The network for 'negative regulation of cell fate specification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cell fate specification

Any process that restricts, stops or prevents a cell from adopting a specific cell fate.

NameDescriptionProbabilityFunc Analog Organism
hmx4H6 family homeobox 40.632
notch2notch homolog 20.495
pcdh8protocadherin 80.494
bmp2bbone morphogenetic protein 2b0.493
dkk1bdickkopf 1b0.442
hoxa11ahomeo box A11a0.437
mespamesoderm posterior a0.370
otx1aorthodenticle homolog 1a0.169
bmp4bone morphogenetic protein 40.161
foxa3forkhead box A30.154
neo1neogenin 10.153
msxcmuscle segment homeobox C0.153
pea3ETS-domain transcription factor pea30.114
foxi1forkhead box I10.112
sfrp1asecreted frizzled-related protein 1a0.108
gbx2gastrulation brain homeo box 20.102
notch3notch homolog 30.095
pnxposterior neuron-specific homeobox0.088
foxd5forkhead box D50.088
six4bsine oculis homeobox homolog 4b0.086
col14a1collagen, type XIV, alpha 10.085
hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.082
nkx2.5NK2 transcription factor related 50.080
gli1GLI-Kruppel family member 10.078
sptbspectrin, beta, erythrocytic0.077
tbx16T-box gene 160.077
her5hairy-related 50.072
tbx18T-box 180.070
fgf3fibroblast growth factor 30.069
tll1tolloid-like 10.068
dhrs3adehydrogenase/reductase (SDR family) member 3a0.063
frem3Fras1 related extracellular matrix 30.063
wnt4awingless-type MMTV integration site family, member 4a0.061
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.060
tbx6T-box gene 60.054
nrg2aneuregulin 2a0.053
mespbmesoderm posterior b0.053
wnt5bwingless-type MMTV integration site family, member 5b0.052
dusp6dual specificity phosphatase 60.050
msxbmuscle segment homeobox B0.048
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.047
bocbrother of CDO0.047
fgfr4fibroblast growth factor receptor 40.046
fgf8bfibroblast growth factor 8 b0.046
flhfloating head0.046
notch1bnotch homolog 1b0.046
vsx2visual system homeobox 20.043
egr2bearly growth response 2b0.042
dspadesmoplakin a0.042
ef1ETS-related factor10.042
fzd7afrizzled homolog 7a0.042
hoxd13ahomeo box D13a0.042
wacaWW domain containing adaptor with coiled-coil a0.041
jag1bjagged 1b0.041
lhx1bLIM homeobox 1b0.041
igf3insulin-like growth factor 30.040
ntn1bnetrin 1b0.040
gata4GATA-binding protein 40.039
wnt11rwingless-type MMTV integration site family, member 11, related0.039
ptgs2aprostaglandin-endoperoxide synthase 2a0.039
hmx2H6 family homeobox 20.038
aldh1a3aldehyde dehydrogenase 1 family, member A30.038
pitx3paired-like homeodomain transcription factor 30.038
snai1bsnail homolog 1b (Drosophila)0.037
fgfr2fibroblast growth factor receptor 20.036
uts2aurotensin 2, alpha0.036
plagl2pleiomorphic adenoma gene-like 20.036
atoh1aatonal homolog 1a0.036
tbx20T-box 200.036
col5a2lcollagen, type V, alpha 2-like0.035
hoxd11ahomeo box D11a0.035
pcdh18aprotocadherin 18a0.033
etv5bets variant 5b0.032
zfand5azinc finger, AN1-type domain 5a0.032
sox17SRY-box containing gene 170.032
wnt8bwingless-type MMTV integration site family, member 8b0.031
lama5laminin, alpha 50.029
tp63tumor protein p630.029
nkd1naked cuticle homolog 1 (Drosophila)0.029
metmet proto-oncogene (hepatocyte growth factor receptor)0.029
ventventral expressed homeobox0.029
ptch1patched 10.028
ext1aexostoses (multiple) 1a0.028
rasl11bRAS-like, family 11, member B0.028
hoxb5ahomeo box B5a0.027
jag1ajagged 1a0.027
mmp14amatrix metalloproteinase 14a (membrane-inserted)0.027
slc8a4bsolute carrier family 8 (sodium/calcium exchanger), member 4b0.027
sox32SRY-box containing gene 320.026
smad1MAD homolog 1 (Drosophila)0.026
ndr2nodal-related 20.026
wif1wnt inhibitory factor 10.024
pcdh10bprotocadherin 10b0.024
bmp7abone morphogenetic protein 7a0.024
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
InRInsulin-like receptor0.543
eveeven skipped0.329
EgfrEpidermal growth factor receptor0.263
argosCG4531 gene product from transcript CG4531-RA0.221
kirrekin of irre0.172
aopanterior open0.152
cicubitus interruptus0.146
foxoforkhead box, sub-group O0.084
dallydivision abnormally delayed0.069
bab1bric a brac 10.066
zfh1Zn finger homeodomain 10.061
ftzfushi tarazu0.060
sogshort gastrulation0.055
ParpPoly-(ADP-ribose) polymerase0.054
emcextra macrochaetae0.049
slp2sloppy paired 20.049
Traf4TNF-receptor-associated factor 40.046
tsgtwisted gastrulation0.044
Eip93FCG18389 gene product from transcript CG18389-RB0.040
lbeladybird early0.039
rolsrolling pebbles0.036
Dsor1Downstream of raf10.030
MadMothers against dpp0.027
CG8290CG8290 gene product from transcript CG8290-RA0.026
bab2CG9102 gene product from transcript CG9102-RA0.026
Hr38Hormone receptor-like in 380.026
abd-Aabdominal A0.026
Toll-6CG7250 gene product from transcript CG7250-RA0.024
Akt1CG4006 gene product from transcript CG4006-RA0.024
amosabsent MD neurons and olfactory sensilla0.021
snssticks and stones0.020
DadDaughters against dpp0.019
Rac2CG8556 gene product from transcript CG8556-RA0.018
wbwing blister0.018
lunaCG33473 gene product from transcript CG33473-RB0.017
elavembryonic lethal abnormal vision0.016
Ras85DRas oncogene at 85D0.016
robo3CG5423 gene product from transcript CG5423-RA0.016
PebProtein ejaculatory bulb0.015
NotumCG13076 gene product from transcript CG13076-RB0.015
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CSNK1Ecasein kinase 1, epsilon0.996
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.986
ARandrogen receptor0.980
DVL3dishevelled, dsh homolog 3 (Drosophila)0.978
BMPR1Abone morphogenetic protein receptor, type IA0.969
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.939
FZD1frizzled homolog 1 (Drosophila)0.880
SMAD1SMAD family member 10.868
CTNNBIP1catenin, beta interacting protein 10.860
APCadenomatous polyposis coli0.827
DAXXdeath-domain associated protein0.804
DVL1dishevelled, dsh homolog 1 (Drosophila)0.751
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.735
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.704
AXIN1axin 10.667
CEP164centrosomal protein 164kDa0.609
ZFYVE9zinc finger, FYVE domain containing 90.582
LRP6low density lipoprotein receptor-related protein 60.500
PSEN1presenilin 10.481
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.406
BMP2bone morphogenetic protein 20.355
CDK11Bcyclin-dependent kinase 11B0.352
NEDD4neural precursor cell expressed, developmentally down-regulated 40.329
TWIST2twist homolog 2 (Drosophila)0.317
WNT5Awingless-type MMTV integration site family, member 5A0.316
CTNND1catenin (cadherin-associated protein), delta 10.310
ZNF512Bzinc finger protein 512B0.288
FGF2fibroblast growth factor 2 (basic)0.272
BMP7bone morphogenetic protein 70.267
MYST2MYST histone acetyltransferase 20.264
FSTL1follistatin-like 10.254
GLIS2GLIS family zinc finger 20.247
CREBBPCREB binding protein0.224
NCOA2nuclear receptor coactivator 20.214
TCF4transcription factor 40.192
ELF5E74-like factor 5 (ets domain transcription factor)0.153
WT1Wilms tumor 10.152
FZD8frizzled homolog 8 (Drosophila)0.148
FOXD3forkhead box D30.143
ERGv-ets erythroblastosis virus E26 oncogene homolog (avian)0.136
JUPjunction plakoglobin0.134
MCCmutated in colorectal cancers0.134
NDPNorrie disease (pseudoglioma)0.126
WNT3Awingless-type MMTV integration site family, member 3A0.122
FOXO1forkhead box O10.122
PRPF3PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)0.119
PITX1paired-like homeodomain 10.118
PIK3CBphosphoinositide-3-kinase, catalytic, beta polypeptide0.113
CDH2cadherin 2, type 1, N-cadherin (neuronal)0.108
RBPMSRNA binding protein with multiple splicing0.103
DSG2desmoglein 20.094
FRS2fibroblast growth factor receptor substrate 20.094
SFRP1secreted frizzled-related protein 10.089
CDH3cadherin 3, type 1, P-cadherin (placental)0.076
SIX1SIX homeobox 10.076
FOSFBJ murine osteosarcoma viral oncogene homolog0.067
NOSTRINnitric oxide synthase trafficker0.066
MXRA5matrix-remodelling associated 50.065
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.064
LRRK2leucine-rich repeat kinase 20.063
BAHD1bromo adjacent homology domain containing 10.062
CDH5cadherin 5, type 2 (vascular endothelium)0.062
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.061
C9orf100chromosome 9 open reading frame 1000.061
FOXF2forkhead box F20.061
SMURF1SMAD specific E3 ubiquitin protein ligase 10.054
JUNjun proto-oncogene0.051
HIC1hypermethylated in cancer 10.051
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.049
PKP4plakophilin 40.047
FERMT2fermitin family member 20.042
FOXA1forkhead box A10.041
CTDSP2CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 20.041
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.040
MSX1msh homeobox 10.040
SCNN1Asodium channel, nonvoltage-gated 1 alpha0.039
BMP4bone morphogenetic protein 40.039
WDYHV1WDYHV motif containing 10.038
SP100SP100 nuclear antigen0.037
CCNKcyclin K0.036
EHFets homologous factor0.035
JAG1jagged 10.034
PTPRJprotein tyrosine phosphatase, receptor type, J0.034
FLNBfilamin B, beta0.034
NKD2naked cuticle homolog 2 (Drosophila)0.033
BMPR1Bbone morphogenetic protein receptor, type IB0.032
MDFIMyoD family inhibitor0.032
SNIP1Smad nuclear interacting protein 10.030
GATA5GATA binding protein 50.030
INHBBinhibin, beta B0.030
HOXB9homeobox B90.029
TWIST1twist homolog 1 (Drosophila)0.029
PLCG1phospholipase C, gamma 10.028
HOXC8homeobox C80.028
GAS1growth arrest-specific 10.027
ETS2v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)0.027
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Gli3GLI-Kruppel family member GLI31.000
Fgfr2fibroblast growth factor receptor 21.000
Vangl2vang-like 2 (van gogh, Drosophila)1.000
Fgfr1fibroblast growth factor receptor 10.999
Prrx1paired related homeobox 10.999
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.999
Pax3paired box gene 30.999
Sox9SRY-box containing gene 90.999
Dvl2dishevelled 2, dsh homolog (Drosophila)0.997
Bmp4bone morphogenetic protein 40.997
Hand1heart and neural crest derivatives expressed transcript 10.996
Meox2mesenchyme homeobox 20.995
Alx4aristaless-like homeobox 40.995
Msx1homeobox, msh-like 10.994
Foxc1forkhead box C10.989
Gli2GLI-Kruppel family member GLI20.988
Otx2orthodenticle homolog 2 (Drosophila)0.987
Tcfap2atranscription factor AP-2, alpha0.982
Foxc2forkhead box C20.981
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.974
Bmp7bone morphogenetic protein 70.970
Ctnnb1catenin (cadherin associated protein), beta 10.967
Fgfr3fibroblast growth factor receptor 30.966
Smosmoothened homolog (Drosophila)0.962
Fgf8fibroblast growth factor 80.959
Eya1eyes absent 1 homolog (Drosophila)0.957
Hand2heart and neural crest derivatives expressed transcript 20.945
Ror2receptor tyrosine kinase-like orphan receptor 20.941
Sox11SRY-box containing gene 110.929
Pitx2paired-like homeodomain transcription factor 20.909
Pax6paired box gene 60.902
Dvl3dishevelled 3, dsh homolog (Drosophila)0.899
Tgfb2transforming growth factor, beta 20.884
Sox2SRY-box containing gene 20.883
Hoxd13homeobox D130.873
Wnt3awingless-related MMTV integration site 3A0.866
Rargretinoic acid receptor, gamma0.838
Ptch1patched homolog 10.819
Vangl1vang-like 1 (van gogh, Drosophila)0.805
Isl1ISL1 transcription factor, LIM/homeodomain0.788
Ptpn11protein tyrosine phosphatase, non-receptor type 110.787
Hes1hairy and enhancer of split 1 (Drosophila)0.769
Gbx2gastrulation brain homeobox 20.764
Nkx2-1NK2 homeobox 10.739
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.739
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.692
Prrx2paired related homeobox 20.689
Gscgoosecoid homeobox0.679
Dlx5distal-less homeobox 50.668
Foxg1forkhead box G10.667
Nkx2-3NK2 transcription factor related, locus 3 (Drosophila)0.665
Lrp6low density lipoprotein receptor-related protein 60.655
Pbx1pre B-cell leukemia transcription factor 10.652
Hoxa13homeobox A130.650
Msx2homeobox, msh-like 20.649
Tbx1T-box 10.637
Sox4SRY-box containing gene 40.606
Lmx1bLIM homeobox transcription factor 1 beta0.595
Pitx1paired-like homeodomain transcription factor 10.591
Fgf10fibroblast growth factor 100.585
Dkk1dickkopf homolog 1 (Xenopus laevis)0.584
Cdh23cadherin 23 (otocadherin)0.563
Pou4f3POU domain, class 4, transcription factor 30.550
Tbx15T-box 150.548
Hhexhematopoietically expressed homeobox0.507
Tcf15transcription factor 150.493
Hoxa3homeobox A30.481
Runx2runt related transcription factor 20.478
Smad6MAD homolog 6 (Drosophila)0.460
Rspo2R-spondin 2 homolog (Xenopus laevis)0.457
Alx1ALX homeobox 10.454
Rxraretinoid X receptor alpha0.446
Gata4GATA binding protein 40.425
Hoxa2homeobox A20.422
Acvr1activin A receptor, type 10.395
LfngLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase0.395
CrebbpCREB binding protein0.389
Nf1neurofibromatosis 10.388
Dll1delta-like 1 (Drosophila)0.380
Alx3aristaless-like homeobox 30.368
Ednraendothelin receptor type A0.367
Nkx3-2NK3 homeobox 20.360
Shesrc homology 2 domain-containing transforming protein E0.357
Chd7chromodomain helicase DNA binding protein 70.354
Rarbretinoic acid receptor, beta0.352
Psen1presenilin 10.341
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.341
Wnt5awingless-related MMTV integration site 5A0.334
Pou5f1POU domain, class 5, transcription factor 10.332
Rararetinoic acid receptor, alpha0.314
Smad7MAD homolog 7 (Drosophila)0.314
Emx2empty spiracles homolog 2 (Drosophila)0.308
Notch3Notch gene homolog 3 (Drosophila)0.302
Hoxa5homeobox A50.276
Emx1empty spiracles homolog 1 (Drosophila)0.268
Lef1lymphoid enhancer binding factor 10.263
Zeb1zinc finger E-box binding homeobox 10.263
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism