The network for 'dna dependent dna replication maintenance of fidelity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dna dependent dna replication maintenance of fidelity

A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair.

NameDescriptionProbabilityFunc Analog Organism
MRC1Mrc1p0.721
RAD53Rad53p0.148
POL2Pol2p0.127
DPB11Dpb11p0.099
HRK1Hrk1p0.097
HSL1Hsl1p0.096
CTF4Ctf4p0.082
DIA2Dia2p0.075
PTK2Ptk2p0.071
PPZ1Ppz1p0.066
YLR177Whypothetical protein0.061
PAM1Pam1p0.058
SLD5Sld5p0.058
EAF1Eaf1p0.057
CSM3Csm3p0.054
DPB2Dpb2p0.053
ACM1Acm1p0.050
POL1Pol1p0.046
YPL260Whypothetical protein0.045
CDC9Cdc9p0.042
KIN82Kin82p0.041
REG1Reg1p0.040
FPK1Fpk1p0.038
KIN1Kin1p0.038
MEC1Mec1p0.037
HAC1Hac1p0.036
SIA1Sia1p0.036
DUN1Dun1p0.035
POL12Pol12p0.035
YPS1Yps1p0.034
NRD1Nrd1p0.033
SUR1Sur1p0.033
POL32Pol32p0.033
YLR257Whypothetical protein0.032
RAD9Rad9p0.031
PRI2Pri2p0.030
BMH1Bmh1p0.030
SMC6Smc6p0.030
HOP1Hop1p0.030
MNR2Mnr2p0.027
TOF1Tof1p0.027
TAX4Tax4p0.025
PSF1Psf1p0.025
MAM1Mam1p0.025
MCM4Mcm4p0.024
RRM3Rrm3p0.022
YOR385Whypothetical protein0.022
YMR102Chypothetical protein0.022
PYC2Pyc2p0.021
RAD5Rad5p0.021
RGC1Rgc1p0.021
ZPS1Zps1p0.020
SDS22Sds22p0.020
RFA1Rfa1p0.020
SAE2Sae2p0.019
PAH1Pah1p0.019
YNL134Chypothetical protein0.019
SNF1Snf1p0.019
YGR205Whypothetical protein0.019
SRD1Srd1p0.019
MGS1Mgs1p0.019
NUR1Nur1p0.018
YPL216Whypothetical protein0.018
RAD55Rad55p0.018
HAA1Haa1p0.018
KCC4Kcc4p0.018
LEU2Leu2p0.018
PTI1Pti1p0.018
ORC6Orc6p0.018
ALY1Aly1p0.018
YKR075Chypothetical protein0.017
YLR162Whypothetical protein0.017
YNL234Whypothetical protein0.017
MER1Mer1p0.017
STU1Stu1p0.017
AZF1Azf1p0.017
PSP1Psp1p0.017
SLG1Slg1p0.017
PBP4Pbp4p0.016
SPL2Spl2p0.016
PRR2Prr2p0.016
VHR1Vhr1p0.016
ADR1Adr1p0.016
GPB2Gpb2p0.016
CDC34Cdc34p0.016
TGL4Tgl4p0.015
YLR264C-Ahypothetical protein0.015
YOL038C-Ahypothetical protein0.015
OCH1Och1p0.015
PDS5Pds5p0.015
STE7Ste7p0.015
PCH2Pch2p0.015
COS111Cos111p0.015
NTH2Nth2p0.015
SCC2Scc2p0.014
POP2Pop2p0.014
CPD1Cpd1p0.014
ARP10Arp10p0.014
APJ1Apj1p0.014
HST3Hst3p0.014
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
NiPp1Nuclear inhibitor of Protein phosphatase 10.061
Pp1alpha-96AProtein phosphatase 1alpha at 96A0.023
Pp2A-29BProtein phosphatase 2A at 29B0.012
MBD-R2CG10042 gene product from transcript CG10042-RB0.012
CG5524CG5524 gene product from transcript CG5524-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FANCAFanconi anemia, complementation group A0.965
BRCA1breast cancer 1, early onset0.628
APITD1apoptosis-inducing, TAF9-like domain 10.232
POLD3polymerase (DNA-directed), delta 3, accessory subunit0.194
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.151
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.137
FANCLFanconi anemia, complementation group L0.124
THOC2THO complex 20.116
FANCMFanconi anemia, complementation group M0.085
BLMBloom syndrome, RecQ helicase-like0.060
THOC5THO complex 50.054
CHAF1Achromatin assembly factor 1, subunit A (p150)0.051
DDX39BDEAD (Asp-Glu-Ala-Asp) box polypeptide 39B0.048
H2AFXH2A histone family, member X0.043
MDC1mediator of DNA-damage checkpoint 10.042
RBM8ARNA binding motif protein 8A0.040
ASF1BASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.032
POLA1polymerase (DNA directed), alpha 1, catalytic subunit0.028
CNOT1CCR4-NOT transcription complex, subunit 10.027
FANCD2Fanconi anemia, complementation group D20.026
CDT1chromatin licensing and DNA replication factor 10.024
FANCGFanconi anemia, complementation group G0.024
NR2E3nuclear receptor subfamily 2, group E, member 30.023
CNOT2CCR4-NOT transcription complex, subunit 20.023
RAD50RAD50 homolog (S. cerevisiae)0.022
HEXIM1hexamethylene bis-acetamide inducible 10.021
NBNnibrin0.021
CCNE1cyclin E10.021
RIF1RAP1 interacting factor homolog (yeast)0.020
FBXW7F-box and WD repeat domain containing 70.020
FANCBFanconi anemia, complementation group B0.019
RAD52RAD52 homolog (S. cerevisiae)0.019
RMI1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)0.018
ZNF830zinc finger protein 8300.018
RPA2replication protein A2, 32kDa0.018
STRA13stimulated by retinoic acid 13 homolog (mouse)0.015
XRCC3X-ray repair complementing defective repair in Chinese hamster cells 30.014
CCNT1cyclin T10.013
TOP3Atopoisomerase (DNA) III alpha0.013
ORC1origin recognition complex, subunit 10.013
RPA1replication protein A1, 70kDa0.012
ATRIPATR interacting protein0.012
NEK1NIMA (never in mitosis gene a)-related kinase 10.012
CHAF1Bchromatin assembly factor 1, subunit B (p60)0.012
RBL1retinoblastoma-like 1 (p107)0.012
THOC6THO complex 6 homolog (Drosophila)0.011
ATMataxia telangiectasia mutated0.011
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.011
CDC45cell division cycle 45 homolog (S. cerevisiae)0.011
LIG1ligase I, DNA, ATP-dependent0.010
CDK2cyclin-dependent kinase 20.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Timelesstimeless homolog (Drosophila)0.987
Smc1astructural maintenance of chromosomes 1A0.941
Brca1breast cancer 10.937
Cdt1chromatin licensing and DNA replication factor 10.744
Brca2breast cancer 20.561
Wdhd1WD repeat and HMG-box DNA binding protein 10.487
Atmataxia telangiectasia mutated homolog (human)0.451
Smc3structural maintenace of chromosomes 30.398
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)0.341
Apcadenomatosis polyposis coli0.297
Trp53transformation related protein 530.288
Lig1ligase I, DNA, ATP-dependent0.274
Mecp2methyl CpG binding protein 20.174
Rad51RAD51 homolog (S. cerevisiae)0.172
Rad51ap1RAD51 associated protein 10.168
1500010J02RikRIKEN cDNA 1500010J02 gene0.163
Rttnrotatin0.131
Mcm5minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)0.126
Chtf18CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)0.115
Mms22lMMS22-like, DNA repair protein0.113
E2f1E2F transcription factor 10.104
Hmgb1high mobility group box 10.100
Slc22a17solute carrier family 22 (organic cation transporter), member 170.094
StilScl/Tal1 interrupting locus0.092
Ppp1caprotein phosphatase 1, catalytic subunit, alpha isoform0.092
Clspnclaspin homolog (Xenopus laevis)0.089
Hexim1hexamethylene bis-acetamide inducible 10.086
Rfc1replication factor C (activator 1) 10.079
Srsf9serine/arginine-rich splicing factor 90.077
Pms2postmeiotic segregation increased 2 (S. cerevisiae)0.077
BlmBloom syndrome, RecQ helicase-like0.076
Dnmt1DNA methyltransferase (cytosine-5) 10.073
Mphosph9M-phase phosphoprotein 90.070
Cspg5chondroitin sulfate proteoglycan 50.068
Cdca7lcell division cycle associated 7 like0.064
Mycmyelocytomatosis oncogene0.063
Incenpinner centromere protein0.060
Apbb1amyloid beta (A4) precursor protein-binding, family B, member 10.059
Mybl2myeloblastosis oncogene-like 20.059
Msh2mutS homolog 2 (E. coli)0.057
MaxMax protein0.056
Syce2synaptonemal complex central element protein 20.055
Mdm2transformed mouse 3T3 cell double minute 20.055
Lmnb1lamin B10.054
Unguracil DNA glycosylase0.052
Mbd4methyl-CpG binding domain protein 40.052
Car11carbonic anhydrase 110.051
Dtldenticleless homolog (Drosophila)0.051
Eif2aeukaryotic translation initiation factor 2A0.049
Wdr90WD repeat domain 900.049
Polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.047
Ewsr1Ewing sarcoma breakpoint region 10.046
Mis18bp1MIS18 binding protein 10.044
Ncapd2non-SMC condensin I complex, subunit D20.044
Tsg101tumor susceptibility gene 1010.042
Pole2polymerase (DNA directed), epsilon 2 (p59 subunit)0.041
Dhfrdihydrofolate reductase0.041
Smc6structural maintenance of chromosomes 60.041
Pola2polymerase (DNA directed), alpha 20.041
Srrm1serine/arginine repetitive matrix 10.041
Hnrnplheterogeneous nuclear ribonucleoprotein L0.040
Ccnd1cyclin D10.040
Fancd2Fanconi anemia, complementation group D20.039
Selmselenoprotein M0.038
H2afxH2A histone family, member X0.036
Refbp2RNA and export factor binding protein 20.036
Gins1GINS complex subunit 1 (Psf1 homolog)0.036
Camk1gcalcium/calmodulin-dependent protein kinase I gamma0.036
Gng3guanine nucleotide binding protein (G protein), gamma 30.035
Ezh2enhancer of zeste homolog 2 (Drosophila)0.035
Rfc2replication factor C (activator 1) 20.035
Srsf2serine/arginine-rich splicing factor 20.035
CtcfCCCTC-binding factor0.034
Lrwd1leucine-rich repeats and WD repeat domain containing 10.033
Hnrnpdheterogeneous nuclear ribonucleoprotein D0.033
Rb1retinoblastoma 10.033
Cdc7cell division cycle 7 (S. cerevisiae)0.031
Exo1exonuclease 10.031
Trotrophinin0.030
4930422G04RikRIKEN cDNA 4930422G04 gene0.030
Recql4RecQ protein-like 40.029
FancmFanconi anemia, complementation group M0.029
Creb1cAMP responsive element binding protein 10.029
Mlh1mutL homolog 1 (E. coli)0.029
Ddx46DEAD (Asp-Glu-Ala-Asp) box polypeptide 460.028
Prkar1bprotein kinase, cAMP dependent regulatory, type I beta0.027
XiapX-linked inhibitor of apoptosis0.027
4930427A07RikRIKEN cDNA 4930427A07 gene0.027
Tcf19transcription factor 190.027
Phf5aPHD finger protein 5A0.026
Plk1polo-like kinase 1 (Drosophila)0.026
Ptges3prostaglandin E synthase 3 (cytosolic)0.026
Rad54lRAD54 like (S. cerevisiae)0.026
Pcnaproliferating cell nuclear antigen0.026
PaskPAS domain containing serine/threonine kinase0.025
Cenptcentromere protein T0.025
Chaf1bchromatin assembly factor 1, subunit B (p60)0.025
Ilf3interleukin enhancer binding factor 30.025
Ncapd3non-SMC condensin II complex, subunit D30.024
Hnrnpa1heterogeneous nuclear ribonucleoprotein A10.024
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism