The network for 'osteoblast differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

osteoblast differentiation

The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.

NameDescriptionProbabilityFunc Analog Organism
shhasonic hedgehog a0.961
bmp2bbone morphogenetic protein 2b0.948
sox9bSRY-box containing gene 9b0.793
sox9aSRY-box containing gene 9a0.718
col1a1acollagen, type I, alpha 1a0.577
runx2brunt-related transcription factor 2b0.520
wnt5bwingless-type MMTV integration site family, member 5b0.515
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.495
ptch2patched 20.374
fgf3fibroblast growth factor 30.251
nf1aneurofibromin 1a0.212
tbx1T-box 10.209
fn1fibronectin 10.155
dusp6dual specificity phosphatase 60.134
sulf1sulfatase 10.106
fgfr1afibroblast growth factor receptor 1a0.103
has2hyaluronan synthase 20.102
col1a2collagen, type I, alpha 20.088
notch2notch homolog 20.087
smosmoothened homolog (Drosophila)0.084
mef2camyocyte enhancer factor 2ca0.078
rargbretinoic acid receptor, gamma b0.076
ptch1patched 10.075
runx2arunt-related transcription factor 2a0.074
twist1atwist1a0.074
twist3twist30.066
jag1bjagged 1b0.065
dlx3bdistal-less homeobox gene 3b0.059
dlx2adistal-less homeobox gene 2a0.059
col5a1procollagen, type V, alpha 10.057
wnt3wingless-type MMTV integration site family, member 30.053
apoebapolipoprotein Eb0.052
msxcmuscle segment homeobox C0.051
bocbrother of CDO0.050
bmp4bone morphogenetic protein 40.050
kitakit receptor a0.043
zgc:158603zgc:1586030.042
chdchordin0.042
sfrp1asecreted frizzled-related protein 1a0.041
spry4sprouty (Drosophila) homolog 40.041
disp1dispatched homolog 1 (Drosophila)0.039
myod1myogenic differentiation 10.038
wnt10awingless-type MMTV integration site family, member 10a0.037
pcdh8protocadherin 80.036
ihhaIndian hedgehog homolog a0.034
igfbp3insulin-like growth factor binding protein 30.034
gli2aGLI-Kruppel family member GLI2a0.033
pax7apaired box gene 7a0.032
dag1dystroglycan 10.032
dachadachshund a0.031
fstl1bfollistatin-like 1b0.031
igfbp1binsulin-like growth factor binding protein 1b0.029
gli3GLI-Kruppel family member GLI30.026
foxp1bforkhead box P1b0.024
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.023
col10a1collagen, type X, alpha 10.022
notch3notch homolog 30.022
tp63tumor protein p630.022
bmpr2abone morphogenetic protein receptor, type II a (serine/threonine kinase)0.022
ctgfconnective tissue growth factor0.021
arl4abADP-ribosylation factor-like 4ab0.021
gdf6agrowth differentiation factor 6a0.020
efnb1ephrin B10.020
acvr2aactivin receptor IIa0.019
wnt11rwingless-type MMTV integration site family, member 11, related0.018
crabp2bcellular retinoic acid binding protein 2, b0.018
loxl3blysyl oxidase-like 3b0.018
gpibglucose phosphate isomerase b0.017
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.016
msxbmuscle segment homeobox B0.016
tgfb1atransforming growth factor, beta 1a0.016
hsp47heat shock protein 470.015
smad5MAD homolog 5 (Drosophila)0.015
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.015
smad3bMAD, mothers against decapentaplegic homolog 3b (Drosophila)0.014
sufusuppressor of fused homolog (Drosophila)0.014
extl3exostoses (multiple)-like 30.013
plagl2pleiomorphic adenoma gene-like 20.013
wu:fv91b12wu:fv91b120.013
frem3Fras1 related extracellular matrix 30.013
foxa3forkhead box A30.013
lfnglunatic fringe homolog0.013
matn4matrilin 40.013
hspa5heat shock protein 50.013
smyhc1slow myosin heavy chain 10.012
gpc4glypican 40.012
foxo3bforkhead box O3b0.012
tpm4tropomyosin 40.011
plod1aprocollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a0.011
nrg2aneuregulin 2a0.011
rag1recombination activating gene 10.011
wif1wnt inhibitory factor 10.011
rplp0ribosomal protein, large, P00.011
il6rinterleukin 6 receptor0.010
fzd7bfrizzled homolog 7b0.010
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.010
btg1B-cell translocation gene 10.010
ldb2aLIM-domain binding factor 2a0.010
mychmyelocytomatosis oncogene homolog0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FHL2four and a half LIM domains 20.996
SKILSKI-like oncogene0.996
FN1fibronectin 10.995
HNRNPKheterogeneous nuclear ribonucleoprotein K0.985
SMAD2SMAD family member 20.979
FBLN1fibulin 10.977
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.974
HNRNPCheterogeneous nuclear ribonucleoprotein C (C1/C2)0.967
SMAD7SMAD family member 70.963
SMAD3SMAD family member 30.962
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.962
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.944
HNRNPDheterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)0.929
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.919
SMAD4SMAD family member 40.888
RUNX1runt-related transcription factor 10.822
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.815
HIPK2homeodomain interacting protein kinase 20.788
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.772
ATF3activating transcription factor 30.762
JUNjun proto-oncogene0.736
HNRNPUheterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)0.735
PRKD2protein kinase D20.734
EGFRepidermal growth factor receptor0.727
FOSFBJ murine osteosarcoma viral oncogene homolog0.726
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.725
BMP2bone morphogenetic protein 20.723
SYNCRIPsynaptotagmin binding, cytoplasmic RNA interacting protein0.720
CAV1caveolin 1, caveolae protein, 22kDa0.707
BMPR1Abone morphogenetic protein receptor, type IA0.689
MMP14matrix metallopeptidase 14 (membrane-inserted)0.686
IFITM2interferon induced transmembrane protein 2 (1-8D)0.659
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.655
ENGendoglin0.635
SOCS3suppressor of cytokine signaling 30.628
PTPRCprotein tyrosine phosphatase, receptor type, C0.615
COL6A1collagen, type VI, alpha 10.604
COL1A1collagen, type I, alpha 10.600
JAG1jagged 10.599
NOTCH3notch 30.587
IFITM1interferon induced transmembrane protein 1 (9-27)0.582
HNRNPA1heterogeneous nuclear ribonucleoprotein A10.582
SMAD5SMAD family member 50.577
ARandrogen receptor0.573
BMP1bone morphogenetic protein 10.552
CTGFconnective tissue growth factor0.542
PAX3paired box 30.522
KHDRBS1KH domain containing, RNA binding, signal transduction associated 10.522
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.499
POU5F1POU class 5 homeobox 10.497
NCOR1nuclear receptor corepressor 10.480
ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix protein0.471
FKBP1AFK506 binding protein 1A, 12kDa0.470
HNRNPFheterogeneous nuclear ribonucleoprotein F0.469
SUFUsuppressor of fused homolog (Drosophila)0.466
CCR5chemokine (C-C motif) receptor 50.453
LTBP4latent transforming growth factor beta binding protein 40.442
CALM1calmodulin 1 (phosphorylase kinase, delta)0.437
BCAR1breast cancer anti-estrogen resistance 10.437
POU3F2POU class 3 homeobox 20.419
LAMC1laminin, gamma 1 (formerly LAMB2)0.414
IFITM3interferon induced transmembrane protein 3 (1-8U)0.410
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.407
SNRNP70small nuclear ribonucleoprotein 70kDa (U1)0.401
BMP7bone morphogenetic protein 70.394
DDX21DEAD (Asp-Glu-Ala-Asp) box polypeptide 210.388
EFTUD2elongation factor Tu GTP binding domain containing 20.379
AXIN1axin 10.372
WNT3Awingless-type MMTV integration site family, member 3A0.372
HNRNPH1heterogeneous nuclear ribonucleoprotein H1 (H)0.372
RALAv-ral simian leukemia viral oncogene homolog A (ras related)0.369
HNRNPA2B1heterogeneous nuclear ribonucleoprotein A2/B10.369
HNRNPH3heterogeneous nuclear ribonucleoprotein H3 (2H9)0.360
COL6A2collagen, type VI, alpha 20.359
NOTCH1notch 10.357
TP53tumor protein p530.356
DHX9DEAH (Asp-Glu-Ala-His) box polypeptide 90.351
SMURF2SMAD specific E3 ubiquitin protein ligase 20.329
TCF4transcription factor 40.321
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.320
FOXF2forkhead box F20.318
TP63tumor protein p630.313
PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)0.310
YBX1Y box binding protein 10.307
PTPN12protein tyrosine phosphatase, non-receptor type 120.301
SFRP1secreted frizzled-related protein 10.294
MSX1msh homeobox 10.289
GABBR2gamma-aminobutyric acid (GABA) B receptor, 20.287
EGR1early growth response 10.286
TAL1T-cell acute lymphocytic leukemia 10.272
WWP2WW domain containing E3 ubiquitin protein ligase 20.270
DDX5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.268
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.267
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.263
FSTL1follistatin-like 10.261
SP1Sp1 transcription factor0.253
HIC1hypermethylated in cancer 10.251
PARVAparvin, alpha0.250
PXNpaxillin0.244
CXXC5CXXC finger protein 50.242
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Nedd4neural precursor cell expressed, developmentally down-regulated 40.584
Id3inhibitor of DNA binding 30.183
Itpr2inositol 1,4,5-triphosphate receptor, type 20.146
Fgfr2fibroblast growth factor receptor 20.144
Tpt1tumor protein, translationally-controlled 10.123
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.120
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.093
Crtapcartilage associated protein0.086
Id1inhibitor of DNA binding 10.076
Bcl2B-cell CLL/lymphoma 20.074
Sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.064
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.062
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.061
Tcfe2atranscription factor E2a0.061
Col12a1collagen, type XII, alpha 10.057
Svep1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 10.055
Mmp23matrix metallopeptidase 230.052
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.051
Atp5a1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle0.050
S100a11S100 calcium binding protein A11 (calizzarin)0.048
Vimvimentin0.047
Twist2twist homolog 2 (Drosophila)0.045
Capn6calpain 60.043
Smad7SMAD family member 70.042
Acta1actin, alpha 1, skeletal muscle0.040
Wnt5awingless-type MMTV integration site family, member 5A0.040
Cct3chaperonin containing Tcp1, subunit 3 (gamma)0.039
Calb2calbindin 20.039
Nfianuclear factor I/A0.038
Col3a1collagen, type III, alpha 10.038
Bmp3bone morphogenetic protein 30.037
Hapln1hyaluronan and proteoglycan link protein 10.036
Nraddneurotrophin receptor associated death domain0.036
Jubjub, ajuba homolog (Xenopus laevis)0.036
Foxd1forkhead box D10.035
Dcndecorin0.035
Bmp4bone morphogenetic protein 40.035
Shox2short stature homeobox 20.035
Col14a1collagen, type XIV, alpha 10.035
Ptpn14protein tyrosine phosphatase, non-receptor type 140.034
Cpxm2carboxypeptidase X (M14 family), member 20.033
Psmc5proteasome (prosome, macropain) 26S subunit, ATPase, 50.032
Slc25a3solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 30.030
Actbactin, beta0.030
Lect1leukocyte cell derived chemotaxin 10.030
Cyp1b1cytochrome P450, family 1, subfamily b, polypeptide 10.030
Efemp2EGF-containing fibulin-like extracellular matrix protein 20.029
Prdm12PR domain containing 120.029
Irs1insulin receptor substrate 10.029
Gja6gap junction protein, alpha 60.028
Gja1gap junction protein, alpha 10.028
Sgk1serum/glucocorticoid regulated kinase 10.028
Fth1ferritin, heavy polypeptide 10.028
Igf2insulin-like growth factor 20.028
Adrb1adrenergic, beta-1-, receptor0.028
Vcanversican0.027
Prrx2paired related homeobox 20.027
Cand1cullin-associated and neddylation-dissociated 10.027
Nr2f2nuclear receptor subfamily 2, group F, member 20.026
Dchs1dachsous 1 (Drosophila)0.025
Fam69bfamily with sequence similarity 69, member B0.025
Rpl19ribosomal protein L190.025
Igfbp5insulin-like growth factor binding protein 50.025
Irs3insulin receptor substrate 30.024
Spta1spectrin, alpha, erythrocytic 1 (elliptocytosis 2)0.024
Fgfr1Fibroblast growth factor receptor 10.024
Col1a2collagen, type I, alpha 20.024
Prrx1paired related homeobox 10.024
Ascl1achaete-scute complex homolog 1 (Drosophila)0.023
Paicsphosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase0.022
Olaholeoyl-ACP hydrolase0.022
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.022
Hist1h2bahistone cluster 1, H2ba0.022
Sod3superoxide dismutase 3, extracellular0.022
Galntl1UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 10.022
Kctd15potassium channel tetramerisation domain containing 150.022
Tgfb2transforming growth factor, beta 20.022
Mid1midline 10.022
Timp3TIMP metallopeptidase inhibitor 30.022
Mafbv-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)0.022
Taglntransgelin0.021
Cxcl2chemokine (C-X-C motif) ligand 20.021
Znf503zinc finger protein 5030.021
TardbpTAR DNA binding protein0.021
Aif1allograft inflammatory factor 10.021
Bocbiregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein0.021
Fgf10fibroblast growth factor 100.021
Foxc2forkhead box C20.020
Prdm2PR domain containing 2, with ZNF domain0.020
Tcp1t-complex 10.020
Ednrbendothelin receptor type B0.020
Aldh1a2aldehyde dehydrogenase 1 family, member A20.020
RGD1311307similar to 1300014I06Rik protein0.020
Leprleptin receptor0.020
Acvr1activin A receptor, type I0.020
Unc5bunc-5 homolog B (C. elegans)0.020
Glg1golgi apparatus protein 10.020
Sparcsecreted protein, acidic, cysteine-rich (osteonectin)0.020
Actg1actin, gamma 10.020
Syn1synapsin I0.019
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism