The network for 'endocardial cushion morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endocardial cushion morphogenesis

The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.

NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 10.993
fgf8afibroblast growth factor 8 a0.987
bmp4bone morphogenetic protein 40.923
bmp2bbone morphogenetic protein 2b0.833
kdrlkinase insert domain receptor like0.684
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.569
aldoabaldolase a, fructose-bisphosphate, b0.512
msxcmuscle segment homeobox C0.508
wlswntless homolog (Drosophila)0.461
pax2apaired box gene 2a0.380
shhasonic hedgehog a0.351
lmo4aLIM domain only 4a0.350
myod1myogenic differentiation 10.332
cdh2cadherin 2, neuronal0.328
aldh1a2aldehyde dehydrogenase 1 family, member A20.322
hand2heart and neural crest derivatives expressed transcript 20.292
tbx5aT-box 5a0.248
tbx18T-box 180.227
vmhcventricular myosin heavy chain0.191
dlx2adistal-less homeobox gene 2a0.166
snai1asnail homolog 1a (Drosophila)0.165
fstafollistatin a0.163
fgf3fibroblast growth factor 30.160
ptch2patched 20.160
wnt5bwingless-type MMTV integration site family, member 5b0.159
hnf1baHNF1 homeobox Ba0.145
foxn4forkhead box N40.139
nkx2.5NK2 transcription factor related 50.136
myf5myogenic factor 50.122
dlx4bdistal-less homeobox gene 4b0.119
pard6gbpar-6 partitioning defective 6 homolog gamma B (C. elegans)0.116
notch1bnotch homolog 1b0.115
actc1aactin, alpha, cardiac muscle 1a0.111
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.108
has2hyaluronan synthase 20.105
hey2hairy/enhancer-of-split related with YRPW motif 20.102
wnt11wingless-type MMTV integration site family, member 110.101
mmp2matrix metalloproteinase 20.099
eya1eyes absent homolog 10.096
wnt11rwingless-type MMTV integration site family, member 11, related0.094
desmadesmin a0.089
myl10myosin, light chain 10, regulatory0.087
tbx16T-box gene 160.083
ntlano tail a0.083
ascl1aachaete-scute complex-like 1a (Drosophila)0.077
myl1myosin, light chain 1, alkali; skeletal, fast0.074
actc1bactin, alpha, cardiac muscle 1b0.072
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.071
ctgfconnective tissue growth factor0.071
vasavasa homolog0.070
cmlc1cardiac myosin light chain-10.069
pld1aphospholipase D1a0.068
myl7myosin, light polypeptide 7, regulatory0.066
hoxa2bhomeo box A2b0.066
rykreceptor-like tyrosine kinase0.064
ptch1patched 10.063
cdh1cadherin 1, epithelial0.063
tnnt2atroponin T2a, cardiac0.060
smad5MAD homolog 5 (Drosophila)0.059
vaspvasodilator-stimulated phosphoprotein0.059
nkx3.2NK3 homeobox 20.058
zfand5azinc finger, AN1-type domain 5a0.058
lhx2bLIM homeobox 2b0.058
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.058
ckmacreatine kinase, muscle a0.055
mibmind bomb0.055
dlx5adistal-less homeobox gene 5a0.054
edn1endothelin 10.054
unc45bunc-45 homolog B (C. elegans)0.054
kbtbd10bkelch repeat and BTB (POZ) domain containing 10b0.054
stat1bsignal transducer and activator of transcription 1b0.053
krt4keratin 40.053
atoh1aatonal homolog 1a0.051
cdh5cadherin 50.050
frem3Fras1 related extracellular matrix 30.049
tgfbitransforming growth factor, beta-induced0.049
oepone-eyed pinhead0.049
dlx3bdistal-less homeobox gene 3b0.048
sox11bSRY-box containing gene 11b0.047
cyp26a1cytochrome P450, subfamily XXVIA, polypeptide 10.047
tfap2atranscription factor AP-2 alpha0.046
tmem2transmembrane protein 20.044
dlx6adistal-less homeobox gene 6a0.044
aplnrbapelin receptor b0.043
tnnc2troponin C type 2 (fast)0.043
sox10SRY-box containing gene 100.042
gapdhglyceraldehyde-3-phosphate dehydrogenase0.042
efna5aephrin A5a0.042
pax3apaired box gene 3a0.042
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.041
tbx2bT-box 2b0.041
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Pitx2paired-like homeodomain transcription factor 21.000
Gata4GATA binding protein 40.999
Fgf8fibroblast growth factor 80.999
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.999
Pax3paired box gene 30.999
Hand2heart and neural crest derivatives expressed transcript 20.996
Otx2orthodenticle homolog 2 (Drosophila)0.994
Foxc1forkhead box C10.987
Tbx3T-box 30.977
Gli3GLI-Kruppel family member GLI30.975
Jag1jagged 10.970
Notch1Notch gene homolog 1 (Drosophila)0.967
Smad4MAD homolog 4 (Drosophila)0.967
Pitx1paired-like homeodomain transcription factor 10.952
Pax6paired box gene 60.939
Tcfap2atranscription factor AP-2, alpha0.934
Meox2mesenchyme homeobox 20.930
Pax2paired box gene 20.922
Fgfr2fibroblast growth factor receptor 20.921
Ascl1achaete-scute complex homolog 1 (Drosophila)0.912
Zic3zinc finger protein of the cerebellum 30.904
Bmp4bone morphogenetic protein 40.901
Hand1heart and neural crest derivatives expressed transcript 10.900
Lhx1LIM homeobox protein 10.890
Hoxa1homeobox A10.881
Tgfbr2transforming growth factor, beta receptor II0.881
Smad6MAD homolog 6 (Drosophila)0.871
Tgfb2transforming growth factor, beta 20.863
Prrx1paired related homeobox 10.849
Hoxd13homeobox D130.833
Bmpr1abone morphogenetic protein receptor, type 1A0.803
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.793
Foxc2forkhead box C20.785
Gscgoosecoid homeobox0.772
Apcadenomatosis polyposis coli0.772
Tlx3T-cell leukemia, homeobox 30.759
Sox11SRY-box containing gene 110.758
Dll4delta-like 4 (Drosophila)0.751
Neurog2neurogenin 20.736
Lhx3LIM homeobox protein 30.714
Wt1Wilms tumor 1 homolog0.710
Snai1snail homolog 1 (Drosophila)0.679
Sox2SRY-box containing gene 20.639
Gata6GATA binding protein 60.639
Isl1ISL1 transcription factor, LIM/homeodomain0.627
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.622
Tbx1T-box 10.601
Alx4aristaless-like homeobox 40.601
Shesrc homology 2 domain-containing transforming protein E0.596
Foxh1forkhead box H10.589
Smad1MAD homolog 1 (Drosophila)0.571
En1engrailed 10.571
Gdnfglial cell line derived neurotrophic factor0.538
Twist2twist homolog 2 (Drosophila)0.523
Sox7SRY-box containing gene 70.523
Hey2hairy/enhancer-of-split related with YRPW motif 20.490
Acvrl1activin A receptor, type II-like 10.488
Neurod1neurogenic differentiation 10.473
Hoxa13homeobox A130.468
Vegfavascular endothelial growth factor A0.458
Sox9SRY-box containing gene 90.458
Foxf1aforkhead box F1a0.451
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.410
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.380
Hoxa11homeobox A110.369
Sox17SRY-box containing gene 170.368
Prrx2paired related homeobox 20.367
Nos3nitric oxide synthase 3, endothelial cell0.366
Lhx9LIM homeobox protein 90.354
Insm1insulinoma-associated 10.353
Nr5a1nuclear receptor subfamily 5, group A, member 10.348
Gbx2gastrulation brain homeobox 20.345
Meox1mesenchyme homeobox 10.319
Alx3aristaless-like homeobox 30.310
Ptf1apancreas specific transcription factor, 1a0.301
Ptpn11protein tyrosine phosphatase, non-receptor type 110.300
Msx1homeobox, msh-like 10.298
Ror2receptor tyrosine kinase-like orphan receptor 20.296
Ebf3early B-cell factor 30.296
Ctnnb1catenin (cadherin associated protein), beta 10.294
Tbx4T-box 40.289
Hes1hairy and enhancer of split 1 (Drosophila)0.288
Pou3f3POU domain, class 3, transcription factor 30.282
Fgf10fibroblast growth factor 100.272
Ntf3neurotrophin 30.272
Kiss1KiSS-1 metastasis-suppressor0.265
Vangl2vang-like 2 (van gogh, Drosophila)0.264
Bnc1basonuclin 10.256
Acvr1activin A receptor, type 10.255
Hspg2perlecan (heparan sulfate proteoglycan 2)0.251
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.244
Lmx1bLIM homeobox transcription factor 1 beta0.238
Tcf21transcription factor 210.236
Hes5hairy and enhancer of split 5 (Drosophila)0.232
Efnb2ephrin B20.231
Onecut1one cut domain, family member 10.224
Smad3MAD homolog 3 (Drosophila)0.220
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism