The network for 'immune system development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

immune system development

The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

NameDescriptionProbabilityFunc Analog Organism
cmybtranscription factor cmyb0.999
spns2spinster homolog 2 (Drosophila)0.998
ikzf1IKAROS family zinc finger 1 (Ikaros)0.988
tfr1atransferrin receptor 1a0.988
plcg1phospholipase C, gamma 10.985
rag1recombination activating gene 10.984
bmp4bone morphogenetic protein 40.983
cdh5cadherin 50.982
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.980
mibmind bomb0.980
runx1runt-related transcription factor 10.978
alas2aminolevulinate, delta-, synthetase 20.975
gdf6agrowth differentiation factor 6a0.973
tp53tumor protein p530.967
etv2ets variant gene 20.962
trim33tripartite motif-containing 330.959
gata6GATA-binding protein 60.958
bmp2bbone morphogenetic protein 2b0.948
notch3notch homolog 30.925
hhiphedgehog interacting protein0.918
fn1fibronectin 10.916
gata3GATA-binding protein 30.908
tie1endothelium-specific receptor tyrosine kinase 10.872
hhexhematopoietically expressed homeobox0.869
prdm1aPR domain containing 1a, with ZNF domain0.868
trpv6transient receptor potential cation channel, subfamily V, member 60.867
kitakit receptor a0.851
mychmyelocytomatosis oncogene homolog0.851
osr1odd-skipped related 1 (Drosophila)0.832
tbx5aT-box 5a0.821
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.820
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.807
jag1bjagged 1b0.803
pax2apaired box gene 2a0.793
LOC566708FL cytokine receptor-like0.791
slc4a1asolute carrier family 4, anion exchanger, member 1a0.784
ndr2nodal-related 20.762
cdx4caudal type homeo box transcription factor 40.761
fgfr4fibroblast growth factor receptor 40.756
unc45aunc-45 homolog A (C. elegans)0.754
tbx1T-box 10.753
wnt9awingless-type MMTV integration site family, member 9A0.753
pcdh18bprotocadherin 18b0.751
wnt2bbwingless-type MMTV integration site family, member 2Bb0.743
rpl11ribosomal protein L110.742
hoxd4ahomeo box D4a0.736
tpm4tropomyosin 40.735
acvr1lactivin A receptor, type I like0.727
socs1suppressor of cytokine signaling 10.707
il7rinterleukin 7 receptor0.703
ldb2aLIM-domain binding factor 2a0.700
aplnrbapelin receptor b0.695
gata5GATA-binding protein 50.694
foxi1forkhead box I10.688
cebpaCCAAT/enhancer binding protein (C/EBP), alpha0.686
pwp2hPWP2 periodic tryptophan protein homolog (yeast)0.681
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.680
notch1anotch homolog 1a0.678
csf1racolony stimulating factor 1 receptor, a0.676
metmet proto-oncogene (hepatocyte growth factor receptor)0.672
sox9bSRY-box containing gene 9b0.667
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.661
vegfcvascular endothelial growth factor c0.658
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.646
pdlim3bPDZ and LIM domain 3b0.638
eomesaeomesodermin homolog a0.636
ptch2patched 20.631
npm1nucleophosmin 10.630
pdcd2programmed cell death 20.629
cbfbcore-binding factor, beta subunit0.616
csnk1a1casein kinase 1, alpha 10.613
gata1aGATA binding protein 1a0.611
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.611
tbx24T-box 240.610
gro1groucho 10.596
cdh6cadherin 60.591
lhx2bLIM homeobox 2b0.590
ephb4aeph receptor B4a0.589
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.585
traf4atnf receptor-associated factor 4a0.584
znfl2azinc finger-like gene 2a0.581
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.580
efnb2aephrin B2a0.577
msh6mutS homolog 6 (E. coli)0.576
osr2odd-skipped related 2 (Drosophila)0.575
sgk1serum/glucocorticoid regulated kinase 10.570
ephb4beph receptor B4b0.569
gata2aGATA-binding protein 2a0.569
cdh1cadherin 1, epithelial0.567
hand2heart and neural crest derivatives expressed transcript 20.562
pkd2polycystic kidney disease 20.558
tfectranscription factor EC0.554
pitx3paired-like homeodomain transcription factor 30.549
tp63tumor protein p630.542
cxcr4bchemokine (C-X-C motif), receptor 4b0.538
pea3ETS-domain transcription factor pea30.538
hbbe3hemoglobin beta embryonic-30.533
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
EgfrEpidermal growth factor receptor0.949
rapretina aberrant in pattern0.669
Src64BSrc oncogene at 64B0.623
cortoCG2530 gene product from transcript CG2530-RA0.622
SmoxSmad on X0.517
Ras85DRas oncogene at 85D0.503
drkdownstream of receptor kinase0.502
PvrPDGF- and VEGF-receptor related0.482
Rac1CG2248 gene product from transcript CG2248-RA0.472
l(2)gllethal (2) giant larvae0.454
aopanterior open0.402
Rac2CG8556 gene product from transcript CG8556-RA0.387
emcextra macrochaetae0.384
eastenhanced adult sensory threshold0.381
zfh1Zn finger homeodomain 10.345
Dsor1Downstream of raf10.341
E(spl)Enhancer of split0.317
mbcmyoblast city0.306
cicubitus interruptus0.294
DadDaughters against dpp0.286
dcodiscs overgrown0.278
Su(H)Suppressor of Hairless0.265
CtBPC-terminal Binding Protein0.254
phlpole hole0.249
hipkhomeodomain interacting protein kinase0.239
ImpIGF-II mRNA-binding protein0.234
betaInt-nubeta[nu] integrin0.207
G-oalpha47AG protein oalpha 47A0.201
elavembryonic lethal abnormal vision0.201
JraJun-related antigen0.191
Atg1Autophagy-specific gene 10.182
RpS6Ribosomal protein S60.176
norpAno receptor potential A0.170
DlicDynein light intermediate chain0.169
Sam-SS-adenosylmethionine Synthetase0.161
MED19Mediator complex subunit 190.161
fogfolded gastrulation0.158
Mef2Myocyte enhancer factor 20.155
Sema-1aCG18405 gene product from transcript CG18405-RD0.153
shotshort stop0.147
HLHm7E(spl) region transcript m70.143
CkIIalphaCasein kinase II alpha subunit0.138
p120ctnAdherens junction protein p1200.137
InRInsulin-like receptor0.135
S6kRPS6-p70-protein kinase0.135
fl(2)dfemale lethal d0.130
Adgf-AAdenosine deaminase-related growth factor A0.130
HLHm3E(spl) region transcript m30.128
slmbsupernumerary limbs0.127
WnkCG7177 gene product from transcript CG7177-RA0.123
psidinphagocyte signaling impaired0.120
poloCG12306 gene product from transcript CG12306-RA0.112
unc-13CG2999 gene product from transcript CG2999-RA0.109
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)1.000
EGFRepidermal growth factor receptor1.000
GRB2growth factor receptor-bound protein 20.999
TRAF1TNF receptor-associated factor 10.999
BRCA1breast cancer 1, early onset0.997
SMAD2SMAD family member 20.997
CASP8caspase 8, apoptosis-related cysteine peptidase0.996
RUNX1runt-related transcription factor 10.995
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.994
BIRC3baculoviral IAP repeat containing 30.993
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.992
SH3KBP1SH3-domain kinase binding protein 10.991
JUNjun proto-oncogene0.989
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.987
NCOR2nuclear receptor corepressor 20.984
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.979
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.977
PTPN6protein tyrosine phosphatase, non-receptor type 60.977
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.975
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.973
CCR5chemokine (C-C motif) receptor 50.970
SHC1SHC (Src homology 2 domain containing) transforming protein 10.964
LCKlymphocyte-specific protein tyrosine kinase0.961
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.961
TAL1T-cell acute lymphocytic leukemia 10.959
MDM2Mdm2 p53 binding protein homolog (mouse)0.959
TNFAIP3tumor necrosis factor, alpha-induced protein 30.959
ICAM1intercellular adhesion molecule 10.957
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.947
CFLARCASP8 and FADD-like apoptosis regulator0.944
ARandrogen receptor0.943
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.939
HDAC3histone deacetylase 30.939
ESR1estrogen receptor 10.926
SYKspleen tyrosine kinase0.926
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.922
CD40CD40 molecule, TNF receptor superfamily member 50.920
DDIT3DNA-damage-inducible transcript 30.918
CCL5chemokine (C-C motif) ligand 50.917
PARP1poly (ADP-ribose) polymerase 10.915
NOTCH1notch 10.914
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.914
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.913
IL8interleukin 80.912
CCL4chemokine (C-C motif) ligand 40.909
FGFR1fibroblast growth factor receptor 10.907
FGFR2fibroblast growth factor receptor 20.904
UBCubiquitin C0.900
IRF1interferon regulatory factor 10.895
DAXXdeath-domain associated protein0.894
IL4Rinterleukin 4 receptor0.891
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.887
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.883
FASFas (TNF receptor superfamily, member 6)0.882
CREBBPCREB binding protein0.878
IL2RBinterleukin 2 receptor, beta0.875
IL10RAinterleukin 10 receptor, alpha0.872
HLA-Cmajor histocompatibility complex, class I, C0.859
CXCL10chemokine (C-X-C motif) ligand 100.857
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.854
SIN3ASIN3 homolog A, transcription regulator (yeast)0.852
CASP3caspase 3, apoptosis-related cysteine peptidase0.851
SP1Sp1 transcription factor0.848
NCOR1nuclear receptor corepressor 10.843
TNFtumor necrosis factor0.840
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.831
EP300E1A binding protein p3000.824
VEGFAvascular endothelial growth factor A0.816
CD86CD86 molecule0.814
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.810
CAV1caveolin 1, caveolae protein, 22kDa0.806
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.804
CCR7chemokine (C-C motif) receptor 70.803
PBX1pre-B-cell leukemia homeobox 10.794
SMAD3SMAD family member 30.793
PMLpromyelocytic leukemia0.778
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.775
HLA-Bmajor histocompatibility complex, class I, B0.774
SOCS3suppressor of cytokine signaling 30.772
TGIF1TGFB-induced factor homeobox 10.770
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.767
AXLAXL receptor tyrosine kinase0.761
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.755
TCF12transcription factor 120.743
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.742
XIAPX-linked inhibitor of apoptosis0.731
ZNF43zinc finger protein 430.718
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.710
TGFB1transforming growth factor, beta 10.708
CXCL9chemokine (C-X-C motif) ligand 90.700
CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b0.697
WDR5WD repeat domain 50.685
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.684
CXCL2chemokine (C-X-C motif) ligand 20.684
KLF4Kruppel-like factor 4 (gut)0.684
CSNK2A1casein kinase 2, alpha 1 polypeptide0.683
STAT1signal transducer and activator of transcription 1, 91kDa0.681
XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)0.680
GATA1GATA binding protein 1 (globin transcription factor 1)0.675
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cd37CD37 molecule0.465
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.397
Junbjun B proto-oncogene0.277
FosFBJ osteosarcoma oncogene0.277
Dusp1dual specificity phosphatase 10.273
Calcrcalcitonin receptor0.255
Bmp6bone morphogenetic protein 60.223
Ccr5chemokine (C-C motif) receptor 50.199
Prrx1paired related homeobox 10.191
LOC100134871beta globin minor gene0.182
Cd247Cd247 molecule0.176
Alas2aminolevulinate, delta-, synthase 20.172
RT1-EC2RT1 class Ib, locus EC20.172
Cd2Cd2 molecule0.166
Bcl2B-cell CLL/lymphoma 20.166
C1qacomplement component 1, q subcomponent, A chain0.163
Tgfbr2transforming growth factor, beta receptor II0.160
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.151
Ctrcchymotrypsin C (caldecrin)0.150
Slfn2schlafen 20.148
Zfp36zinc finger protein 360.142
Cfpcomplement factor properdin0.138
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.138
Cd5Cd5 molecule0.132
Ccl5chemokine (C-C motif) ligand 50.130
Jak1Janus kinase 10.129
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.120
RT1-DaRT1 class II, locus Da0.119
TcrbT-cell receptor beta chain0.119
LOC287167globin, alpha0.117
Flt4fms-related tyrosine kinase 40.117
Sec14l3SEC14-like 3 (S. cerevisiae)0.107
Mylk2myosin light chain kinase 20.103
Gna15guanine nucleotide binding protein, alpha 150.102
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.100
Pmfbp1polyamine modulated factor 1 binding protein 10.097
Ccl3chemokine (C-C motif) ligand 30.095
Hckhemopoietic cell kinase0.095
Cfbcomplement factor B0.092
Cd4Cd4 molecule0.091
Tgfbr3transforming growth factor, beta receptor III0.082
Cxcr4chemokine (C-X-C motif) receptor 40.081
Arhgap4Rho GTPase activating protein 40.078
Nfyanuclear transcription factor-Y alpha0.076
Il8rbinterleukin 8 receptor, beta0.076
Smad7SMAD family member 70.074
Btg2BTG family, member 20.071
Olr837olfactory receptor 8370.069
Prf1perforin 1 (pore forming protein)0.069
Barhl2BarH-like homeobox 20.069
Ier2immediate early response 20.068
Jak2Janus kinase 20.068
Akap1A kinase (PRKA) anchor protein 10.065
Foxd3forkhead box D30.064
Man2b1mannosidase, alpha, class 2B, member 10.064
RT1-A3RT1 class I, locus A30.062
Tnrtenascin R0.062
Rararetinoic acid receptor, alpha0.060
Stat4signal transducer and activator of transcription 40.060
Sellselectin L0.060
Apol3apolipoprotein L, 30.060
Aif1allograft inflammatory factor 10.059
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.059
Map4k1mitogen activated protein kinase kinase kinase kinase 10.058
Smek2SMEK homolog 2, suppressor of mek1 (Dictyostelium)0.058
Itgamintegrin, alpha M0.058
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.058
Rt1.aaMHC class I RT1.Aa alpha-chain0.058
Atp2b4ATPase, Ca++ transporting, plasma membrane 40.057
Ctsjcathepsin J0.055
Cd3gCD3 molecule, gamma0.054
Brd4bromodomain containing 40.053
Il1rninterleukin 1 receptor antagonist0.053
Neurog3neurogenin 30.052
Ntn1netrin 10.050
Lifrleukemia inhibitory factor receptor alpha0.050
Nek9NIMA (never in mitosis gene a)- related kinase 90.050
Egr1early growth response 10.050
Napsanapsin A aspartic peptidase0.049
Il2rbinterleukin 2 receptor, beta0.049
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.048
Rhobras homolog gene family, member B0.048
Klf4Kruppel-like factor 4 (gut)0.048
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.048
Hbe1hemoglobin, epsilon 10.048
Ccr2chemokine (C-C motif) receptor 20.047
Slco1a5solute carrier organic anion transporter family, member 1a50.047
Acacbacetyl-Coenzyme A carboxylase beta0.047
RGD1564664similar to LOC387763 protein0.046
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.045
Adora2aadenosine A2a receptor0.045
Cmklr1chemokine-like receptor 10.045
LOC687711similar to small nuclear ribonucleoprotein D30.045
Rab3il1RAB3A interacting protein (rabin3)-like 10.044
Il6interleukin 60.044
Tmem176btransmembrane protein 176B0.043
Cd40lgCD40 ligand0.043
Cd74Cd74 molecule, major histocompatibility complex, class II invariant chain0.043
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism