The network for 'cellular response to superoxide' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to superoxide

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion.

NameDescriptionProbabilityFunc Analog Organism
gstp1glutathione S-transferase pi0.571
cmybtranscription factor cmyb0.571
sod1superoxide dismutase 1, soluble0.537
sod2superoxide dismutase 2, mitochondrial0.290
park7parkinson disease (autosomal recessive, early onset) 70.226
acadmacyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain0.202
prdx4peroxiredoxin 40.184
prdx2peroxiredoxin 20.144
tfr1atransferrin receptor 1a0.101
nme2b.1non-metastatic cells 2b.1, protein (NM23B) expressed in0.087
cbr1lcarbonyl reductase 1-like0.070
slc4a1asolute carrier family 4, anion exchanger, member 1a0.068
aldh7a1aldehyde dehydrogenase 7 family, member A10.067
dhfrdihydrofolate reductase0.055
cyp3c1cytochrome P450, family 3, subfamily c, polypeptide 10.054
gstt1bglutathione S-transferase theta 1b0.054
mifmacrophage migration inhibitory factor0.053
epb41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)0.049
hbae1hemoglobin alpha embryonic-10.048
acadlacyl-Coenzyme A dehydrogenase, long chain0.039
coq3coenzyme Q3 homolog, methyltransferase (yeast)0.039
esdesterase D/formylglutathione hydrolase0.038
cpa5carboxypeptidase A50.037
gata1aGATA binding protein 1a0.034
got2bglutamic-oxaloacetic transaminase 2b, mitochondrial (aspartate aminotransferase 2)0.031
tmem14ctransmembrane protein 14C0.029
snx3sorting nexin 30.029
ahcyS-adenosylhomocysteine hydrolase0.028
got2aglutamic-oxaloacetic transaminase 2a, mitochondrial (aspartate aminotransferase 2)0.027
uroduroporphyrinogen decarboxylase0.027
hsd3b7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase0.026
brca2breast cancer 2, early onset0.024
mmp13amatrix metalloproteinase 13a0.024
prdx3peroxiredoxin 30.023
adh5alcohol dehydrogenase 50.022
ppoxprotoporphyrinogen oxidase0.022
cox5abcytochrome c oxidase subunit Vab0.022
ndufa9NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 90.021
atp5gATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9)0.019
aldh9a1aaldehyde dehydrogenase 9 family, member A1a0.018
hspb2heat shock protein, alpha-crystallin-related, b20.017
blvrbbiliverdin reductase B (flavin reductase (NADPH))0.017
rnf128aring finger protein 128a0.016
stat1asignal transduction and activation of transcription 1a0.016
gstmglutathione S-transferase M0.015
atp5a1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle0.015
cahzcarbonic anhydrase0.014
uxs1UDP-glucuronic acid decarboxylase 10.014
tk2thymidine kinase 2, mitochondrial0.014
fam20bfamily with sequence similarity 20, member B (H. sapiens)0.014
glrxglutaredoxin (thioltransferase)0.014
gapdhglyceraldehyde-3-phosphate dehydrogenase0.014
sybusyntabulin (syntaxin-interacting)0.014
ldhbalactate dehydrogenase Ba0.014
dera2-deoxyribose-5-phosphate aldolase homolog (C. elegans)0.014
ddtD-dopachrome tautomerase0.014
anapc11APC11 anaphase promoting complex subunit 11 homolog (yeast)0.013
fdx1ferredoxin 10.013
ctszcathepsin Z0.012
cpt2carnitine palmitoyltransferase II0.012
obscnobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.012
hbbe2hemoglobin beta embryonic-20.012
bpnt1bisphosphate nucleotidase 10.012
scn4aasodium channel, voltage-gated, type IV, alpha, a0.011
alas2aminolevulinate, delta-, synthetase 20.011
fancbFanconi anemia, complementation group B0.011
decr12,4-dienoyl CoA reductase 1, mitochondrial0.011
keap1akelch-like ECH-associated protein 1a0.011
slc35b2solute carrier family 35, member B20.011
ifnphi1interferon phi 10.011
ociad1OCIA domain containing 10.011
LOC792474annexin A4-like0.010
fanceFanconi anemia, complementation group E0.010
manfmesencephalic astrocyte-derived neurotrophic factor0.010
rab20RAB20, member RAS oncogene family0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
TpiTriose phosphate isomerase0.083
NP15.6CG6008 gene product from transcript CG6008-RA0.021
Sod2Superoxide dismutase 2 (Mn)0.013
CG6543CG6543 gene product from transcript CG6543-RA0.012
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PRDX1peroxiredoxin 10.999
SOD1superoxide dismutase 1, soluble0.997
PRDX4peroxiredoxin 40.967
PARK7Parkinson disease (autosomal recessive, early onset) 70.842
PDZD11PDZ domain containing 110.271
PRDX6peroxiredoxin 60.268
PRDX3peroxiredoxin 30.259
PDIA6protein disulfide isomerase family A, member 60.098
PRDX2peroxiredoxin 20.095
DAD1defender against cell death 10.064
DUSP23dual specificity phosphatase 230.064
KEAP1kelch-like ECH-associated protein 10.061
APOA2apolipoprotein A-II0.050
FGAfibrinogen alpha chain0.049
TXNDC5thioredoxin domain containing 5 (endoplasmic reticulum)0.044
ING1inhibitor of growth family, member 10.034
APOC3apolipoprotein C-III0.029
LCATlecithin-cholesterol acyltransferase0.023
IFNGR1interferon gamma receptor 10.021
TBXA2Rthromboxane A2 receptor0.019
EIF2AK3eukaryotic translation initiation factor 2-alpha kinase 30.018
XRCC1X-ray repair complementing defective repair in Chinese hamster cells 10.015
CD320CD320 molecule0.014
DYNLL1dynein, light chain, LC8-type 10.014
DBIdiazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)0.011
MDC1mediator of DNA-damage checkpoint 10.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Fbn1fibrillin 10.923
Tgfbr2transforming growth factor, beta receptor II0.664
Apoeapolipoprotein E0.561
Loxlysyl oxidase0.545
Mmp2matrix metallopeptidase 20.444
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.391
Ldlrlow density lipoprotein receptor0.350
Atp7aATPase, Cu++ transporting, alpha polypeptide0.246
Slc31a1solute carrier family 31, member 10.179
Col6a1collagen, type VI, alpha 10.134
Hbb-b1hemoglobin, beta adult major chain0.124
Fbln5fibulin 50.118
Tgfbr1transforming growth factor, beta receptor I0.117
Loxl1lysyl oxidase-like 10.109
Ltbp2latent transforming growth factor beta binding protein 20.092
Fam96afamily with sequence similarity 96, member A0.086
Ifngr1interferon gamma receptor 10.076
Col1a2collagen, type I, alpha 20.071
Lamp2lysosomal-associated membrane protein 20.071
Leprel2leprecan-like 20.068
Tgfb2transforming growth factor, beta 20.067
Slc39a4solute carrier family 39 (zinc transporter), member 40.065
Romo1reactive oxygen species modulator 10.065
Mt1metallothionein 10.065
Duox2dual oxidase 20.064
Col6a2collagen, type VI, alpha 20.059
Agtr1aangiotensin II receptor, type 1a0.057
Cav1caveolin 1, caveolae protein0.056
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.054
Mcl1myeloid cell leukemia sequence 10.053
Smosmoothened homolog (Drosophila)0.049
Steap3STEAP family member 30.049
Mt2metallothionein 20.048
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.047
Creg1cellular repressor of E1A-stimulated genes 10.046
Gcshglycine cleavage system protein H (aminomethyl carrier)0.044
Mfap4microfibrillar-associated protein 40.043
E2f1E2F transcription factor 10.043
Prnpprion protein0.042
Tmed10transmembrane emp24-like trafficking protein 10 (yeast)0.041
Pkd1polycystic kidney disease 1 homolog0.041
Sod3superoxide dismutase 3, extracellular0.039
Ngpneutrophilic granule protein0.039
Slc12a6solute carrier family 12, member 60.039
Tlr4toll-like receptor 40.036
Tgfb1transforming growth factor, beta 10.035
Pcolceprocollagen C-endopeptidase enhancer protein0.035
Tgfb3transforming growth factor, beta 30.033
Cyb5cytochrome b-50.032
Aebp1AE binding protein 10.032
Iduaiduronidase, alpha-L-0.032
Dbidiazepam binding inhibitor0.031
Hif1anhypoxia-inducible factor 1, alpha subunit inhibitor0.030
Col1a1collagen, type I, alpha 10.029
Gypaglycophorin A0.029
Ndufa9NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 90.029
Scara3scavenger receptor class A, member 30.029
Thrbthyroid hormone receptor beta0.028
Elaneelastase, neutrophil expressed0.028
Figfc-fos induced growth factor0.027
Tmem14ctransmembrane protein 14C0.027
Bcap31B-cell receptor-associated protein 310.027
Thbs3thrombospondin 30.026
Lamb2laminin, beta 20.026
Col6a3collagen, type VI, alpha 30.025
Campcathelicidin antimicrobial peptide0.024
Efemp2epidermal growth factor-containing fibulin-like extracellular matrix protein 20.024
Slc12a4solute carrier family 12, member 40.024
Mrc2mannose receptor, C type 20.024
Col4a5collagen, type IV, alpha 50.023
Gata1GATA binding protein 10.023
Fam136afamily with sequence similarity 136, member A0.023
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.023
Ctsgcathepsin G0.022
Col16a1collagen, type XVI, alpha 10.022
Prelpproline arginine-rich end leucine-rich repeat0.022
Pgk1phosphoglycerate kinase 10.022
Agpat21-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)0.021
Gp1baglycoprotein 1b, alpha polypeptide0.021
Fzd2frizzled homolog 2 (Drosophila)0.021
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.021
Lass2LAG1 homolog, ceramide synthase 20.021
Adsladenylosuccinate lyase0.020
Tgfb1i1transforming growth factor beta 1 induced transcript 10.020
Suclg1succinate-CoA ligase, GDP-forming, alpha subunit0.020
Sulf1sulfatase 10.020
Klf1Kruppel-like factor 1 (erythroid)0.020
Pdgfbplatelet derived growth factor, B polypeptide0.019
F2rcoagulation factor II (thrombin) receptor0.019
Col3a1collagen, type III, alpha 10.018
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.018
Adamts1a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10.018
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.018
Fgfr3fibroblast growth factor receptor 30.018
Pax8paired box gene 80.018
Tal1T-cell acute lymphocytic leukemia 10.017
Atp5a1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 10.017
Aifm1apoptosis-inducing factor, mitochondrion-associated 10.017
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cox6a1cytochrome c oxidase, subunit VIa, polypeptide 10.406
Cyb5acytochrome b5 type A (microsomal)0.350
Oaz1ornithine decarboxylase antizyme 10.196
Cox8acytochrome c oxidase subunit VIIIa0.175
Gstp1glutathione S-transferase pi 10.152
Gadd45agrowth arrest and DNA-damage-inducible, alpha0.114
Akr1a1aldo-keto reductase family 1, member A1 (aldehyde reductase)0.086
Ndufa9NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 90.078
Lpllipoprotein lipase0.065
Mifmacrophage migration inhibitory factor0.047
Aldh6a1aldehyde dehydrogenase 6 family, member A10.043
Ghrgrowth hormone receptor0.037
MdficMyoD family inhibitor domain containing0.036
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.033
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.019
Akr1c14aldo-keto reductase family 1, member C140.019
Gclmglutamate cysteine ligase, modifier subunit0.018
Pirpirin (iron-binding nuclear protein)0.017
Gsta3glutathione S-transferase A30.016
Pebp1phosphatidylethanolamine binding protein 10.016
Cdk4cyclin-dependent kinase 40.015
Prdx2peroxiredoxin 20.014
Ghitmgrowth hormone inducible transmembrane protein0.014
Ndufv2NADH dehydrogenase (ubiquinone) flavoprotein 20.014
Eif4heukaryotic translation initiation factor 4H0.013
RGD1309779similar to ENSANGP000000213910.012
Gstm1glutathione S-transferase mu 10.012
Mgst1microsomal glutathione S-transferase 10.012
Sod1superoxide dismutase 1, soluble0.010
St13suppression of tumorigenicity 130.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism