The network for 'establishment of protein localization to vacuole' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

establishment of protein localization to vacuole

The directed movement of a protein to a specific location in a vacuole.

NameDescriptionProbabilityFunc Analog Organism
VPS21Vps21p0.997
VPS28Vps28p0.991
ATG9Atg9p0.986
ATG7Atg7p0.980
VPS41Vps41p0.978
APL5Apl5p0.961
VPS36Vps36p0.959
LSB3Lsb3p0.957
COG5Cog5p0.943
ATG12Atg12p0.931
ATG3Atg3p0.927
COG7Cog7p0.927
VPS35Vps35p0.926
COG6Cog6p0.925
COG8Cog8p0.917
SRN2Srn2p0.893
YPT6Ypt6p0.879
BRO1Bro1p0.872
ATG4Atg4p0.825
VPS4Vps4p0.808
COG4Cog4p0.806
VPS20Vps20p0.788
VPS3Vps3p0.775
APL6Apl6p0.762
ATG20Atg20p0.728
YPT52Ypt52p0.704
SNX4Snx4p0.702
VPS30Vps30p0.696
ATG1Atg1p0.687
COG1Cog1p0.678
COG3Cog3p0.678
YPT7Ypt7p0.661
ATG23Atg23p0.650
ATG13Atg13p0.650
ATG21Atg21p0.637
ATG10Atg10p0.583
PEP3Pep3p0.562
VAM7Vam7p0.547
ATG26Atg26p0.531
VPS52Vps52p0.514
BSD2Bsd2p0.508
VTI1Vti1p0.505
ATG14Atg14p0.503
MON1Mon1p0.484
VAM6Vam6p0.470
ATG11Atg11p0.462
APM3Apm3p0.425
TRS85Trs85p0.401
PEP1Pep1p0.382
PEP5Pep5p0.371
TLG2Tlg2p0.366
DID4Did4p0.364
STP22Stp22p0.351
HSV2Hsv2p0.346
VPS16Vps16p0.335
VPS13Vps13p0.322
VPS8Vps8p0.311
VPS17Vps17p0.287
ATG29Atg29p0.286
ATG16Atg16p0.281
PEP8Pep8p0.279
ATG5Atg5p0.276
RIM21Rim21p0.276
ATG8Atg8p0.270
ECM21Ecm21p0.269
VPS38Vps38p0.260
YPT53Ypt53p0.258
GYL1Gyl1p0.243
BPT1Bpt1p0.227
SNF8Snf8p0.220
RAV1Rav1p0.214
IST1Ist1p0.209
YPR091Chypothetical protein0.195
COT1Cot1p0.190
VPS9Vps9p0.185
CMP2Cmp2p0.184
ATG19Atg19p0.182
CSR2Csr2p0.181
MON2Mon2p0.178
LSB1Lsb1p0.177
CNB1Cnb1p0.175
SLG1Slg1p0.166
ATG17Atg17p0.160
ATG27Atg27p0.160
VPS60Vps60p0.159
VMA8Vma8p0.156
ASI1Asi1p0.154
VPS5Vps5p0.147
RGP1Rgp1p0.144
CCZ1Ccz1p0.144
YJL185Chypothetical protein0.137
BBC1Bbc1p0.134
SYS1Sys1p0.134
VMA16Vma16p0.133
PHO84Pho84p0.132
VPS24Vps24p0.131
SLA2Sla2p0.131
VTA1Vta1p0.125
VPS33Vps33p0.124
COG2Cog2p0.123
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
atp6v1fATPase, H+ transporting, V1 subunit F0.358
paqr8progestin and adipoQ receptor family member VIII0.202
zgc:73134zgc:731340.087
atp6v0d1ATPase, H+ transporting, V0 subunit D isoform 10.063
creb3l3lcAMP responsive element binding protein 3-like 3 like0.060
rab5aaRAB5A, member RAS oncogene family, a0.054
arhgdiaRho GDP dissociation inhibitor (GDI) alpha0.052
cltcaclathrin, heavy polypeptide a (Hc)0.046
atp6v1e1bATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b0.045
zgc:77849zgc:778490.043
sdf4stromal cell derived factor 40.042
atp6v1dATPase, H+ transporting, V1 subunit D and ATPase, H+ transporting, V1 subunit D0.040
snx5sorting nexin 50.040
cyp17a1cytochrome P450, family 17, subfamily A, polypeptide 10.033
scamp2secretory carrier membrane protein 20.032
lhbluteinizing hormone, beta polypeptide0.031
vps35vacuolar protein sorting 35 (yeast)0.030
pfn2profilin 20.029
si:dkey-181m9.9si:dkey-181m9.90.028
stambpaSTAM binding protein a0.027
clcn7chloride channel 70.027
vps26blvacuolar protein sorting 26 homolog B, like0.026
syap1synapse associated protein 10.024
gdf9growth differentiation factor 90.024
rab7RAB7, member RAS oncogene family0.023
LOC559201similar to Neuromedin-K receptor (NKR) (Neurokinin B receptor) (NK-3 receptor) (NK-3R) (Tachykinin receptor 3)0.023
jak1Janus kinase 10.023
vps28vacuolar protein sorting 28 (yeast)0.023
maffv-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian)0.023
atp6ap2ATPase, H+ transporting, lysosomal accessory protein 20.022
inhbabinhibin, beta Ab0.022
rab5abRAB5A, member RAS oncogene family, b0.021
ikbkginhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.021
nanos3nanos homolog 30.021
bsdc1BSD domain containing 10.021
gabarapaGABA(A) receptor-associated protein a0.021
gdi2GDP dissociation inhibitor 20.021
rspo1R-spondin homolog (Xenopus laevis)0.020
zgc:55671zgc:556710.020
uck2auridine-cytidine kinase 2a0.019
wipi1WD repeat domain, phosphoinositide interacting 10.019
kopaskopos0.019
atp6v1c1aATPase, H+ transporting, lysosomal, V1 subunit C, isoform 1a0.019
zgc:152984zgc:1529840.018
LOC569642hypothetical protein LOC5696420.018
sbf1SET binding factor 10.018
arih2ariadne homolog 2 (Drosophila)0.017
cpne1copine I0.017
plekha3pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 30.017
arcn1larchain 1 like0.017
pafah1b3platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit0.016
ddx6DEAD (Asp-Glu-Ala-Asp) box polypeptide 60.016
atf4b2activating transcription factor 4b20.016
cldn2claudin 20.016
iqgap1IQ motif containing GTPase activating protein 10.016
slc30a5solute carrier family 30 (zinc transporter), member 50.015
yipf4Yip1 domain family, member 40.015
ndfip1Nedd4 family interacting protein 10.015
sass6spindle assembly 6 homolog (C. elegans)0.015
LOC555482tachykinin receptor 3-like0.015
apg3lAPG3 autophagy 3-like0.015
arid4aAT rich interactive domain 4A (RBP1-like)0.015
capza1acapping protein (actin filament) muscle Z-line, alpha 1a0.015
tmem9bTMEM9 domain family, member B0.014
phf20bPHD finger protein 20, b0.014
tm9sf2transmembrane 9 superfamily member 20.014
tmem129transmembrane protein 1290.014
kiss2kisspeptin 20.014
mtmr6myotubularin related protein 60.014
zgc:114097zgc:1140970.014
tpsntapasin0.014
ftsjd1FtsJ methyltransferase domain containing 10.014
brapBRCA1 associated protein0.014
letm1leucine zipper-EF-hand containing transmembrane protein 10.014
fshbfollicle stimulating hormone, beta polypeptide0.014
rab2aRAB2A, member RAS oncogene family0.014
slc7a6ossolute carrier family 7, member 6 opposite strand0.013
tpd52l2btumor protein D52-like 2b0.013
zgc:113121zgc:1131210.013
tbc1d15TBC1 domain family, member 150.013
aktipakt interacting protein0.013
arpc4lactin related protein 2/3 complex, subunit 4, like0.013
zgc:56010zgc:560100.013
spns1spinster homolog 1 (Drosophila)0.013
chic2cysteine-rich hydrophobic domain 20.013
arpc5aactin related protein 2/3 complex, subunit 5A0.013
igf3insulin-like growth factor 30.013
ppme1protein phosphatase methylesterase 10.013
cln6ceroid-lipofuscinosis, neuronal 6, late infantile, variant0.013
zgc:152900zgc:1529000.013
viparvps33b interacting protein, apical-basolateral polarity regulator0.013
nedd1neural precursor cell expressed, developmentally down-regulated 10.012
zgc:64161zgc:641610.012
zgc:77817zgc:778170.012
pik3c3phosphoinositide-3-kinase, class 30.012
pigaphosphatidylinositol glycan anchor biosynthesis, class A0.012
LOC559976similar to glutamate receptor, ionotropic, NMDA2B (epsilon 2)0.012
tmem199transmembrane protein 1990.012
gosr1golgi SNAP receptor complex member 10.012
ube2q2ubiquitin-conjugating enzyme E2Q family member 20.012
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SMURF2SMAD specific E3 ubiquitin protein ligase 20.550
GGA1golgi-associated, gamma adaptin ear containing, ARF binding protein 10.429
RNF11ring finger protein 110.403
SQSTM1sequestosome 10.133
ATG3ATG3 autophagy related 3 homolog (S. cerevisiae)0.128
WWP1WW domain containing E3 ubiquitin protein ligase 10.081
EEA1early endosome antigen 10.062
RABEP1rabaptin, RAB GTPase binding effector protein 10.040
ATG7ATG7 autophagy related 7 homolog (S. cerevisiae)0.038
SNF8SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)0.031
SMURF1SMAD specific E3 ubiquitin protein ligase 10.027
SLC2A3solute carrier family 2 (facilitated glucose transporter), member 30.025
NEDD4neural precursor cell expressed, developmentally down-regulated 40.023
ANKRD13Aankyrin repeat domain 13A0.023
SORT1sortilin 10.020
GABARAPGABA(A) receptor-associated protein0.018
SMAD4SMAD family member 40.018
LRRK2leucine-rich repeat kinase 20.015
ARPC5actin related protein 2/3 complex, subunit 5, 16kDa0.014
ATG12ATG12 autophagy related 12 homolog (S. cerevisiae)0.014
GABARAPL2GABA(A) receptor-associated protein-like 20.014
TSG101tumor susceptibility gene 1010.013
ELLelongation factor RNA polymerase II0.013
NEDD9neural precursor cell expressed, developmentally down-regulated 90.012
TMED2transmembrane emp24 domain trafficking protein 20.012
WASLWiskott-Aldrich syndrome-like0.012
WWP2WW domain containing E3 ubiquitin protein ligase 20.011
RAB6ARAB6A, member RAS oncogene family0.010
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Atg12autophagy-related 12 (yeast)0.596
Chmp1bchromatin modifying protein 1B0.248
Stx7syntaxin 70.155
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.153
Rnf11ring finger protein 110.123
8430410K20RikRIKEN cDNA 8430410K20 gene0.122
Rnf103ring finger protein 1030.096
Sec23aSEC23A (S. cerevisiae)0.092
Grb10growth factor receptor bound protein 100.084
Lystlysosomal trafficking regulator0.076
Axin1axin 10.073
Pldnpallidin0.070
Ghrgrowth hormone receptor0.062
Tbx3T-box 30.060
Rbbp9retinoblastoma binding protein 90.054
Gsk3bglycogen synthase kinase 3 beta0.054
Hps4Hermansky-Pudlak syndrome 4 homolog (human)0.051
Ctnnb1catenin (cadherin associated protein), beta 10.051
Dram2VDNA-damage regulated autophagy modulator 20.050
Rab27aRAB27A, member RAS oncogene family0.049
Stam2signal transducing adaptor molecule (SH3 domain and ITAM motif) 20.049
Ndfip1Nedd4 family interacting protein 10.046
Chmchoroidermia0.044
Shdsrc homology 2 domain-containing transforming protein D0.044
Traf6TNF receptor-associated factor 60.042
Lrrk2leucine-rich repeat kinase 20.042
Hps1Hermansky-Pudlak syndrome 1 homolog (human)0.041
Pdclphosducin-like0.039
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.039
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.037
Fpgtfucose-1-phosphate guanylyltransferase0.037
Dnajb9DnaJ (Hsp40) homolog, subfamily B, member 90.036
Atp6ap2ATPase, H+ transporting, lysosomal accessory protein 20.036
Samd4bsterile alpha motif domain containing 4B0.036
Syap1synapse associated protein 10.036
Lysmd3LysM, putative peptidoglycan-binding, domain containing 30.036
Kitkit oncogene0.035
Rab1RAB1, member RAS oncogene family0.034
Tbrachyury0.034
Hps5Hermansky-Pudlak syndrome 5 homolog (human)0.033
Mobkl3MOB1, Mps One Binder kinase activator-like 3 (yeast)0.033
Apoeapolipoprotein E0.033
Rab33bRAB33B, member of RAS oncogene family0.032
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.032
Arandrogen receptor0.032
Csgalnact2chondroitin sulfate N-acetylgalactosaminyltransferase 20.031
Dmxl1Dmx-like 10.031
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.030
Dpy19l4dpy-19-like 4 (C. elegans)0.030
Crtc3CREB regulated transcription coactivator 30.030
Rnf115ring finger protein 1150.030
Lrp6low density lipoprotein receptor-related protein 60.029
Sos2son of sevenless homolog 2 (Drosophila)0.029
Traf2TNF receptor-associated factor 20.029
C78339expressed sequence C783390.028
Chukconserved helix-loop-helix ubiquitous kinase0.028
Klhl2kelch-like 2, Mayven (Drosophila)0.028
Tmem33transmembrane protein 330.028
BlnkB-cell linker0.028
Lrp5low density lipoprotein receptor-related protein 50.028
Adamts1a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10.028
RragcRas-related GTP binding C0.026
Tmem30atransmembrane protein 30A0.026
Gga2golgi associated, gamma adaptin ear containing, ARF binding protein 20.026
Pofut1protein O-fucosyltransferase 10.026
Inhainhibin alpha0.026
Hdlbphigh density lipoprotein (HDL) binding protein0.026
Mitfmicrophthalmia-associated transcription factor0.025
Lamp2lysosomal-associated membrane protein 20.025
Gjb2gap junction protein, beta 20.025
Asah1N-acylsphingosine amidohydrolase 10.025
Fshrfollicle stimulating hormone receptor0.025
Dynlt1bdynein light chain Tctex-type 1D0.025
Nipsnap3bnipsnap homolog 3B (C. elegans)0.024
Tmx3thioredoxin-related transmembrane protein 30.024
Kcnj10potassium inwardly-rectifying channel, subfamily J, member 100.024
Gtf2igeneral transcription factor II I0.023
Zfp758zinc finger protein 7580.023
Stxbp3asyntaxin binding protein 3A0.023
Fam18bfamily with sequence similarity 18, member B0.023
Pnpla8patatin-like phospholipase domain containing 80.023
Esr1estrogen receptor 1 (alpha)0.023
Mesdc2mesoderm development candidate 20.023
Pdcd10programmed cell death 100.023
Fabp4fatty acid binding protein 4, adipocyte0.022
Sertad2SERTA domain containing 20.022
Pls3plastin 3 (T-isoform)0.022
Cttncortactin0.022
Actr3ARP3 actin-related protein 3 homolog (yeast)0.022
Prkcdprotein kinase C, delta0.022
Dynlt3dynein light chain Tctex-type 30.022
Mark4MAP/microtubule affinity-regulating kinase 40.021
Wbp2WW domain binding protein 20.021
Mocs1molybdenum cofactor synthesis 10.021
Prrg2proline-rich Gla (G-carboxyglutamic acid) polypeptide 20.021
Slc12a6solute carrier family 12, member 60.021
Clockcircadian locomotor output cycles kaput0.021
Bmp7bone morphogenetic protein 70.021
Pmepa1prostate transmembrane protein, androgen induced 10.020
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.020
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism