The network for 'regulation of rig i signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of rig i signaling pathway

Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA.

NameDescriptionProbabilityFunc Analog Organism
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.570
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.536
IFI44interferon-induced protein 440.533
IFIT3interferon-induced protein with tetratricopeptide repeats 30.220
STAT1signal transducer and activator of transcription 1, 91kDa0.171
IFIT5interferon-induced protein with tetratricopeptide repeats 50.165
IFIT1interferon-induced protein with tetratricopeptide repeats 10.161
SP110SP110 nuclear body protein0.107
IFI44Linterferon-induced protein 44-like0.099
SP100SP100 nuclear antigen0.081
XAF1XIAP associated factor 10.068
DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.065
OAS12',5'-oligoadenylate synthetase 1, 40/46kDa0.063
OAS22'-5'-oligoadenylate synthetase 2, 69/71kDa0.063
IFIT2interferon-induced protein with tetratricopeptide repeats 20.051
HERC5hect domain and RLD 50.050
SAMD9sterile alpha motif domain containing 90.050
SAMD9Lsterile alpha motif domain containing 9-like0.035
TDRD7tudor domain containing 70.030
EPSTI1epithelial stromal interaction 1 (breast)0.028
MX1myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)0.028
IFIH1interferon induced with helicase C domain 10.028
PARP12poly (ADP-ribose) polymerase family, member 120.023
TRIM21tripartite motif containing 210.023
RSAD2radical S-adenosyl methionine domain containing 20.022
PARP9poly (ADP-ribose) polymerase family, member 90.021
TRIM25tripartite motif containing 250.019
PLSCR1phospholipid scramblase 10.018
DTX3Ldeltex 3-like (Drosophila)0.018
IRF9interferon regulatory factor 90.018
ISG15ISG15 ubiquitin-like modifier0.016
CYLDcylindromatosis (turban tumor syndrome)0.016
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.014
MX2myxovirus (influenza virus) resistance 2 (mouse)0.014
OAS32'-5'-oligoadenylate synthetase 3, 100kDa0.014
RTP4receptor (chemosensory) transporter protein 40.013
DDX60LDEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like0.012
TRIM5tripartite motif containing 50.012
TRIM22tripartite motif containing 220.012
EIF2C2eukaryotic translation initiation factor 2C, 20.011
ADARadenosine deaminase, RNA-specific0.011
IFI16interferon, gamma-inducible protein 160.011
GBP1guanylate binding protein 1, interferon-inducible0.010
NMIN-myc (and STAT) interactor0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.963
Ifit1interferon-induced protein with tetratricopeptide repeats 10.839
Stat1signal transducer and activator of transcription 10.765
Rtp4receptor transporter protein 40.634
Usp18ubiquitin specific peptidase 180.627
Irgm1immunity-related GTPase family M member 10.570
Gbp7guanylate binding protein 70.477
Irf7interferon regulatory factor 70.459
Irgm2immunity-related GTPase family M member 20.452
Ifi35interferon-induced protein 350.427
Irf9interferon regulatory factor 90.424
Oasl22'-5' oligoadenylate synthetase-like 20.391
Ifit3interferon-induced protein with tetratricopeptide repeats 30.333
Trim30atripartite motif-containing 30A0.332
Isg15ISG15 ubiquitin-like modifier0.292
Rsad2radical S-adenosyl methionine domain containing 20.258
Parp14poly (ADP-ribose) polymerase family, member 140.251
Ifi44interferon-induced protein 440.231
Apcadenomatosis polyposis coli0.218
Igtpinterferon gamma induced GTPase0.217
Trim25tripartite motif-containing 250.215
Ifih1interferon induced with helicase C domain 10.214
Trim21tripartite motif-containing 210.205
Gbp3guanylate binding protein 30.183
Gbp2guanylate binding protein 20.134
Iigp1interferon inducible GTPase 10.120
Zbp1Z-DNA binding protein 10.103
Parp12poly (ADP-ribose) polymerase family, member 120.097
Samd9lsterile alpha motif domain containing 9-like0.097
Parp9poly (ADP-ribose) polymerase family, member 90.094
Ddx58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.082
Mrpl3mitochondrial ribosomal protein L30.082
Ifi47interferon gamma inducible protein 470.074
Cmpk2cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial0.061
Oas1a2'-5' oligoadenylate synthetase 1A0.058
BC006779cDNA sequence BC0067790.053
Sp100nuclear antigen Sp1000.051
Ifit2interferon-induced protein with tetratricopeptide repeats 20.047
Tgtp2T-cell specific GTPase 20.047
Oasl12'-5' oligoadenylate synthetase-like 10.046
Smad4MAD homolog 4 (Drosophila)0.045
Trim30dtripartite motif-containing 30D0.040
Lgals3bplectin, galactoside-binding, soluble, 3 binding protein0.039
D14Ertd668eDNA segment, Chr 14, ERATO Doi 668, expressed0.038
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.036
Dtx3ldeltex 3-like (Drosophila)0.034
Uba7ubiquitin-like modifier activating enzyme 70.034
Mx2myxovirus (influenza virus) resistance 20.034
Epsti1epithelial stromal interaction 1 (breast)0.033
Oas1b2'-5' oligoadenylate synthetase 1B0.032
Stat2signal transducer and activator of transcription 20.029
Atad3aATPase family, AAA domain containing 3A0.029
Parp10poly (ADP-ribose) polymerase family, member 100.028
Oas22'-5' oligoadenylate synthetase 20.028
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.027
Ifi203interferon activated gene 2030.027
Timm10translocase of inner mitochondrial membrane 10 homolog (yeast)0.026
Ptpn11protein tyrosine phosphatase, non-receptor type 110.025
Herc6hect domain and RLD 60.024
NmiN-myc (and STAT) interactor0.024
Oas32'-5' oligoadenylate synthetase 30.023
Erap1endoplasmic reticulum aminopeptidase 10.021
Ube2l6ubiquitin-conjugating enzyme E2L 60.019
Npc1Niemann Pick type C10.019
Gbp6guanylate binding protein 60.018
Mx1myxovirus (influenza virus) resistance 10.018
Kitkit oncogene0.016
Atrataxia telangiectasia and Rad3 related0.015
Rnf135ring finger protein 1350.015
AW112010expressed sequence AW1120100.015
Mndalmyeloid nuclear differentiation antigen like0.014
Lgals9lectin, galactose binding, soluble 90.014
Cxcl10chemokine (C-X-C motif) ligand 100.014
Droshadrosha, ribonuclease type III0.014
Tlr3toll-like receptor 30.014
Zc3hav1zinc finger CCCH type, antiviral 10.014
Bst2bone marrow stromal cell antigen 20.013
Bmpr1abone morphogenetic protein receptor, type 1A0.013
Dhx58DEXH (Asp-Glu-X-His) box polypeptide 580.012
Amhr2anti-Mullerian hormone type 2 receptor0.012
Safbscaffold attachment factor B0.012
Tor3atorsin family 3, member A0.012
Ndufa12NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 120.011
Cd274CD274 antigen0.011
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.011
Rxraretinoid X receptor alpha0.010
Plekha5pleckstrin homology domain containing, family A member 50.010
Mcl1myeloid cell leukemia sequence 10.010
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism