The network for 'water homeostasis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

water homeostasis

Any process involved in the maintenance of an internal steady state of water within an organism or cell.

NameDescriptionProbabilityFunc Analog Organism
krt4keratin 40.741
fgfrl1bfibroblast growth factor receptor-like 1b0.593
ascl1aachaete-scute complex-like 1a (Drosophila)0.544
tp63tumor protein p630.461
bhlhe22basic helix-loop-helix family, member e220.372
atp1b1bATPase, Na+/K+ transporting, beta 1b polypeptide0.335
klf2bKruppel-like factor 2b0.273
mab21l2mab-21-like 20.242
foxa1forkhead box A10.206
krt5keratin 50.206
grhl1grainyhead-like 1 (Drosophila)0.206
foxa2forkhead box A20.200
foxi3bforkhead box I3b0.196
irf6interferon regulatory factor 60.176
nr2e1nuclear receptor subfamily 2, group E, member 10.170
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.156
sox10SRY-box containing gene 100.152
aldobaldolase b, fructose-bisphosphate0.152
foxi1forkhead box I10.151
foxc1aforkhead box C1a0.148
pou3f3bPOU class 3 homeobox 3b0.146
lmx1b.1LIM homeobox transcription factor 1, beta 10.139
kiss1KiSS-1 metastasis-suppressor0.133
tfe3btranscription factor binding to IGHM enhancer 3b0.130
vsx2visual system homeobox 20.127
nme2b.2non-metastatic cells 2b.2, protein (NM23B) expressed in0.126
mab21l1mab-21-like 10.125
jag1bjagged 1b0.123
krt18keratin 180.118
aqp8a.1aquaporin 8a, tandem duplicate 10.116
tagln2transgelin 20.116
nkx2.3NK2 transcription factor related 30.115
foxi3aforkhead box I3a0.112
ctsl1bcathepsin L, 1 b0.109
cx27.5connexin 27.50.109
cldneclaudin e0.107
pou1f1POU domain, class 1, transcription factor 10.103
pitx1paired-like homeodomain transcription factor 10.102
hmx4H6 family homeobox 40.101
tp73tumor protein p730.101
vwfvon Willebrand factor0.100
cldniclaudin i0.100
anxa2aannexin A2a0.098
nppanatriuretic peptide precursor A0.097
sox2SRY-box containing gene 20.096
col15a1bcollagen, type XV, alpha 1b0.095
perpPERP, TP53 apoptosis effector0.092
rab11fip4aRAB11 family interacting protein 4 (class II) a0.087
dao.2D-amino-acid oxidase 20.087
cpla2cytosolic phospholipase a20.084
neurod4neurogenic differentiation 40.083
plp1aproteolipid protein 1a0.083
sox9bSRY-box containing gene 9b0.082
pcsk9proprotein convertase subtilisin/kexin type 90.079
rx2retinal homeobox gene 20.078
cldnhclaudin h0.077
otx2orthodenticle homolog 20.076
cldn15aclaudin 15a0.076
aqp10aaquaporin 10a0.075
ca2carbonic anhydrase II0.075
mylz3myosin, light polypeptide 3, skeletal muscle0.072
lhx5LIM homeobox 50.071
nkx2.1bNK2 homeobox 1b0.070
dnmt4DNA (cytosine-5-)-methyltransferase 40.069
lass5LAG1 homolog, ceramide synthase 5 (S. cerevisiae)0.067
tmem88atransmembrane protein 88 a0.067
hoxb3ahomeo box B3a0.067
cldn5bclaudin 5b0.067
smtnlsmoothelin, like0.066
nr2f5nuclear receptor subfamily 2, group F, member 50.066
xbp1X-box binding protein 10.065
ldb3aLIM-domain binding factor 3a0.065
pou3f2POU class 3 homeobox 20.065
gapdhglyceraldehyde-3-phosphate dehydrogenase0.065
pitx2paired-like homeodomain transcription factor 20.064
six4bsine oculis homeobox homolog 4b0.063
starsteroidogenic acute regulatory protein0.062
aqp11aquaporin 110.060
gnrh2gonadotropin-releasing hormone 20.059
ovol1ovo-like 1 (Drosophila)0.059
aqp10baquaporin 10b0.058
sox19aSRY-box containing gene 19a0.057
actn3bactinin alpha 3b0.056
col6a2collagen, type VI, alpha 20.056
hoxa4ahomeo box A4a0.056
ahi1Abelson helper integration site 10.056
nkx2.2bNK2 transcription factor related 2b0.055
trpc6transient receptor potential cation channel, subfamily C, member 60.055
atp1a1a.2ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide0.054
pbx1apre-B-cell leukemia transcription factor 1a0.054
fshbfollicle stimulating hormone, beta polypeptide0.054
tp53bp2tumor protein p53 binding protein, 20.053
col14a1collagen, type XIV, alpha 10.053
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
soc-2Protein SOC-20.045
nep-17Protein NEP-170.038
pyc-1Protein PYC-10.038
F46H5.7Protein F46H5.70.037
pmt-1Protein PMT-10.033
sucg-1Protein SUCG-10.032
mex-5Protein MEX-50.030
ogdh-1Protein OGDH-10.029
hif-1Protein HIF-10.023
ZK616.5Protein ZK616.50.021
Y71F9AL.17Protein Y71F9AL.170.018
cpar-1Protein CPAR-10.017
toe-1Protein TOE-10.017
cpg-2Protein CPG-20.016
tag-260Protein TAG-2600.015
fmi-1Protein FMI-10.014
nsy-4Protein NSY-40.014
gfi-1Protein GFI-10.014
C01G8.1Protein C01G8.10.013
F53F10.2Protein F53F10.20.013
puf-8Protein PUF-80.013
oma-1Protein OMA-10.013
F49E2.2Protein F49E2.20.012
wago-4Protein WAGO-40.012
pkg-1Protein PKG-10.012
C46C11.3Protein C46C11.30.011
puf-3Protein PUF-30.011
T08B1.1Protein T08B1.10.010
unc-1Protein UNC-10.010
T27A3.1Protein T27A3.10.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG33289CG33289 gene product from transcript CG33289-RA0.394
Nmdar2NMDA receptor 20.304
CG32792CG32792 gene product from transcript CG32792-RF0.275
ppk11pickpocket 110.273
Gr32aGustatory receptor 32a0.161
NachCG8178 gene product from transcript CG8178-RA0.100
Irk3Inwardly rectifying potassium channel 30.097
CG13568CG13568 gene product from transcript CG13568-RG0.068
Spn77BaSerpin 77Ba0.066
Gr33aGustatory receptor 33a0.065
spensplit ends0.051
nompCno mechanoreceptor potential C0.049
Gr59cGustatory receptor 59c0.049
TehaoCG7121 gene product from transcript CG7121-RA0.045
snostrawberry notch0.045
rpkripped pocket0.045
ppk25pickpocket 250.041
Gr64fGustatory receptor 64f0.039
Nmdar1NMDA receptor 10.037
fd19Bforkhead domain 19B0.037
fnefound in neurons0.036
CG15096CG15096 gene product from transcript CG15096-RA0.035
Tsp29FbTetraspanin 29Fb0.035
SdhASuccinate dehydrogenase A0.035
Karybeta3Karyopherin beta 30.035
CG1572CG1572 gene product from transcript CG1572-RA0.034
ppk23pickpocket 230.032
Sodh-1Sorbitol dehydrogenase 10.031
CG3270CG3270 gene product from transcript CG3270-RA0.031
Mi-2CG8103 gene product from transcript CG8103-RA0.030
CG5381CG5381 gene product from transcript CG5381-RA0.029
CG8486CG8486 gene product from transcript CG8486-RE0.028
CG13117CG13117 gene product from transcript CG13117-RA0.027
yellow-e3CG17045 gene product from transcript CG17045-RA0.027
Letm1CG4589 gene product from transcript CG4589-RB0.027
5-HT7Serotonin receptor 70.027
PebIIIEjaculatory bulb protein III0.026
CG10486CG10486 gene product from transcript CG10486-RB0.026
CG34382CG34382 gene product from transcript CG34382-RC0.026
Gr43aGustatory receptor 43a0.026
NAAT1Nutrient Amino Acid Transporter 10.026
Tps1Trehalose-6-phosphate synthase 10.025
CG12522CG12522 gene product from transcript CG12522-RA0.024
CG11585CG11585 gene product from transcript CG11585-RB0.024
Rapgap1CG34374 gene product from transcript CG34374-RD0.024
Sc2CG10849 gene product from transcript CG10849-RA0.023
CG13725CG13725 gene product from transcript CG13725-RA0.023
ppk19pickpocket 190.023
CG17838CG17838 gene product from transcript CG17838-RA0.022
PicotCG8098 gene product from transcript CG8098-RA0.022
Gr64aGustatory receptor 64a0.022
Gr64bGustatory receptor 64b0.022
CG3457CG3457 gene product from transcript CG3457-RA0.022
CG7778CG7778 gene product from transcript CG7778-RA0.022
Or10aOdorant receptor 10a0.021
CG12438CG12438 gene product from transcript CG12438-RA0.021
CG31065CG31065 gene product from transcript CG31065-RB0.021
Or85dOdorant receptor 85d0.021
CG34325CG34325 gene product from transcript CG34325-RA0.021
ppk28pickpocket 280.021
CG6910CG6910 gene product from transcript CG6910-RB0.020
CG18110CG18110 gene product from transcript CG18110-RA0.020
Cyp12a4CG6042 gene product from transcript CG6042-RA0.020
CG7568CG7568 gene product from transcript CG7568-RB0.020
nikinimA-like kinase0.020
CG12640CG12640 gene product from transcript CG12640-RA0.020
CG34109CG34109 gene product from transcript CG34109-RC0.020
DopRDopamine receptor0.020
Gr98dGustatory receptor 98d0.020
CG31933CG31933 gene product from transcript CG31933-RA0.020
CheB42aChemosensory protein B 42a0.020
CG7431CG7431 gene product from transcript CG7431-RA0.019
CG34110CG34110 gene product from transcript CG34110-RC0.019
nulloCG14426 gene product from transcript CG14426-RB0.019
CG2781CG2781 gene product from transcript CG2781-RA0.019
CG12289CG12289 gene product from transcript CG12289-RA0.019
Gr36cGustatory receptor 36c0.019
CG15082CG15082 gene product from transcript CG15082-RA0.019
CG7912CG7912 gene product from transcript CG7912-RA0.019
CG14422CG14422 gene product from transcript CG14422-RA0.019
CG15227CG15227 gene product from transcript CG15227-RA0.019
CkIIbeta2Casein kinase II beta2 subunit0.019
TbhTyramine beta hydroxylase0.019
Or85aOdorant receptor 85a0.018
schlankCG3576 gene product from transcript CG3576-RB0.018
HspB8CG14207 gene product from transcript CG14207-RB0.018
Obp99dOdorant-binding protein 99d0.018
Gr39aGustatory receptor 39a0.018
CG34388CG34388 gene product from transcript CG34388-RC0.018
Gr28aGustatory receptor 28a0.018
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TACSTD2tumor-associated calcium signal transducer 20.996
RORARAR-related orphan receptor A0.992
SMN1survival of motor neuron 1, telomeric0.985
SCNN1Bsodium channel, nonvoltage-gated 1, beta0.982
SOX10SRY (sex determining region Y)-box 100.982
NEDD4neural precursor cell expressed, developmentally down-regulated 40.969
KRT5keratin 50.954
PAX3paired box 30.878
CTNND1catenin (cadherin-associated protein), delta 10.783
ATP13A2ATPase type 13A20.621
MKL1megakaryoblastic leukemia (translocation) 10.526
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.450
HMOX2heme oxygenase (decycling) 20.419
SCNN1Asodium channel, nonvoltage-gated 1 alpha0.375
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.352
ADAMTSL4ADAMTS-like 40.336
TJP3tight junction protein 3 (zona occludens 3)0.297
EFEMP2EGF containing fibulin-like extracellular matrix protein 20.280
INADLInaD-like (Drosophila)0.241
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.225
SATB2SATB homeobox 20.187
SPDEFSAM pointed domain containing ets transcription factor0.165
CABLES1Cdk5 and Abl enzyme substrate 10.160
MYOGmyogenin (myogenic factor 4)0.141
KCTD17potassium channel tetramerisation domain containing 170.111
CYP4F2cytochrome P450, family 4, subfamily F, polypeptide 20.108
EPN1epsin 10.100
FAM107Afamily with sequence similarity 107, member A0.096
CDH3cadherin 3, type 1, P-cadherin (placental)0.092
CLDN3claudin 30.086
MEOX2mesenchyme homeobox 20.084
CYP4F12cytochrome P450, family 4, subfamily F, polypeptide 120.075
MDFIMyoD family inhibitor0.073
RHOXF2Rhox homeobox family, member 20.072
CLDN16claudin 160.067
KRT6Ckeratin 6C0.062
SCNN1Gsodium channel, nonvoltage-gated 1, gamma0.059
CLDN4claudin 40.054
NR5A1nuclear receptor subfamily 5, group A, member 10.050
CHAC1ChaC, cation transport regulator homolog 1 (E. coli)0.049
PTPRJprotein tyrosine phosphatase, receptor type, J0.046
GLTPD1glycolipid transfer protein domain containing 10.044
SULT2B1sulfotransferase family, cytosolic, 2B, member 10.042
TMEM40transmembrane protein 400.042
KRTAP4-12keratin associated protein 4-120.041
CYP4F3cytochrome P450, family 4, subfamily F, polypeptide 30.039
RAPGEF2Rap guanine nucleotide exchange factor (GEF) 20.038
CYP2A6cytochrome P450, family 2, subfamily A, polypeptide 60.037
MYOD1myogenic differentiation 10.037
SCGB1A1secretoglobin, family 1A, member 1 (uteroglobin)0.036
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.036
LYPD3LY6/PLAUR domain containing 30.032
SPINT1serine peptidase inhibitor, Kunitz type 10.031
SFTPBsurfactant protein B0.031
EP300E1A binding protein p3000.031
HOXA1homeobox A10.031
PGRprogesterone receptor0.029
ALOX15Barachidonate 15-lipoxygenase, type B0.028
CYP3A43cytochrome P450, family 3, subfamily A, polypeptide 430.028
ALOX12Barachidonate 12-lipoxygenase, 12R type0.027
PKP3plakophilin 30.027
FRMD5FERM domain containing 50.026
CYP4F11cytochrome P450, family 4, subfamily F, polypeptide 110.026
AP1M2adaptor-related protein complex 1, mu 2 subunit0.026
PRKAA1protein kinase, AMP-activated, alpha 1 catalytic subunit0.024
AKR1B10aldo-keto reductase family 1, member B10 (aldose reductase)0.024
WFDC2WAP four-disulfide core domain 20.024
CYP2C9cytochrome P450, family 2, subfamily C, polypeptide 90.023
SOX21SRY (sex determining region Y)-box 210.023
EEF2Keukaryotic elongation factor-2 kinase0.023
FAT2FAT tumor suppressor homolog 2 (Drosophila)0.022
KLK5kallikrein-related peptidase 50.022
CYP2B6cytochrome P450, family 2, subfamily B, polypeptide 60.022
TMPRSS2transmembrane protease, serine 20.022
ST14suppression of tumorigenicity 14 (colon carcinoma)0.022
PAX8paired box 80.021
TMEM30Btransmembrane protein 30B0.021
ELF3E74-like factor 3 (ets domain transcription factor, epithelial-specific )0.021
IRF6interferon regulatory factor 60.021
SLC17A1solute carrier family 17 (sodium phosphate), member 10.020
CLDN7claudin 70.020
POU3F4POU class 3 homeobox 40.020
SLC6A13solute carrier family 6 (neurotransmitter transporter, GABA), member 130.019
PSEN1presenilin 10.019
LAD1ladinin 10.019
MUC1mucin 1, cell surface associated0.018
RBM11RNA binding motif protein 110.018
KLK13kallikrein-related peptidase 130.018
CYP4F8cytochrome P450, family 4, subfamily F, polypeptide 80.018
CLEC3BC-type lectin domain family 3, member B0.018
AZGP1alpha-2-glycoprotein 1, zinc-binding0.018
TBX6T-box 60.018
FUT6fucosyltransferase 6 (alpha (1,3) fucosyltransferase)0.017
LINGO1leucine rich repeat and Ig domain containing 10.017
CYP4B1cytochrome P450, family 4, subfamily B, polypeptide 10.017
PRSS8protease, serine, 80.017
CYP3A5cytochrome P450, family 3, subfamily A, polypeptide 50.017
RAMP3receptor (G protein-coupled) activity modifying protein 30.017
CLCA2chloride channel accessory 20.017
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Kiss1KiSS-1 metastasis-suppressor0.936
Trp63transformation related protein 630.745
Ghrgrowth hormone receptor0.726
Esr1estrogen receptor 1 (alpha)0.679
Ins2insulin II0.619
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.618
Foxn1forkhead box N10.599
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.574
Krt5keratin 50.517
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.444
Npc1Niemann Pick type C10.443
Krt19keratin 190.433
Ptenphosphatase and tensin homolog0.420
Sall1sal-like 1 (Drosophila)0.396
Irf6interferon regulatory factor 60.349
Klk6kallikrein related-peptidase 60.338
Amhr2anti-Mullerian hormone type 2 receptor0.330
Pax8paired box gene 80.316
Nr5a1nuclear receptor subfamily 5, group A, member 10.310
Cela3bchymotrypsin-like elastase family, member 3B0.304
Pkp1plakophilin 10.292
Arandrogen receptor0.290
Serpinb5serine (or cysteine) peptidase inhibitor, clade B, member 50.279
Krt6akeratin 6A0.268
Krt17keratin 170.266
Prlrprolactin receptor0.248
Rdh8retinol dehydrogenase 80.246
Nos1nitric oxide synthase 1, neuronal0.244
Krt18keratin 180.241
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.215
Tgm3transglutaminase 3, E polypeptide0.202
Fshrfollicle stimulating hormone receptor0.194
Pgrprogesterone receptor0.185
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.180
Bglapbone gamma carboxyglutamate protein0.175
Dsg2desmoglein 20.173
Lgals7lectin, galactose binding, soluble 70.170
Pthlhparathyroid hormone-like peptide0.169
Psapl1prosaposin-like 10.168
Krt36keratin 360.163
Krtap3-1keratin associated protein 3-10.155
Duox2dual oxidase 20.148
Trpv5transient receptor potential cation channel, subfamily V, member 50.147
Krt8keratin 80.144
Wnt7bwingless-related MMTV integration site 7B0.143
Krt33bkeratin 33B0.142
Krtap8-1keratin associated protein 8-10.139
Krt71keratin 710.138
NrkNik related kinase0.134
Pax2paired box gene 20.131
AxlAXL receptor tyrosine kinase0.130
1600029D21RikRIKEN cDNA 1600029D21 gene0.126
Gm13011predicted gene 130110.125
Trp73transformation related protein 730.124
Cdx2caudal type homeobox 20.123
Scnn1gsodium channel, nonvoltage-gated 1 gamma0.123
Cgaglycoprotein hormones, alpha subunit0.115
Clpscolipase, pancreatic0.114
Wfdc2WAP four-disulfide core domain 20.113
Krt15keratin 150.113
Krt14keratin 140.113
Kcne1lpotassium voltage-gated channel, Isk-related family, member 1-like, pseudogene0.110
Bglap2bone gamma-carboxyglutamate protein 20.109
Esr2estrogen receptor 2 (beta)0.107
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.106
Wnt10awingless related MMTV integration site 10a0.102
Mybphmyosin binding protein H0.102
Slc6a13solute carrier family 6 (neurotransmitter transporter, GABA), member 130.100
Ptch2patched homolog 20.100
Krt31keratin 310.098
Tjp1tight junction protein 10.095
BsndBartter syndrome, infantile, with sensorineural deafness (Barttin)0.095
Celcarboxyl ester lipase0.094
Slc22a6solute carrier family 22 (organic anion transporter), member 60.094
Il1f5interleukin 1 family, member 5 (delta)0.094
Tmprss2transmembrane protease, serine 20.093
Cldn3claudin 30.092
Krt13keratin 130.092
Fgf10fibroblast growth factor 100.091
S100a10S100 calcium binding protein A10 (calpactin)0.091
Crb3crumbs homolog 3 (Drosophila)0.091
Krt32keratin 320.089
Sprr1asmall proline-rich protein 1A0.089
Tcfap2ctranscription factor AP-2, gamma0.089
Bhlha15basic helix-loop-helix family, member a150.088
Mpdzmultiple PDZ domain protein0.088
Dlx5distal-less homeobox 50.087
Irx4Iroquois related homeobox 4 (Drosophila)0.086
Krt75keratin 750.086
Csf1rcolony stimulating factor 1 receptor0.085
2210010C04RikRIKEN cDNA 2210010C04 gene0.084
Slc18a3solute carrier family 18 (vesicular monoamine), member 30.083
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism