The network for 'neural crest cell development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

neural crest cell development

The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.

NameDescriptionProbabilityFunc Analog Organism
sox10SRY-box containing gene 100.999
lmx1b.1LIM homeobox transcription factor 1, beta 10.995
shhasonic hedgehog a0.983
foxi1forkhead box I10.972
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.968
notch1anotch homolog 1a0.928
mitfamicrophthalmia-associated transcription factor a0.917
prdm1aPR domain containing 1a, with ZNF domain0.913
aldh1a2aldehyde dehydrogenase 1 family, member A20.909
rx3retinal homeobox gene 30.890
six3bsine oculis homeobox homolog 3b0.875
foxd3forkhead box D30.869
dlx2adistal-less homeobox gene 2a0.854
tfectranscription factor EC0.852
hand2heart and neural crest derivatives expressed transcript 20.847
tll1tolloid-like 10.837
pitx3paired-like homeodomain transcription factor 30.837
raraaretinoic acid receptor, alpha a0.821
lef1lymphocyte enhancer binding factor 10.796
mecomMDS1 and EVI1 complex locus0.765
foxa3forkhead box A30.752
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.749
kitakit receptor a0.722
sema3aasemaphorin 3aa0.678
six3asine oculis homeobox homolog 3a0.658
tp63tumor protein p630.601
cdh2cadherin 2, neuronal0.600
gria3aglutamate receptor, ionotropic, AMPA 3a0.589
sox9aSRY-box containing gene 9a0.561
egr2bearly growth response 2b0.546
prdm5PR domain containing 50.538
otx2orthodenticle homolog 20.536
myod1myogenic differentiation 10.534
bmp4bone morphogenetic protein 40.533
bmp2bbone morphogenetic protein 2b0.532
tp53tumor protein p530.527
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.519
cdx4caudal type homeo box transcription factor 40.511
sox2SRY-box containing gene 20.509
col15a1bcollagen, type XV, alpha 1b0.508
barhl2BarH-like 20.485
tfap2atranscription factor AP-2 alpha0.477
tbx5aT-box 5a0.469
pax2apaired box gene 2a0.466
bmperBMP binding endothelial regulator0.461
gata3GATA-binding protein 30.447
plcb3phospholipase C, beta 3 (phosphatidylinositol-specific)0.437
zic5zic family member 5 (odd-paired homolog, Drosophila)0.435
eya1eyes absent homolog 10.424
egr1early growth response 10.423
gria3bglutamate receptor, ionotrophic, AMPA 3b0.422
pax7apaired box gene 7a0.419
pcdh18bprotocadherin 18b0.403
pcdh10aprotocadherin 10a0.381
neurodneurogenic differentiation0.377
nrp2bneuropilin 2b0.375
tgfb3transforming growth factor, beta 30.373
unc5bunc-5 homolog B (C. elegans)0.360
gria4aglutamate receptor, ionotropic, AMPA 4a0.358
gdf6agrowth differentiation factor 6a0.347
tbx1T-box 10.335
her1hairy-related 10.320
pax6bpaired box gene 6b0.319
ret1receptor tyrosine kinase0.317
nrp1bneuropilin 1b0.313
crabp2acellular retinoic acid binding protein 2, a0.311
gpr126G protein-coupled receptor 1260.310
sema3dsemaphorin 3d0.302
tmem2transmembrane protein 20.294
zic2bzic family member 2 (odd-paired homolog, Drosophila) b0.292
osr2odd-skipped related 2 (Drosophila)0.289
snai1bsnail homolog 1b (Drosophila)0.283
wnt11wingless-type MMTV integration site family, member 110.270
foxa2forkhead box A20.266
efna5bephrin A5b0.265
shhbsonic hedgehog b0.260
hey1hairy/enhancer-of-split related with YRPW motif 10.243
sox1aSRY-box containing gene 1a0.239
pax7bpaired box gene 7b0.235
pax9paired box gene 90.232
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.229
prdm16PR domain containing 160.227
meis2.1myeloid ecotropic viral integration site 2.10.227
ascl1aachaete-scute complex-like 1a (Drosophila)0.225
fgf20bfibroblast growth factor 20b0.222
spns2spinster homolog 2 (Drosophila)0.219
gria4bglutamate receptor, ionotropic, AMPA 4b0.219
rargbretinoic acid receptor, gamma b0.215
lmo4aLIM domain only 4a0.214
notch1bnotch homolog 1b0.212
cdh6cadherin 60.212
pea3ETS-domain transcription factor pea30.212
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
POU5F1POU class 5 homeobox 10.999
EGFRepidermal growth factor receptor0.998
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.996
NOTCH1notch 10.991
SOX10SRY (sex determining region Y)-box 100.991
WWP2WW domain containing E3 ubiquitin protein ligase 20.989
POU3F2POU class 3 homeobox 20.983
VEGFAvascular endothelial growth factor A0.970
BMP2bone morphogenetic protein 20.961
PAX3paired box 30.961
NOTCH3notch 30.958
EP300E1A binding protein p3000.933
SETD8SET domain containing (lysine methyltransferase) 80.931
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.915
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.905
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.870
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.856
HIPK2homeodomain interacting protein kinase 20.852
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.846
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.841
MEOX2mesenchyme homeobox 20.838
SMAD4SMAD family member 40.829
NR4A1nuclear receptor subfamily 4, group A, member 10.822
SMAD3SMAD family member 30.814
JAG1jagged 10.766
ANKS1Bankyrin repeat and sterile alpha motif domain containing 1B0.724
MEF2Amyocyte enhancer factor 2A0.716
TECPR1tectonin beta-propeller repeat containing 10.714
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.708
SOX2SRY (sex determining region Y)-box 20.700
EPAS1endothelial PAS domain protein 10.669
ARandrogen receptor0.630
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.565
TFAP2Ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.543
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.514
SHC1SHC (Src homology 2 domain containing) transforming protein 10.503
NOTCH2notch 20.477
SMAD7SMAD family member 70.458
EGR1early growth response 10.441
EIF2C2eukaryotic translation initiation factor 2C, 20.433
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.415
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.413
MEF2Cmyocyte enhancer factor 2C0.408
ACTG1actin, gamma 10.380
COL4A1collagen, type IV, alpha 10.338
PIAS1protein inhibitor of activated STAT, 10.337
COL7A1collagen, type VII, alpha 10.334
COL6A2collagen, type VI, alpha 20.330
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.295
RUNX1runt-related transcription factor 10.284
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.279
SH3BP4SH3-domain binding protein 40.274
YY1YY1 transcription factor0.267
LIMK1LIM domain kinase 10.259
TCF4transcription factor 40.257
NTRK1neurotrophic tyrosine kinase, receptor, type 10.253
NRP1neuropilin 10.252
CDH5cadherin 5, type 2 (vascular endothelium)0.239
EIF3Ceukaryotic translation initiation factor 3, subunit C0.236
EHMT2euchromatic histone-lysine N-methyltransferase 20.236
PCOLCEprocollagen C-endopeptidase enhancer0.216
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.210
BBS10Bardet-Biedl syndrome 100.207
ZMYND11zinc finger, MYND-type containing 110.204
JAG2jagged 20.201
IPO13importin 130.199
EIF2C1eukaryotic translation initiation factor 2C, 10.197
PIN1peptidylprolyl cis/trans isomerase, NIMA-interacting 10.195
JUBjub, ajuba homolog (Xenopus laevis)0.191
SOX11SRY (sex determining region Y)-box 110.186
ZFYVE9zinc finger, FYVE domain containing 90.180
KAT2BK(lysine) acetyltransferase 2B0.180
SMURF1SMAD specific E3 ubiquitin protein ligase 10.175
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.168
AHRaryl hydrocarbon receptor0.167
HOXD13homeobox D130.166
DLG4discs, large homolog 4 (Drosophila)0.159
MARCKSmyristoylated alanine-rich protein kinase C substrate0.158
KCTD1potassium channel tetramerisation domain containing 10.157
CREBBPCREB binding protein0.155
TUBA1Ctubulin, alpha 1c0.140
PTK6PTK6 protein tyrosine kinase 60.135
TUBA1Btubulin, alpha 1b0.134
SHC3SHC (Src homology 2 domain containing) transforming protein 30.131
QKIquaking homolog, KH domain RNA binding (mouse)0.130
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.123
ACVR1activin A receptor, type I0.121
MMP14matrix metallopeptidase 14 (membrane-inserted)0.119
LAMA5laminin, alpha 50.118
EDNRAendothelin receptor type A0.115
TLE1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)0.114
DDR2discoidin domain receptor tyrosine kinase 20.112
DLL1delta-like 1 (Drosophila)0.110
APPamyloid beta (A4) precursor protein0.109
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.107
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.107
FOXA1forkhead box A10.106
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.106
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pax3paired box gene 31.000
Shhsonic hedgehog1.000
Fgf8fibroblast growth factor 81.000
Fgfr2fibroblast growth factor receptor 21.000
Tcfap2atranscription factor AP-2, alpha1.000
Pax2paired box gene 21.000
Pitx2paired-like homeodomain transcription factor 21.000
Otx2orthodenticle homolog 2 (Drosophila)0.999
Isl1ISL1 transcription factor, LIM/homeodomain0.998
Gli3GLI-Kruppel family member GLI30.998
Foxc1forkhead box C10.997
Foxg1forkhead box G10.996
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.993
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.992
Eya1eyes absent 1 homolog (Drosophila)0.990
Bmp4bone morphogenetic protein 40.990
Gbx2gastrulation brain homeobox 20.990
Tbx1T-box 10.985
Chd7chromodomain helicase DNA binding protein 70.984
Vegfavascular endothelial growth factor A0.983
Hand2heart and neural crest derivatives expressed transcript 20.982
Jag1jagged 10.981
Gdnfglial cell line derived neurotrophic factor0.972
Dlx5distal-less homeobox 50.969
Acvr1activin A receptor, type 10.967
Tbx3T-box 30.964
Prrx1paired related homeobox 10.950
Ascl1achaete-scute complex homolog 1 (Drosophila)0.948
Tlx3T-cell leukemia, homeobox 30.942
Gata4GATA binding protein 40.942
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.931
Sox2SRY-box containing gene 20.926
Retret proto-oncogene0.926
Ctnnb1catenin (cadherin associated protein), beta 10.925
Pax6paired box gene 60.923
Hand1heart and neural crest derivatives expressed transcript 10.922
Tgfb2transforming growth factor, beta 20.921
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.920
Hoxa1homeobox A10.915
Phox2bpaired-like homeobox 2b0.914
Ednraendothelin receptor type A0.912
Sox9SRY-box containing gene 90.908
Ptpn11protein tyrosine phosphatase, non-receptor type 110.898
Fgf10fibroblast growth factor 100.890
Gscgoosecoid homeobox0.890
Efnb2ephrin B20.863
Pitx1paired-like homeodomain transcription factor 10.861
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.853
Neurog2neurogenin 20.847
Hmx3H6 homeobox 30.846
Fgfr1fibroblast growth factor receptor 10.840
Msx1homeobox, msh-like 10.800
Alx4aristaless-like homeobox 40.799
Lmx1aLIM homeobox transcription factor 1 alpha0.793
Meox2mesenchyme homeobox 20.784
Foxc2forkhead box C20.769
Lhx3LIM homeobox protein 30.765
Rargretinoic acid receptor, gamma0.758
Ece1endothelin converting enzyme 10.749
En1engrailed 10.748
Lmx1bLIM homeobox transcription factor 1 beta0.746
Hes5hairy and enhancer of split 5 (Drosophila)0.744
Rxraretinoid X receptor alpha0.744
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.738
Ntf3neurotrophin 30.733
Zic3zinc finger protein of the cerebellum 30.715
Tgfbr2transforming growth factor, beta receptor II0.694
Nf1neurofibromatosis 10.693
Sox10SRY-box containing gene 100.690
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.675
Nhlh1nescient helix loop helix 10.662
Vangl2vang-like 2 (van gogh, Drosophila)0.658
Sox7SRY-box containing gene 70.646
Neurod1neurogenic differentiation 10.623
UncxUNC homeobox0.620
Wt1Wilms tumor 1 homolog0.618
Sox11SRY-box containing gene 110.597
Hes1hairy and enhancer of split 1 (Drosophila)0.596
Hoxd13homeobox D130.586
Sox3SRY-box containing gene 30.571
Snai1snail homolog 1 (Drosophila)0.565
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.545
Pou3f2POU domain, class 3, transcription factor 20.530
Dll1delta-like 1 (Drosophila)0.530
Msx2homeobox, msh-like 20.523
Gata6GATA binding protein 60.516
Bmpr1abone morphogenetic protein receptor, type 1A0.512
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.504
Nr5a1nuclear receptor subfamily 5, group A, member 10.503
Prrx2paired related homeobox 20.497
Hoxa13homeobox A130.487
Emx2empty spiracles homolog 2 (Drosophila)0.478
Bdnfbrain derived neurotrophic factor0.465
Adrb1adrenergic receptor, beta 10.465
Pitx3paired-like homeodomain transcription factor 30.460
Hoxa11homeobox A110.458
Smad6MAD homolog 6 (Drosophila)0.451
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 20.180
Gata6GATA binding protein 60.179
Ap2m1adaptor-related protein complex 2, mu 1 subunit0.131
Actbactin, beta0.124
Slc1a3solute carrier family 1 (glial high affinity glutamate transporter), member 30.117
Grip1glutamate receptor interacting protein 10.116
Ireb2iron responsive element binding protein 20.105
Igfbp5insulin-like growth factor binding protein 50.104
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.087
Marcksmyristoylated alanine rich protein kinase C substrate0.083
Tcf4transcription factor 40.077
Rasa1RAS p21 protein activator (GTPase activating protein) 10.070
Lrrc59leucine rich repeat containing 590.066
Foxi2forkhead box I20.065
Pxdnperoxidasin homolog (Drosophila)0.064
Rock2Rho-associated coiled-coil containing protein kinase 20.061
Leprleptin receptor0.061
Hrh1histamine receptor H 10.061
Col9a1collagen, type IX, alpha 10.060
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.057
Slc4a4solute carrier family 4, sodium bicarbonate cotransporter, member 40.056
Gria3glutamate receptor, ionotrophic, AMPA 30.055
F13a1coagulation factor XIII, A1 polypeptide0.055
Lphn2latrophilin 20.055
Calcrlcalcitonin receptor-like0.054
Il1r1interleukin 1 receptor, type I0.054
Slc7a2solute carrier family 7 (cationic amino acid transporter, y+ system), member 20.053
Fgf1fibroblast growth factor 10.052
Ptprkprotein tyrosine phosphatase, receptor type, K, extracellular region0.052
Tatdn2TatD DNase domain containing 20.051
Ptprgprotein tyrosine phosphatase, receptor type, G0.050
Eif3deukaryotic translation initiation factor 3, subunit D0.047
Uba1ubiquitin-like modifier activating enzyme 10.046
Ednraendothelin receptor type A0.045
Ptprz1protein tyrosine phosphatase, receptor-type, Z polypeptide 10.045
Dab2disabled homolog 2 (Drosophila)0.044
Prrx1paired related homeobox 10.044
Bmpr1abone morphogenetic protein receptor, type IA0.043
Rftn2raftlin family member 20.042
Robo1roundabout homolog 1 (Drosophila)0.042
Aqp4aquaporin 40.041
LOC286987hemiferrin, transferrin-like protein0.040
Cald1caldesmon 10.039
Pdha2pyruvate dehydrogenase (lipoamide) alpha 20.038
Ebf1early B-cell factor 10.037
Maneamannosidase, endo-alpha0.036
Atp7aATPase, Cu++ transporting, alpha polypeptide0.036
Ptpn12protein tyrosine phosphatase, non-receptor type 120.036
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.036
Tgfbr2transforming growth factor, beta receptor II0.036
Aardalanine and arginine rich domain containing protein0.036
Pld1phospholipase D10.035
Prkaa1protein kinase, AMP-activated, alpha 1 catalytic subunit0.035
Insrinsulin receptor0.035
Strnstriatin, calmodulin binding protein0.035
Robo2roundabout homolog 2 (Drosophila)0.035
Hist1h2bahistone cluster 1, H2ba0.034
Hoxc4homeo box C40.034
Ddr2discoidin domain receptor tyrosine kinase 20.034
Sp1Sp1 transcription factor0.034
Gja1gap junction protein, alpha 10.034
Nfianuclear factor I/A0.033
Klk1c10l2kallikrein 1-related peptidase c10-like 20.033
Pls3plastin 3 (T-isoform)0.032
Vhlvon Hippel-Lindau tumor suppressor0.032
Glra1glycine receptor, alpha 10.032
Muc5acmucin 5AC, oligomeric mucus/gel-forming0.032
Clcn5chloride channel 50.031
Six1SIX homeobox 10.031
Kcnj16potassium inwardly-rectifying channel, subfamily J, member 160.031
Tuba1ctubulin, alpha 1C0.030
Ddr1discoidin domain receptor tyrosine kinase 10.030
Arpc4actin related protein 2/3 complex, subunit 40.030
Pitpnaphosphatidylinositol transfer protein, alpha0.030
Klk1b3kallikrein 1-related peptidase b30.030
Mmp16matrix metallopeptidase 160.029
Cmklr1chemokine-like receptor 10.029
Pde5aphosphodiesterase 5A, cGMP-specific0.029
Yarstyrosyl-tRNA synthetase0.029
Ddah1dimethylarginine dimethylaminohydrolase 10.028
Foxe3forkhead box E30.028
Capn6calpain 60.028
Ccnd2cyclin D20.028
Ceacam1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)0.028
Irs1insulin receptor substrate 10.028
Cadm1cell adhesion molecule 10.028
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.027
Slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.027
Bmp4bone morphogenetic protein 40.027
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.027
Lims1LIM and senescent cell antigen-like domains 10.027
Dcaf17DDB1 and CUL4 associated factor 170.027
Cdc2l5cell division cycle 2-like 5 (cholinesterase-related cell division controller)0.027
Cpxm2carboxypeptidase X (M14 family), member 20.026
Retret proto-oncogene0.026
Ipo4importin 40.026
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism