The network for 'regulation of response to extracellular stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of response to extracellular stimulus

Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus.

NameDescriptionProbabilityFunc Analog Organism
foxa3forkhead box A30.716
LOC100332193growth hormone secretagogue receptor type 1-like0.406
pafah1b1bplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b0.398
sst1.1somatostatin 1, tandem duplicate 10.266
inka1ainduced in neural crest by AP2, 1a0.259
zbtb4zinc finger and BTB domain containing 40.200
gro2groucho 20.173
sox9bSRY-box containing gene 9b0.165
trim13tripartite motif-containing 130.149
ift88intraflagellar transport 88 homolog0.128
dusp4dual specificity phosphatase 40.116
mapk3mitogen-activated protein kinase 30.107
ntlano tail a0.105
fgf3fibroblast growth factor 30.104
stmn4stathmin-like 40.103
gata3GATA-binding protein 30.093
cftrcystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)0.085
gata6GATA-binding protein 60.075
ptk2.1protein tyrosine kinase 2a0.075
ptprkprotein tyrosine phosphatase, receptor type, K0.073
frzbfrizzled-related protein0.070
ptpraprotein tyrosine phosphatase, receptor type, A0.066
nos2anitric oxide synthase 2a, inducible0.065
piwil2piwi-like 2 (Drosophila)0.063
xbp1X-box binding protein 10.063
her1hairy-related 10.063
foxp2forkhead box P20.062
kif17kinesin family member 170.060
igf1rbinsulin-like growth factor 1b receptor0.057
aldh2aaldehyde dehydrogenase 2 family (mitochondrial)a0.056
adrb2badrenergic receptor, beta 2b0.056
rhoaaras homolog gene family, member Aa0.056
oprd1bopioid receptor, delta 1b0.056
stk11serine/threonine kinase 110.054
pias4aprotein inhibitor of activated STAT, 4a0.054
odc1ornithine decarboxylase 10.054
foxa1forkhead box A10.052
pld1aphospholipase D1a0.052
dag1dystroglycan 10.051
faf2Fas associated factor family member 20.050
pbx1apre-B-cell leukemia transcription factor 1a0.050
ep300bE1A binding protein p300 b0.050
fzd5frizzled homolog 50.050
cldniclaudin i0.050
ralgapa1Ral GTPase activating protein, alpha subunit 1 (catalytic)0.049
mapk4mitogen-activated protein kinase 40.048
igf1insulin-like growth factor 10.047
npy4rneuropeptide Y receptor Y40.047
grnbgranulin b0.046
cdh1cadherin 1, epithelial0.046
atp2b4ATPase, Ca++ transporting, plasma membrane 40.046
mnx1motor neuron and pancreas homeobox 10.046
bbs2Bardet-Biedl syndrome 20.046
nlgn4aneuroligin 4a0.046
si:dkey-108d22.4si:dkey-108d22.40.045
dlg1discs, large (Drosophila) homolog 10.045
cecr1acat eye syndrome chromosome region, candidate 1a0.045
brd2abromodomain-containing 2a0.045
mpp6bmembrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6)0.044
prkceaprotein kinase C, epsilon a0.044
zgc:101598zgc:1015980.043
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.043
ldb1aLIM-domain binding factor 1a0.043
ints6integrator complex subunit 60.043
esr2bestrogen receptor 2b0.042
ptpn1protein tyrosine phosphatase, non-receptor type 10.042
ncoa2nuclear receptor coactivator 20.042
foxa2forkhead box A20.041
zgc:101761zgc:1017610.041
gro1groucho 10.041
ntmneurotrimin0.041
igf2ainsulin-like growth factor 2a0.041
c11orf2c11orf2 homolog (H. sapiens)0.041
xgbx globin0.040
pmchpro-melanin concentrating hormone0.040
zgc:92745zgc:927450.040
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.040
per2period homolog 2 (Drosophila)0.040
crsp7cofactor required for Sp1 transcriptional activation, subunit 70.039
snf8SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)0.039
zgc:175214zgc:1752140.038
abl1c-abl oncogene 1, non-receptor tyrosine kinase0.038
ispdisoprenoid synthase domain containing0.037
npc1Niemann-Pick disease, type C10.037
ndr1nodal-related 10.037
btbd2BTB (POZ) domain containing 20.037
mxi1max interacting protein0.037
hlxb9lahomeo box HB9 like a0.037
krt5keratin 50.036
hnf1baHNF1 homeobox Ba0.036
cry3cryptochrome 30.036
siah2lseven in absentia homolog 2 (Drosophila)-like0.035
tp63tumor protein p630.035
foxl1forkhead box L10.035
krt4keratin 40.035
bidaBH3 interacting domain death agonist0.035
zgc:73134zgc:731340.034
zgc:172101zgc:1721010.034
wwp2WW domain containing E3 ubiquitin protein ligase 20.034
angptl1angiopoietin-like 10.034
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
rprreaper0.933
Ras85DRas oncogene at 85D0.668
RelRelish0.447
foxoforkhead box, sub-group O0.422
p53CG33336 gene product from transcript CG33336-RB0.349
ththread0.315
Akt1CG4006 gene product from transcript CG4006-RA0.257
Pi3K92ECG4141 gene product from transcript CG4141-RB0.223
Atg13Autophagy-specific gene 130.203
Atg1Autophagy-specific gene 10.193
grimCG4345 gene product from transcript CG4345-RA0.183
drkdownstream of receptor kinase0.145
gekgenghis khan0.137
ThorCG8846 gene product from transcript CG8846-RA0.125
Rab7Rab-protein 70.110
rlrolled0.108
KrKruppel0.107
Lk6CG17342 gene product from transcript CG17342-RA0.099
nosnanos0.098
AGO2Argonaute 20.095
BG4CG12297 gene product from transcript CG12297-RA0.090
bynbrachyenteron0.088
KrnKeren0.086
spospook0.085
RASSF8CG5053 gene product from transcript CG5053-RA0.081
Atg18Autophagy-specific gene 180.080
drprdraper0.078
Atg8aAutophagy-specific gene 8a0.077
dmdiminutive0.075
imdimmune deficiency0.075
shdshade0.065
RhebCG1081 gene product from transcript CG1081-RA0.063
debcldeath executioner Bcl-2 homologue0.062
MioMlx interactor0.057
RagACG11968 gene product from transcript CG11968-RA0.056
hppyhappyhour0.056
Hdac3Histone deacetylase 30.055
CG32486CG32486 gene product from transcript CG32486-RD0.055
Syx7Syntaxin 70.055
cswcorkscrew0.054
carcarnation0.048
Rab14Rab-protein 140.048
Klp31ECG5300 gene product from transcript CG5300-RD0.047
pr-set7CG3307 gene product from transcript CG3307-RC0.046
Ilp2Insulin-like peptide 20.045
sroshroud0.043
Traf4TNF-receptor-associated factor 40.037
Dsor1Downstream of raf10.037
edlETS-domain lacking0.036
bskbasket0.036
pucpuckered0.035
dibdisembodied0.035
wtswarts0.035
IceCG7788 gene product from transcript CG7788-RA0.034
rempAreduced mechanoreceptor potential A0.034
PtenCG5671 gene product from transcript CG5671-RB0.034
CG18754CG18754 gene product from transcript CG18754-RB0.033
BEAF-32Boundary element-associated factor of 32kD0.032
TrhTryptophan hydroxylase0.031
meltmelted0.031
ArkApaf-1-related-killer0.030
kluklumpfuss0.029
CG7220CG7220 gene product from transcript CG7220-RD0.029
npfneuropeptide F0.028
flflfalafel0.028
pntpointed0.027
JraJun-related antigen0.027
Dcp-1Death caspase-10.027
nudECG8104 gene product from transcript CG8104-RB0.026
sklsickle0.026
CdsACDP diglyceride synthetase0.026
Pi4KIIalphaCG2929 gene product from transcript CG2929-RC0.025
CG32581CG32581 gene product from transcript CG32581-RB0.025
Xbp1X box binding protein-10.022
mttmangetout0.022
cercrammer0.021
tefutelomere fusion0.021
Ptp61FProtein tyrosine phosphatase 61F0.021
NcNedd2-like caspase0.020
HmgcrHMG Coenzyme A reductase0.020
CG8974CG8974 gene product from transcript CG8974-RD0.020
Sox14Sox box protein 140.020
Su(z)2Suppressor of zeste 20.020
X11LCG5675 gene product from transcript CG5675-RB0.019
Syx17Syntaxin 170.019
GLazGlial Lazarillo0.019
14-3-3epsilonCG31196 gene product from transcript CG31196-RA0.019
Rab1Rab-protein 10.019
Atg2Autophagy-specific gene 20.018
yataCG1973 gene product from transcript CG1973-RA0.018
CG9801CG9801 gene product from transcript CG9801-RC0.018
Src42ASrc oncogene at 42A0.018
lokloki0.018
sNPFshort neuropeptide F precursor0.018
eveeven skipped0.017
CG30344CG30344 gene product from transcript CG30344-RA0.017
CG16721CG16721 gene product from transcript CG16721-RA0.017
Eip74EFEcdysone-induced protein 74EF0.017
hughugin0.017
fs(1)M3female sterile (1) M30.017
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.266
MAP2K1mitogen-activated protein kinase kinase 10.059
GABARAPL2GABA(A) receptor-associated protein-like 20.056
SQSTM1sequestosome 10.040
GFM1G elongation factor, mitochondrial 10.039
ATG3ATG3 autophagy related 3 homolog (S. cerevisiae)0.038
MAPK8mitogen-activated protein kinase 80.036
CREBBPCREB binding protein0.033
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.032
IRS2insulin receptor substrate 20.031
MDM2Mdm2 p53 binding protein homolog (mouse)0.024
ATG13ATG13 autophagy related 13 homolog (S. cerevisiae)0.023
AKT1v-akt murine thymoma viral oncogene homolog 10.022
RRAGARas-related GTP binding A0.021
NCOA1nuclear receptor coactivator 10.019
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.019
PRKAB2protein kinase, AMP-activated, beta 2 non-catalytic subunit0.018
BBS2Bardet-Biedl syndrome 20.018
SESN2sestrin 20.017
GABARAPGABA(A) receptor-associated protein0.015
POLR2Apolymerase (RNA) II (DNA directed) polypeptide A, 220kDa0.015
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.015
ARandrogen receptor0.014
TRIM63tripartite motif containing 630.014
MAPK1mitogen-activated protein kinase 10.013
NCOR1nuclear receptor corepressor 10.013
PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.013
SIRT1sirtuin 10.013
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.012
RHEBRas homolog enriched in brain0.012
OCRLoculocerebrorenal syndrome of Lowe0.012
ACACAacetyl-CoA carboxylase alpha0.012
SH3GL2SH3-domain GRB2-like 20.012
CREB1cAMP responsive element binding protein 10.012
SCHIP1schwannomin interacting protein 10.011
ATG9AATG9 autophagy related 9 homolog A (S. cerevisiae)0.011
MAP2K2mitogen-activated protein kinase kinase 20.011
PDCD6programmed cell death 60.011
RUSC2RUN and SH3 domain containing 20.011
PTPN23protein tyrosine phosphatase, non-receptor type 230.011
GOLGA2golgin A20.011
BBS1Bardet-Biedl syndrome 10.010
COASYCoA synthase0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Chrna4cholinergic receptor, nicotinic, alpha 40.017
Shank2SH3 and multiple ankyrin repeat domains 20.011
Zfp706zinc finger protein 7060.011
Fkbp4FK506 binding protein 40.011
Hpcahippocalcin0.011
Chst10carbohydrate sulfotransferase 100.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
ATG13Atg13p0.361
TRA1Tra1p0.361
KSP1Ksp1p0.250
MIG1Mig1p0.222
ATG9Atg9p0.213
NET1Net1p0.204
PCL8Pcl8p0.172
HRK1Hrk1p0.171
YKR015Chypothetical protein0.168
SEC2Sec2p0.132
TPK1Tpk1p0.125
SLG1Slg1p0.124
BOI1Boi1p0.122
KOG1Kog1p0.112
VID24Vid24p0.109
KIN2Kin2p0.095
FPK1Fpk1p0.080
VHS1Vhs1p0.078
KCC4Kcc4p0.077
IOC4Ioc4p0.076
YKR075Chypothetical protein0.075
MIG3Mig3p0.074
SNT1Snt1p0.071
ATG4Atg4p0.063
NTO1Nto1p0.063
RPD3Rpd3p0.062
TEC1Tec1p0.060
SSK1Ssk1p0.059
GAT2Gat2p0.057
HXT3Hxt3p0.054
REG1Reg1p0.054
CKA1Cka1p0.053
MDS3Mds3p0.053
GLN3Gln3p0.053
PHO81Pho81p0.051
CDC15Cdc15p0.049
EAF1Eaf1p0.048
PCL2Pcl2p0.047
SKS1Sks1p0.047
SAP185Sap185p0.047
FOB1Fob1p0.045
TOF2Tof2p0.042
CRZ1Crz1p0.042
YNL234Whypothetical protein0.042
HMS1Hms1p0.041
MIG2Mig2p0.041
EAF3Eaf3p0.041
STD1Std1p0.041
HHO1Hho1p0.041
PPH3Pph3p0.041
DOT6Dot6p0.041
MHP1Mhp1p0.041
DSS4Dss4p0.040
SNF4Snf4p0.040
CLB3Clb3p0.039
ESA1Esa1p0.039
SSK2Ssk2p0.038
YHR009Chypothetical protein0.038
POG1Pog1p0.038
YMR102Chypothetical protein0.037
YPL260Whypothetical protein0.037
YLR177Whypothetical protein0.037
SEF1Sef1p0.037
MON1Mon1p0.036
PRR2Prr2p0.035
BMH1Bmh1p0.035
TGL4Tgl4p0.035
TRK1Trk1p0.034
YAK1Yak1p0.032
GIS4Gis4p0.032
CSR2Csr2p0.032
SAS5Sas5p0.031
UBP9Ubp9p0.031
ICY2Icy2p0.030
ISR1Isr1p0.029
MET4Met4p0.029
ROX1Rox1p0.029
YPT32Ypt32p0.029
ATG1Atg1p0.029
PRS2Prs2p0.029
STP1Stp1p0.029
KIN82Kin82p0.028
AVO1Avo1p0.028
TOM1Tom1p0.027
YPT35Ypt35p0.027
RGS2Rgs2p0.027
SFL1Sfl1p0.026
HXT1Hxt1p0.025
RPI1Rpi1p0.025
CAT8Cat8p0.025
YPL014Whypothetical protein0.025
YRO2Yro2p0.024
VAC7Vac7p0.024
EAF5Eaf5p0.023
TYE7Tye7p0.023
HRR25Hrr25p0.023
SNF1Snf1p0.023
ICY1Icy1p0.023
MKS1Mks1p0.023
USO1Uso1p0.022