The network for 'negative regulation of vasculature development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of vasculature development

Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development.

NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.088
bmp4bone morphogenetic protein 40.077
etv2ets variant gene 20.063
kdrlkinase insert domain receptor like0.052
wt1awilms tumor 1a0.041
ccm2cerebral cavernous malformation 20.033
plcg1phospholipase C, gamma 10.031
notch3notch homolog 30.029
nrp1aneuropilin 1a0.028
cdh5cadherin 50.023
plxnd1plexin D10.021
tie2endothelium-specific receptor tyrosine kinase 20.021
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.020
vegfcvascular endothelial growth factor c0.019
col2a1acollagen type II, alpha-1a0.017
hoxb4ahomeo box B4a0.017
ergv-ets erythroblastosis virus E26 oncogene like (avian)0.015
efnb2aephrin B2a0.014
mibmind bomb0.014
cdh17cadherin 17, LI cadherin (liver-intestine)0.013
angptl7angiopoietin-like 70.012
pitx3paired-like homeodomain transcription factor 30.012
cx43connexin 430.011
ccbe1collagen and calcium binding EGF domains 10.011
hoxa9bhomeo box A9b0.011
trpv4transient receptor potential cation channel, subfamily V, member 40.010
hnf1baHNF1 homeobox Ba0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TEKTEK tyrosine kinase, endothelial0.998
YAP1Yes-associated protein 10.960
JAG1jagged 10.893
BMPR1Abone morphogenetic protein receptor, type IA0.877
IL2RBinterleukin 2 receptor, beta0.865
COL4A2collagen, type IV, alpha 20.847
COL4A1collagen, type IV, alpha 10.836
NOTCH1notch 10.800
NOTCH3notch 30.798
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.753
HOXB5homeobox B50.705
CXCL10chemokine (C-X-C motif) ligand 100.652
IFNGinterferon, gamma0.644
SKILSKI-like oncogene0.562
PLAUplasminogen activator, urokinase0.530
HOXA5homeobox A50.526
ANGPT2angiopoietin 20.496
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.487
JAK1Janus kinase 10.480
MAP3K5mitogen-activated protein kinase kinase kinase 50.458
TP53tumor protein p530.453
CCR2chemokine (C-C motif) receptor 20.449
COL4A3collagen, type IV, alpha 3 (Goodpasture antigen)0.438
FGAfibrinogen alpha chain0.437
CREBBPCREB binding protein0.397
PTPN1protein tyrosine phosphatase, non-receptor type 10.369
GFI1Bgrowth factor independent 1B transcription repressor0.341
PLATplasminogen activator, tissue0.336
JAK2Janus kinase 20.336
CXCR3chemokine (C-X-C motif) receptor 30.320
HOXA7homeobox A70.306
HOXA10homeobox A100.305
MEF2Cmyocyte enhancer factor 2C0.295
MAP3K3mitogen-activated protein kinase kinase kinase 30.286
COL4A4collagen, type IV, alpha 40.274
CXCL11chemokine (C-X-C motif) ligand 110.268
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.255
CXCL9chemokine (C-X-C motif) ligand 90.252
MAPK7mitogen-activated protein kinase 70.244
ANGPT1angiopoietin 10.229
CCR7chemokine (C-C motif) receptor 70.228
NID1nidogen 10.220
CXCR6chemokine (C-X-C motif) receptor 60.217
F13A1coagulation factor XIII, A1 polypeptide0.207
IRF9interferon regulatory factor 90.202
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.197
CCL5chemokine (C-C motif) ligand 50.188
IL4Rinterleukin 4 receptor0.182
CFLARCASP8 and FADD-like apoptosis regulator0.178
CCR5chemokine (C-C motif) receptor 50.175
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.169
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.169
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.167
LAMC1laminin, gamma 1 (formerly LAMB2)0.162
KLF4Kruppel-like factor 4 (gut)0.158
TIE1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.158
HOXA4homeobox A40.157
CASP10caspase 10, apoptosis-related cysteine peptidase0.155
IFNAR2interferon (alpha, beta and omega) receptor 20.154
DLL1delta-like 1 (Drosophila)0.151
CD93CD93 molecule0.150
HOXC10homeobox C100.150
COL4A5collagen, type IV, alpha 50.146
MAP3K2mitogen-activated protein kinase kinase kinase 20.143
HOXA11homeobox A110.142
HOXB7homeobox B70.140
PF4platelet factor 40.140
HOXB3homeobox B30.137
TIMP3TIMP metallopeptidase inhibitor 30.135
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.130
COL4A6collagen, type IV, alpha 60.125
HOXB6homeobox B60.122
CD40LGCD40 ligand0.121
FASFas (TNF receptor superfamily, member 6)0.117
RHOAras homolog gene family, member A0.114
CCL8chemokine (C-C motif) ligand 80.112
AMOTL1angiomotin like 10.110
CCR4chemokine (C-C motif) receptor 40.107
HOXA6homeobox A60.107
ITGA2Bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)0.104
FGGfibrinogen gamma chain0.102
NCOR1nuclear receptor corepressor 10.101
IL12RB2interleukin 12 receptor, beta 20.101
JUNjun proto-oncogene0.099
KLF6Kruppel-like factor 60.099
CXCL13chemokine (C-X-C motif) ligand 130.098
NOTCH2notch 20.096
IRF4interferon regulatory factor 40.096
TIMP2TIMP metallopeptidase inhibitor 20.094
STAT2signal transducer and activator of transcription 2, 113kDa0.094
DAXXdeath-domain associated protein0.093
LTAlymphotoxin alpha (TNF superfamily, member 1)0.093
CYR61cysteine-rich, angiogenic inducer, 610.092
HOXB9homeobox B90.092
FOXP3forkhead box P30.091
ZBTB16zinc finger and BTB domain containing 160.091
CASP8caspase 8, apoptosis-related cysteine peptidase0.091
HSD11B1hydroxysteroid (11-beta) dehydrogenase 10.090
PLXND1plexin D10.089
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ccr2chemokine (C-C motif) receptor 20.848
Leprleptin receptor0.750
Cd44CD44 antigen0.741
Col3a1collagen, type III, alpha 10.593
Ptgs2prostaglandin-endoperoxide synthase 20.581
Bmp5bone morphogenetic protein 50.559
Ccr1chemokine (C-C motif) receptor 10.525
Clockcircadian locomotor output cycles kaput0.489
Col4a1collagen, type IV, alpha 10.469
Pgrprogesterone receptor0.452
Ccl2chemokine (C-C motif) ligand 20.394
Prl8a2prolactin family 8, subfamily a, member 20.387
Cyr61cysteine rich protein 610.387
Col4a2collagen, type IV, alpha 20.380
Col4a5collagen, type IV, alpha 50.330
Apcadenomatosis polyposis coli0.316
Postnperiostin, osteoblast specific factor0.300
BmperBMP-binding endothelial regulator0.288
Loxlysyl oxidase0.253
Cd59aCD59a antigen0.241
Col5a2collagen, type V, alpha 20.213
Pcdh12protocadherin 120.212
Nab2Ngfi-A binding protein 20.211
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.199
Lyz2lysozyme 20.185
Dusp1dual specificity phosphatase 10.176
Apoeapolipoprotein E0.173
Pmp22peripheral myelin protein 220.163
Fzd1frizzled homolog 1 (Drosophila)0.158
Ikzf1IKAROS family zinc finger 10.158
Arntlaryl hydrocarbon receptor nuclear translocator-like0.156
Cry2cryptochrome 2 (photolyase-like)0.155
Cfhcomplement component factor h0.154
Ccr5chemokine (C-C motif) receptor 50.150
Prrx1paired related homeobox 10.149
Cd19CD19 antigen0.146
Thbs1thrombospondin 10.146
Ccl3chemokine (C-C motif) ligand 30.146
Adamts1a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10.144
Ctgfconnective tissue growth factor0.135
Ifnginterferon gamma0.134
Psg19pregnancy specific glycoprotein 190.134
Prdm1PR domain containing 1, with ZNF domain0.133
Prf1perforin 1 (pore forming protein)0.126
Smad3MAD homolog 3 (Drosophila)0.123
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.120
Nos2nitric oxide synthase 2, inducible0.111
Ncor2nuclear receptor co-repressor 20.110
Selpselectin, platelet0.109
BmxBMX non-receptor tyrosine kinase0.108
Gfra3glial cell line derived neurotrophic factor family receptor alpha 30.105
Tlr4toll-like receptor 40.104
Rhbdf1rhomboid family 1 (Drosophila)0.101
Ren1renin 1 structural0.099
H2-Obhistocompatibility 2, O region beta locus0.099
Ptgfrprostaglandin F receptor0.098
Rb1retinoblastoma 10.097
Tgfbr3transforming growth factor, beta receptor III0.097
Fstl1follistatin-like 10.096
Klrk1killer cell lectin-like receptor subfamily K, member 10.096
Il1r1interleukin 1 receptor, type I0.094
Per1period homolog 1 (Drosophila)0.092
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.090
Nr3c1nuclear receptor subfamily 3, group C, member 10.088
Ciitaclass II transactivator0.086
Gprc6aG protein-coupled receptor, family C, group 6, member A0.084
Col6a3collagen, type VI, alpha 30.083
Ltblymphotoxin B0.083
Tpbpatrophoblast specific protein alpha0.081
Ctsrcathepsin R0.080
Olfr64olfactory receptor 640.079
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.077
Col4a3collagen, type IV, alpha 30.076
Gzmcgranzyme C0.076
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.075
Fgf7fibroblast growth factor 70.074
Ceacam9carcinoembryonic antigen-related cell adhesion molecule 90.074
Map3k14mitogen-activated protein kinase kinase kinase 140.072
Gli2GLI-Kruppel family member GLI20.071
Dock1dedicator of cytokinesis 10.071
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.070
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.070
Sox17SRY-box containing gene 170.070
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.069
Icam1intercellular adhesion molecule 10.069
Stab2stabilin 20.068
Klrd1killer cell lectin-like receptor, subfamily D, member 10.068
Rp1retinitis pigmentosa 1 (human)0.068
Thbs2thrombospondin 20.067
Snai1snail homolog 1 (Drosophila)0.067
Nf2neurofibromatosis 20.066
Ctnnb1catenin (cadherin associated protein), beta 10.066
Tcf21transcription factor 210.065
Foxf1aforkhead box F1a0.064
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ccl4chemokine (C-C motif) ligand 40.321
Il6interleukin 60.282
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.254
Ccl2chemokine (C-C motif) ligand 20.239
Cxcl2chemokine (C-X-C motif) ligand 20.177
Prdm2PR domain containing 2, with ZNF domain0.164
Fosl1fos-like antigen 10.108
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.102
Dio2deiodinase, iodothyronine, type II0.089
Rup2urinary protein 20.074
Asgr2asialoglycoprotein receptor 20.068
Cxcl10chemokine (C-X-C motif) ligand 100.063
Iappislet amyloid polypeptide0.051
Map3k8mitogen-activated protein kinase kinase kinase 80.051
Spp2secreted phosphoprotein 20.050
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.045
Syt8synaptotagmin VIII0.042
Twist2twist homolog 2 (Drosophila)0.042
Fgf2fibroblast growth factor 20.040
Mbl1mannose-binding lectin (protein A) 10.036
LOC299282Serine protease inhibitor0.036
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.035
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.033
Cyp2c13cytochrome P450, family 2, subfamily c, polypeptide 130.033
Edn1endothelin 10.032
Prl3d1Prolactin family 3, subfamily d, member 10.032
Procprotein C0.031
Serpind1serpin peptidase inhibitor, clade D (heparin cofactor), member 10.030
Cyp4f4cytochrome P450, family 4, subfamily f, polypeptide 40.029
Gpr116G protein-coupled receptor 1160.029
Ctshcathepsin H0.029
Serpinb7serpin peptidase inhibitor, clade B (ovalbumin), member 70.027
Tacr2tachykinin receptor 20.027
Ltb4r2leukotriene B4 receptor 20.024
Apoa5apolipoprotein A-V0.024
Ccr2chemokine (C-C motif) receptor 20.022
Pemtphosphatidylethanolamine N-methyltransferase0.022
Fgbfibrinogen beta chain0.022
Cxcr5chemokine (C-X-C motif) receptor 50.021
Tnni1troponin I type 1 (skeletal, slow)0.021
Il9rinterleukin 9 receptor0.020
Col10a1collagen, type X, alpha 10.020
Cmtm2aCKLF-like MARVEL transmembrane domain containing 2A0.020
Mbl2mannose-binding lectin (protein C) 20.020
Ifit3interferon-induced protein with tetratricopeptide repeats 30.020
Ngfnerve growth factor (beta polypeptide)0.019
Gucy1b2guanylate cyclase 1, soluble, beta 20.018
Gfapglial fibrillary acidic protein0.018
Pitx3paired-like homeodomain 30.018
Fgfr2fibroblast growth factor receptor 20.018
LOC100364500RT1 class I, locus CE11-like0.016
Il1ainterleukin 1 alpha0.016
Cyp2b12cytochrome P450, family 2, subfamily b, polypeptide 120.016
Has2hyaluronan synthase 20.016
Apohapolipoprotein H (beta-2-glycoprotein I)0.016
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.016
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.016
Ccl20chemokine (C-C motif) ligand 200.016
Ptpn12protein tyrosine phosphatase, non-receptor type 120.016
Gcgroup specific component0.016
Scpep1serine carboxypeptidase 10.015
Nos3nitric oxide synthase 3, endothelial cell0.015
Cgaglycoprotein hormones, alpha polypeptide0.015
Chrna6cholinergic receptor, nicotinic, alpha 60.015
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.015
Il1rninterleukin 1 receptor antagonist0.015
Mmp12matrix metallopeptidase 120.015
Wisp2WNT1 inducible signaling pathway protein 20.015
Tdo2tryptophan 2,3-dioxygenase0.014
Apoa2apolipoprotein A-II0.014
Kcna3potassium voltage-gated channel, shaker-related subfamily, member 30.014
Fgf14fibroblast growth factor 140.014
Serpina11serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 110.014
Olr416olfactory receptor 4160.014
Fgafibrinogen alpha chain0.014
Apcsamyloid P component, serum0.013
Mbtps1membrane-bound transcription factor peptidase, site 10.013
Csrp3cysteine and glycine-rich protein 30.013
Aqp8aquaporin 80.013
Crhbpcorticotropin releasing hormone binding protein0.013
Adora2aadenosine A2a receptor0.013
Celsr3cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)0.013
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.013
Folh1folate hydrolase 10.013
Trim28tripartite motif-containing 280.013
Cpa3carboxypeptidase A3, mast cell0.012
Testintestin gene0.012
Arl5cADP-ribosylation factor-like 5C0.012
Tlr4toll-like receptor 40.012
Atf3activating transcription factor 30.012
RGD1308165similar to hypothetical protein MGC173370.012
Col8a1collagen, type VIII, alpha 10.012
Ms4a8amembrane-spanning 4-domains, subfamily A, member 8A0.012
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism