The network for 'double strand break repair via single strand annealing' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

double strand break repair via single strand annealing

Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats.

NameDescriptionProbabilityFunc Analog Organism
RAD1Rad1p0.981
RAD10Rad10p0.745
SAW1Saw1p0.135
RAD14Rad14p0.128
RAD59Rad59p0.110
DUN1Dun1p0.069
MEC1Mec1p0.063
DDC1Ddc1p0.053
MSH3Msh3p0.052
SLX4Slx4p0.037
RAD53Rad53p0.034
SRD1Srd1p0.030
RAD51Rad51p0.030
RFA1Rfa1p0.029
MMS21Mms21p0.026
LEU2Leu2p0.026
CUP1-1Cup1-1p0.024
YOL038C-Ahypothetical protein0.024
YLR162Whypothetical protein0.024
YAR068Whypothetical protein0.023
LIF1Lif1p0.023
SPL2Spl2p0.022
RMI1Rmi1p0.022
YLR264C-Ahypothetical protein0.021
ARP10Arp10p0.021
MLH1Mlh1p0.020
MER1Mer1p0.020
YPR157Whypothetical protein0.019
HXT3Hxt3p0.017
ATP6Atp6p0.017
NTG1Ntg1p0.017
DNA2Dna2p0.017
ZPS1Zps1p0.017
YLR042Chypothetical protein0.016
TOP3Top3p0.015
YAR066Whypothetical protein0.015
YBR013Chypothetical protein0.015
MMS4Mms4p0.015
HPF1Hpf1p0.015
SCM4Scm4p0.015
AUA1Aua1p0.015
MF(ALPHA)2Mf(alpha)2p0.014
ADH2Adh2p0.014
MUS81Mus81p0.013
IZH4Izh4p0.013
YOL013W-Ahypothetical protein0.013
UPS3Ups3p0.013
MFA2Mfa2p0.013
FMT1Fmt1p0.013
CRP1Crp1p0.013
CPD1Cpd1p0.013
SWC7Swc7p0.012
CHA1Cha1p0.012
YIR035Chypothetical protein0.012
RAD55Rad55p0.012
GYL1Gyl1p0.012
YKR075Chypothetical protein0.012
BSC1Bsc1p0.012
OPT2Opt2p0.012
YAL064Whypothetical protein0.012
YAL037C-Ahypothetical protein0.011
PTI1Pti1p0.011
ARG8Arg8p0.011
YLR040Chypothetical protein0.011
SAE2Sae2p0.011
RAD52Rad52p0.011
DIC1Dic1p0.011
HOR2Hor2p0.011
NRG2Nrg2p0.011
REV3Rev3p0.011
YPR096Chypothetical protein0.011
YGL006W-Ahypothetical protein0.010
RTT105Rtt105p0.010
YML003Whypothetical protein0.010
RNP1Rnp1p0.010
RRN5Rrn5p0.010
TYE7Tye7p0.010
RMD6Rmd6p0.010
ENA5Ena5p0.010
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Ras85DRas oncogene at 85D0.052
NNotch0.031
DlDelta0.023
armarmadillo0.021
phlpole hole0.013
EgfrEpidermal growth factor receptor0.012
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BRCA1breast cancer 1, early onset1.000
WRNWerner syndrome, RecQ helicase-like0.995
MUS81MUS81 endonuclease homolog (S. cerevisiae)0.988
H2AFXH2A histone family, member X0.985
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.972
NBNnibrin0.972
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.963
EME1essential meiotic endonuclease 1 homolog 1 (S. pombe)0.925
MSH6mutS homolog 6 (E. coli)0.915
TERF2telomeric repeat binding factor 20.911
RAD50RAD50 homolog (S. cerevisiae)0.895
FANCD2Fanconi anemia, complementation group D20.861
MSH2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)0.848
BRCA2breast cancer 2, early onset0.771
RPA1replication protein A1, 70kDa0.768
MDC1mediator of DNA-damage checkpoint 10.763
CHEK1CHK1 checkpoint homolog (S. pombe)0.618
CHEK2CHK2 checkpoint homolog (S. pombe)0.609
ERCC4excision repair cross-complementing rodent repair deficiency, complementation group 40.603
BRIP1BRCA1 interacting protein C-terminal helicase 10.603
MLH1mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)0.523
TOP3Atopoisomerase (DNA) III alpha0.368
C20orf94chromosome 20 open reading frame 940.366
ATMataxia telangiectasia mutated0.341
TERF2IPtelomeric repeat binding factor 2, interacting protein0.246
BLMBloom syndrome, RecQ helicase-like0.165
TP53tumor protein p530.164
TOPBP1topoisomerase (DNA) II binding protein 10.152
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.152
PALB2partner and localizer of BRCA20.146
RBL1retinoblastoma-like 1 (p107)0.140
BARD1BRCA1 associated RING domain 10.135
PLK1polo-like kinase 10.106
RAD18RAD18 homolog (S. cerevisiae)0.105
PSMB2proteasome (prosome, macropain) subunit, beta type, 20.103
EXO1exonuclease 10.086
MSH3mutS homolog 3 (E. coli)0.086
RPA2replication protein A2, 32kDa0.066
FANCAFanconi anemia, complementation group A0.064
PSMA3proteasome (prosome, macropain) subunit, alpha type, 30.064
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.054
PSMD6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.053
PMS1PMS1 postmeiotic segregation increased 1 (S. cerevisiae)0.053
RIF1RAP1 interacting factor homolog (yeast)0.050
RMI1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)0.045
RB1retinoblastoma 10.036
CLSPNclaspin0.034
SMC1Astructural maintenance of chromosomes 1A0.031
SLC25A13solute carrier family 25, member 13 (citrin)0.031
TTI1Tel2 interacting protein 1 homolog (S. pombe)0.031
RAD51L3RAD51-like 3 (S. cerevisiae)0.030
TP53BP1tumor protein p53 binding protein 10.029
CUX1cut-like homeobox 10.025
TIMM17Btranslocase of inner mitochondrial membrane 17 homolog B (yeast)0.024
THAP11THAP domain containing 110.024
RFC1replication factor C (activator 1) 1, 145kDa0.020
POLA1polymerase (DNA directed), alpha 1, catalytic subunit0.019
PSMA6proteasome (prosome, macropain) subunit, alpha type, 60.019
CTBP1C-terminal binding protein 10.017
XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)0.015
DUSP10dual specificity phosphatase 100.015
PSMA5proteasome (prosome, macropain) subunit, alpha type, 50.014
E2F3E2F transcription factor 30.013
ATRataxia telangiectasia and Rad3 related0.013
PMS2PMS2 postmeiotic segregation increased 2 (S. cerevisiae)0.012
DCLRE1BDNA cross-link repair 1B0.012
XRCC2X-ray repair complementing defective repair in Chinese hamster cells 20.012
POMPproteasome maturation protein0.012
FKBP10FK506 binding protein 10, 65 kDa0.011
PSMB7proteasome (prosome, macropain) subunit, beta type, 70.011
PSMA1proteasome (prosome, macropain) subunit, alpha type, 10.011
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.011
ORC2origin recognition complex, subunit 20.011
DCLRE1CDNA cross-link repair 1C0.010
POLD3polymerase (DNA-directed), delta 3, accessory subunit0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism