The network for 'intrinsic apoptotic signaling pathway in response to oxidative stress' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

intrinsic apoptotic signaling pathway in response to oxidative stress

A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered.

NameDescriptionProbabilityFunc Analog Organism
fxr1fragile X mental retardation, autosomal homolog 10.336
park7parkinson disease (autosomal recessive, early onset) 70.327
cx45.6connexin 45.60.304
mt2metallothionein 20.273
sod1superoxide dismutase 1, soluble0.267
cyp1acytochrome P450, family 1, subfamily A0.266
scn1basodium channel, voltage-gated, type I, beta a0.265
mcl1bmyeloid cell leukemia sequence 1b0.233
bcl2l1bcl2-like 10.232
mcl1amyeloid cell leukemia sequence 1a0.214
socs1suppressor of cytokine signaling 10.193
smyhc1slow myosin heavy chain 10.189
smyd1bSET and MYND domain containing 1b0.181
socs3asuppressor of cytokine signaling 3a0.166
tnnc1btroponin C type 1b (slow)0.157
sf1splicing factor 10.156
dag1dystroglycan 10.141
unc45bunc-45 homolog B (C. elegans)0.129
cacnb4bcalcium channel, voltage-dependent, beta 4b subunit0.125
baxabcl2-associated X protein, a0.113
trpv6transient receptor potential cation channel, subfamily V, member 60.108
stc1lstanniocalcin 1, like0.107
scn4absodium channel, voltage-gated, type IV, alpha, b0.107
fabp7afatty acid binding protein 7, brain, a0.103
sod2superoxide dismutase 2, mitochondrial0.101
gstp1glutathione S-transferase pi0.095
rp2retinitis pigmentosa 2 (X-linked recessive)0.093
LOC100000332e3 ubiquitin-protein ligase RNF182-like0.092
acadmacyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain0.090
gapdhglyceraldehyde-3-phosphate dehydrogenase0.083
bidaBH3 interacting domain death agonist0.083
vdravitamin D receptor a0.081
ptgs2aprostaglandin-endoperoxide synthase 2a0.078
clrn1clarin 10.078
prom1aprominin 1a0.078
got2aglutamic-oxaloacetic transaminase 2a, mitochondrial (aspartate aminotransferase 2)0.075
pafah1b1bplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b0.072
nppanatriuretic peptide precursor A0.068
mmp9matrix metalloproteinase 90.068
pth1aparathyroid hormone 1a0.065
fosv-fos FBJ murine osteosarcoma viral oncogene homolog0.064
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)0.064
badBCL2-antagonist of cell death0.063
cacnb2acalcium channel, voltage-dependent, beta 2a0.063
gpiaglucose phosphate isomerase a0.062
fabp11afatty acid binding protein 11a0.060
pafah1b1aplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a0.059
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.058
myod1myogenic differentiation 10.055
smarce1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 10.054
junjun proto-oncogene0.053
pikfyvephosphoinositide kinase, FYVE finger containing0.052
trpv4transient receptor potential cation channel, subfamily V, member 40.052
sat1aspermidine/spermine N1-acetyltransferase 1a0.051
znf207azinc finger protein 207, a0.050
ahi1Abelson helper integration site 10.050
npy8brneuropeptide Y receptor Y8b0.050
mapk3mitogen-activated protein kinase 30.049
LOC566020Gig2-like protein DreO0.049
slc9a8solute carrier family 9 (sodium/hydrogen exchanger), member 80.047
mapk6mitogen-activated protein kinase 60.046
stac3SH3 and cysteine rich domain 30.046
crhcorticotropin releasing hormone0.046
slc25a25asolute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a0.045
popdc2popeye domain containing 20.044
lgi1bleucine-rich, glioma inactivated 1b0.044
mapk14amitogen-activated protein kinase 14a0.044
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.043
tm9sf2transmembrane 9 superfamily member 20.043
smyd3SET and MYND domain containing 30.043
myhz2myosin, heavy polypeptide 2, fast muscle specific0.042
adh5alcohol dehydrogenase 50.042
mifmacrophage migration inhibitory factor0.042
hsd17b12bhydroxysteroid (17-beta) dehydrogenase 12b0.041
leprleptin receptor0.041
epb41l5erythrocyte membrane protein band 4.1 like 50.040
scn12absodium channel, voltage gated, type XII, alpha b0.040
epas1bendothelial PAS domain protein 1b0.039
rhoabras homolog gene family, member Ab0.038
LOC567131calcitonin gene-related peptide type 1 receptor-like0.038
cyp3c1cytochrome P450, family 3, subfamily c, polypeptide 10.038
chrm2acholinergic receptor, muscarinic 2a0.037
hbegfaheparin-binding EGF-like growth factor a0.037
nkx2.5NK2 transcription factor related 50.037
limk2LIM domain kinase 20.037
trpc1transient receptor potential cation channel, subfamily C, member 10.037
pi4kbphosphatidylinositol 4-kinase, catalytic, beta0.036
pdlim7PDZ and LIM domain 70.036
acadlacyl-Coenzyme A dehydrogenase, long chain0.036
cacnb2bcalcium channel, voltage-dependent, beta 2b0.036
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BCL2L1BCL2-like 11.000
BCL2B-cell CLL/lymphoma 20.996
BAXBCL2-associated X protein0.966
BCL2L11BCL2-like 11 (apoptosis facilitator)0.947
MAFGv-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)0.860
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.839
SQSTM1sequestosome 10.721
STRN3striatin, calmodulin binding protein 30.699
MAP2K5mitogen-activated protein kinase kinase 50.637
BADBCL2-associated agonist of cell death0.634
CASP9caspase 9, apoptosis-related cysteine peptidase0.620
KEAP1kelch-like ECH-associated protein 10.569
DAXXdeath-domain associated protein0.515
NFE2L2nuclear factor (erythroid-derived 2)-like 20.508
AKT1v-akt murine thymoma viral oncogene homolog 10.481
FBXO7F-box protein 70.401
BIDBH3 interacting domain death agonist0.366
XIAPX-linked inhibitor of apoptosis0.348
PDIA4protein disulfide isomerase family A, member 40.344
WBP4WW domain binding protein 4 (formin binding protein 21)0.301
APAF1apoptotic peptidase activating factor 10.300
FASFas (TNF receptor superfamily, member 6)0.291
ZNF746zinc finger protein 7460.240
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.237
VHLvon Hippel-Lindau tumor suppressor0.229
ASB2ankyrin repeat and SOCS box containing 20.221
PARK2parkinson protein 2, E3 ubiquitin protein ligase (parkin)0.218
BAG3BCL2-associated athanogene 30.217
ERO1LERO1-like (S. cerevisiae)0.210
SOCS1suppressor of cytokine signaling 10.209
RIPK2receptor-interacting serine-threonine kinase 20.200
BAK1BCL2-antagonist/killer 10.196
SOD1superoxide dismutase 1, soluble0.188
NAMPTnicotinamide phosphoribosyltransferase0.188
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.184
HNRNPUheterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)0.173
PDIA3protein disulfide isomerase family A, member 30.172
TP53tumor protein p530.171
EGLN1egl nine homolog 1 (C. elegans)0.169
STRN4striatin, calmodulin binding protein 40.162
RUNX1runt-related transcription factor 10.156
IFNGR1interferon gamma receptor 10.129
DCTN1dynactin 10.115
BIRC3baculoviral IAP repeat containing 30.110
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.110
HSPB8heat shock 22kDa protein 80.109
SGK3serum/glucocorticoid regulated kinase family, member 30.102
ARNTaryl hydrocarbon receptor nuclear translocator0.101
CREBBPCREB binding protein0.100
PRDX1peroxiredoxin 10.089
FAM40Bfamily with sequence similarity 40, member B0.080
KAT2BK(lysine) acetyltransferase 2B0.080
MAP3K5mitogen-activated protein kinase kinase kinase 50.080
HSF1heat shock transcription factor 10.076
EGLN3egl nine homolog 3 (C. elegans)0.073
EP300E1A binding protein p3000.070
PPIBpeptidylprolyl isomerase B (cyclophilin B)0.070
PRDX4peroxiredoxin 40.067
MDM4Mdm4 p53 binding protein homolog (mouse)0.066
IL8interleukin 80.064
STAT1signal transducer and activator of transcription 1, 91kDa0.061
BANPBTG3 associated nuclear protein0.060
HSP90B1heat shock protein 90kDa beta (Grp94), member 10.057
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.056
HDAC1histone deacetylase 10.053
TNFAIP3tumor necrosis factor, alpha-induced protein 30.052
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.052
CRYABcrystallin, alpha B0.051
STK24serine/threonine kinase 240.051
TP53BP2tumor protein p53 binding protein, 20.046
PRDX2peroxiredoxin 20.045
CASP8caspase 8, apoptosis-related cysteine peptidase0.044
CCNE1cyclin E10.043
RNF144Bring finger protein 144B0.042
SOCS3suppressor of cytokine signaling 30.039
EEDembryonic ectoderm development0.039
SDCBPsyndecan binding protein (syntenin)0.038
DAB2IPDAB2 interacting protein0.038
CCDC6coiled-coil domain containing 60.038
CTTNBP2NLCTTNBP2 N-terminal like0.035
FUSfused in sarcoma0.034
SLC1A2solute carrier family 1 (glial high affinity glutamate transporter), member 20.034
TGIF1TGFB-induced factor homeobox 10.034
RPS6KB1ribosomal protein S6 kinase, 70kDa, polypeptide 10.034
GSK3Bglycogen synthase kinase 3 beta0.034
INSRinsulin receptor0.033
SNCAsynuclein, alpha (non A4 component of amyloid precursor)0.032
BCL2L2BCL2-like 20.032
VDAC1voltage-dependent anion channel 10.032
ZFYVE9zinc finger, FYVE domain containing 90.029
EFTUD2elongation factor Tu GTP binding domain containing 20.028
HM13histocompatibility (minor) 130.028
GABARAPL2GABA(A) receptor-associated protein-like 20.028
BCL2A1BCL2-related protein A10.027
AHRaryl hydrocarbon receptor0.027
LRRK2leucine-rich repeat kinase 20.026
BACH1BTB and CNC homology 1, basic leucine zipper transcription factor 10.026
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.995
Trp53transformation related protein 530.971
Casp4caspase 4, apoptosis-related cysteine peptidase0.966
FasFas (TNF receptor superfamily member 6)0.868
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.797
BaxBCL2-associated X protein0.734
Ptenphosphatase and tensin homolog0.684
Rb1retinoblastoma 10.652
Vhlvon Hippel-Lindau tumor suppressor0.545
Stat3signal transducer and activator of transcription 30.478
Tlr4toll-like receptor 40.463
Ighimmunoglobulin heavy chain complex0.417
Itgb1integrin beta 1 (fibronectin receptor beta)0.379
Bcl2B-cell leukemia/lymphoma 20.368
Cryabcrystallin, alpha B0.218
Ifngr1interferon gamma receptor 10.217
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.209
Cdkn1bcyclin-dependent kinase inhibitor 1B0.191
Kitkit oncogene0.187
Lyz2lysozyme 20.186
Bak1BCL2-antagonist/killer 10.168
Nr3c1nuclear receptor subfamily 3, group C, member 10.156
Casp1caspase 10.146
Mfn2mitofusin 20.145
Il18interleukin 180.144
XiapX-linked inhibitor of apoptosis0.135
Ppargperoxisome proliferator activated receptor gamma0.134
Nos3nitric oxide synthase 3, endothelial cell0.123
Cd151CD151 antigen0.122
Ep300E1A binding protein p3000.120
Adam17a disintegrin and metallopeptidase domain 170.117
Tgfbr1transforming growth factor, beta receptor I0.110
Rbl1retinoblastoma-like 1 (p107)0.103
TcrdT-cell receptor delta chain0.102
Slc10a6solute carrier family 10 (sodium/bile acid cotransporter family), member 60.098
Il6stinterleukin 6 signal transducer0.094
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.087
Ncoa3nuclear receptor coactivator 30.083
TcrbT-cell receptor beta chain0.080
Vegfavascular endothelial growth factor A0.077
Hif1ahypoxia inducible factor 1, alpha subunit0.075
Tgfb1transforming growth factor, beta 10.074
Gbp5guanylate binding protein 50.074
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.065
Mdm2transformed mouse 3T3 cell double minute 20.063
Kcne1potassium voltage-gated channel, Isk-related subfamily, member 10.063
Gpx1glutathione peroxidase 10.060
Osmroncostatin M receptor0.057
Notch2Notch gene homolog 2 (Drosophila)0.057
Prkab1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.056
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.056
Dhx15DEAH (Asp-Glu-Ala-His) box polypeptide 150.055
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.055
Casp3caspase 30.052
Apaf1apoptotic peptidase activating factor 10.052
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.052
Leprleptin receptor0.052
Hspb1heat shock protein 10.051
Egln1EGL nine homolog 1 (C. elegans)0.050
Mt1metallothionein 10.048
Spp1secreted phosphoprotein 10.043
Thbs1thrombospondin 10.043
Rxraretinoid X receptor alpha0.043
Cul4acullin 4A0.042
Prkag1protein kinase, AMP-activated, gamma 1 non-catalytic subunit0.040
Bag3BCL2-associated athanogene 30.039
Siah1bseven in absentia 1B0.039
Dpep1dipeptidase 1 (renal)0.039
Foxo3forkhead box O30.038
Cdk4cyclin-dependent kinase 40.038
Il1binterleukin 1 beta0.038
Gbp7guanylate binding protein 70.038
Cnot6CCR4-NOT transcription complex, subunit 60.038
Ctnnb1catenin (cadherin associated protein), beta 10.037
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.037
Ptpn11protein tyrosine phosphatase, non-receptor type 110.036
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.036
Cav1caveolin 1, caveolae protein0.035
Tnnt2troponin T2, cardiac0.035
Fam164cfamily with sequence similarity 164, member C0.035
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.035
Casp7caspase 70.034
DaxxFas death domain-associated protein0.034
Tmem93transmembrane protein 930.034
BidBH3 interacting domain death agonist0.034
Cyldcylindromatosis (turban tumor syndrome)0.034
Lystlysosomal trafficking regulator0.033
Usp25ubiquitin specific peptidase 250.033
Epas1endothelial PAS domain protein 10.033
Gcshglycine cleavage system protein H (aminomethyl carrier)0.033
Cd44CD44 antigen0.032
Ccnd1cyclin D10.031
Foxc1forkhead box C10.031
Ptprcprotein tyrosine phosphatase, receptor type, C0.031
E2f1E2F transcription factor 10.031
Ptgs2prostaglandin-endoperoxide synthase 20.031
Adam10a disintegrin and metallopeptidase domain 100.031
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism