264C-Ahypothetical protein0.028
TAX4Tax4p0.028
CAM1Cam1p0.028
IZH3Izh3p0.027
RXT3Rxt3p0.027
SET1Set1p0.027
YMR259Chypothetical protein0.027
YLR162Whypothetical protein0.027
YBL029Whypothetical protein0.027
YOL038C-Ahypothetical protein0.027
YLR278Chypothetical protein0.026
MDS3Mds3p0.025
LEU2Leu2p0.025
SRS2Srs2p0.025
SOD1Sod1p0.024
ATP1Atp1p0.024
URA3Ura3p0.023
YAR068Whypothetical protein0.023
OPI1Opi1p0.023
RRN5Rrn5p0.022
MER1Mer1p0.022
OSH3Osh3p0.022
CCT2Cct2p0.021
GLN4Gln4p0.021
ARP4Arp4p0.021
UBP1Ubp1p0.021
CPR5Cpr5p0.021
YJL181Whypothetical protein0.021
UBP8Ubp8p0.021
EPL1Epl1p0.021
SAE2Sae2p0.021
ARG8Arg8p0.020
SPL2Spl2p0.020
PUF2Puf2p0.020
FMT1Fmt1p0.020
PRI1Pri1p0.019
PRS2Prs2p0.019
SWM2Swm2p0.019
ACP1Acp1p0.019
OAF1Oaf1p0.019
CUP1-1Cup1-1p0.019
SWC3Swc3p0.019
GAL7Gal7p0.019
TIP1Tip1p0.019
AQR1Aqr1p0.018
RNR2Rnr2p0.018
YBR013Chypothetical protein0.018
PZF1Pzf1p0.018
YLR363W-Ahypothetical protein0.018
YAR066Whypothetical protein0.018
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
rargaretinoic acid receptor gamma a0.118
mibmind bomb0.104
pbx4pre-B-cell leukemia transcription factor 40.092
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.082
tcf12transcription factor 120.075
rereaarginine-glutamic acid dipeptide (RE) repeats a0.051
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.049
axin2axin 2 (conductin, axil)0.039
wu:fv91b12wu:fv91b120.038
ripply1ripply10.036
wnt5bwingless-type MMTV integration site family, member 5b0.035
crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.034
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.034
dzip1DAZ interacting protein 10.033
cart1cartilage paired-class homeoprotein 10.032
rbfox2RNA binding protein, fox-1 homolog (C. elegans) 20.029
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.027
lamb1alaminin, beta 1a0.027
lama1laminin, alpha 10.026
ctnnb1catenin (cadherin-associated protein), beta 10.024
znf703zinc finger protein 7030.023
skianuclear oncoprotein skia0.023
slit2slit (Drosophila) homolog 20.022
csf1racolony stimulating factor 1 receptor, a0.021
inka1ainduced in neural crest by AP2, 1a0.021
ptprsaprotein tyrosine phosphatase, receptor type, s, a0.020
hsp47heat shock protein 470.020
ier5limmediate early response 5-like0.020
zgc:123177zgc:1231770.019
efna5aephrin A5a0.019
tcf7transcription factor 7 (T-cell specific, HMG-box)0.019
tomm40ltranslocase of outer mitochondrial membrane 40 homolog, like0.019
tfebtranscription factor EB0.019
arl8baADP-ribosylation factor-like 8Ba0.019
foxi2forkhead box I20.019
ptpraprotein tyrosine phosphatase, receptor type, A0.018
lmx1b.1LIM homeobox transcription factor 1, beta 10.018
dram2DNA-damage regulated autophagy modulator 20.018
cnn2calponin 20.018
dpp3dipeptidylpeptidase 30.018
dab2ipDAB2 interacting protein0.018
zgc:158605zgc:1586050.018
LOC321521peptidyl-prolyl cis-trans isomerase D-like0.017
eya2eyes absent homolog 2 (Drosophila)0.017
gli2aGLI-Kruppel family member GLI2a0.017
mknk2bMAP kinase-interacting serine/threonine kinase 2b0.017
extl3exostoses (multiple)-like 30.017
ndufs8aNADH dehydrogenase (ubiquinone) Fe-S protein 8a0.017
prkciprotein kinase C, iota0.017
zgc:77929zgc:779290.016
terttelomerase reverse transcriptase0.016
gle1GLE1 RNA export mediator homolog (yeast)0.016
sox9aSRY-box containing gene 9a0.016
lmo4aLIM domain only 4a0.016
gbgt1l1globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 10.016
zgc:63587zgc:635870.016
spry2sprouty homolog 20.016
ogt.1O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 10.016
wdr45WD repeat domain 450.016
epb41l5erythrocyte membrane protein band 4.1 like 50.016
twist1atwist1a0.015
zgc:77155zgc:771550.015
disp1dispatched homolog 1 (Drosophila)0.015
tmem144btransmembrane protein 144b0.015
cpvlcarboxypeptidase, vitellogenic-like0.015
usp14ubiquitin specific protease 14 (tRNA-guanine transglycosylase)0.015
LOC100536021spectrin beta chain, brain 1-like0.015
tfe3atranscription factor binding to IGHM enhancer 3a0.015
hdac9bhistone deacetylase 9b0.015
plag1pleiomorphic adenoma gene 10.015
rnd1lRho family GTPase 1 like0.015
zgc:77262zgc:772620.015
sephs1selenophosphate synthetase 10.015
ech1enoyl CoA hydratase 1, peroxisomal0.015
myh11amyosin, heavy polypeptide 11, smooth muscle a0.015
gpc4glypican 40.015
gsk3bglycogen synthase kinase 3 beta0.015
bonbonnie and clyde0.015
pspc1paraspeckle component 10.014
zgc:66449zgc:664490.014
zgc:158603zgc:1586030.014
tubgcp2tubulin, gamma complex associated protein 20.014
smad7MAD, mothers against decapentaplegic homolog 7 (Drosophila)0.014
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)0.014
snx6sorting nexin 60.014
zgc:103471zgc:1034710.014
fzd9bfrizzled homolog 9b0.014
fasFas (TNF receptor superfamily, member 6)0.014
smc3structural maintenance of chromosomes 30.014
alx4aaristaless-like homeobox 4a0.014
zgc:77396zgc:773960.014
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.014
zgc:103481zgc:1034810.014
supt3hsuppressor of Ty 3 homolog (S. cerevisiae)0.014
ptrfbpolymerase I and transcript release factor b0.014
praf2PRA1 domain family, member 20.014
kptnkaptin (actin binding protein)0.014
cnn3acalponin 3, acidic a0.014
si:rp71-39b20.7si:rp71-39b20.70.014
chst11carbohydrate (chondroitin 4) sulfotransferase 110.014
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CtBPC-terminal Binding Protein0.477
argosCG4531 gene product from transcript CG4531-RA0.154
exexpanded0.135
snasnail0.081
Tip60CG6121 gene product from transcript CG6121-RA0.072
klgklingon0.069
Snr1Snf5-related 10.052
elBelbow B0.045
sosine oculis0.039
dcodiscs overgrown0.039
edechinoid0.037
Jarid2CG3654 gene product from transcript CG3654-RD0.030
Sir2CG5216 gene product from transcript CG5216-RA0.030
acachaete0.028
larkCG8597 gene product from transcript CG8597-RD0.027
Bx42CG8264 gene product from transcript CG8264-RA0.027
kek1kekkon-10.026
Taf1TBP-associated factor 10.025
CadNCadherin-N0.022
Deaf1Deformed epidermal autoregulatory factor-10.021
araaraucan0.021
cpxcomplexin0.020
Xbp1X box binding protein-10.020
pxbCG33207 gene product from transcript CG33207-RB0.020
CG11138CG11138 gene product from transcript CG11138-RC0.020
Rsf1Repressor splicing factor 10.020
CycKCyclin K0.019
Su(H)Suppressor of Hairless0.019
Akt1CG4006 gene product from transcript CG4006-RA0.018
DdcDopa decarboxylase0.018
eebony0.017
CG16972CG16972 gene product from transcript CG16972-RA0.017
Dsor1Downstream of raf10.017
brmbrahma0.017
Gp150CG5820 gene product from transcript CG5820-RA0.017
S6kIIRPS6-protein kinase-II0.017
G-salpha60AG protein salpha 60A0.016
Applbeta amyloid protein precursor-like0.016
SsdpSequence-specific single-stranded DNA-binding protein0.015
alaristaless0.015
NrtNeurotactin0.014
CG10992CG10992 gene product from transcript CG10992-RA0.014
molmoladietz0.014
nvynervy0.014
14-3-3zetaCG17870 gene product from transcript CG17870-RB0.014
gcmglial cells missing0.014
morguemodifier of rpr and grim, ubiquitously expressed0.013
notnon-stop0.013
tantantalus0.013
ksrkinase suppressor of ras0.012
grogroucho0.012
pnrpannier0.012
dmtdalmatian0.012
waplwings apart-like0.012
MadMothers against dpp0.012
neurneuralized0.012
CG42709CG42709 gene product from transcript CG42709-RC0.012
His2AvHistone H2A variant0.012
ktokohtalo0.012
mirrmirror0.011
sevsevenless0.011
NrgNeuroglian0.011
dwgdeformed wings0.011
Nrx-1Neurexin 10.010
netCG11450 gene product from transcript CG11450-RB0.010
dawdawdle0.010
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HDAC1histone deacetylase 11.000
SIN3ASIN3 homolog A, transcription regulator (yeast)0.997
HDAC2histone deacetylase 20.995
NCOR2nuclear receptor corepressor 20.914
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.891
KDM1Alysine (K)-specific demethylase 1A0.789
TGIF1TGFB-induced factor homeobox 10.760
RBBP4retinoblastoma binding protein 40.663
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.607
ATF2activating transcription factor 20.554
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.499
HIPK2homeodomain interacting protein kinase 20.468
IRF2BP1interferon regulatory factor 2 binding protein 10.442
TP53tumor protein p530.397
NRP1neuropilin 10.369
RB1retinoblastoma 10.363
MRFAP1Morf4 family associated protein 10.351
CHD4chromodomain helicase DNA binding protein 40.229
MAPK14mitogen-activated protein kinase 140.226
MAP2K4mitogen-activated protein kinase kinase 40.223
ENGendoglin0.211
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 10.202
HDAC9histone deacetylase 90.194
BRMS1breast cancer metastasis suppressor 10.185
HDAC4histone deacetylase 40.181
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.172
BCL6B-cell CLL/lymphoma 60.169
MTA3metastasis associated 1 family, member 30.164
HDAC6histone deacetylase 60.154
SUDS3suppressor of defective silencing 3 homolog (S. cerevisiae)0.143
JUNjun proto-oncogene0.139
TBL1XR1transducin (beta)-like 1 X-linked receptor 10.132
RCOR1REST corepressor 10.116
CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae)0.114
CDC5LCDC5 cell division cycle 5-like (S. pombe)0.108
CREBBPCREB binding protein0.105
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.105
MAP3K1mitogen-activated protein kinase kinase kinase 10.101
MEF2Cmyocyte enhancer factor 2C0.094
ARRB1arrestin, beta 10.092
CSNK1Ecasein kinase 1, epsilon0.092
EP300E1A binding protein p3000.087
NCOR1nuclear receptor corepressor 10.086
MTA1metastasis associated 10.084
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.084
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.083
CUX1cut-like homeobox 10.083
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.080
IKZF3IKAROS family zinc finger 3 (Aiolos)0.076
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.076
ADRBK1adrenergic, beta, receptor kinase 10.075
RBBP7retinoblastoma binding protein 70.068
C16orf70chromosome 16 open reading frame 700.060
CEP70centrosomal protein 70kDa0.059
SMAD4SMAD family member 40.056
ESR1estrogen receptor 10.055
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.051
SIRT3sirtuin 30.050
KAT2BK(lysine) acetyltransferase 2B0.049
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)0.049
GATAD2AGATA zinc finger domain containing 2A0.048
SETD7SET domain containing (lysine methyltransferase) 70.046
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.044
MDM4Mdm4 p53 binding protein homolog (mouse)0.043
KIAA0182KIAA01820.043
CUL7cullin 70.042
HDAC3histone deacetylase 30.042
VIMvimentin0.041
SNAI1snail homolog 1 (Drosophila)0.041
HDAC7histone deacetylase 70.040
GATAD2BGATA zinc finger domain containing 2B0.039
HCFC1host cell factor C1 (VP16-accessory protein)0.039
SIRT1sirtuin 10.039
CPNE6copine VI (neuronal)0.038
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.038
MPRIPmyosin phosphatase Rho interacting protein0.037
PDGFAplatelet-derived growth factor alpha polypeptide0.037
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.035
MAPK8mitogen-activated protein kinase 80.035
SAP30Sin3A-associated protein, 30kDa0.034
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.032
NONOnon-POU domain containing, octamer-binding0.031
DUSP1dual specificity phosphatase 10.030
TSC22D1TSC22 domain family, member 10.030
HES1hairy and enhancer of split 1, (Drosophila)0.030
PTPRBprotein tyrosine phosphatase, receptor type, B0.030
MYST1MYST histone acetyltransferase 10.030
DYRK1Bdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B0.030
BBS10Bardet-Biedl syndrome 100.029
ARID2AT rich interactive domain 2 (ARID, RFX-like)0.029
CHD3chromodomain helicase DNA binding protein 30.029
YY1YY1 transcription factor0.028
HDAC5histone deacetylase 50.028
SIRT5sirtuin 50.027
DCAF7DDB1 and CUL4 associated factor 70.027
MED15mediator complex subunit 150.027
GNAQguanine nucleotide binding protein (G protein), q polypeptide0.026
BAZ2Bbromodomain adjacent to zinc finger domain, 2B0.026
OGTO-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)0.026
TRIM28tripartite motif containing 280.026
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Sin3atranscriptional regulator, SIN3A (yeast)0.996
Hdac1histone deacetylase 10.986
Mef2dmyocyte enhancer factor 2D0.981
Arid1aAT rich interactive domain 1A (SWI-like)0.976
Sall4sal-like 4 (Drosophila)0.915
SkilSKI-like0.911
NanogNanog homeobox0.893
JunJun oncogene0.832
Sox2SRY-box containing gene 20.787
Suds3suppressor of defective silencing 3 homolog (S. cerevisiae)0.724
Hdac2histone deacetylase 20.713
Pou5f1POU domain, class 5, transcription factor 10.573
Mta1metastasis associated 10.555
Trp53transformation related protein 530.500
Cry2cryptochrome 2 (photolyase-like)0.482
Zeb1zinc finger E-box binding homeobox 10.470
Mta2metastasis-associated gene family, member 20.457
Nacc1nucleus accumbens associated 1, BEN and BTB (POZ) domain containing0.418
Cry1cryptochrome 1 (photolyase-like)0.411
Clockcircadian locomotor output cycles kaput0.340
Yy1YY1 transcription factor0.331
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.327
Vaspvasodilator-stimulated phosphoprotein0.320
Thrathyroid hormone receptor alpha0.274
Rxraretinoid X receptor alpha0.271
EvlEna-vasodilator stimulated phosphoprotein0.265
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.257
Ncor1nuclear receptor co-repressor 10.249
Chd4chromodomain helicase DNA binding protein 40.230
Hdac5histone deacetylase 50.222
Nr4a1nuclear receptor subfamily 4, group A, member 10.220
Enahenabled homolog (Drosophila)0.212
Ncor2nuclear receptor co-repressor 20.202
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.196
Nr0b1nuclear receptor subfamily 0, group B, member 10.196
Kdm5blysine (K)-specific demethylase 5B0.189
Csnk1ecasein kinase 1, epsilon0.173
Smarcd1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.173
Cyr61cysteine rich protein 610.152
Runx1runt related transcription factor 10.147
Plin1perilipin 10.143
Arid1bAT rich interactive domain 1B (SWI-like)0.141
Ppargperoxisome proliferator activated receptor gamma0.141
Arntlaryl hydrocarbon receptor nuclear translocator-like0.136
Ptenphosphatase and tensin homolog0.135
Wfikkn2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.134
Smad7MAD homolog 7 (Drosophila)0.127
Rnf2ring finger protein 20.125
Cyldcylindromatosis (turban tumor syndrome)0.125
Map3k8mitogen-activated protein kinase kinase kinase 80.124
Mdm4transformed mouse 3T3 cell double minute 40.116
Trp63transformation related protein 630.115
Per2period homolog 2 (Drosophila)0.113
Casp8caspase 80.112
Bptfbromodomain PHD finger transcription factor0.111
Mll1myeloid/lymphoid or mixed-lineage leukemia 10.104
Rb1retinoblastoma 10.104
Dusp1dual specificity phosphatase 10.102
5430411K18RikRIKEN cDNA 5430411K18 gene0.101
Csrp2bpcysteine and glycine-rich protein 2 binding protein0.099
Mdm2transformed mouse 3T3 cell double minute 20.098
Maffv-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)0.098
Sall1sal-like 1 (Drosophila)0.097
Gatad2aGATA zinc finger domain containing 2A0.096
Atf3activating transcription factor 30.095
Srfserum response factor0.094
Rnf44ring finger protein 440.094
Yeats2YEATS domain containing 20.092
DaxxFas death domain-associated protein0.091
Jarid2jumonji, AT rich interactive domain 20.088
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.087
Zfp362zinc finger protein 3620.084
Sin3btranscriptional regulator, SIN3B (yeast)0.081
Usp2ubiquitin specific peptidase 20.080
FosFBJ osteosarcoma oncogene0.079
Sfnstratifin0.078
Rbbp4retinoblastoma binding protein 40.078
Map3k7mitogen-activated protein kinase kinase kinase 70.078
Sntb2syntrophin, basic 20.077
WwoxWW domain-containing oxidoreductase0.077
Itga5integrin alpha 5 (fibronectin receptor alpha)0.077
Tnfaip3tumor necrosis factor, alpha-induced protein 30.077
Kdm2blysine (K)-specific demethylase 2B0.076
Smarca2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.076
Mll3myeloid/lymphoid or mixed-lineage leukemia 30.075
Tnftumor necrosis factor0.075
Nr4a2nuclear receptor subfamily 4, group A, member 20.073
Itchitchy, E3 ubiquitin protein ligase0.072
Ets1E26 avian leukemia oncogene 1, 5' domain0.070
Huwe1HECT, UBA and WWE domain containing 10.068
Serpine1serine (or cysteine) peptidase inhibitor, clade E, member 10.068
Hdac4histone deacetylase 40.068
Spry4sprouty homolog 4 (Drosophila)0.065
Adamts1a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10.065
Suz12suppressor of zeste 12 homolog (Drosophila)0.064
Rararetinoic acid receptor, alpha0.064
Hcfc1host cell factor C10.062
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.062
Plaurplasminogen activator, urokinase receptor0.062
Gli3GLI-Kruppel family member GLI30.061
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism