The network for 'macromolecule modification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

macromolecule modification

The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties.

NameDescriptionProbabilityFunc Analog Organism
efnb2aephrin B2a0.734
kdrlkinase insert domain receptor like0.719
bmp2bbone morphogenetic protein 2b0.683
lcp1lymphocyte cytosolic plastin 10.545
tp53tumor protein p530.492
evx1even-skipped homeobox 10.423
suv39h1asuppressor of variegation 3-9 homolog 1a0.386
tbpl2TATA box binding protein like 20.384
gro1groucho 10.374
cmybtranscription factor cmyb0.347
per3period homolog 3 (Drosophila)0.343
hif1abhypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b0.316
myogmyogenin0.312
znf703zinc finger protein 7030.300
sass6spindle assembly 6 homolog (C. elegans)0.297
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.294
klf4Kruppel-like factor 40.292
foxd3forkhead box D30.291
rarabretinoic acid receptor, alpha b0.290
sfrp5secreted frizzled-related protein 50.287
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.285
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.266
notch3notch homolog 30.263
wnt11rwingless-type MMTV integration site family, member 11, related0.258
mcm5MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)0.240
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.232
cyp19a1acytochrome P450, family 19, subfamily A, polypeptide 1a0.225
sox7SRY-box containing gene 70.222
crklv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.221
socs3asuppressor of cytokine signaling 3a0.220
nanos3nanos homolog 30.217
dnmt1DNA (cytosine-5-)-methyltransferase 10.216
gro2groucho 20.210
bocbrother of CDO0.208
whsc1Wolf-Hirschhorn syndrome candidate 10.207
sema3aasemaphorin 3aa0.202
mapk14amitogen-activated protein kinase 14a0.201
map2k4amitogen-activated protein kinase kinase 4a0.198
shhasonic hedgehog a0.198
cav1caveolin 10.196
flt4fms-related tyrosine kinase 40.191
runx2brunt-related transcription factor 2b0.189
suv39h1bsuppressor of variegation 3-9 homolog 1b0.188
dusp6dual specificity phosphatase 60.188
zbtb4zinc finger and BTB domain containing 40.188
eif4e1beukaryotic translation initiation factor 4e 1b0.182
wnt10awingless-type MMTV integration site family, member 10a0.182
ccnb1cyclin B10.177
sox11aSRY-box containing gene 11a0.177
rbmxRNA binding motif protein, X-linked0.176
jak1Janus kinase 10.176
irf6interferon regulatory factor 60.171
spns2spinster homolog 2 (Drosophila)0.169
rfx2regulatory factor X, 2 (influences HLA class II expression)0.168
kif23kinesin family member 230.168
pak1p21/Cdc42/Rac1-activated kinase 10.167
pdgfaaplatelet-derived growth factor alpha a0.166
wnt2bbwingless-type MMTV integration site family, member 2Bb0.166
supt5hsuppressor of Ty 5 homolog (S. cerevisiae)0.164
wnt4awingless-type MMTV integration site family, member 4a0.163
lmo4aLIM domain only 4a0.158
mpped2metallophosphoesterase domain containing 20.158
dlddeltaD0.158
zgc:111944zgc:1119440.158
bmp4bone morphogenetic protein 40.155
dkk1bdickkopf 1b0.155
mmp9matrix metalloproteinase 90.153
si:rp71-39b20.7si:rp71-39b20.70.152
brd4bromodomain containing 40.151
nrg2aneuregulin 2a0.150
ezh2enhancer of zeste homolog 2 (Drosophila)0.150
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.149
wnt3wingless-type MMTV integration site family, member 30.149
plagl2pleiomorphic adenoma gene-like 20.148
calcrlacalcitonin receptor-like a0.146
chdchordin0.144
largelike-glycosyltransferase0.144
ahctf1AT hook containing transcription factor 10.144
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.144
mbnl2muscleblind-like 2 (Drosophila)0.143
xrcc5X-ray repair complementing defective repair in Chinese hamster cells 50.143
jag1bjagged 1b0.140
dzip1DAZ interacting protein 10.140
acvr2aactivin receptor IIa0.139
klf2bKruppel-like factor 2b0.138
foxi1forkhead box I10.138
nusap1nucleolar and spindle associated protein 10.135
pomt1protein-O-mannosyltransferase 10.135
oprm1opioid receptor, mu 10.134
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.134
ptenaphosphatase and tensin homolog A0.134
znfl2azinc finger-like gene 2a0.133
st8sia3ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 30.133
mycbp2MYC binding protein 20.132
nrp2bneuropilin 2b0.132
nrp1aneuropilin 1a0.132
ercc2excision repair cross-complementing rodent repair deficiency, complementation group 20.131
e2f5E2F transcription factor 50.130
smad3bMAD, mothers against decapentaplegic homolog 3b (Drosophila)0.130
mapk12mitogen-activated protein kinase 120.130
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
his-64Protein HIS-640.632
bir-1Protein BIR-10.532
mel-26Protein MEL-260.488
sli-1Protein SLI-10.466
sma-1Protein SMA-10.454
klp-7Protein KLP-70.432
D1081.8Protein D1081.80.413
mat-3Protein MAT-30.408
taf-5Protein TAF-50.400
egl-18Protein EGL-180.398
egl-8Protein EGL-80.380
R11A8.7Protein R11A8.70.367
csn-5Protein CSN-50.361
M01A8.2Protein M01A8.20.351
pmk-1Protein PMK-10.346
wnk-1Protein WNK-10.344
mdf-2Protein MDF-20.342
rpt-3Protein RPT-30.332
kle-2Protein KLE-20.329
ocrl-1Protein OCRL-10.323
ZK507.6Protein ZK507.60.321
eps-8Protein EPS-80.315
npp-22Protein NPP-220.315
dnc-2Protein DNC-20.311
sma-6Protein SMA-60.308
zyg-11Protein ZYG-110.307
pat-6Protein PAT-60.298
csn-1Protein CSN-10.297
ubc-12Protein UBC-120.297
ddb-1Protein DDB-10.296
klc-2Protein KLC-20.290
ztf-7Protein ZTF-70.285
sur-2Protein SUR-20.284
pqn-59Protein PQN-590.282
spc-1Protein SPC-10.273
CELE_K08F4.1Protein K08F4.10.271
CELE_C17H12.13Protein C17H12.130.270
H24G06.1Protein H24G06.10.268
hrdl-1Protein HRDL-10.268
skn-1Protein SKN-10.265
glp-1Protein GLP-10.258
C56G2.7Protein C56G2.70.255
C35D10.1Protein C35D10.10.253
fshr-1Protein FSHR-10.246
pde-2Protein PDE-20.246
spd-5Protein SPD-50.245
C05D10.4Protein C05D10.40.243
gsy-1Protein GSY-10.243
lin-23Protein LIN-230.242
nap-1Protein NAP-10.236
cst-1Protein CST-10.234
his-1Protein HIS-10.233
pqn-44Protein PQN-440.232
swsn-2.1Protein SWSN-2.10.228
C13B9.3Protein C13B9.30.228
C34D10.2Protein C34D10.20.227
rpn-7Protein RPN-70.224
lag-1Protein LAG-10.223
lis-1Protein LIS-10.223
F21A10.2Protein F21A10.20.218
pkc-3Protein PKC-30.215
elt-6Protein ELT-60.214
sun-1Protein SUN-10.214
inx-13Protein INX-130.210
hda-3Protein HDA-30.208
cpt-1Protein CPT-10.201
C13F10.5Protein C13F10.50.201
akt-2Protein AKT-20.200
W03F8.4Protein W03F8.40.199
trr-1Protein TRR-10.198
ubr-1Protein UBR-10.198
frm-2Protein FRM-20.198
his-46Protein HIS-460.197
dph-1Protein DPH-10.197
toe-4Protein TOE-40.197
bub-1Protein BUB-10.197
mig-15Protein MIG-150.196
T27F6.7Protein T27F6.70.195
zyg-8Protein ZYG-80.194
F39B2.1Protein F39B2.10.194
lin-25Protein LIN-250.193
mys-1Protein MYS-10.193
mes-3Protein MES-30.191
his-5Protein HIS-50.190
let-502Protein LET-5020.190
hum-5Protein HUM-50.190
dep-1Protein DEP-10.188
C41H7.6Protein C41H7.60.187
klp-18Protein KLP-180.185
cct-6Protein CCT-60.185
sgt-1Protein SGT-10.183
vab-3Protein VAB-30.183
his-32Protein HIS-320.182
F10B5.8Protein F10B5.80.182
rpt-2Protein RPT-20.181
skp-1Protein SKP-10.181
aap-1Protein AAP-10.181
sqv-4Protein SQV-40.179
lin-53Protein LIN-530.179
F54C4.4Protein F54C4.40.178
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism