The network for 'dna hypermethylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dna hypermethylation

An increase in the epigenetic methylation of cytosine and adenosine residues in DNA.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Su(var)205Suppressor of variegation 2050.105
BEAF-32Boundary element-associated factor of 32kD0.035
Cap-GCG34438 gene product from transcript CG34438-RF0.017
His2AvHistone H2A variant0.015
gemininCG3183 gene product from transcript CG3183-RA0.013
Snr1Snf5-related 10.011
Su(var)3-7Suppressor of variegation 3-70.011
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CBX5chromobox homolog 51.000
CBX3chromobox homolog 31.000
CBX1chromobox homolog 10.995
LBRlamin B receptor0.934
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.929
UHRF1ubiquitin-like with PHD and ring finger domains 10.827
MBD1methyl-CpG binding domain protein 10.799
HIST1H3Bhistone cluster 1, H3b0.732
DNMT1DNA (cytosine-5-)-methyltransferase 10.619
CHAF1Achromatin assembly factor 1, subunit A (p150)0.608
SUV39H1suppressor of variegation 3-9 homolog 1 (Drosophila)0.547
EEDembryonic ectoderm development0.532
SETDB1SET domain, bifurcated 10.520
POGZpogo transposable element with ZNF domain0.428
ADNPactivity-dependent neuroprotector homeobox0.393
DNMT3ADNA (cytosine-5-)-methyltransferase 3 alpha0.257
RBBP4retinoblastoma binding protein 40.254
EZH2enhancer of zeste homolog 2 (Drosophila)0.243
NSL1NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)0.223
LRIF1ligand dependent nuclear receptor interacting factor 10.151
SUZ12suppressor of zeste 12 homolog (Drosophila)0.148
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.095
H3F3BH3 histone, family 3B (H3.3B)0.066
INCENPinner centromere protein antigens 135/155kDa0.044
TRIM28tripartite motif containing 280.038
PARP1poly (ADP-ribose) polymerase 10.033
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.021
NINninein (GSK3B interacting protein)0.018
PRR14proline rich 140.017
ANP32Eacidic (leucine-rich) nuclear phosphoprotein 32 family, member E0.015
NRIP1nuclear receptor interacting protein 10.015
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.015
EHMT2euchromatic histone-lysine N-methyltransferase 20.014
LRRK2leucine-rich repeat kinase 20.014
H2AFVH2A histone family, member V0.013
HDAC2histone deacetylase 20.013
AXIN1axin 10.012
SGOL1shugoshin-like 1 (S. pombe)0.012
CHAF1Bchromatin assembly factor 1, subunit B (p60)0.012
HMGN1high mobility group nucleosome binding domain 10.012
TOPBP1topoisomerase (DNA) II binding protein 10.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Dnmt3aDNA methyltransferase 3A1.000
Dnmt3bDNA methyltransferase 3B0.998
Ezh2enhancer of zeste homolog 2 (Drosophila)0.997
Hellshelicase, lymphoid specific0.968
Kdm2blysine (K)-specific demethylase 2B0.875
Trim24tripartite motif-containing 240.842
Trim28tripartite motif-containing 280.836
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.337
Axin1axin 10.322
Suz12suppressor of zeste 12 homolog (Drosophila)0.300
Dnmt3lDNA (cytosine-5-)-methyltransferase 3-like0.267
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.266
Ncoa3nuclear receptor coactivator 30.175
Cbx3chromobox homolog 3 (Drosophila HP1 gamma)0.156
Rnf2ring finger protein 20.148
Pou5f1POU domain, class 5, transcription factor 10.136
Sufusuppressor of fused homolog (Drosophila)0.120
Hdac1histone deacetylase 10.110
Stmn1stathmin 10.109
Jarid2jumonji, AT rich interactive domain 20.108
Rbbp4retinoblastoma binding protein 40.104
Ergavian erythroblastosis virus E-26 (v-ets) oncogene related0.098
Apcadenomatosis polyposis coli0.097
Ctnnb1catenin (cadherin associated protein), beta 10.095
Runx1runt related transcription factor 10.095
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.090
Lig1ligase I, DNA, ATP-dependent0.087
Lrp6low density lipoprotein receptor-related protein 60.087
Trp53transformation related protein 530.065
Mtf2metal response element binding transcription factor 20.064
U2af2U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 20.059
Brca1breast cancer 10.057
Nucks1nuclear casein kinase and cyclin-dependent kinase substrate 10.057
Gsk3bglycogen synthase kinase 3 beta0.056
Psen1presenilin 10.053
Ehmt1euchromatic histone methyltransferase 10.052
CrebbpCREB binding protein0.049
Dnmt1DNA methyltransferase (cytosine-5) 10.036
Rbm14RNA binding motif protein 140.036
Casp8ap2caspase 8 associated protein 20.034
Hnrnpul1heterogeneous nuclear ribonucleoprotein U-like 10.032
Chaf1achromatin assembly factor 1, subunit A (p150)0.031
Csnk2a1casein kinase 2, alpha 1 polypeptide0.030
Mll3myeloid/lymphoid or mixed-lineage leukemia 30.029
Ccnd1cyclin D10.027
Tubb5tubulin, beta 50.026
Nup155nucleoporin 1550.026
Parp1poly (ADP-ribose) polymerase family, member 10.026
Brd4bromodomain containing 40.025
Tuba1btubulin, alpha 1B0.025
Rbbp7retinoblastoma binding protein 70.024
RybpRING1 and YY1 binding protein0.024
Myef2myelin basic protein expression factor 2, repressor0.023
Nup85nucleoporin 850.023
Eri2exoribonuclease 20.022
Ncapd3non-SMC condensin II complex, subunit D30.022
Rfc2replication factor C (activator 1) 20.022
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.021
Ilf2interleukin enhancer binding factor 20.021
NanogNanog homeobox0.020
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)0.020
Brca2breast cancer 20.020
Ctbp1C-terminal binding protein 10.019
Prim1DNA primase, p49 subunit0.018
Rad21RAD21 homolog (S. pombe)0.018
Supt16hsuppressor of Ty 16 homolog (S. cerevisiae)0.018
Pold3polymerase (DNA-directed), delta 3, accessory subunit0.017
Skp2S-phase kinase-associated protein 2 (p45)0.017
C330027C09RikRIKEN cDNA C330027C09 gene0.017
MgaMAX gene associated0.017
2610039C10RikRIKEN cDNA 2610039C10 gene0.017
Hmgb1high mobility group box 10.017
Donsondownstream neighbor of SON0.016
Rag1recombination activating gene 10.016
Zbtb33zinc finger and BTB domain containing 330.016
Chd4chromodomain helicase DNA binding protein 40.016
Mcm7minichromosome maintenance deficient 7 (S. cerevisiae)0.016
Hcfc1host cell factor C10.015
Srsf4serine/arginine-rich splicing factor 40.015
Fam33afamily with sequence similarity 33, member A0.015
Gsk3aglycogen synthase kinase 3 alpha0.015
Smc2structural maintenance of chromosomes 20.015
BcorBCL6 interacting corepressor0.014
Hist1h1ehistone cluster 1, H1e0.014
Ilf3interleukin enhancer binding factor 30.014
Ctbp2C-terminal binding protein 20.014
Ptmaprothymosin alpha0.013
Ints7integrator complex subunit 70.013
Ints9integrator complex subunit 90.013
Chek2CHK2 checkpoint homolog (S. pombe)0.013
Aicdaactivation-induced cytidine deaminase0.013
Ncaphnon-SMC condensin I complex, subunit H0.013
Cdc7cell division cycle 7 (S. cerevisiae)0.012
Rrm2ribonucleotide reductase M20.012
Mphosph9M-phase phosphoprotein 90.012
Khdrbs1KH domain containing, RNA binding, signal transduction associated 10.012
Ikzf1IKAROS family zinc finger 10.012
Sf3a2splicing factor 3a, subunit 20.012
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Scaf1SR-related CTD-associated factor 10.016
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism