The network for 'adenylate cyclase activating g protein coupled receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

adenylate cyclase activating g protein coupled receptor signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Atf-2Activating transcription factor-20.239
ShawShaker cognate w0.220
CG13253CG13253 gene product from transcript CG13253-RB0.133
RanBPMRan-binding protein M0.106
CG42629CG42629 gene product from transcript CG42629-RB0.095
CG34400CG34400 gene product from transcript CG34400-RD0.082
Nmdar1NMDA receptor 10.053
CG18437CG18437 gene product from transcript CG18437-RB0.048
Nhe2Na[+]/H[+] hydrogen exchanger 20.046
drkdownstream of receptor kinase0.042
Gyc76CGuanylyl cyclase at 76C0.042
CG14989CG14989 gene product from transcript CG14989-RB0.041
Socs36ESuppressor of cytokine signaling at 36E0.039
unc79CG5237 gene product from transcript CG5237-RB0.035
norpAno receptor potential A0.033
CG15088CG15088 gene product from transcript CG15088-RC0.032
oa2octopamine receptor 20.032
PIP5K59BCG3682 gene product from transcript CG3682-RE0.031
Ef1alpha48DElongation factor 1alpha48D0.026
CG13579CG13579 gene product from transcript CG13579-RA0.026
fd85Eforkhead domain 85E0.026
Pdp1PAR-domain protein 10.025
TbhTyramine beta hydroxylase0.024
CG11317CG11317 gene product from transcript CG11317-RA0.022
Eaat2Excitatory amino acid transporter 20.022
dpr5CG5308 gene product from transcript CG5308-RA0.021
dnr1defense repressor 10.019
Gr8aGustatory receptor 8a0.018
cnglCNG channel-like0.018
Vsx2CG33980 gene product from transcript CG33980-RA0.017
CG34353CG34353 gene product from transcript CG34353-RA0.017
Ir76bIonotropic receptor 76b0.016
5-HT1BSerotonin receptor 1B0.016
DatDopamine N acetyltransferase0.016
Pde8Phosphodiesterase 80.015
Octbeta2RCG33976 gene product from transcript CG33976-RA0.015
CanA1Calcineurin A10.015
Gr28bGustatory receptor 28b0.015
5-HT1ASerotonin receptor 1A0.014
CG14340CG14340 gene product from transcript CG14340-RA0.013
NPFR1neuropeptide F receptor0.013
CG3009CG3009 gene product from transcript CG3009-RA0.013
CG12239CG12239 gene product from transcript CG12239-RA0.013
CCKLR-17D1CCK-like receptor at 17D10.012
CG34139CG34139 gene product from transcript CG34139-RD0.012
CorinCG2105 gene product from transcript CG2105-RB0.012
RicRas which interacts with Calmodulin0.012
2mitCG42573 gene product from transcript CG42573-RA0.012
stetstem cell tumor0.012
Pp2B-14DProtein phosphatase 2B at 14D0.012
beat-VbCG31298 gene product from transcript CG31298-RA0.011
l(3)82FdCG32464 gene product from transcript CG32464-RR0.011
jebjelly belly0.011
Ilp3Insulin-like peptide 30.011
CrebB-17ACyclic-AMP response element binding protein B at 17A0.011
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CALM1calmodulin 1 (phosphorylase kinase, delta)1.000
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.992
RALAv-ral simian leukemia viral oncogene homolog A (ras related)0.960
ARRB1arrestin, beta 10.928
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 10.852
RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.832
MPDZmultiple PDZ domain protein0.810
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.781
PTGIRprostaglandin I2 (prostacyclin) receptor (IP)0.771
TBXA2Rthromboxane A2 receptor0.764
CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.692
RAP1ARAP1A, member of RAS oncogene family0.686
NEDD4neural precursor cell expressed, developmentally down-regulated 40.630
CRHcorticotropin releasing hormone0.630
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.569
CDV3CDV3 homolog (mouse)0.506
ROD1ROD1 regulator of differentiation 1 (S. pombe)0.480
GNAI3guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 30.463
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.461
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.413
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.409
PTENphosphatase and tensin homolog0.370
ADORA2Aadenosine A2a receptor0.337
RIN1Ras and Rab interactor 10.333
NUCB1nucleobindin 10.331
RALBP1ralA binding protein 10.313
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.282
KCNJ5potassium inwardly-rectifying channel, subfamily J, member 50.265
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.230
MEOX2mesenchyme homeobox 20.229
NAMPTnicotinamide phosphoribosyltransferase0.227
KCNH1potassium voltage-gated channel, subfamily H (eag-related), member 10.226
BZW1basic leucine zipper and W2 domains 10.218
NECAB2N-terminal EF-hand calcium binding protein 20.199
GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)0.190
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.186
RALGDSral guanine nucleotide dissociation stimulator0.173
ADRB2adrenergic, beta-2-, receptor, surface0.169
STK4serine/threonine kinase 40.156
CXCR5chemokine (C-X-C motif) receptor 50.151
DRD2dopamine receptor D20.132
CALCRcalcitonin receptor0.132
ADRA1Dadrenergic, alpha-1D-, receptor0.125
DR1down-regulator of transcription 1, TBP-binding (negative cofactor 2)0.114
SLC9A3R2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.111
ARRDC3arrestin domain containing 30.111
GMFBglia maturation factor, beta0.110
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.098
NRASneuroblastoma RAS viral (v-ras) oncogene homolog0.097
CALCAcalcitonin-related polypeptide alpha0.091
HTR45-hydroxytryptamine (serotonin) receptor 40.091
ADORA1adenosine A1 receptor0.083
SLC9A3solute carrier family 9 (sodium/hydrogen exchanger), member 30.081
PTGER3prostaglandin E receptor 3 (subtype EP3)0.078
GHRHRgrowth hormone releasing hormone receptor0.078
FKBP8FK506 binding protein 8, 38kDa0.078
DRD1dopamine receptor D10.069
OPRM1opioid receptor, mu 10.068
TMOD3tropomodulin 3 (ubiquitous)0.067
RAB8BRAB8B, member RAS oncogene family0.065
TSHRthyroid stimulating hormone receptor0.064
FGF8fibroblast growth factor 8 (androgen-induced)0.064
GNG2guanine nucleotide binding protein (G protein), gamma 20.063
CP110CP110 protein0.062
ACTR3ARP3 actin-related protein 3 homolog (yeast)0.062
ADRB3adrenergic, beta-3-, receptor0.062
HTR1A5-hydroxytryptamine (serotonin) receptor 1A0.058
KIF5Bkinesin family member 5B0.058
OPRD1opioid receptor, delta 10.058
PAX3paired box 30.057
MAPK10mitogen-activated protein kinase 100.053
GHRLghrelin/obestatin prepropeptide0.052
CEND1cell cycle exit and neuronal differentiation 10.051
RAMP3receptor (G protein-coupled) activity modifying protein 30.048
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.048
SCYL2SCY1-like 2 (S. cerevisiae)0.047
SCTRsecretin receptor0.046
SLC6A7solute carrier family 6 (neurotransmitter transporter, L-proline), member 70.046
SLC2A4solute carrier family 2 (facilitated glucose transporter), member 40.044
RASSF5Ras association (RalGDS/AF-6) domain family member 50.043
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.042
SLC22A7solute carrier family 22 (organic anion transporter), member 70.041
CCKBRcholecystokinin B receptor0.041
CHRNA4cholinergic receptor, nicotinic, alpha 40.041
RASGRF1Ras protein-specific guanine nucleotide-releasing factor 10.039
YY1YY1 transcription factor0.039
PDZD3PDZ domain containing 30.038
CRHR2corticotropin releasing hormone receptor 20.037
ACTR2ARP2 actin-related protein 2 homolog (yeast)0.036
RAB10RAB10, member RAS oncogene family0.036
GFAPglial fibrillary acidic protein0.036
GRIN1glutamate receptor, ionotropic, N-methyl D-aspartate 10.035
ACTN4actinin, alpha 40.034
PDZK1PDZ domain containing 10.033
BCRbreakpoint cluster region0.032
GABRG2gamma-aminobutyric acid (GABA) A receptor, gamma 20.030
KCND3potassium voltage-gated channel, Shal-related subfamily, member 30.030
PPP3R1protein phosphatase 3, regulatory subunit B, alpha0.030
ADAMTS7ADAM metallopeptidase with thrombospondin type 1 motif, 70.030
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Esr1estrogen receptor 1 (alpha)0.997
Drd2dopamine receptor D20.994
Slc34a1solute carrier family 34 (sodium phosphate), member 10.963
Cckbrcholecystokinin B receptor0.958
Pgrprogesterone receptor0.922
Kcnd1potassium voltage-gated channel, Shal-related family, member 10.916
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.882
Adrb1adrenergic receptor, beta 10.838
Sstr1somatostatin receptor 10.836
Kcna4potassium voltage-gated channel, shaker-related subfamily, member 40.794
Arandrogen receptor0.794
Thrbthyroid hormone receptor beta0.743
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.694
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.682
Lhcgrluteinizing hormone/choriogonadotropin receptor0.675
Sstr4somatostatin receptor 40.669
Nos1nitric oxide synthase 1, neuronal0.640
Kiss1KiSS-1 metastasis-suppressor0.613
Oprk1opioid receptor, kappa 10.606
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.571
Adra1aadrenergic receptor, alpha 1a0.561
Adora2aadenosine A2a receptor0.548
Dlg4discs, large homolog 4 (Drosophila)0.545
Npy2rneuropeptide Y receptor Y20.538
Cgaglycoprotein hormones, alpha subunit0.494
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.478
Adra2aadrenergic receptor, alpha 2a0.459
Oprm1opioid receptor, mu 10.448
Esr2estrogen receptor 2 (beta)0.425
Tac2tachykinin 20.424
Npy5rneuropeptide Y receptor Y50.411
Grin2aglutamate receptor, ionotropic, NMDA2A (epsilon 1)0.402
Prlrprolactin receptor0.388
Pnpla2patatin-like phospholipase domain containing 20.387
Gabrg3gamma-aminobutyric acid (GABA) A receptor, subunit gamma 30.377
Has1hyaluronan synthase10.368
Npy1rneuropeptide Y receptor Y10.365
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.363
Kcnb1potassium voltage gated channel, Shab-related subfamily, member 10.363
Crhr1corticotropin releasing hormone receptor 10.345
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.341
Duox2dual oxidase 20.337
Gnrhrgonadotropin releasing hormone receptor0.333
Adra2badrenergic receptor, alpha 2b0.327
S1pr2sphingosine-1-phosphate receptor 20.320
Rgs9regulator of G-protein signaling 90.319
Wnt2bwingless related MMTV integration site 2b0.304
Tpothyroid peroxidase0.298
Sncbsynuclein, beta0.298
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.296
Kcns2K+ voltage-gated channel, subfamily S, 20.295
Sstr2somatostatin receptor 20.292
Fshrfollicle stimulating hormone receptor0.286
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.276
Ikzf4IKAROS family zinc finger 40.276
Trhthyrotropin releasing hormone0.274
Cnr1cannabinoid receptor 1 (brain)0.274
Cdkn1bcyclin-dependent kinase inhibitor 1B0.269
Ccbp2chemokine binding protein 20.267
Shc3src homology 2 domain-containing transforming protein C30.259
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.258
Nr3c1nuclear receptor subfamily 3, group C, member 10.249
Avparginine vasopressin0.247
Ghrgrowth hormone receptor0.245
Lhx3LIM homeobox protein 30.244
Gpr12G-protein coupled receptor 120.244
Nos3nitric oxide synthase 3, endothelial cell0.236
Slc12a5solute carrier family 12, member 50.227
Plcb1phospholipase C, beta 10.223
Htr75-hydroxytryptamine (serotonin) receptor 70.212
Fshbfollicle stimulating hormone beta0.211
FosbFBJ osteosarcoma oncogene B0.209
Mc5rmelanocortin 5 receptor0.209
Gpr83G protein-coupled receptor 830.207
Cntn3contactin 30.205
Kcnh1potassium voltage-gated channel, subfamily H (eag-related), member 10.192
Cntn4contactin 40.189
Slc9a3r2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.183
Chrm1cholinergic receptor, muscarinic 1, CNS0.178
Cox8ccytochrome c oxidase, subunit VIIIc0.177
Nhedc2Na+/H+ exchanger domain containing 20.173
Htr45 hydroxytryptamine (serotonin) receptor 40.172
Gng4guanine nucleotide binding protein (G protein), gamma 40.171
Syn2synapsin II0.169
Ptgirprostaglandin I receptor (IP)0.169
Atp4aATPase, H+/K+ exchanging, gastric, alpha polypeptide0.166
Tacr1tachykinin receptor 10.165
Foxf2forkhead box F20.164
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.160
Plxna1plexin A10.159
Ptprnprotein tyrosine phosphatase, receptor type, N0.157
Pdgfbplatelet derived growth factor, B polypeptide0.152
Nptx1neuronal pentraxin 10.152
Neurog3neurogenin 30.152
Slc5a5solute carrier family 5 (sodium iodide symporter), member 50.152
Fam164cfamily with sequence similarity 164, member C0.152
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.887
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.507
Olr416olfactory receptor 4160.411
Ncr1natural cytotoxicity triggering receptor 10.320
Htr75-hydroxytryptamine (serotonin) receptor 70.247
Folh1folate hydrolase 10.220
Olr287olfactory receptor 2870.199
Cckbrcholecystokinin B receptor0.193
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.176
Slc14a2solute carrier family 14 (urea transporter), member 20.175
Syt8synaptotagmin VIII0.166
Ntrk1neurotrophic tyrosine kinase, receptor, type 10.153
Glp1rglucagon-like peptide 1 receptor0.152
Csrnp2cysteine-serine-rich nuclear protein 20.148
RGD1564664similar to LOC387763 protein0.137
Fgf14fibroblast growth factor 140.133
Drd2dopamine receptor D20.123
Klhl14kelch-like 14 (Drosophila)0.122
Avparginine vasopressin0.121
Adora2aadenosine A2a receptor0.119
Adora1adenosine A1 receptor0.115
Aqp2aquaporin 2 (collecting duct)0.114
Phkg1phosphorylase kinase, gamma 10.113
Cckarcholecystokinin A receptor0.113
Clstn3calsyntenin 30.105
Fgf2fibroblast growth factor 20.096
Odf4outer dense fiber of sperm tails 40.082
Sstr5somatostatin receptor 50.082
Gpr6G protein-coupled receptor 60.081
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.081
Avpr1barginine vasopressin receptor 1B0.080
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.080
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.078
Eporerythropoietin receptor0.077
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.077
Scn10asodium channel, voltage-gated, type X, alpha subunit0.075
Rgs9regulator of G-protein signaling 90.075
Chrna7cholinergic receptor, nicotinic, alpha 70.075
Plauplasminogen activator, urokinase0.075
Hrh3histamine receptor H30.074
Ptger2prostaglandin E receptor 2 (subtype EP2)0.073
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.072
Fgf10fibroblast growth factor 100.072
Drd1adopamine receptor D1A0.070
Csf1colony stimulating factor 1 (macrophage)0.069
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.067
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.066
Cx3cr1chemokine (C-X3-C motif) receptor 10.066
Gfra2GDNF family receptor alpha 20.065
Uhmk1U2AF homology motif (UHM) kinase 10.064
Dccdeleted in colorectal carcinoma0.062
Gad1glutamate decarboxylase 10.061
Cdc34cell division cycle 34 homolog (S. cerevisiae)0.061
Ptp4a2protein tyrosine phosphatase 4a20.060
Cxcr5chemokine (C-X-C motif) receptor 50.060
Cfpcomplement factor properdin0.059
Apba1amyloid beta (A4) precursor protein-binding, family A, member 10.059
Calcacalcitonin-related polypeptide alpha0.058
Chrna4cholinergic receptor, nicotinic, alpha 40.058
Shank2SH3 and multiple ankyrin repeat domains 20.056
Adora3adenosine A3 receptor0.056
Tpsb2tryptase beta 20.056
Ccbp2chemokine binding protein 20.056
Oxtroxytocin receptor0.056
Gpr88G-protein coupled receptor 880.056
Chrm4cholinergic receptor, muscarinic 40.055
Gpr1G protein-coupled receptor 10.053
Olr226olfactory receptor 2260.052
Tbxa2rthromboxane A2 receptor0.051
Cyp21a1cytochrome P450, family 21, subfamily a, polypeptide 10.051
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.051
Nf2neurofibromin 2 (merlin)0.051
Olr1078olfactory receptor 10780.050
Accn2amiloride-sensitive cation channel 2, neuronal0.050
Il9rinterleukin 9 receptor0.050
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.050
Oprd1opioid receptor, delta 10.050
Prp15proline-rich protein 150.048
RGD1310262hypothetical LOC3046500.048
Gzmkgranzyme K0.047
Cd79bCd79b molecule, immunoglobulin-associated beta0.047
Grin3aglutamate receptor, ionotropic, N-methyl-D-aspartate 3A0.047
P2rx1purinergic receptor P2X, ligand-gated ion channel, 10.047
Grprgastrin releasing peptide receptor0.045
Kcna3potassium voltage-gated channel, shaker-related subfamily, member 30.045
Cgaglycoprotein hormones, alpha polypeptide0.045
Klrb1akiller cell lectin-like receptor subfamily B, member 1A0.045
Trhr2thyrotropin releasing hormone receptor 20.044
Scn4asodium channel, voltage-gated, type IV, alpha subunit0.044
Adra1aadrenergic, alpha-1A-, receptor0.044
Testintestin gene0.043
Kcnj15potassium inwardly-rectifying channel, subfamily J, member 150.042
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.042
Calcrcalcitonin receptor0.041