The network for 'response to lead ion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to lead ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
GSTM2glutathione S-transferase mu 2 (muscle)0.142
BCL2B-cell CLL/lymphoma 20.097
EZH2enhancer of zeste homolog 2 (Drosophila)0.059
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.051
NOSTRINnitric oxide synthase trafficker0.037
UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)0.035
UHRF1ubiquitin-like with PHD and ring finger domains 10.032
VAC14Vac14 homolog (S. cerevisiae)0.019
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.019
GSTM4glutathione S-transferase mu 40.017
BIKBCL2-interacting killer (apoptosis-inducing)0.013
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.013
SP1Sp1 transcription factor0.011
GASTgastrin0.010
ESR2estrogen receptor 2 (ER beta)0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cyp2c13cytochrome P450, family 2, subfamily c, polypeptide 130.417
LOC100134871beta globin minor gene0.376
Gstp1glutathione S-transferase pi 10.374
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.366
Ephx1epoxide hydrolase 1, microsomal0.277
Hbbhemoglobin, beta0.264
Gstm1glutathione S-transferase mu 10.254
Orm1orosomucoid 10.240
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.218
LOC100363106LRRG00130-like0.174
LOC100364265ribosomal protein L19-like0.136
LOC100359522LRRGT00191-like0.136
Cyp2d2cytochrome P450, family 2, subfamily d, polypeptide 20.120
Apoa2apolipoprotein A-II0.105
Mettl7bmethyltransferase like 7B0.101
Ahsgalpha-2-HS-glycoprotein0.092
Hmbshydroxymethylbilane synthase0.090
Fgafibrinogen alpha chain0.090
C9complement component 90.085
LOC689064beta-globin0.079
Qdprquinoid dihydropteridine reductase0.079
Gstm2glutathione S-transferase mu 20.077
Hpxhemopexin0.075
Gsta3glutathione S-transferase A30.074
Cyp4a10cytochrome P450, family 4, subfamily a, polypeptide 100.074
A1i3alpha-1-inhibitor III0.073
Pitx3paired-like homeodomain 30.071
Gcgroup specific component0.061
Hrh4histamine receptor H40.060
C3complement component 30.060
Pim1pim-1 oncogene0.059
Ppardperoxisome proliferator-activated receptor delta0.058
Apoeapolipoprotein E0.058
Tpt1tumor protein, translationally-controlled 10.057
Apoa5apolipoprotein A-V0.056
Agxt2alanine-glyoxylate aminotransferase 20.054
Spink3serine peptidase inhibitor, Kazal type 30.050
Trhrthyrotropin releasing hormone receptor0.050
Albalbumin0.048
Apcsamyloid P component, serum0.047
Il8rbinterleukin 8 receptor, beta0.046
Azgp1alpha-2-glycoprotein 1, zinc-binding0.045
Csf3colony stimulating factor 3 (granulocyte)0.044
LOC287167globin, alpha0.042
F9coagulation factor IX0.042
Aldh2aldehyde dehydrogenase 2 family (mitochondrial)0.040
Cyb5r3cytochrome b5 reductase 30.040
Cyp2c22cytochrome P450, family 2, subfamily c, polypeptide 220.039
Bcl2B-cell CLL/lymphoma 20.039
Tubb5tubulin, beta 50.037
Mpstmercaptopyruvate sulfurtransferase0.037
Slc22a7solute carrier family 22 (organic anion transporter), member 70.036
Spp2secreted phosphoprotein 20.035
Ttrtransthyretin0.035
Mcm6minichromosome maintenance complex component 60.035
S100bS100 calcium binding protein B0.034
Tstthiosulfate sulfurtransferase0.034
Hba-a2hemoglobin alpha, adult chain 20.033
Mgst1microsomal glutathione S-transferase 10.033
Prdx1peroxiredoxin 10.033
Cdc42bpbCDC42 binding protein kinase beta (DMPK-like)0.032
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.032
Cdk4cyclin-dependent kinase 40.031
Cyb5acytochrome b5 type A (microsomal)0.031
Olr226olfactory receptor 2260.031
Aqp9aquaporin 90.031
Csn1s2acasein alpha s2-like A0.030
Fn1fibronectin 10.030
Gucy2fguanylate cyclase 2F0.030
Hbb-b1hemoglobin, beta adult major chain0.029
Slc25a11solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 110.029
Ctsbcathepsin B0.028
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.028
Serpind1serpin peptidase inhibitor, clade D (heparin cofactor), member 10.028
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.028
Abcc6ATP-binding cassette, subfamily C (CFTR/MRP), member 60.027
Apex1APEX nuclease (multifunctional DNA repair enzyme) 10.027
Apohapolipoprotein H (beta-2-glycoprotein I)0.027
RGD1562618similar to RIKEN cDNA 6030419C18 gene0.027
Pecrperoxisomal trans-2-enoyl-CoA reductase0.027
Cyp4f1cytochrome P450, family 4, subfamily f, polypeptide 10.027
Sqstm1sequestosome 10.027
Anxa5annexin A50.027
RGD1306474similar to RIKEN cDNA 9530003J230.026
Slc22a1solute carrier family 22 (organic cation transporter), member 10.026
Gckrglucokinase (hexokinase 4) regulator0.026
Itih3inter-alpha trypsin inhibitor, heavy chain 30.026
Ambpalpha-1-microglobulin/bikunin precursor0.026
Foxe1forkhead box E1 (thyroid transcription factor 2)0.025
Rdh7retinol dehydrogenase 70.025
Mosc2MOCO sulphurase C-terminal domain containing 20.025
Hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.024
Fasnfatty acid synthase0.024
Slc13a2solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 20.024
Apoa1apolipoprotein A-I0.024
Nlrp6NLR family, pyrin domain containing 60.024
Hsd17b1hydroxysteroid (17-beta) dehydrogenase 10.024
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.023
Atp4bATPase, H+/K+ exchanging, beta polypeptide0.023
Fetubfetuin B0.023