The network for 'cardiac chamber morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cardiac chamber morphogenesis

The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.

NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 10.993
nkx2.5NK2 transcription factor related 50.823
hhexhematopoietically expressed homeobox0.782
wif1wnt inhibitory factor 10.611
wnt11rwingless-type MMTV integration site family, member 11, related0.503
hey2hairy/enhancer-of-split related with YRPW motif 20.460
isl1islet10.416
foxi1forkhead box I10.372
tnni1btroponin I, skeletal, slow b0.339
myod1myogenic differentiation 10.333
cdh2cadherin 2, neuronal0.295
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.281
tmem88atransmembrane protein 88 a0.259
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.256
gata5GATA-binding protein 50.249
ttnatitin a0.223
pcdh8protocadherin 80.192
pax8paired box gene 80.182
alcamaactivated leukocyte cell adhesion molecule a0.171
slc8a1asolute carrier family 8 (sodium/calcium exchanger), member 1a0.171
fgf8afibroblast growth factor 8 a0.165
gpr126G protein-coupled receptor 1260.164
flt4fms-related tyrosine kinase 40.159
unc45bunc-45 homolog B (C. elegans)0.156
tal1T-cell acute lymphocytic leukemia 10.145
lmo4aLIM domain only 4a0.141
lft2lefty20.131
aplnrbapelin receptor b0.129
six4bsine oculis homeobox homolog 4b0.124
tbx20T-box 200.116
tyrtyrosinase0.114
vmhcventricular myosin heavy chain0.113
xirp1xin actin-binding repeat containing 10.112
gata2aGATA-binding protein 2a0.112
smyhc1lslow myosin heavy chain 1, like0.111
cmlc1cardiac myosin light chain-10.108
myl7myosin, light polypeptide 7, regulatory0.106
fn1fibronectin 10.103
dlx4bdistal-less homeobox gene 4b0.102
hand2heart and neural crest derivatives expressed transcript 20.092
actc1aactin, alpha, cardiac muscle 1a0.092
gata4GATA-binding protein 40.092
spawsouthpaw0.084
aldh1a2aldehyde dehydrogenase 1 family, member A20.083
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.078
fibinfin bud initiation factor0.075
pax2apaired box gene 2a0.074
hoxa2bhomeo box A2b0.074
pid1phosphotyrosine interaction domain containing 10.072
nkx3.2NK3 homeobox 20.071
LOC100000500sclerostin-like0.068
ogg18-oxoguanine DNA glycosylase0.067
tpm4tropomyosin 40.066
bmp2bbone morphogenetic protein 2b0.066
tgfb3transforming growth factor, beta 30.064
wnt2bbwingless-type MMTV integration site family, member 2Bb0.062
tbx16T-box gene 160.061
has2hyaluronan synthase 20.060
lft1lefty10.059
znf148zinc finger protein 1480.059
shhasonic hedgehog a0.058
tnnc1atroponin C type 1a (slow)0.053
atp2a2aATPase, Ca++ transporting, cardiac muscle, slow twitch 2a0.052
gata3GATA-binding protein 30.051
gja3gap junction protein, alpha 30.051
smyd1bSET and MYND domain containing 1b0.050
nr5a2nuclear receptor subfamily 5, group A, member 20.049
ckmacreatine kinase, muscle a0.047
bmp3bone morphogenetic protein 30.047
flncbfilamin C, gamma b (actin binding protein 280)0.046
tbx5bT-box 5b0.045
tnnc2troponin C type 2 (fast)0.045
rx3retinal homeobox gene 30.044
hnf1baHNF1 homeobox Ba0.043
lmo2LIM domain only 2 (rhombotin-like 1)0.042
foxc1aforkhead box C1a0.042
cx36.7connexin 36.70.041
tnnt3atroponin T3a, skeletal, fast0.041
tnni2a.4troponin I, skeletal, fast 2a.40.040
actc1bactin, alpha, cardiac muscle 1b0.039
apcadenomatosis polyposis coli0.039
rbm24aRNA binding motif protein 24a0.039
mespamesoderm posterior a0.037
notch3notch homolog 30.036
alcambactivated leukocyte cell adhesion molecule b0.035
fgf18afibroblast growth factor 18a0.035
col9a2procollagen, type IX, alpha 20.034
dctdopachrome tautomerase0.034
foxa2forkhead box A20.034
wlswntless homolog (Drosophila)0.034
hmx4H6 family homeobox 40.033
mab21l1mab-21-like 10.032
tp53bp2tumor protein p53 binding protein, 20.032
spon1bspondin 1b0.032
six4asine oculis homeobox homolog 4a0.032
klf2aKruppel-like factor 2a0.032
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.031
wnt5bwingless-type MMTV integration site family, member 5b0.031
mef2cbmyocyte enhancer factor 2cb0.031
tnnc1btroponin C type 1b (slow)0.031
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
JAG1jagged 10.999
CSNK1Ecasein kinase 1, epsilon0.996
TNNC1troponin C type 1 (slow)0.992
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.987
TAL1T-cell acute lymphocytic leukemia 10.985
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.952
NOTCH3notch 30.928
TNNI1troponin I type 1 (skeletal, slow)0.925
TPM1tropomyosin 1 (alpha)0.921
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.909
FKBP1AFK506 binding protein 1A, 12kDa0.789
MYOD1myogenic differentiation 10.782
TBX5T-box 50.700
GATA4GATA binding protein 40.667
NOTCH1notch 10.597
SMAD7SMAD family member 70.557
AXIN1axin 10.534
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.500
MYH9myosin, heavy chain 9, non-muscle0.490
SMYD1SET and MYND domain containing 10.484
CTGFconnective tissue growth factor0.469
HAP1huntingtin-associated protein 10.464
EPAS1endothelial PAS domain protein 10.456
SMAD9SMAD family member 90.423
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.422
EP300E1A binding protein p3000.400
TNNT2troponin T type 2 (cardiac)0.394
TNNT3troponin T type 3 (skeletal, fast)0.345
ESR1estrogen receptor 10.344
ACVR1activin A receptor, type I0.339
BMP2bone morphogenetic protein 20.328
ACVR1Bactivin A receptor, type IB0.324
MYL12Amyosin, light chain 12A, regulatory, non-sarcomeric0.313
TTRtransthyretin0.308
CKMcreatine kinase, muscle0.276
TPM2tropomyosin 2 (beta)0.271
SMAD3SMAD family member 30.263
RXRAretinoid X receptor, alpha0.259
COX6A2cytochrome c oxidase subunit VIa polypeptide 20.250
NR4A1nuclear receptor subfamily 4, group A, member 10.229
ATP2A1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.212
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.210
MYOGmyogenin (myogenic factor 4)0.199
CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.196
HNF4Ahepatocyte nuclear factor 4, alpha0.194
TGFB1transforming growth factor, beta 10.191
AKAP12A kinase (PRKA) anchor protein 120.186
GATA2GATA binding protein 20.185
PDE4DIPphosphodiesterase 4D interacting protein0.182
SMURF2SMAD specific E3 ubiquitin protein ligase 20.178
MYL2myosin, light chain 2, regulatory, cardiac, slow0.176
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.168
MYH7myosin, heavy chain 7, cardiac muscle, beta0.167
ANGPT2angiopoietin 20.163
SIRT1sirtuin 10.159
SETD8SET domain containing (lysine methyltransferase) 80.157
ESR2estrogen receptor 2 (ER beta)0.154
ACTA1actin, alpha 1, skeletal muscle0.150
RARAretinoic acid receptor, alpha0.149
MAML1mastermind-like 1 (Drosophila)0.146
CREBBPCREB binding protein0.141
FSTL1follistatin-like 10.138
MYH2myosin, heavy chain 2, skeletal muscle, adult0.137
RUNX1runt-related transcription factor 10.129
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.129
KRT18keratin 180.123
KRT14keratin 140.122
FGF10fibroblast growth factor 100.121
ANGPT1angiopoietin 10.114
DLL1delta-like 1 (Drosophila)0.113
TGFBR1transforming growth factor, beta receptor 10.110
DSPdesmoplakin0.110
WNT3Awingless-type MMTV integration site family, member 3A0.100
GDF5growth differentiation factor 50.098
ENGendoglin0.097
JUPjunction plakoglobin0.097
MYL1myosin, light chain 1, alkali; skeletal, fast0.097
GATA1GATA binding protein 1 (globin transcription factor 1)0.096
ILKintegrin-linked kinase0.096
ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix protein0.095
PDX1pancreatic and duodenal homeobox 10.095
SP1Sp1 transcription factor0.093
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.093
MSX1msh homeobox 10.093
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.086
SMAD6SMAD family member 60.085
PTRFpolymerase I and transcript release factor0.084
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.082
DVL1dishevelled, dsh homolog 1 (Drosophila)0.082
PRKG1protein kinase, cGMP-dependent, type I0.081
TNNT1troponin T type 1 (skeletal, slow)0.081
FAM83Dfamily with sequence similarity 83, member D0.078
MED25mediator complex subunit 250.078
PKP4plakophilin 40.071
HIC1hypermethylated in cancer 10.070
LDB3LIM domain binding 30.067
FGF1fibroblast growth factor 1 (acidic)0.065
MYH1myosin, heavy chain 1, skeletal muscle, adult0.063
FZD1frizzled homolog 1 (Drosophila)0.063
HIPK2homeodomain interacting protein kinase 20.062
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pitx2paired-like homeodomain transcription factor 21.000
Hand2heart and neural crest derivatives expressed transcript 21.000
Shhsonic hedgehog1.000
Fgf8fibroblast growth factor 81.000
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)1.000
Fgfr2fibroblast growth factor receptor 21.000
Gli3GLI-Kruppel family member GLI31.000
Tbx3T-box 31.000
Nodalnodal0.999
Tbx1T-box 10.999
Otx2orthodenticle homolog 2 (Drosophila)0.999
Pax2paired box gene 20.999
Meox2mesenchyme homeobox 20.999
Gata4GATA binding protein 40.999
Sox2SRY-box containing gene 20.998
Fgfr1fibroblast growth factor receptor 10.998
Foxh1forkhead box H10.998
Sall4sal-like 4 (Drosophila)0.997
Bmp4bone morphogenetic protein 40.997
Foxc2forkhead box C20.997
Pax3paired box gene 30.997
Vangl2vang-like 2 (van gogh, Drosophila)0.997
Pitx1paired-like homeodomain transcription factor 10.995
Nognoggin0.993
Ctnnb1catenin (cadherin associated protein), beta 10.993
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.992
Foxc1forkhead box C10.992
Mesp1mesoderm posterior 10.992
Lhx1LIM homeobox protein 10.992
Rargretinoic acid receptor, gamma0.991
Tcfap2atranscription factor AP-2, alpha0.987
Tgfb2transforming growth factor, beta 20.986
Hand1heart and neural crest derivatives expressed transcript 10.986
Zic3zinc finger protein of the cerebellum 30.985
Sox9SRY-box containing gene 90.984
Hoxa13homeobox A130.983
Smad6MAD homolog 6 (Drosophila)0.983
Foxg1forkhead box G10.982
Foxa2forkhead box A20.981
Notch1Notch gene homolog 1 (Drosophila)0.978
Gli2GLI-Kruppel family member GLI20.978
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.977
Bmp7bone morphogenetic protein 70.972
Eya1eyes absent 1 homolog (Drosophila)0.970
Hoxa1homeobox A10.969
Hoxd11homeobox D110.966
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.957
Gata6GATA binding protein 60.956
Tlx3T-cell leukemia, homeobox 30.946
Hoxd13homeobox D130.946
Pou3f3POU domain, class 3, transcription factor 30.943
Isl1ISL1 transcription factor, LIM/homeodomain0.940
Fgf10fibroblast growth factor 100.937
Rarbretinoic acid receptor, beta0.926
Chrdchordin0.925
Jag1jagged 10.923
Axin1axin 10.915
Wnt6wingless-related MMTV integration site 60.911
Vegfavascular endothelial growth factor A0.908
Ptpn11protein tyrosine phosphatase, non-receptor type 110.901
Msx1homeobox, msh-like 10.893
Gscgoosecoid homeobox0.888
Tcf15transcription factor 150.886
Sox7SRY-box containing gene 70.885
Pax6paired box gene 60.882
Gbx2gastrulation brain homeobox 20.882
Ascl1achaete-scute complex homolog 1 (Drosophila)0.869
Shesrc homology 2 domain-containing transforming protein E0.869
Sall1sal-like 1 (Drosophila)0.857
Efnb2ephrin B20.851
Esrrbestrogen related receptor, beta0.850
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.843
Gpc3glypican 30.836
Arid1aAT rich interactive domain 1A (SWI-like)0.830
Foxf1aforkhead box F1a0.830
Insm1insulinoma-associated 10.827
Chd7chromodomain helicase DNA binding protein 70.821
Pou5f1POU domain, class 5, transcription factor 10.812
Emx2empty spiracles homolog 2 (Drosophila)0.811
Snai1snail homolog 1 (Drosophila)0.807
Sox4SRY-box containing gene 40.804
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.802
Dvl2dishevelled 2, dsh homolog (Drosophila)0.802
Fgfr3fibroblast growth factor receptor 30.801
Acvr1activin A receptor, type 10.801
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.794
Alx4aristaless-like homeobox 40.792
Prrx1paired related homeobox 10.788
Fgf15fibroblast growth factor 150.782
Twist2twist homolog 2 (Drosophila)0.779
Dlx1distal-less homeobox 10.776
Fgf18fibroblast growth factor 180.775
Wnt3awingless-related MMTV integration site 3A0.774
Prrx2paired related homeobox 20.773
Col4a1collagen, type IV, alpha 10.762
Pthlhparathyroid hormone-like peptide0.751
Klk1b11kallikrein 1-related peptidase b110.747
Pax8paired box gene 80.745
Hmx3H6 homeobox 30.741
Dlx2distal-less homeobox 20.730
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism