The network for 'regulation of histone methylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of histone methylation

Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones.

NameDescriptionProbabilityFunc Analog Organism
gata1aGATA binding protein 1a0.362
pwp2hPWP2 periodic tryptophan protein homolog (yeast)0.312
whsc1Wolf-Hirschhorn syndrome candidate 10.248
prdm9PR domain containing 90.239
dnmt5DNA (cytosine-5-)-methyltransferase 50.235
mpxmyeloid-specific peroxidase0.202
ikzf1IKAROS family zinc finger 1 (Ikaros)0.155
setdb1aSET domain, bifurcated 1a0.120
si:ch211-57k11.10si:ch211-57k11.100.104
ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.103
pnp4apurine nucleoside phosphorylase 4a0.100
setd5SET domain containing 50.097
dnmt7DNA (cytosine-5-)-methyltransferase 70.096
dnmt1DNA (cytosine-5-)-methyltransferase 10.095
csf1racolony stimulating factor 1 receptor, a0.093
rif1RAP1 interacting factor homolog (yeast)0.092
dnmt3DNA (cytosine-5-)-methyltransferase 30.090
ezh2enhancer of zeste homolog 2 (Drosophila)0.087
top2atopoisomerase (DNA) II alpha0.082
cbx1achromobox homolog 1a (HP1 beta homolog Drosophila)0.072
mcm7MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)0.069
ssrp1astructure specific recognition protein 1a0.068
ilf3ainterleukin enhancer binding factor 3a0.064
rag1recombination activating gene 10.062
ncapd2non-SMC condensin I complex, subunit D20.060
lyzlysozyme0.058
mettl3methyltransferase like 30.057
brd4bromodomain containing 40.056
setd2SET domain containing 20.055
LOC100151531zinc finger protein Gfi-1b-like0.051
wu:fi04c06wu:fi04c060.049
ube2iubiquitin-conjugating enzyme E2I0.048
pknox1.2pbx/knotted 1 homeobox 1.20.046
ahctf1AT hook containing transcription factor 10.046
suv39h1asuppressor of variegation 3-9 homolog 1a0.046
arglu1barginine and glutamate rich 1b0.045
ncaphnon-SMC condensin I complex, subunit H0.045
suv39h1bsuppressor of variegation 3-9 homolog 1b0.043
setd8bSET domain containing (lysine methyltransferase) 8b0.042
dnmt8DNA (cytosine-5-)-methyltransferase 80.041
paicsphosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase0.041
apex1APEX nuclease (multifunctional DNA repair enzyme) 10.041
pds5bPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.040
rx2retinal homeobox gene 20.040
chtf18CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)0.039
prdm8bPR domain containing 8b0.039
smc3structural maintenance of chromosomes 30.039
hirip3HIRA interacting protein 30.039
egr2bearly growth response 2b0.038
cdc23CDC23 (cell division cycle 23, yeast, homolog)0.038
prdm2bPR domain containing 2, with ZNF domain b0.038
ehmt1aeuchromatic histone-lysine N-methyltransferase 1a0.038
smyd3SET and MYND domain containing 30.038
rspo3R-spondin 3 homolog (Xenopus laevis)0.038
skiv2l2superkiller viralicidic activity 2-like 20.038
arid4aAT rich interactive domain 4A (RBP1-like)0.037
smarcd1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.037
nrp1bneuropilin 1b0.037
msh2mutS homolog 2 (E. coli)0.036
rtf1Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.035
prdm11PR domain containing 110.035
nktrnatural killer-tumor recognition sequence0.035
atad5aATPase family, AAA domain containing 5a0.035
ipo9importin 90.035
arglu1aarginine and glutamate rich 1a0.035
myef2myelin expression factor 20.035
sass6spindle assembly 6 homolog (C. elegans)0.035
foxi1forkhead box I10.034
wdr18WD repeat domain 180.034
zbtb4zinc finger and BTB domain containing 40.033
il7rinterleukin 7 receptor0.033
bcas2breast carcinoma amplified sequence 20.033
smyd5SMYD family member 50.032
foxe3forkhead box E30.032
setd6SET domain containing 60.031
foxo3bforkhead box O3b0.031
pdcd4aprogrammed cell death 4a0.031
pold1polymerase (DNA directed), delta 1, catalytic subunit0.031
med4mediator complex subunit 40.030
ehmt2euchromatic histone-lysine N-methyltransferase 20.029
suv420h1suppressor of variegation 4-20 homolog 1 (Drosophila)0.029
mll4amyeloid/lymphoid or mixed-lineage leukemia 4a0.029
hdac4histone deacetylase 40.028
si:ch211-198a12.6si:ch211-198a12.60.028
pou3f3aPOU class 3 homeobox 3a0.027
rbbp5retinoblastoma binding protein 50.027
hat1histone acetyltransferase 10.027
elk4ELK4, ETS-domain protein0.027
ep300bE1A binding protein p300 b0.027
bub3BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)0.027
mcm3MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)0.026
chaf1bchromatin assembly factor 1, subunit B0.026
csf3rcolony stimulating factor 3 receptor (granulocyte)0.026
pbrm1lpolybromo 1, like0.026
ehmt1beuchromatic histone-lysine N-methyltransferase 1b0.026
rbbp6retinoblastoma binding protein 60.026
tcea1transcription elongation factor A (SII), 10.026
pnnpinin, desmosome associated protein0.025
eedembryonic ectoderm development0.025
pax7apaired box gene 7a0.025
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
trr-1Protein TRR-10.018
CELE_F19F10.9Protein F19F10.90.014
his-24Protein HIS-240.013
cpsf-2Protein CPSF-20.013
sop-2Protein SOP-20.013
dcr-1Protein DCR-10.012
lin-7Protein LIN-70.011
lst-3Protein LST-30.011
mig-38Protein MIG-380.010
B0464.2Protein B0464.20.010
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
BicDBicaudal D0.024
GugGrunge0.019
pnutpeanut0.017
Nup154Nucleoporin 1540.016
AbiAbelson interacting protein0.015
Rab11Rab-protein 110.014
EcREcdysone receptor0.014
ChcClathrin heavy chain0.014
MoeMoesin0.014
DlDelta0.013
mRpL33mitochondrial ribosomal protein L330.013
Tif-IACG3278 gene product from transcript CG3278-RA0.012
eIF-4EEukaryotic initiation factor 4E0.012
l(2)03709lethal (2) 037090.011
Arp66BActin-related protein 66B0.011
Aats-ileIsoleucyl-tRNA synthetase0.011
bsblistered0.011
dlg1discs large 10.010
KhcKinesin heavy chain0.010
CG11267CG11267 gene product from transcript CG11267-RA0.010
HemHEM-protein0.010
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CBX5chromobox homolog 50.860
EEDembryonic ectoderm development0.781
EZH2enhancer of zeste homolog 2 (Drosophila)0.502
HDAC1histone deacetylase 10.447
DNMT1DNA (cytosine-5-)-methyltransferase 10.436
SUZ12suppressor of zeste 12 homolog (Drosophila)0.279
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.249
SUV39H1suppressor of variegation 3-9 homolog 1 (Drosophila)0.218
UHRF1ubiquitin-like with PHD and ring finger domains 10.187
SIN3ASIN3 homolog A, transcription regulator (yeast)0.110
LIN9lin-9 homolog (C. elegans)0.105
RTF1Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.102
WDR5WD repeat domain 50.102
HIST1H3Bhistone cluster 1, H3b0.085
BCL9B-cell CLL/lymphoma 90.083
EP300E1A binding protein p3000.068
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.066
MGEA5meningioma expressed antigen 5 (hyaluronidase)0.064
IKIK cytokine, down-regulator of HLA II0.063
CBX3chromobox homolog 30.063
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.051
DNMT3ADNA (cytosine-5-)-methyltransferase 3 alpha0.049
KDM2Blysine (K)-specific demethylase 2B0.041
TSC22D1TSC22 domain family, member 10.039
POLR2Apolymerase (RNA) II (DNA directed) polypeptide A, 220kDa0.035
MYST3MYST histone acetyltransferase (monocytic leukemia) 30.034
ADNPactivity-dependent neuroprotector homeobox0.034
ASH2Lash2 (absent, small, or homeotic)-like (Drosophila)0.032
HNRNPA2B1heterogeneous nuclear ribonucleoprotein A2/B10.028
PAF1Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)0.027
RBBP4retinoblastoma binding protein 40.025
CHD8chromodomain helicase DNA binding protein 80.024
MDC1mediator of DNA-damage checkpoint 10.023
NCOA6nuclear receptor coactivator 60.023
PRRC2Bproline-rich coiled-coil 2B0.023
AFF1AF4/FMR2 family, member 10.023
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.023
LIN54lin-54 homolog (C. elegans)0.021
SUPT5Hsuppressor of Ty 5 homolog (S. cerevisiae)0.020
CHAF1Achromatin assembly factor 1, subunit A (p150)0.018
CCNT1cyclin T10.018
ZNF512Bzinc finger protein 512B0.018
CDC73cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.018
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.017
E2F4E2F transcription factor 4, p107/p130-binding0.017
HCFC1host cell factor C1 (VP16-accessory protein)0.016
SETDB1SET domain, bifurcated 10.016
PARP1poly (ADP-ribose) polymerase 10.016
ASXL1additional sex combs like 1 (Drosophila)0.016
PCNAproliferating cell nuclear antigen0.015
CBX1chromobox homolog 10.015
SUV39H2suppressor of variegation 3-9 homolog 2 (Drosophila)0.015
HIST1H3Ahistone cluster 1, H3a0.014
STAG1stromal antigen 10.014
LARP7La ribonucleoprotein domain family, member 70.014
PCGF1polycomb group ring finger 10.013
POGZpogo transposable element with ZNF domain0.013
RLFrearranged L-myc fusion0.013
HEXIM1hexamethylene bis-acetamide inducible 10.013
CSNK2A1casein kinase 2, alpha 1 polypeptide0.013
MEN1multiple endocrine neoplasia I0.013
TAF10TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa0.013
REREarginine-glutamic acid dipeptide (RE) repeats0.013
RBBP5retinoblastoma binding protein 50.012
SOCS1suppressor of cytokine signaling 10.012
LRIF1ligand dependent nuclear receptor interacting factor 10.011
L3MBTL1l(3)mbt-like 1 (Drosophila)0.011
CDCA4cell division cycle associated 40.011
MLL2myeloid/lymphoid or mixed-lineage leukemia 20.011
HIST2H3Chistone cluster 2, H3c0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ezh2enhancer of zeste homolog 2 (Drosophila)0.999
Kdm2blysine (K)-specific demethylase 2B0.998
Suz12suppressor of zeste 12 homolog (Drosophila)0.997
CrebbpCREB binding protein0.967
Jarid2jumonji, AT rich interactive domain 20.943
Ncoa6nuclear receptor coactivator 60.913
Rnf2ring finger protein 20.895
Sin3atranscriptional regulator, SIN3A (yeast)0.882
Mll1myeloid/lymphoid or mixed-lineage leukemia 10.879
Dnmt3aDNA methyltransferase 3A0.866
Trp53transformation related protein 530.837
Trim28tripartite motif-containing 280.815
Msx1homeobox, msh-like 10.812
Pax2paired box gene 20.727
Rbbp4retinoblastoma binding protein 40.708
Trim24tripartite motif-containing 240.689
Pax3paired box gene 30.655
Mtf2metal response element binding transcription factor 20.590
Clk1CDC-like kinase 10.548
Kdm1alysine (K)-specific demethylase 1A0.541
Kdm5alysine (K)-specific demethylase 5A0.415
Hand1heart and neural crest derivatives expressed transcript 10.408
Lef1lymphoid enhancer binding factor 10.405
Ep300E1A binding protein p3000.405
Cdkn1bcyclin-dependent kinase inhibitor 1B0.388
Arid1aAT rich interactive domain 1A (SWI-like)0.380
Ezh1enhancer of zeste homolog 1 (Drosophila)0.356
Ubtfupstream binding transcription factor, RNA polymerase I0.355
Msh2mutS homolog 2 (E. coli)0.343
Atrxalpha thalassemia/mental retardation syndrome X-linked homolog (human)0.341
Hoxa1homeobox A10.337
Brca2breast cancer 20.326
Rb1retinoblastoma 10.323
Brd8bromodomain containing 80.315
Lmx1aLIM homeobox transcription factor 1 alpha0.314
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.314
Ccnt2cyclin T20.303
Atmataxia telangiectasia mutated homolog (human)0.290
Foxo3forkhead box O30.289
Chd2chromodomain helicase DNA binding protein 20.284
Aebp2AE binding protein 20.280
Tbx1T-box 10.266
Fgf10fibroblast growth factor 100.255
Brd4bromodomain containing 40.248
Notch1Notch gene homolog 1 (Drosophila)0.239
Hist1h3ghistone cluster 1, H3g0.232
Zfp292zinc finger protein 2920.230
Runx1runt related transcription factor 10.219
Gata3GATA binding protein 30.213
Setxsenataxin0.207
Zeb1zinc finger E-box binding homeobox 10.196
Clk4CDC like kinase 40.186
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.184
Bap1Brca1 associated protein 10.179
Stk38serine/threonine kinase 380.176
Cbx3chromobox homolog 3 (Drosophila HP1 gamma)0.165
Gfi1bgrowth factor independent 1B0.165
Eya1eyes absent 1 homolog (Drosophila)0.165
Foxg1forkhead box G10.153
Ilf3interleukin enhancer binding factor 30.152
Chaf1achromatin assembly factor 1, subunit A (p150)0.150
Zfp592zinc finger protein 5920.147
Brca1breast cancer 10.144
Eedembryonic ectoderm development0.143
Fbrsfibrosin0.139
Hdac1histone deacetylase 10.134
Zfp740zinc finger protein 7400.131
Parp1poly (ADP-ribose) polymerase family, member 10.130
Fnbp4formin binding protein 40.124
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.122
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.118
Sfrs18serine/arginine-rich splicing factor 180.116
Csnk2a1casein kinase 2, alpha 1 polypeptide0.111
Ddx17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.110
Brwd1bromodomain and WD repeat domain containing 10.108
Tnrc6btrinucleotide repeat containing 6b0.105
Ctbp1C-terminal binding protein 10.101
Rxraretinoid X receptor alpha0.099
Numa1nuclear mitotic apparatus protein 10.097
Smg1SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)0.097
Safbscaffold attachment factor B0.094
Mbd6methyl-CpG binding domain protein 60.093
Pogzpogo transposable element with ZNF domain0.091
Gata1GATA binding protein 10.090
Tnrc6ctrinucleotide repeat containing 6C0.086
Tal1T-cell acute lymphocytic leukemia 10.086
Ylpm1YLP motif containing 10.086
Rerearginine glutamic acid dipeptide (RE) repeats0.085
RictorRPTOR independent companion of MTOR, complex 20.082
Cbx1chromobox homolog 1 (Drosophila HP1 beta)0.081
Epc1enhancer of polycomb homolog 1 (Drosophila)0.081
Mll2myeloid/lymphoid or mixed-lineage leukemia 20.081
Hirahistone cell cycle regulation defective homolog A (S. cerevisiae)0.080
Dsg4desmoglein 40.080
Ciccapicua homolog (Drosophila)0.079
Yy1YY1 transcription factor0.078
Mdm2transformed mouse 3T3 cell double minute 20.077
Trp53bp1transformation related protein 53 binding protein 10.077
Huwe1HECT, UBA and WWE domain containing 10.075
Wdr5WD repeat domain 50.074
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
CTR9Ctr9p0.287
RTF1Rtf1p0.270
LEO1Leo1p0.116
CKA1Cka1p0.072
PAF1Paf1p0.059
SPT5Spt5p0.053
SPT16Spt16p0.030
TMA22Tma22p0.029
SPT6Spt6p0.024
CCT2Cct2p0.017
LEU2Leu2p0.014
SRD1Srd1p0.014
YLR264C-Ahypothetical protein0.013
HRB1Hrb1p0.013
YLR162Whypothetical protein0.013
MF(ALPHA)2Mf(alpha)2p0.012
MER1Mer1p0.011
YOL038C-Ahypothetical protein0.011
ARP10Arp10p0.011
PTI1Pti1p0.011
MF(ALPHA)1Mf(alpha)1p0.011
YPR157Whypothetical protein0.011
YLR042Chypothetical protein0.011
ARG8Arg8p0.010
TFA1Tfa1p0.010
HXT3Hxt3p0.010
YAR068Whypothetical protein0.010
HOHop0.010
CRP1Crp1p0.010