The network for 'regulation of cytokine production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of cytokine production

Any process that modulates the frequency, rate, or extent of production of a cytokine.

NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.764
fn1fibronectin 10.630
tal1T-cell acute lymphocytic leukemia 10.584
sulf2lsulfatase 2, like0.546
sulf1sulfatase 10.543
shhasonic hedgehog a0.524
tlr3toll-like receptor 30.440
gpiaglucose phosphate isomerase a0.385
LOC557072caspase recruitment domain-containing protein 11-like0.382
c3bcomplement component c3b0.380
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.375
pcdh18bprotocadherin 18b0.361
ip6k2inositol hexaphosphate kinase 20.314
osr1odd-skipped related 1 (Drosophila)0.311
rarabretinoic acid receptor, alpha b0.294
nr2f2nuclear receptor subfamily 2, group F, member 20.288
foxi3aforkhead box I3a0.279
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.278
alcamaactivated leukocyte cell adhesion molecule a0.267
fgf8afibroblast growth factor 8 a0.265
cmybtranscription factor cmyb0.262
il6stinterleukin 6 signal transducer0.261
itga2bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)0.260
ripk2receptor-interacting serine-threonine kinase 20.254
pglyrp5peptidoglycan recognition protein 50.242
nod1nucleotide-binding oligomerization domain containing 10.240
gata6GATA-binding protein 60.232
stat1bsignal transducer and activator of transcription 1b0.228
il1binterleukin 1, beta and interleukin 1, beta0.228
ighmimmunoglobulin heavy constant mu and immunoglobulin heavy constant mu0.226
caspacaspase a0.221
sqstm1sequestosome 10.221
axin2axin 2 (conductin, axil)0.211
prox1prospero-related homeobox gene 10.209
birc5bbaculoviral IAP repeat-containing 5B0.208
tnfatumor necrosis factor a (TNF superfamily, member 2)0.203
npy8brneuropeptide Y receptor Y8b0.202
irx3airoquois homeobox protein 3a0.202
etv2ets variant gene 20.200
ptger2aprostaglandin E receptor 2a (subtype EP2)0.199
il7rinterleukin 7 receptor0.193
eporerythropoietin receptor0.192
tlr18toll-like receptor 180.192
anxa1bannexin A1b0.189
rhagRhesus blood group-associated glycoprotein0.189
dnmt8DNA (cytosine-5-)-methyltransferase 80.183
sox11aSRY-box containing gene 11a0.181
LOC100332193growth hormone secretagogue receptor type 1-like0.180
ifnphi1interferon phi 10.178
tiraptoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.177
irak4interleukin-1 receptor-associated kinase 40.173
vegfcvascular endothelial growth factor c0.172
st8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.171
matn4matrilin 40.171
sod2superoxide dismutase 2, mitochondrial0.171
cdh1cadherin 1, epithelial0.161
nphs2nephrosis 2, idiopathic, steroid-resistant (podocin)0.160
furinafurin (paired basic amino acid cleaving enzyme) a0.159
lfnglunatic fringe homolog0.158
ldb1aLIM-domain binding factor 1a0.158
bsk146brain specific kinase 1460.156
flhfloating head0.155
abcb3l1ATP-binding cassette, sub-family B (MDR/TAP), member 3 like 10.152
mpxmyeloid-specific peroxidase0.151
igf2binsulin-like growth factor 2b0.151
hcrthypocretin (orexin) neuropeptide precursor0.150
btkBruton agammaglobulinemia tyrosine kinase0.149
ikzf1IKAROS family zinc finger 1 (Ikaros)0.147
plagl2pleiomorphic adenoma gene-like 20.144
foxi2forkhead box I20.142
tmprss4atransmembrane protease, serine 4a0.138
tlr21toll-like receptor 210.135
dbx1adeveloping brain homeobox 1a0.133
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.133
col12a1collagen, type XII, alpha 10.131
lcp1lymphocyte cytosolic plastin 10.131
clec14aC-type lectin domain family 14, member A0.129
fzd7bfrizzled homolog 7b0.126
ifng1-2interferon, gamma 1-20.126
il8interleukin 80.126
sgk1serum/glucocorticoid regulated kinase 10.124
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.124
LOC100003514protein kinase C alpha type-like0.123
nfycnuclear transcription factor Y, gamma0.123
igf1insulin-like growth factor 10.122
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.122
rpe65bretinal pigment epithelium-specific protein 65b0.122
st8sia2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.121
atp6v1baATPase, H+ transporting, lysosomal, V1 subunit B, member a0.120
foxj1aforkhead box J1a0.120
hspa5heat shock protein 50.117
smc1alstructural maintenance of chromosomes 1A, like0.116
ighzimmunoglobulin heavy constant zeta0.116
dusp1dual specificity phosphatase 10.115
c1qccomplement component 1, q subcomponent, C chain0.114
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)1.000
MYD88myeloid differentiation primary response gene (88)0.999
IRAK1interleukin-1 receptor-associated kinase 10.999
MAPK14mitogen-activated protein kinase 140.999
CREBBPCREB binding protein0.998
BIRC3baculoviral IAP repeat containing 30.998
SMAD3SMAD family member 30.997
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.997
IRAK2interleukin-1 receptor-associated kinase 20.996
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.996
SYKspleen tyrosine kinase0.994
TRAF3TNF receptor-associated factor 30.994
TRAF1TNF receptor-associated factor 10.992
TRAF6TNF receptor-associated factor 60.991
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.991
RIPK2receptor-interacting serine-threonine kinase 20.990
CD80CD80 molecule0.990
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.990
EGFRepidermal growth factor receptor0.987
IL4Rinterleukin 4 receptor0.975
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.975
SMAD4SMAD family member 40.975
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.974
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.973
IL8interleukin 80.967
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.966
SP1Sp1 transcription factor0.965
SOCS3suppressor of cytokine signaling 30.964
CXCL10chemokine (C-X-C motif) ligand 100.961
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.961
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.960
C1QAcomplement component 1, q subcomponent, A chain0.958
ESR1estrogen receptor 10.956
STAT1signal transducer and activator of transcription 1, 91kDa0.953
SHC1SHC (Src homology 2 domain containing) transforming protein 10.951
SMAD1SMAD family member 10.950
ARRB1arrestin, beta 10.943
SH2D1ASH2 domain containing 1A0.941
CEBPDCCAAT/enhancer binding protein (C/EBP), delta0.941
CCL4chemokine (C-C motif) ligand 40.939
CXCL9chemokine (C-X-C motif) ligand 90.936
HCKhemopoietic cell kinase0.934
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.933
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.925
IL1Binterleukin 1, beta0.919
CHUKconserved helix-loop-helix ubiquitous kinase0.909
IL10interleukin 100.901
IL1R1interleukin 1 receptor, type I0.900
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.890
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.885
HLA-Bmajor histocompatibility complex, class I, B0.885
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.881
CSF2RAcolony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)0.880
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.878
HLA-Cmajor histocompatibility complex, class I, C0.876
ARandrogen receptor0.875
CD86CD86 molecule0.871
UBCubiquitin C0.867
APOEapolipoprotein E0.858
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.858
IL10RAinterleukin 10 receptor, alpha0.858
HLA-Emajor histocompatibility complex, class I, E0.851
ANXA1annexin A10.849
SLAMF1signaling lymphocytic activation molecule family member 10.846
CCL2chemokine (C-C motif) ligand 20.835
JUNjun proto-oncogene0.830
HLA-Fmajor histocompatibility complex, class I, F0.829
CCL22chemokine (C-C motif) ligand 220.825
CXCL2chemokine (C-X-C motif) ligand 20.822
CCL5chemokine (C-C motif) ligand 50.821
CCR5chemokine (C-C motif) receptor 50.817
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.805
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.797
BTN3A1butyrophilin, subfamily 3, member A10.794
DUSP1dual specificity phosphatase 10.774
INSRinsulin receptor0.768
HLA-Gmajor histocompatibility complex, class I, G0.764
TNFAIP3tumor necrosis factor, alpha-induced protein 30.758
TLR2toll-like receptor 20.757
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.754
BLNKB-cell linker0.750
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.744
BTN3A3butyrophilin, subfamily 3, member A30.738
SMAD2SMAD family member 20.737
NCOA3nuclear receptor coactivator 30.731
CCR1chemokine (C-C motif) receptor 10.729
CD163CD163 molecule0.729
ICAM1intercellular adhesion molecule 10.720
CCR7chemokine (C-C motif) receptor 70.718
CCL8chemokine (C-C motif) ligand 80.713
LTAlymphotoxin alpha (TNF superfamily, member 1)0.710
SMURF2SMAD specific E3 ubiquitin protein ligase 20.708
EPAS1endothelial PAS domain protein 10.707
PRKD2protein kinase D20.705
BTN3A2butyrophilin, subfamily 3, member A20.704
IRF7interferon regulatory factor 70.702
IRF1interferon regulatory factor 10.701
IL6interleukin 6 (interferon, beta 2)0.698
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Stat3signal transducer and activator of transcription 31.000
Tlr4toll-like receptor 40.998
Casp4caspase 4, apoptosis-related cysteine peptidase0.997
Cd40CD40 antigen0.996
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.995
Myd88myeloid differentiation primary response gene 880.995
Casp1caspase 10.993
Tnftumor necrosis factor0.991
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.989
Il1r1interleukin 1 receptor, type I0.986
Apoeapolipoprotein E0.984
FaslFas ligand (TNF superfamily, member 6)0.981
Lyz2lysozyme 20.980
Ccl4chemokine (C-C motif) ligand 40.972
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.964
Inhbainhibin beta-A0.963
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.961
Traf6TNF receptor-associated factor 60.960
Icosinducible T-cell co-stimulator0.955
Il1binterleukin 1 beta0.955
Cd28CD28 antigen0.953
Tnfaip3tumor necrosis factor, alpha-induced protein 30.949
Gbp7guanylate binding protein 70.941
Slamf1signaling lymphocytic activation molecule family member 10.941
Fshrfollicle stimulating hormone receptor0.939
Il2rginterleukin 2 receptor, gamma chain0.937
Osmroncostatin M receptor0.930
Irf9interferon regulatory factor 90.930
Stat1signal transducer and activator of transcription 10.929
Nos2nitric oxide synthase 2, inducible0.929
Map3k14mitogen-activated protein kinase kinase kinase 140.929
AxlAXL receptor tyrosine kinase0.925
Gata4GATA binding protein 40.920
Batfbasic leucine zipper transcription factor, ATF-like0.919
Ncr1natural cytotoxicity triggering receptor 10.917
Il4interleukin 40.915
F2rl2coagulation factor II (thrombin) receptor-like 20.913
Pax8paired box gene 80.913
Tlr2toll-like receptor 20.912
Itgalintegrin alpha L0.911
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.910
Klrg1killer cell lectin-like receptor subfamily G, member 10.898
Csf1colony stimulating factor 1 (macrophage)0.893
Ltalymphotoxin A0.892
Il10rainterleukin 10 receptor, alpha0.892
Ikzf1IKAROS family zinc finger 10.889
Ccl2chemokine (C-C motif) ligand 20.889
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.888
Tgfb2transforming growth factor, beta 20.887
Cd4CD4 antigen0.885
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.884
Inpp5dinositol polyphosphate-5-phosphatase D0.884
Trim30atripartite motif-containing 30A0.883
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.881
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.880
Il2rbinterleukin 2 receptor, beta chain0.880
Irgm1immunity-related GTPase family M member 10.874
Il1rninterleukin 1 receptor antagonist0.859
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.858
Xcl1chemokine (C motif) ligand 10.856
Unc93b1unc-93 homolog B1 (C. elegans)0.850
Irf1interferon regulatory factor 10.850
Pax2paired box gene 20.838
Map3k8mitogen-activated protein kinase kinase kinase 80.836
Birc3baculoviral IAP repeat-containing 30.835
Foxf1aforkhead box F1a0.832
Gpr33G protein-coupled receptor 330.828
Ccr1chemokine (C-C motif) receptor 10.828
Leprleptin receptor0.828
Slc11a1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 10.818
Chrna3cholinergic receptor, nicotinic, alpha polypeptide 30.818
Cd86CD86 antigen0.816
Stat5asignal transducer and activator of transcription 5A0.815
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.815
Pdcd1programmed cell death 10.813
Iigp1interferon inducible GTPase 10.813
Notch2Notch gene homolog 2 (Drosophila)0.810
Cd14CD14 antigen0.801
Ighimmunoglobulin heavy chain complex0.801
Gzmkgranzyme K0.799
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.797
Socs3suppressor of cytokine signaling 30.796
Stat5bsignal transducer and activator of transcription 5B0.793
Jak2Janus kinase 20.793
Cybbcytochrome b-245, beta polypeptide0.793
Klrk1killer cell lectin-like receptor subfamily K, member 10.787
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.787
Gpr132G protein-coupled receptor 1320.787
Ctswcathepsin W0.786
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.786
Bcl3B-cell leukemia/lymphoma 30.780
Sh2d2aSH2 domain protein 2A0.775
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.774
Cxcl10chemokine (C-X-C motif) ligand 100.772
P2rx7purinergic receptor P2X, ligand-gated ion channel, 70.772
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.766
Ifi203interferon activated gene 2030.764
Relreticuloendotheliosis oncogene0.757
Socs1suppressor of cytokine signaling 10.757
Lag3lymphocyte-activation gene 30.756
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Plauplasminogen activator, urokinase0.634
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.587
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.555
Icam1intercellular adhesion molecule 10.552
Il1binterleukin 1 beta0.508
Il2rbinterleukin 2 receptor, beta0.470
Ccl3chemokine (C-C motif) ligand 30.453
Hckhemopoietic cell kinase0.368
Cd80Cd80 molecule0.337
Il6interleukin 60.329
Socs3suppressor of cytokine signaling 30.305
Ptger2prostaglandin E receptor 2 (subtype EP2)0.303
Mca32mast cell antigen 320.272
Cxcl10chemokine (C-X-C motif) ligand 100.269
Arl11ADP-ribosylation factor-like 110.262
Ccl2chemokine (C-C motif) ligand 20.255
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.236
Il2rginterleukin 2 receptor, gamma0.219
Il1r2interleukin 1 receptor, type II0.218
Cd14CD14 molecule0.216
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.207
F2rl2coagulation factor II (thrombin) receptor-like 20.194
Ptger4prostaglandin E receptor 4 (subtype EP4)0.194
Casp3caspase 30.183
Cxcl2chemokine (C-X-C motif) ligand 20.169
Igsf6immunoglobulin superfamily, member 60.167
Mmp12matrix metallopeptidase 120.167
Gzmkgranzyme K0.155
Jak1Janus kinase 10.154
Ccl4chemokine (C-C motif) ligand 40.154
Nrasneuroblastoma ras oncogene0.144
Tnftumor necrosis factor (TNF superfamily, member 2)0.141
Ciitaclass II, major histocompatibility complex, transactivator0.135
Ccl7chemokine (C-C motif) ligand 70.131
Arhgap4Rho GTPase activating protein 40.126
Cd44Cd44 molecule0.126
S1pr2sphingosine-1-phosphate receptor 20.119
Xdhxanthine dehydrogenase0.119
RatNP-3bdefensin RatNP-3 precursor0.109
Hoxa2homeo box A20.107
Cfpcomplement factor properdin0.107
Plaurplasminogen activator, urokinase receptor0.106
Cd2Cd2 molecule0.105
Stat3signal transducer and activator of transcription 30.105
Ptpn1protein tyrosine phosphatase, non-receptor type 10.103
Cd38CD38 molecule0.099
Ccl22chemokine (C-C motif) ligand 220.099
Trim47tripartite motif-containing 470.097
Oprk1opioid receptor, kappa 10.097
Casp12caspase 120.097
Mr1major histocompatibility complex, class I-related0.096
Smad1SMAD family member 10.092
Il1rl1interleukin 1 receptor-like 10.091
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.088
Fosl1fos-like antigen 10.088
Tlr4toll-like receptor 40.085
JunJun oncogene0.084
Il8rbinterleukin 8 receptor, beta0.082
Sellselectin L0.082
Mmp8matrix metallopeptidase 80.077
Ptprcprotein tyrosine phosphatase, receptor type, C0.077
RGD1559748similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein)0.077
C5ar1complement component 5a receptor 10.076
Stx11syntaxin 110.075
Csf1colony stimulating factor 1 (macrophage)0.074
S100a9S100 calcium binding protein A90.074
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.072
Jak2Janus kinase 20.070
Cd8bCD8b molecule0.070
Gfi1growth factor independent 1 transcription repressor0.069
Myo1bmyosin Ib0.068
Adora2aadenosine A2a receptor0.068
Rab32RAB32, member RAS oncogene family0.068
Ralgdsral guanine nucleotide dissociation stimulator0.068
Hspa1aheat shock 70kD protein 1A0.067
Apol3apolipoprotein L, 30.067
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.065
Cideacell death-inducing DFFA-like effector a0.065
Hcls1hematopoietic cell specific Lyn substrate 10.065
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.064
RT1-BaRT1 class II, locus Ba0.063
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.063
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.061
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.061
Ch25hcholesterol 25-hydroxylase0.061
Tbxas1thromboxane A synthase 1, platelet0.060
Akr1c14aldo-keto reductase family 1, member C140.059
Selpselectin P0.058
Plscr1phospholipid scramblase 10.058
Il4interleukin 40.057
Krt5keratin 50.056
Elk3ELK3, ETS-domain protein0.056
Ctla4cytotoxic T-lymphocyte-associated protein 40.055
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.055
Fgf16fibroblast growth factor 160.055
Ptprqprotein tyrosine phosphatase, receptor type, Q0.055
Id3inhibitor of DNA binding 30.054
Arhgap17Rho GTPase activating protein 170.054
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism