The network for 'smooth muscle contraction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

smooth muscle contraction

A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length.

NameDescriptionProbabilityFunc Analog Organism
myh11amyosin, heavy polypeptide 11, smooth muscle a0.778
etv2ets variant gene 20.699
ppargperoxisome proliferator activated receptor gamma0.589
calcrlacalcitonin receptor-like a0.542
epas1bendothelial PAS domain protein 1b0.536
cdh5cadherin 50.523
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.506
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.468
lmnalamin A0.363
fabp6fatty acid binding protein 6, ileal (gastrotropin)0.334
gfra1agdnf family receptor alpha 1a0.271
drd2bdopamine receptor D2b0.196
gata6GATA-binding protein 60.193
tie2endothelium-specific receptor tyrosine kinase 20.148
klf2aKruppel-like factor 2a0.146
ptgs1prostaglandin-endoperoxide synthase 10.145
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.143
adrb2aadrenergic receptor, beta 2a0.142
gja3gap junction protein, alpha 30.141
s100a1S100 calcium binding protein A10.134
scn1asodium channel, voltage-gated, type I, alpha0.132
LOC100332193growth hormone secretagogue receptor type 1-like0.129
alpialkaline phosphatase, intestinal0.127
p2rx3apurinergic receptor P2X, ligand-gated ion channel, 3a0.126
duoxdual oxidase0.123
vegfcvascular endothelial growth factor c0.111
rhogbras homolog gene family, member Gb0.111
entpd3ectonucleoside triphosphate diphosphohydrolase 30.110
rnasel1ribonuclease like 10.105
kdrkinase insert domain receptor (a type III receptor tyrosine kinase)0.103
ift52intraflagellar transport protein 520.099
tie1endothelium-specific receptor tyrosine kinase 10.099
gfra1bgdnf family receptor alpha 1b0.096
cntn1acontactin 1a0.093
prox1bprospero-related homeobox gene 1b0.093
mchr1amelanin-concentrating hormone receptor 1a0.091
vegfaavascular endothelial growth factor Aa0.089
mchr1bmelanin-concentrating hormone receptor 1b0.084
emilin2belastin microfibril interfacer 2b0.082
gria4aglutamate receptor, ionotropic, AMPA 4a0.081
lifrbleukemia inhibitory factor receptor alpha b0.080
dll4delta-like 4 (Drosophila)0.080
nkx2.5NK2 transcription factor related 50.079
cyp24a1cytochrome P450, family 24, subfamily A, polypeptide 10.079
mcambmelanoma cell adhesion molecule b0.078
trpa1btransient receptor potential cation channel, subfamily A, member 1b0.078
cbfbcore-binding factor, beta subunit0.078
phox2bpaired-like homeobox 2b0.076
mst1macrophage stimulating 1 (hepatocyte growth factor-like)0.074
ergv-ets erythroblastosis virus E26 oncogene like (avian)0.073
sulf1sulfatase 10.073
bbs7Bardet-Biedl syndrome 70.072
tal1T-cell acute lymphocytic leukemia 10.072
prdm5PR domain containing 50.072
crb3bcrumbs homolog 3b0.071
pmelapremelanosome protein a0.071
fabp11afatty acid binding protein 11a0.070
fmnl2aformin-like 2a0.070
s1pr2sphingosine-1-phosphate receptor 20.069
ednrb1endothelin receptor B0.069
stab2stabilin 20.068
p2rx3bpurinergic receptor P2X, ligand-gated ion channel, 3b0.067
fevFEV (ETS oncogene family)0.064
gpiaglucose phosphate isomerase a0.062
bbs4Bardet-Biedl syndrome 40.062
lats1LATS, large tumor suppressor, homolog 1 (Drosophila)0.061
wt1awilms tumor 1a0.061
drgxdorsal root ganglia homeobox0.060
igf1rainsulin-like growth factor 1a receptor0.060
ntrk3bneurotrophic tyrosine kinase, receptor, type 3b0.060
scn8absodium channel, voltage-gated, type VIII, alpha b0.058
gperG protein-coupled estrogen receptor 10.058
ltkleukocyte tyrosine kinase0.057
ccbe1collagen and calcium binding EGF domains 10.057
tac1tachykinin 10.056
actn2actinin, alpha 20.056
itm2bbintegral membrane protein 2Bb0.056
mrc1amannose receptor, C type 1a0.055
fabp2fatty acid binding protein 2, intestinal0.055
esamaendothelial cell adhesion molecule a0.054
drd2ldopamine receptor D2 like0.053
gyg1glycogenin 10.053
plxnd1plexin D10.052
myf6myogenic factor 60.052
tbx18T-box 180.051
nlgn1neuroligin 10.051
pnxposterior neuron-specific homeobox0.051
sgcdsarcoglycan, delta (dystrophin-associated glycoprotein)0.051
leprleptin receptor0.051
tmem88atransmembrane protein 88 a0.051
adora2aaadenosine A2a receptor a0.049
lmx1b.1LIM homeobox transcription factor 1, beta 10.049
nfatc4nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 40.049
aplnrbapelin receptor b0.048
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
msp-78Protein MSP-780.857
msp-36Protein MSP-360.473
msp-59Protein MSP-590.412
msp-74Protein MSP-740.365
msp-40Protein MSP-400.332
msp-19Protein MSP-190.331
msp-55Protein MSP-550.329
msp-76Protein MSP-760.248
msp-77Protein MSP-770.211
msp-10Protein MSP-100.169
msp-3Protein MSP-30.138
msp-152Protein MSP-1520.133
msp-38Protein MSP-380.131
CELE_Y59E9AR.7Protein Y59E9AR.70.121
msp-63Protein MSP-630.089
msp-45Protein MSP-450.086
msp-31Protein MSP-310.070
msp-53Protein MSP-530.065
msp-33Protein MSP-330.064
Y59H11AM.1Protein Y59H11AM.10.058
msp-79Protein MSP-790.053
msp-50Protein MSP-500.038
ZK1248.17Protein ZK1248.170.036
msp-65Protein MSP-650.029
msp-32Protein MSP-320.027
nspa-8Protein NSPA-80.025
ZK1248.4Protein ZK1248.40.023
msp-64Protein MSP-640.023
msp-142Protein MSP-1420.021
dyc-1Protein DYC-10.019
vav-1Protein VAV-10.019
mpk-1Protein MPK-10.016
ssp-19Protein SSP-190.013
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
srpk79Dserine-arginine protein kinase at 79D0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SRFserum response factor (c-fos serum response element-binding transcription factor)0.990
MPDZmultiple PDZ domain protein0.940
ADORA2Aadenosine A2a receptor0.458
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.366
ADAM17ADAM metallopeptidase domain 170.128
MKL1megakaryoblastic leukemia (translocation) 10.117
PTPRBprotein tyrosine phosphatase, receptor type, B0.117
CAV2caveolin 20.104
CAV1caveolin 1, caveolae protein, 22kDa0.083
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.068
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.063
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.058
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.055
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.050
PTGIRprostaglandin I2 (prostacyclin) receptor (IP)0.046
PTENphosphatase and tensin homolog0.041
LDLRlow density lipoprotein receptor0.037
ACTA2actin, alpha 2, smooth muscle, aorta0.033
LATlinker for activation of T cells0.033
PGFplacental growth factor0.032
KITLGKIT ligand0.031
ARRDC3arrestin domain containing 30.023
SDPRserum deprivation response0.022
LBX1ladybird homeobox 10.022
MYH11myosin, heavy chain 11, smooth muscle0.021
PRKG1protein kinase, cGMP-dependent, type I0.021
EDNRAendothelin receptor type A0.021
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.020
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.020
KCNMA1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.019
MYOD1myogenic differentiation 10.019
VPS29vacuolar protein sorting 29 homolog (S. cerevisiae)0.018
ARAFv-raf murine sarcoma 3611 viral oncogene homolog0.018
SMAD1SMAD family member 10.018
GHRgrowth hormone receptor0.017
KCNMB1potassium large conductance calcium-activated channel, subfamily M, beta member 10.017
SSTR3somatostatin receptor 30.017
F2Rcoagulation factor II (thrombin) receptor0.017
NTRK2neurotrophic tyrosine kinase, receptor, type 20.017
ITGA8integrin, alpha 80.017
PBKPDZ binding kinase0.017
CALCRLcalcitonin receptor-like0.016
MMP1matrix metallopeptidase 1 (interstitial collagenase)0.016
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.014
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.014
RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.014
PTGISprostaglandin I2 (prostacyclin) synthase0.014
MYOGmyogenin (myogenic factor 4)0.013
MKL2MKL/myocardin-like 20.012
RGS2regulator of G-protein signaling 2, 24kDa0.012
ACTC1actin, alpha, cardiac muscle 10.012
TAC1tachykinin, precursor 10.012
ERGv-ets erythroblastosis virus E26 oncogene homolog (avian)0.011
CYBAcytochrome b-245, alpha polypeptide0.011
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.011
MRVI1murine retrovirus integration site 1 homolog0.011
CTSBcathepsin B0.011
CD34CD34 molecule0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.991
Nos1nitric oxide synthase 1, neuronal0.987
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.930
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.859
Bbs4Bardet-Biedl syndrome 4 (human)0.852
Nos3nitric oxide synthase 3, endothelial cell0.837
Chrm3cholinergic receptor, muscarinic 3, cardiac0.822
Cd247CD247 antigen0.750
Cckbrcholecystokinin B receptor0.746
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.737
Chrnb4cholinergic receptor, nicotinic, beta polypeptide 40.716
Myh11myosin, heavy polypeptide 11, smooth muscle0.701
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.668
Pnpla2patatin-like phospholipase domain containing 20.667
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.568
Ptgirprostaglandin I receptor (IP)0.531
Sstr4somatostatin receptor 40.506
Ppargperoxisome proliferator activated receptor gamma0.485
Adrb1adrenergic receptor, beta 10.484
Gdnfglial cell line derived neurotrophic factor0.466
Plcg1phospholipase C, gamma 10.463
Cacnb2calcium channel, voltage-dependent, beta 2 subunit0.456
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.428
Grin2aglutamate receptor, ionotropic, NMDA2A (epsilon 1)0.410
Ptgs2prostaglandin-endoperoxide synthase 20.399
Fbn1fibrillin 10.398
NsfN-ethylmaleimide sensitive fusion protein0.395
Cav1caveolin 1, caveolae protein0.391
Dmddystrophin, muscular dystrophy0.384
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.379
Gucy1b3guanylate cyclase 1, soluble, beta 30.372
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.367
Leprleptin receptor0.356
Pgrprogesterone receptor0.352
Sstr1somatostatin receptor 10.342
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.337
Galr2galanin receptor 20.337
Mrvi1MRV integration site 10.332
Edn1endothelin 10.308
Adra1aadrenergic receptor, alpha 1a0.306
Prkg1protein kinase, cGMP-dependent, type I0.279
Htr75-hydroxytryptamine (serotonin) receptor 70.278
Slc5a11solute carrier family 5 (sodium/glucose cotransporter), member 110.277
Kcns2K+ voltage-gated channel, subfamily S, 20.268
Chrm2cholinergic receptor, muscarinic 2, cardiac0.265
Actbactin, beta0.261
Ptrfpolymerase I and transcript release factor0.256
Chrna6cholinergic receptor, nicotinic, alpha polypeptide 60.255
Plcb1phospholipase C, beta 10.246
Has1hyaluronan synthase10.240
Plauplasminogen activator, urokinase0.238
Grid1glutamate receptor, ionotropic, delta 10.236
Lmnalamin A0.236
Drd2dopamine receptor D20.230
Rapsnreceptor-associated protein of the synapse0.220
Fgf7fibroblast growth factor 70.215
Thrbthyroid hormone receptor beta0.215
Tacr1tachykinin receptor 10.204
Cacna1bcalcium channel, voltage-dependent, N type, alpha 1B subunit0.200
Ednrbendothelin receptor type B0.199
Grm2glutamate receptor, metabotropic 20.198
Cyp8b1cytochrome P450, family 8, subfamily b, polypeptide 10.190
Kitlkit ligand0.185
Bdkrb2bradykinin receptor, beta 20.183
Ryr1ryanodine receptor 1, skeletal muscle0.168
Prkccprotein kinase C, gamma0.161
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.161
Nrp1neuropilin 10.155
FosbFBJ osteosarcoma oncogene B0.155
Actg2actin, gamma 2, smooth muscle, enteric0.154
Syt7synaptotagmin VII0.153
Grm1glutamate receptor, metabotropic 10.153
Kcna4potassium voltage-gated channel, shaker-related subfamily, member 40.152
Adipoqadiponectin, C1Q and collagen domain containing0.148
Cfl1cofilin 1, non-muscle0.147
Oprl1opioid receptor-like 10.145
Kcnc3potassium voltage gated channel, Shaw-related subfamily, member 30.144
Cnn1calponin 10.141
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.141
Prkceprotein kinase C, epsilon0.139
Prkar1bprotein kinase, cAMP dependent regulatory, type I beta0.139
Prima1proline rich membrane anchor 10.135
Cyp1b1cytochrome P450, family 1, subfamily b, polypeptide 10.134
Kcnq2potassium voltage-gated channel, subfamily Q, member 20.131
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.130
Dlx4distal-less homeobox 40.129
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.128
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.120
Actn1actinin, alpha 10.119
Fndc7fibronectin type III domain containing 70.118
Adora2aadenosine A2a receptor0.117
Insrinsulin receptor0.116
Cldn26claudin 260.115
Wnt6wingless-related MMTV integration site 60.115
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.564
Adora2aadenosine A2a receptor0.461
Itgamintegrin, alpha M0.385
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.360
Cyp21a1cytochrome P450, family 21, subfamily a, polypeptide 10.348
Csf1colony stimulating factor 1 (macrophage)0.285
Gfra2GDNF family receptor alpha 20.262
Ptafrplatelet-activating factor receptor0.248
C5ar1complement component 5a receptor 10.214
Adam2ADAM metallopeptidase domain 20.184
Cd4Cd4 molecule0.182
Zp2zona pellucida glycoprotein 2 (sperm receptor)0.178
Olr226olfactory receptor 2260.173
Egr4early growth response 40.172
Adra2cadrenergic, alpha-2C-, receptor0.167
Hrh3histamine receptor H30.163
Agtr1aangiotensin II receptor, type 1a0.154
Arandrogen receptor0.142
Testintestin gene0.134
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.129
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.128
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.124
Kcna3potassium voltage-gated channel, shaker-related subfamily, member 30.121
Prss3protease, serine, 30.120
Spt1salivary protein 10.118
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.114
Ptgfrprostaglandin F receptor0.109
Pnma1paraneoplastic antigen MA10.109
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.109
Aqp6aquaporin 6, kidney specific0.109
Pnliprp2pancreatic lipase-related protein 20.105
Myl7myosin, light chain 7, regulatory0.103
Hpcal4hippocalcin-like 40.102
Il1rninterleukin 1 receptor antagonist0.099
Agxt2alanine-glyoxylate aminotransferase 20.098
Gfra1GDNF family receptor alpha 10.096
Syt8synaptotagmin VIII0.096
Strnstriatin, calmodulin binding protein0.093
Phkg1phosphorylase kinase, gamma 10.088
Tbxa2rthromboxane A2 receptor0.086
Tacr1tachykinin receptor 10.084
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.083
Olr1641olfactory receptor 16410.081
Fosl1fos-like antigen 10.079
Hsd3b5hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 50.079
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.078
Avparginine vasopressin0.077
Syn3synapsin III0.076
Gpr6G protein-coupled receptor 60.075
Slc5a2solute carrier family 5 (sodium/glucose cotransporter), member 20.075
Rgs14regulator of G-protein signaling 140.073
Kiss1rKISS1 receptor0.072
LOC100360919Immunoglobulin lambda-like polypeptide 1-like0.072
Gucy1b3guanylate cyclase 1, soluble, beta 30.072
Tpsb2tryptase beta 20.072
Olr1413olfactory receptor 14130.071
Cd38CD38 molecule0.071
Galr2galanin receptor 20.070
Grm6glutamate receptor, metabotropic 60.069
Procprotein C0.069
Reg3gregenerating islet-derived 3 gamma0.068
Npy5rneuropeptide Y receptor Y50.068
Oprd1opioid receptor, delta 10.066
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.065
Sparcl1SPARC-like 1 (hevin)0.065
Slc1a2solute carrier family 1 (glial high affinity glutamate transporter), member 20.065
Fgf2fibroblast growth factor 20.065
Dmrta1DMRT-like family A10.064
Gcnt3glucosaminyl (N-acetyl) transferase 3, mucin type0.062
Ccl20chemokine (C-C motif) ligand 200.062
Trhrthyrotropin releasing hormone receptor0.062
Galgalanin prepropeptide0.061
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.061
Apoa5apolipoprotein A-V0.061
Pde1bphosphodiesterase 1B, calmodulin-dependent0.061
Ins2insulin 20.059
Il9rinterleukin 9 receptor0.059
Slc9a4solute carrier family 9 (sodium/hydrogen exchanger), member 40.059
Htr75-hydroxytryptamine (serotonin) receptor 70.058
Cdh6cadherin 60.058
Pthlhparathyroid hormone-like hormone0.057
Mchr1melanin-concentrating hormone receptor 10.056
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.056
Tcof1Treacher Collins-Franceschetti syndrome 1 homolog (human)0.054
Krt34keratin 340.054
Slco2b1solute carrier organic anion transporter family, member 2b10.054
Col10a1collagen, type X, alpha 10.052
Crhbpcorticotropin releasing hormone binding protein0.052
Kcnmb1potassium large conductance calcium-activated channel, subfamily M, beta member 10.052
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.051
Havcr1hepatitis A virus cellular receptor 10.050
Shank1SH3 and multiple ankyrin repeat domains 10.050
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism