The network for 'positive regulation of macromolecule biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of macromolecule biosynthetic process

Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

NameDescriptionProbabilityFunc Analog Organism
shhasonic hedgehog a0.952
tp53tumor protein p530.943
ndr2nodal-related 20.937
notch1anotch homolog 1a0.914
crabp2acellular retinoic acid binding protein 2, a0.881
gata3GATA-binding protein 30.879
pitx3paired-like homeodomain transcription factor 30.868
isl1islet10.864
fgf8afibroblast growth factor 8 a0.754
eya1eyes absent homolog 10.727
mef2dmyocyte enhancer factor 2d0.663
kitakit receptor a0.660
flhfloating head0.655
six4bsine oculis homeobox homolog 4b0.638
eomesaeomesodermin homolog a0.634
fgf4fibroblast growth factor 40.634
fn1fibronectin 10.624
pitx2paired-like homeodomain transcription factor 20.621
klf4Kruppel-like factor 40.597
egr1early growth response 10.583
hoxa2bhomeo box A2b0.539
tbx20T-box 200.536
evx1even-skipped homeobox 10.529
kdrlkinase insert domain receptor like0.526
gli1GLI-Kruppel family member 10.512
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.483
ascl1aachaete-scute complex-like 1a (Drosophila)0.469
myf5myogenic factor 50.445
irx7iroquois homeobox protein 70.443
runx2brunt-related transcription factor 2b0.441
osr1odd-skipped related 1 (Drosophila)0.441
irx4biroquois homeobox protein 4b0.440
zic4zic family member 40.439
hnf1baHNF1 homeobox Ba0.435
notch3notch homolog 30.429
otpaorthopedia homolog a0.426
jag2jagged 20.413
mab21l2mab-21-like 20.410
wnt3awingless-type MMTV integration site family, member 3A0.395
wnt4awingless-type MMTV integration site family, member 4a0.388
tshbthyroid stimulating hormone, beta subunit0.386
nkx3.2NK3 homeobox 20.385
atoh1aatonal homolog 1a0.384
foxi1forkhead box I10.383
nkx2.2aNK2 transcription factor related 2a0.379
pax7apaired box gene 7a0.376
tfap2atranscription factor AP-2 alpha0.375
hoxc4ahomeo box C4a0.373
nkx2.5NK2 transcription factor related 50.369
bmp2bbone morphogenetic protein 2b0.367
dlx2adistal-less homeobox gene 2a0.359
tfap2btranscription factor AP-2 beta0.356
chdchordin0.354
lft1lefty10.347
prox1prospero-related homeobox gene 10.341
fzd8afrizzled homolog 8a0.337
pax8paired box gene 80.332
nr2e3nuclear receptor subfamily 2, group E, member 30.331
sox19aSRY-box containing gene 19a0.331
sox1aSRY-box containing gene 1a0.318
tll1tolloid-like 10.312
ripk2receptor-interacting serine-threonine kinase 20.308
myogmyogenin0.299
dlcdeltaC0.291
sall4sal-like 4 (Drosophila)0.283
col2a1acollagen type II, alpha-1a0.276
foxj1aforkhead box J1a0.275
ptf1apancreas specific transcription factor, 1a0.269
myf6myogenic factor 60.268
twist3twist30.267
wt1awilms tumor 1a0.265
gbx2gastrulation brain homeo box 20.259
fgfr4fibroblast growth factor receptor 40.258
cdh1cadherin 1, epithelial0.257
lhx1aLIM homeobox 1a0.246
lhx1bLIM homeobox 1b0.242
oprk1opioid receptor, kappa 10.241
dladeltaA0.235
tbx16T-box gene 160.234
hoxb1bhomeo box B1b0.227
barhl2BarH-like 20.226
hoxb5ahomeo box B5a0.221
foxd3forkhead box D30.218
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.217
hmx3homeo box (H6 family) 30.217
gdnfglial cell derived neurotrophic factor0.215
acvr2bactivin receptor IIb0.212
rx2retinal homeobox gene 20.210
fgfr3fibroblast growth factor receptor 30.205
barx1BarH-like homeobox 10.197
pcdh18bprotocadherin 18b0.193
pdlim7PDZ and LIM domain 70.191
dlx5adistal-less homeobox gene 5a0.187
gh1growth hormone 10.186
atoh1batonal homolog 1b0.186
junbljun B proto-oncogene, like0.185
foxp2forkhead box P20.185
hoxd13ahomeo box D13a0.184
zic5zic family member 5 (odd-paired homolog, Drosophila)0.183
tal1T-cell acute lymphocytic leukemia 10.182
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.999
pha-4Protein PHA-40.999
elt-6Protein ELT-60.987
vab-3Protein VAB-30.973
unc-42Protein UNC-420.939
rad-26Protein RAD-260.878
nhr-49Protein NHR-490.872
pbrm-1Protein PBRM-10.843
eya-1Protein EYA-10.842
skp-1Protein SKP-10.840
nhr-67Protein NHR-670.833
zip-7Protein ZIP-70.810
fkh-2Protein FKH-20.782
mab-5Protein MAB-50.767
ten-1Protein TEN-10.739
mat-3Protein MAT-30.734
lin-17Protein LIN-170.704
cam-1Protein CAM-10.700
hbl-1Protein HBL-10.692
sma-6Protein SMA-60.690
bar-1Protein BAR-10.674
his-64Protein HIS-640.650
his-1Protein HIS-10.645
egl-46Protein EGL-460.625
unc-62Protein UNC-620.617
hlh-2Protein HLH-20.591
hnd-1Protein HND-10.585
pry-1Protein PRY-10.554
lin-11Protein LIN-110.554
daf-1Protein DAF-10.547
tbx-8Protein TBX-80.529
ced-9Protein CED-90.519
glp-1Protein GLP-10.506
unc-43Protein UNC-430.497
his-5Protein HIS-50.495
F12F6.1Protein F12F6.10.493
cnd-1Protein CND-10.491
ceh-27Protein CEH-270.485
zyg-1Protein ZYG-10.480
mig-15Protein MIG-150.469
unc-73Protein UNC-730.458
cfim-2Protein CFIM-20.450
pop-1Protein POP-10.445
unc-40Protein UNC-400.437
npp-2Protein NPP-20.432
tax-4Protein TAX-40.424
let-60Protein LET-600.423
K10D6.4Protein K10D6.40.421
kin-10Protein KIN-100.420
gei-4Protein GEI-40.418
sax-3Protein SAX-30.413
unc-37Protein UNC-370.400
lsy-22Protein LSY-220.397
pax-3Protein PAX-30.397
ain-1Protein AIN-10.382
mep-1Protein MEP-10.381
sas-4Protein SAS-40.380
flh-2Protein FLH-20.379
Y47D3A.29Protein Y47D3A.290.378
lin-35Protein LIN-350.369
set-1Protein SET-10.365
hmg-4Protein HMG-40.364
F33H2.5Protein F33H2.50.361
dlk-1Protein DLK-10.338
mix-1Protein MIX-10.335
soc-2Protein SOC-20.328
lntl-1Protein LNTL-10.322
mab-31Protein MAB-310.320
lmn-1Protein LMN-10.316
plx-2Protein PLX-20.314
nhr-34Protein NHR-340.306
mdf-2Protein MDF-20.306
his-46Protein HIS-460.305
lag-1Protein LAG-10.302
nhr-25Protein NHR-250.295
icd-1Protein ICD-10.292
his-31Protein HIS-310.291
sas-5Protein SAS-50.289
hrp-1Protein HRP-10.288
peb-1Protein PEB-10.286
prp-21Protein PRP-210.282
eef-1A.1Protein EEF-1A.10.280
daf-3Protein DAF-30.278
F53F10.2Protein F53F10.20.271
rps-2Protein RPS-20.271
fox-1Protein FOX-10.271
CELE_ZK337.2Protein ZK337.20.270
saeg-1Protein SAEG-10.267
dpf-3Protein DPF-30.267
hif-1Protein HIF-10.267
ceh-22Protein CEH-220.267
ceh-20Protein CEH-200.264
ztf-2Protein ZTF-20.262
chk-1Protein CHK-10.260
T28F4.1Protein T28F4.10.259
odd-2Protein ODD-20.257
daf-14Protein DAF-140.256
panl-2Protein PANL-20.253
F46H5.7Protein F46H5.70.252
nhr-6Protein NHR-60.246
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
EgfrEpidermal growth factor receptor0.999
wgwingless0.995
brmbrahma0.983
Pp2B-14DProtein phosphatase 2B at 14D0.981
UbxUltrabithorax0.978
ushu-shaped0.974
grogroucho0.970
phlpole hole0.969
MedMedea0.968
eygeyegone0.967
Akt1CG4006 gene product from transcript CG4006-RA0.963
exdextradenticle0.961
Pi3K92ECG4141 gene product from transcript CG4141-RB0.958
EcREcdysone receptor0.955
cicubitus interruptus0.952
sdscalloped0.947
Su(H)Suppressor of Hairless0.946
Hrb27CHeterogeneous nuclear ribonucleoprotein at 27C0.946
dmdiminutive0.940
CG4699CG4699 gene product from transcript CG4699-RJ0.926
kiskismet0.921
dsxdoublesex0.918
psqpipsqueak0.905
kluklumpfuss0.902
trxtrithorax0.900
domdomino0.899
e(y)3enhancer of yellow 30.899
E(spl)Enhancer of split0.899
Snr1Snf5-related 10.894
Ras85DRas oncogene at 85D0.892
SmoxSmad on X0.890
shnschnurri0.886
bowlbrother of odd with entrails limited0.885
MoeMoesin0.873
gsbgooseberry0.872
mormoira0.862
ebiCG4063 gene product from transcript CG4063-RA0.849
ssspineless0.849
amosabsent MD neurons and olfactory sensilla0.847
panpangolin0.842
aopanterior open0.840
GugGrunge0.840
Fmr1CG6203 gene product from transcript CG6203-RC0.831
B-H2BarH20.830
emcextra macrochaetae0.828
Cp190Centrosomal protein 190kD0.827
cnccap-n-collar0.825
ecdecdysoneless0.822
PcPolycomb0.821
Src42ASrc oncogene at 42A0.820
CG11347CG11347 gene product from transcript CG11347-RE0.819
nmonemo0.815
bsblistered0.814
G-salpha60AG protein salpha 60A0.809
araaraucan0.802
CkIIalphaCasein kinase II alpha subunit0.789
kaykayak0.786
InRInsulin-like receptor0.784
AntpAntennapedia0.769
fzfrizzled0.768
hephemipterous0.763
Bre1CG10542 gene product from transcript CG10542-RA0.758
pdm2POU domain protein 20.749
BRWD3CG31132 gene product from transcript CG31132-RA0.748
dacdachshund0.745
pbproboscipedia0.745
hephhephaestus0.742
tintinman0.740
Abd-BAbdominal B0.739
ewgerect wing0.737
SerSerrate0.734
OptixCG18455 gene product from transcript CG18455-RA0.731
dcodiscs overgrown0.729
senssenseless0.728
sbbscribbler0.723
Doc2Dorsocross20.717
rkrickets0.716
drkdownstream of receptor kinase0.714
CDC45LCG3658 gene product from transcript CG3658-RA0.710
ftz-f1ftz transcription factor 10.710
SnooSno oncogene0.708
shotshort stop0.707
hkbhuckebein0.706
smt3CG4494 gene product from transcript CG4494-RA0.703
traltrailer hitch0.702
HLHm7E(spl) region transcript m70.701
Pka-C1cAMP-dependent protein kinase 10.699
tlltailless0.689
hthhomothorax0.686
cgcombgap0.680
CG32685CG32685 gene product from transcript CG32685-RC0.679
snasnail0.677
oddodd skipped0.673
escextra sexcombs0.670
otuovarian tumor0.667
RbfRetinoblastoma-family protein0.666
abd-Aabdominal A0.665
rhorhomboid0.663
18w18 wheeler0.662
stwlstonewall0.660
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Nr4a3nuclear receptor subfamily 4, group A, member 30.708
Ccl4chemokine (C-C motif) ligand 40.635
Ddr1discoidin domain receptor tyrosine kinase 10.607
Tgfbr2transforming growth factor, beta receptor II0.599
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.598
CrebbpCREB binding protein0.593
Tcfe2atranscription factor E2a0.590
Junbjun B proto-oncogene0.585
Zfp36zinc finger protein 360.579
Nclnucleolin0.564
Klf6Kruppel-like factor 60.550
Jak2Janus kinase 20.547
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.518
Ccl3chemokine (C-C motif) ligand 30.516
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.493
Egr3early growth response 30.493
Aqp2aquaporin 2 (collecting duct)0.493
Prf1perforin 1 (pore forming protein)0.479
Rararetinoic acid receptor, alpha0.474
Metmet proto-oncogene0.445
Tcf4transcription factor 40.436
Nr2f2nuclear receptor subfamily 2, group F, member 20.418
Slc12a1solute carrier family 12 (sodium/potassium/chloride transporters), member 10.404
Mapk1mitogen activated protein kinase 10.393
C5ar1complement component 5a receptor 10.390
Nr4a2nuclear receptor subfamily 4, group A, member 20.380
Dusp1dual specificity phosphatase 10.368
Adam17ADAM metallopeptidase domain 170.364
A4galtalpha 1,4-galactosyltransferase0.363
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.361
Fgfr1Fibroblast growth factor receptor 10.355
Lig3ligase III, DNA, ATP-dependent0.350
Adrb1adrenergic, beta-1-, receptor0.346
Tcp11t-complex protein 110.334
Nr1d1nuclear receptor subfamily 1, group D, member 10.332
Iappislet amyloid polypeptide0.332
Trim28tripartite motif-containing 280.331
Smad1SMAD family member 10.331
FosFBJ osteosarcoma oncogene0.329
Gata6GATA binding protein 60.326
LOC684996similar to chromosome 7 open reading frame 110.322
Foxa3forkhead box A30.321
Atxn1ataxin 10.318
Gja5gap junction protein, alpha 50.318
Lin7clin-7 homolog C (C. elegans)0.316
Klf13Kruppel-like factor 130.316
Col12a1collagen, type XII, alpha 10.315
Ascl1achaete-scute complex homolog 1 (Drosophila)0.311
Errfi1ERBB receptor feedback inhibitor 10.306
Cd40lgCD40 ligand0.305
Jak1Janus kinase 10.304
Runx1runt-related transcription factor 10.301
Hand2heart and neural crest derivatives expressed 20.301
Dlx5distal-less homeobox 50.301
Acvr1activin A receptor, type I0.294
Mpripmyosin phosphatase Rho interacting protein0.289
Nkg7natural killer cell group 7 sequence0.289
Mef2dmyocyte enhancer factor 2D0.283
Fgf10fibroblast growth factor 100.283
Prrx1paired related homeobox 10.283
Il2rginterleukin 2 receptor, gamma0.282
Clpscolipase, pancreatic0.279
Mycmyelocytomatosis oncogene0.275
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.274
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.273
Nr4a1nuclear receptor subfamily 4, group A, member 10.273
Il2rainterleukin 2 receptor, alpha0.270
Syt10synaptotagmin X0.267
Tas2r13taste receptor, type 2, member 130.266
Slc5a1solute carrier family 5 (sodium/glucose cotransporter), member 10.265
Phf12PHD finger protein 120.265
Irs1insulin receptor substrate 10.265
Npr3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)0.259
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.257
Fut4fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)0.256
Psma1proteasome (prosome, macropain) subunit, alpha type 10.252
Nfibnuclear factor I/B0.248
Ciitaclass II, major histocompatibility complex, transactivator0.248
Olr1500olfactory receptor 15000.246
Ncr1natural cytotoxicity triggering receptor 10.246
Myd88myeloid differentiation primary response gene 880.243
Rbl2retinoblastoma-like 20.243
RGD1561143similar to cell surface receptor FDFACT0.242
Plcg2phospholipase C, gamma 20.242
Nrp1neuropilin 10.240
Jtbjumping translocation breakpoint0.240
Nfat5nuclear factor of activated T-cells 50.237
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.236
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.235
Map4k1mitogen activated protein kinase kinase kinase kinase 10.234
Hmgb1high mobility group box 10.233
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.232
Foxe3forkhead box E30.230
Hnrpdheterogeneous nuclear ribonucleoprotein D0.230
Gata4GATA binding protein 40.229
Map3k1mitogen activated protein kinase kinase kinase 10.229
Lphn2latrophilin 20.225
Fgfr2fibroblast growth factor receptor 20.223
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.223
Ptprsprotein tyrosine phosphatase, receptor type, S0.220
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
YAP1Yap1p0.982
SIN3Sin3p0.972
LSM1Lsm1p0.970
RTF1Rtf1p0.970
URE2Ure2p0.945
GAL11Gal11p0.930
ADA2Ada2p0.924
SPT15Spt15p0.924
SNF6Snf6p0.918
RIM101Rim101p0.915
GLN3Gln3p0.913
SWI6Swi6p0.890
RPD3Rpd3p0.866
CTR9Ctr9p0.854
CTK3Ctk3p0.819
MKS1Mks1p0.813
CCR4Ccr4p0.806
MCM1Mcm1p0.803
RGR1Rgr1p0.802
SWI1Swi1p0.784
RXT2Rxt2p0.778
GCN5Gcn5p0.774
CHD1Chd1p0.773
SRB4Srb4p0.769
SSN3Ssn3p0.769
HOG1Hog1p0.768
CYC8Cyc8p0.766
FKH1Fkh1p0.762
CTI6Cti6p0.751
MKK2Mkk2p0.751
ESA1Esa1p0.749
SNF5Snf5p0.742
YTA7Yta7p0.741
HSP78Hsp78p0.729
MSN2Msn2p0.720
RSP5Rsp5p0.719
CTK1Ctk1p0.716
YAK1Yak1p0.712
FKH2Fkh2p0.707
SSN2Ssn2p0.698
ARG81Arg81p0.686
MED6Med6p0.683
CGI121Cgi121p0.676
HST1Hst1p0.673
PGD1Pgd1p0.670
LEU3Leu3p0.667
CAF40Caf40p0.663
SNF2Snf2p0.655
SDS3Sds3p0.654
HMO1Hmo1p0.638
MFT1Mft1p0.635
RAS2Ras2p0.629
HHT1Hht1p0.606
RAP1Rap1p0.605
HAP5Hap5p0.600
RTG3Rtg3p0.599
FLO8Flo8p0.598
CPR1Cpr1p0.598
SIN4Sin4p0.587
UTP7Utp7p0.583
MSN4Msn4p0.580
MED2Med2p0.574
HAP4Hap4p0.573
SNF1Snf1p0.570
SUB2Sub2p0.568
NUT2Nut2p0.566
HTA2Hta2p0.559
CAT8Cat8p0.547
KSS1Kss1p0.543
SET3Set3p0.536
DOT6Dot6p0.529
CKS1Cks1p0.529
UBP3Ubp3p0.525
CDC36Cdc36p0.524
NUP100Nup100p0.522
RAM2Ram2p0.517
KDX1Kdx1p0.514
STE12Ste12p0.513
ROM2Rom2p0.512
SPT8Spt8p0.510
WHI3Whi3p0.509
PSH1Psh1p0.504
CDC39Cdc39p0.494
MED1Med1p0.492
CDC43Cdc43p0.490
GAL80Gal80p0.483
RSC58Rsc58p0.481
PHO23Pho23p0.478
ATG1Atg1p0.477
NRG1Nrg1p0.477
SPT5Spt5p0.476
AEP1Aep1p0.474
MED8Med8p0.474
SFL1Sfl1p0.473
SRB5Srb5p0.469
PCC1Pcc1p0.468
MSN1Msn1p0.467
GAL4Gal4p0.463
ROX3Rox3p0.463
VID24Vid24p0.459