The network for 'positive regulation of dna metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of dna metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA.

NameDescriptionProbabilityFunc Analog Organism
CDC28Cdc28p0.189
SIC1Sic1p0.071
CLN2Cln2p0.066
RAD51Rad51p0.058
MIG1Mig1p0.056
HST1Hst1p0.055
RAD5Rad5p0.054
MMS22Mms22p0.051
MOT1Mot1p0.051
CLN1Cln1p0.045
IES3Ies3p0.043
FHL1Fhl1p0.040
CDC14Cdc14p0.039
CLB3Clb3p0.037
SNF12Snf12p0.036
IFH1Ifh1p0.036
SWI5Swi5p0.035
NDD1Ndd1p0.035
GLN3Gln3p0.035
FKH1Fkh1p0.035
PSY4Psy4p0.034
RAD52Rad52p0.033
MBR1Mbr1p0.033
FKH2Fkh2p0.032
MBP1Mbp1p0.032
MIG2Mig2p0.032
CLB1Clb1p0.031
SNF5Snf5p0.031
HXT3Hxt3p0.031
PIF1Pif1p0.031
HSF1Hsf1p0.030
RAD53Rad53p0.030
ISW2Isw2p0.029
CKS1Cks1p0.029
YPL014Whypothetical protein0.029
GFD2Gfd2p0.027
ARP8Arp8p0.027
CAK1Cak1p0.027
MSA2Msa2p0.026
CLB4Clb4p0.026
YKR075Chypothetical protein0.026
UTP22Utp22p0.026
KIC1Kic1p0.026
MIG3Mig3p0.025
UBC13Ubc13p0.025
NBP2Nbp2p0.025
SLT2Slt2p0.025
VAC7Vac7p0.024
CTR9Ctr9p0.024
PBS2Pbs2p0.024
ROX1Rox1p0.024
WHI5Whi5p0.023
RNR2Rnr2p0.022
APN2Apn2p0.022
MOT3Mot3p0.022
SNF6Snf6p0.022
LYS5Lys5p0.021
PSK2Psk2p0.021
YML6Yml6p0.021
STI1Sti1p0.020
PET494Pet494p0.020
TBF1Tbf1p0.020
MDJ1Mdj1p0.020
IMG1Img1p0.020
SIN3Sin3p0.020
SKS1Sks1p0.020
CSR2Csr2p0.020
CDC37Cdc37p0.020
HAL5Hal5p0.019
YLR063Whypothetical protein0.019
SKM1Skm1p0.019
DUN1Dun1p0.019
SGV1Sgv1p0.019
DEF1Def1p0.019
NRG1Nrg1p0.019
RIM13Rim13p0.019
SUM1Sum1p0.019
IES2Ies2p0.019
SWE1Swe1p0.019
SPP41Spp41p0.018
ELM1Elm1p0.018
HDA2Hda2p0.018
RNR4Rnr4p0.018
RSC8Rsc8p0.018
PRM8Prm8p0.018
HHF2Hhf2p0.018
CLB6Clb6p0.017
CUP9Cup9p0.017
RIF1Rif1p0.017
SIR3Sir3p0.017
ECM22Ecm22p0.017
PIN4Pin4p0.017
HOR2Hor2p0.017
ORC3Orc3p0.017
TBS1Tbs1p0.016
CDC55Cdc55p0.016
SAP1Sap1p0.016
GIS4Gis4p0.016
GAL80Gal80p0.016
LDB19Ldb19p0.016
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
chek1CHK1 checkpoint homolog (S. pombe)0.271
hmga1ahigh mobility group AT-hook 1a0.239
igf1rbinsulin-like growth factor 1b receptor0.170
hoxd4ahomeo box D4a0.151
cdh2cadherin 2, neuronal0.123
mybl2myeloblastosis oncogene-like 20.122
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae)0.122
mkksMcKusick-Kaufman syndrome0.118
spc24SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.117
si:ch211-239j15.4si:ch211-239j15.40.117
rbb4retinoblastoma binding protein 40.115
bmp2bbone morphogenetic protein 2b0.108
dctdopachrome tautomerase0.107
pola2polymerase (DNA directed), alpha 20.106
si:dkey-9k8.1si:dkey-9k8.10.097
arf2ADP-ribosylation factor 20.091
mus81MUS81 endonuclease homolog (yeast)0.091
atf3activating transcription factor 30.088
sumo3aSMT3 suppressor of mif two 3 homolog 3a0.087
nrg2aneuregulin 2a0.086
tp53tumor protein p530.085
morf4l1mortality factor 4 like 10.084
slbpstem-loop binding protein0.083
cbx1achromobox homolog 1a (HP1 beta homolog Drosophila)0.080
ncapgnon-SMC condensin I complex, subunit G0.078
ilf3ainterleukin enhancer binding factor 3a0.077
zgc:110231zgc:1102310.074
sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.073
lmnb1lamin B10.073
si:dkeyp-22b2.3si:dkeyp-22b2.30.072
myst2MYST histone acetyltransferase 20.072
npatnuclear protein, ataxia-telangiectasia locus0.072
usp1ubiquitin specific protease 10.072
cx43.4connexin 43.40.071
hirip3HIRA interacting protein 30.069
wnt10awingless-type MMTV integration site family, member 10a0.069
rad51crad51 homolog C (S. cerevisiae)0.069
ube2nbubiquitin-conjugating enzyme E2Nb0.068
ofd1oral-facial-digital syndrome 10.067
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.067
rhoabras homolog gene family, member Ab0.067
kif14kinesin family member 140.066
apex1APEX nuclease (multifunctional DNA repair enzyme) 10.066
shhasonic hedgehog a0.065
psen1presenilin 10.065
lamc1laminin, gamma 10.063
rad54lRAD54-like (S. cerevisiae)0.062
hdac1histone deacetylase 10.061
rap1aRAP1A, member of RAS oncogene family0.060
ywhaqbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b0.060
setdb1aSET domain, bifurcated 1a0.059
krit1KRIT1, ankyrin repeat containing0.059
stilTAL1 (SCL) interrupting locus0.058
tgfb2transforming growth factor, beta 20.058
disp1dispatched homolog 1 (Drosophila)0.057
nkx2.3NK2 transcription factor related 30.057
otud7bOTU domain containing 7B0.057
zgc:56197zgc:561970.056
dnmt3DNA (cytosine-5-)-methyltransferase 30.056
angptl1angiopoietin-like 10.054
srmspermidine synthase0.054
e2f7E2F transcription factor 70.054
plod1aprocollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a0.053
sephs1selenophosphate synthetase 10.053
mapk1mitogen-activated protein kinase 10.051
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.051
tgfb3transforming growth factor, beta 30.051
ckap5cytoskeleton associated protein 50.051
mycamyelocytomatosis oncogene a0.050
nup155nucleoporin 1550.049
prdm9PR domain containing 90.049
arpp19acAMP-regulated phosphoprotein 19a0.049
slc25a14solute carrier family 25 (mitochondrial carrier, brain), member 140.049
zgc:162329zgc:1623290.048
LOC554173abnormal spindles0.048
tfectranscription factor EC0.047
bcl2l10BCL2-like 10 (apoptosis facilitator)0.047
calm3bcalmodulin 3b (phosphorylase kinase, delta)0.046
kifc1kinesin family member C10.046
krcpkelch repeat-containing protein0.045
suv39h1bsuppressor of variegation 3-9 homolog 1b0.045
zgc:100817zgc:1008170.044
dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.044
mcm7MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)0.044
gmpsguanine monphosphate synthetase0.044
LOC567638hypothetical LOC5676380.043
cxcr3.2chemokine (C-X-C motif) receptor 3.20.043
junbljun B proto-oncogene, like0.043
gro2groucho 20.043
nos2bnitric oxide synthase 2b, inducible0.043
nusap1nucleolar and spindle associated protein 10.042
bmp2abone morphogenetic protein 2a0.042
traipTRAF-interacting protein0.042
paxip1PAX interacting (with transcription-activation domain) protein 10.042
gro1groucho 10.042
si:ch211-147d7.3si:ch211-147d7.30.042
mapk3mitogen-activated protein kinase 30.041
zgc:110540zgc:1105400.041
si:ch211-278b8.3si:ch211-278b8.30.041
sox11bSRY-box containing gene 11b0.041
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
His2AvHistone H2A variant0.063
Akt1CG4006 gene product from transcript CG4006-RA0.044
dshdishevelled0.034
Chd1Chromodomain-helicase-DNA-binding protein 10.030
nejnejire0.027
Su(var)205Suppressor of variegation 2050.025
Mcm6Minichromosome maintenance 60.025
armarmadillo0.024
CG10267CG10267 gene product from transcript CG10267-RB0.022
rlrolled0.019
kelkelch0.019
hdhumpty dumpty0.018
hhhedgehog0.017
Df31Decondensation factor 310.017
mei-9meiotic 90.017
chicchickadee0.016
spn-Bspindle B0.016
Ras85DRas oncogene at 85D0.015
bskbasket0.015
PvrPDGF- and VEGF-receptor related0.014
BEAF-32Boundary element-associated factor of 32kD0.013
timtimeless0.012
Rho1CG8416 gene product from transcript CG8416-RB0.012
spispitz0.012
Btk29ABtk family kinase at 29A0.012
scbscab0.011
InvadolysinCG3953 gene product from transcript CG3953-RA0.011
rdgCretinal degeneration C0.011
Pi3K92ECG4141 gene product from transcript CG4141-RB0.011
PdfPigment-dispersing factor0.011
mus209mutagen-sensitive 2090.011
CycECyclin E0.011
domedomeless0.011
CycBCyclin B0.010
CG5524CG5524 gene product from transcript CG5524-RA0.010
cdc2CG5363 gene product from transcript CG5363-RA0.010
shishibire0.010
pngpan gu0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 20.998
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.998
CDK2cyclin-dependent kinase 20.998
EGFRepidermal growth factor receptor0.990
BRCA1breast cancer 1, early onset0.987
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.986
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.985
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.980
FGF1fibroblast growth factor 1 (acidic)0.959
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.911
WRNWerner syndrome, RecQ helicase-like0.887
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.883
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.881
CCNE1cyclin E10.875
IL4Rinterleukin 4 receptor0.849
E2F8E2F transcription factor 80.743
SHC1SHC (Src homology 2 domain containing) transforming protein 10.725
BRCC3BRCA1/BRCA2-containing complex, subunit 30.725
TERF1telomeric repeat binding factor (NIMA-interacting) 10.725
FAM175Afamily with sequence similarity 175, member A0.721
H2AFXH2A histone family, member X0.712
PTPN6protein tyrosine phosphatase, non-receptor type 60.710
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.706
VEGFAvascular endothelial growth factor A0.706
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.696
BCL2B-cell CLL/lymphoma 20.687
E2F7E2F transcription factor 70.676
APPamyloid beta (A4) precursor protein0.652
LATlinker for activation of T cells0.642
BCL2L1BCL2-like 10.640
CKS1BCDC28 protein kinase regulatory subunit 1B0.637
PARP1poly (ADP-ribose) polymerase 10.574
BMPR1Abone morphogenetic protein receptor, type IA0.569
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.559
CALM1calmodulin 1 (phosphorylase kinase, delta)0.557
YY1YY1 transcription factor0.538
TINF2TERF1 (TRF1)-interacting nuclear factor 20.538
NRP1neuropilin 10.519
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.516
BAXBCL2-associated X protein0.484
BLMBloom syndrome, RecQ helicase-like0.481
BREbrain and reproductive organ-expressed (TNFRSF1A modulator)0.450
CBX5chromobox homolog 50.446
ACDadrenocortical dysplasia homolog (mouse)0.441
CBX3chromobox homolog 30.440
TERF2telomeric repeat binding factor 20.436
CBX1chromobox homolog 10.424
FGFR1fibroblast growth factor receptor 10.419
BMPR1Bbone morphogenetic protein receptor, type IB0.394
FYNFYN oncogene related to SRC, FGR, YES0.388
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.384
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.379
MAPK9mitogen-activated protein kinase 90.366
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.342
NBNnibrin0.324
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.322
KHDRBS1KH domain containing, RNA binding, signal transduction associated 10.320
MDC1mediator of DNA-damage checkpoint 10.319
CKS2CDC28 protein kinase regulatory subunit 20.312
LRP1low density lipoprotein receptor-related protein 10.308
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.305
BABAM1BRISC and BRCA1 A complex member 10.304
IGF1Rinsulin-like growth factor 1 receptor0.303
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.284
PLCG1phospholipase C, gamma 10.275
SUFUsuppressor of fused homolog (Drosophila)0.261
GSK3Bglycogen synthase kinase 3 beta0.258
HNRNPRheterogeneous nuclear ribonucleoprotein R0.257
UIMC1ubiquitin interaction motif containing 10.256
BCL2L11BCL2-like 11 (apoptosis facilitator)0.254
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.254
MAPK8mitogen-activated protein kinase 80.253
ERCC6excision repair cross-complementing rodent repair deficiency, complementation group 60.250
CAV1caveolin 1, caveolae protein, 22kDa0.245
S100A4S100 calcium binding protein A40.235
HSPA4heat shock 70kDa protein 40.235
CHAF1Achromatin assembly factor 1, subunit A (p150)0.231
UBE2Nubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)0.217
DDIT3DNA-damage-inducible transcript 30.210
TRAF3TNF receptor-associated factor 30.210
ORC2origin recognition complex, subunit 20.208
PIK3CAphosphoinositide-3-kinase, catalytic, alpha polypeptide0.196
SIAH1seven in absentia homolog 1 (Drosophila)0.192
BAK1BCL2-antagonist/killer 10.188
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.185
NTRK1neurotrophic tyrosine kinase, receptor, type 10.183
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.181
ARID1BAT rich interactive domain 1B (SWI1-like)0.167
SYKspleen tyrosine kinase0.165
UHRF2ubiquitin-like with PHD and ring finger domains 20.165
HIF1ANhypoxia inducible factor 1, alpha subunit inhibitor0.164
FSTL1follistatin-like 10.162
TNFRSF13Btumor necrosis factor receptor superfamily, member 13B0.160
NOXA1NADPH oxidase activator 10.159
ARID1AAT rich interactive domain 1A (SWI-like)0.157
RIF1RAP1 interacting factor homolog (yeast)0.157
INSRinsulin receptor0.152
GRAP2GRB2-related adaptor protein 20.152
RALAv-ral simian leukemia viral oncogene homolog A (ras related)0.151
RCC1regulator of chromosome condensation 10.151
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Top2atopoisomerase (DNA) II alpha0.123
Cfl1cofilin 1, non-muscle0.118
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.078
Arpc1bactin related protein 2/3 complex, subunit 1B0.076
Ptprcprotein tyrosine phosphatase, receptor type, C0.070
Fkbp3FK506 binding protein 30.056
Pfn1profilin 10.050
Pcnaproliferating cell nuclear antigen0.049
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.048
Ripk3receptor-interacting serine-threonine kinase 30.045
Nclnucleolin0.044
Myo1fmyosin IF0.040
Golph3golgi phosphoprotein 3 (coat-protein)0.040
Vimvimentin0.040
Myo1gmyosin IG0.039
Cd53Cd53 molecule0.039
Lsm5LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)0.038
Mapk1mitogen activated protein kinase 10.038
C5ar1complement component 5a receptor 10.036
P4hbprolyl 4-hydroxylase, beta polypeptide0.036
Tubb5tubulin, beta 50.032
Pdia4protein disulfide isomerase family A, member 40.032
Mapk9mitogen-activated protein kinase 90.031
Psmc6proteasome (prosome, macropain) 26S subunit, ATPase, 60.031
Gadd45agrowth arrest and DNA-damage-inducible, alpha0.030
Creb1cAMP responsive element binding protein 10.030
Il1r1interleukin 1 receptor, type I0.030
Ptafrplatelet-activating factor receptor0.030
Casp1caspase 10.029
Prkcdprotein kinase C, delta0.029
Cd37CD37 molecule0.028
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.028
ArhgdibRho, GDP dissociation inhibitor (GDI) beta0.028
Ptpn6protein tyrosine phosphatase, non-receptor type 60.027
Slit1slit homolog 1 (Drosophila)0.027
Kcne1potassium voltage-gated channel, Isk-related family, member 10.027
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.027
Scn11asodium channel, voltage-gated, type XI, alpha0.027
Fgfr1Fibroblast growth factor receptor 10.026
Cybbcytochrome b-245, beta polypeptide0.026
Racgap1Rac GTPase-activating protein 10.026
Anxa5annexin A50.025
Prkciprotein kinase C, iota0.025
Map3k1mitogen activated protein kinase kinase kinase 10.025
Hckhemopoietic cell kinase0.024
Myadmmyeloid-associated differentiation marker0.024
Hprt1hypoxanthine phosphoribosyltransferase 10.024
Laptm5lysosomal protein transmembrane 50.024
CebpzCCAAT/enhancer binding protein zeta0.024
Timp2TIMP metallopeptidase inhibitor 20.024
Pdia3protein disulfide isomerase family A, member 30.024
Ly6blymphocyte antigen 6 complex, locus B0.023
Hmgb1high mobility group box 10.023
Fgd4FYVE, RhoGEF and PH domain containing 40.023
Stip1stress-induced phosphoprotein 10.023
Senp2Sumo1/sentrin/SMT3 specific peptidase 20.023
Plekpleckstrin0.023
Gja5gap junction protein, alpha 50.023
Efhd2EF-hand domain family, member D20.023
Ubl5ubiquitin-like 50.023
Ccne1cyclin E10.022
Ptges3prostaglandin E synthase 3 (cytosolic)0.022
Tmsb4xthymosin beta 4, X-linked0.022
Cxcr4chemokine (C-X-C motif) receptor 40.022
Itgamintegrin, alpha M0.021
Il2rginterleukin 2 receptor, gamma0.021
S100a10S100 calcium binding protein A100.021
Mcm6minichromosome maintenance complex component 60.021
Atp12aATPase, H+/K+ transporting, nongastric, alpha polypeptide0.021
F13a1coagulation factor XIII, A1 polypeptide0.021
Cdk4cyclin-dependent kinase 40.021
Mapk8mitogen-activated protein kinase 80.021
Sftpdsurfactant protein D0.021
Dctn4dynactin 40.021
Sirpasignal-regulatory protein alpha0.021
Ccl4chemokine (C-C motif) ligand 40.020
Mgea5meningioma expressed antigen 5 (hyaluronidase)0.020
Ccr5chemokine (C-C motif) receptor 50.020
Cd86CD86 molecule0.020
Rgs14regulator of G-protein signaling 140.020
Slc44a2solute carrier family 44, member 20.020
Slco1a5solute carrier organic anion transporter family, member 1a50.020
Fkbp1aFK506 binding protein 1a0.020
Cd4Cd4 molecule0.020
Adam10ADAM metallopeptidase domain 100.020
Ceacam1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)0.020
Taok1TAO kinase 10.019
Il1binterleukin 1 beta0.019
Ppidpeptidylprolyl isomerase D (cyclophilin D)0.019
Epha2Eph receptor A20.019
Hspd1heat shock protein 1 (chaperonin)0.019
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.019
Rrm2ribonucleotide reductase M20.019
Kifc1kinesin family member C10.019
Col17a1collagen, type XVII, alpha 10.019
XiapX-linked inhibitor of apoptosis0.019
Prss22protease, serine, 220.018
Tpm3tropomyosin 3, gamma0.018
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.018
Lnpepleucyl/cystinyl aminopeptidase0.018