The network for 'regulation of guanylate cyclase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of guanylate cyclase activity

Any process that modulates the frequency, rate or extent of guanylate cyclase activity.

NameDescriptionProbabilityFunc Analog Organism
gc3guanylyl cyclase 30.586
synj1synaptojanin 10.445
grk7aG-protein-coupled receptor kinase 7a0.412
opn1lw1opsin 1 (cone pigments), long-wave-sensitive, 10.306
pi4kbphosphatidylinositol 4-kinase, catalytic, beta0.274
gnat2guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 20.173
fgfrl1bfibroblast growth factor receptor-like 1b0.122
grk1bG protein-coupled receptor kinase 1 b0.084
aanat2arylalkylamine N-acetyltransferase0.076
pdcaphosducin a0.074
mpp5bmembrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5b)0.073
sst3somatostatin 30.066
cntn1bcontactin 1b0.063
pde6cphosphodiesterase 6C, cGMP-specific, cone, alpha prime0.063
cplx4acomplexin 4a0.063
kif5ckinesin family member 5C0.062
guca1dguanylate cyclase activator 1d0.060
gdnfglial cell derived neurotrophic factor0.059
crb3bcrumbs homolog 3b0.056
hint2histidine triad nucleotide binding protein 20.055
sagaS-antigen; retina and pineal gland (arrestin) a0.051
msxemuscle segment homeobox E0.047
cyb5d1cytochrome b5 domain containing 10.044
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)0.041
her12hairy-related 120.040
npyneuropeptide Y0.039
chpfchondroitin polymerizing factor0.037
opn1mw2opsin 1 (cone pigments), medium-wave-sensitive, 20.034
pppyrophosphatase (inorganic)0.033
sagbS-antigen; retina and pineal gland (arrestin) b0.031
neurod2neurogenic differentiation 20.029
opn1sw1opsin 1 (cone pigments), short-wave-sensitive 10.027
guca1cguanylate cyclase activator 1C0.025
gnat1guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 10.024
arf1ADP-ribosylation factor 10.024
aldocaaldolase C, fructose-bisphosphate, a0.023
hapln3hyaluronan and proteoglycan link protein 30.023
crb2bcrumbs homolog 2b0.023
opn1sw2opsin 1 (cone pigments), short-wave-sensitive 20.022
pde6aphosphodiesterase 6A, cGMP-specific, rod, alpha0.022
atp1b3aATPase, Na+/K+ transporting, beta 3a polypeptide0.021
ptpraprotein tyrosine phosphatase, receptor type, A0.021
bsk146brain specific kinase 1460.021
LOC100006249carbohydrate sulfotransferase 2-like0.020
prkcbbprotein kinase C, beta b0.020
rab28RAB28, member RAS oncogene family0.020
aanat1arylalkylamine N-acetyltransferase 10.020
drd4adopamine receptor D4a0.019
ncs1bneuronal calcium sensor 1b0.019
slc6a8solute carrier family 6 (neurotransmitter transporter, creatine), member 80.019
dachadachshund a0.018
atp1a1a.5ATPase, Na+/K+ transporting, alpha 1a.5 polypeptide0.017
cx55.5connexin 55.50.017
nkx2.5NK2 transcription factor related 50.016
rbp4lretinol binding protein 4, like0.015
nrlneural retina leucine zipper0.015
clec14aC-type lectin domain family 14, member A0.015
smoxspermine oxidase0.015
nbl1neuroblastoma, suppression of tumorigenicity 10.015
guca1eguanylate cyclase activator 1e0.014
arr3barrestin 3b, retinal (X-arrestin)0.014
esr1estrogen receptor 10.014
slc1a2asolute carrier family 1 (glial high affinity glutamate transporter), member 2a0.013
LOC799612prolactin 20.013
ahi1Abelson helper integration site 10.013
rs1retinoschisis (X-linked, juvenile) 10.013
chrnb3acholinergic receptor, nicotinic, beta polypeptide 3a0.012
guca1aguanylate cyclase activator 1A0.012
foxg1bforkhead box G1b0.012
rtn4rl2areticulon 4 receptor-like 2 a0.012
ttc8tetratricopeptide repeat domain 80.012
atxn7l3ataxin 7-like 30.012
gdf11growth differentiation factor 110.012
asah2N-acylsphingosine amidohydrolase 20.011
slc15a1bsolute carrier family 15 (oligopeptide transporter), member 1b0.011
arl3l2ADP-ribosylation factor-like 3, like 20.011
znfl2azinc finger-like gene 2a0.011
pdlim3aPDZ and LIM domain 3a0.011
pcdh2ab7protocadherin 2 alpha b 70.011
nkx2.9NK2 transcription factor related, locus 9 (Drosophila)0.011
pld1aphospholipase D1a0.011
cldnkclaudin k0.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
VmatVesicular monoamine transporter0.049
GluRIIAGlutamate receptor IIA0.046
CaMKIICalcium/calmodulin-dependent protein kinase II0.026
CG2219CG2219 gene product from transcript CG2219-RA0.026
CG31146CG31146 gene product from transcript CG31146-RD0.019
mipleCG1221 gene product from transcript CG1221-RA0.019
SamDCS-adenosylmethionine decarboxylase0.012
CG6983CG6983 gene product from transcript CG6983-RA0.012
CG8229CG8229 gene product from transcript CG8229-RE0.011
CG12187CG12187 gene product from transcript CG12187-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)1.000
SLC9A3R2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.934
GOPCgolgi-associated PDZ and coiled-coil motif containing0.934
GUCY2Cguanylate cyclase 2C (heat stable enterotoxin receptor)0.934
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.844
NOSTRINnitric oxide synthase trafficker0.802
TBC1D10ATBC1 domain family, member 10A0.797
VAC14Vac14 homolog (S. cerevisiae)0.422
BCRbreakpoint cluster region0.404
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.389
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.237
PDZK1PDZ domain containing 10.143
DTX2deltex homolog 2 (Drosophila)0.071
PTENphosphatase and tensin homolog0.067
P2RY1purinergic receptor P2Y, G-protein coupled, 10.062
SLC26A3solute carrier family 26, member 30.059
CLCN3chloride channel 30.054
FYNFYN oncogene related to SRC, FGR, YES0.052
ADRB2adrenergic, beta-2-, receptor, surface0.035
LGALS4lectin, galactoside-binding, soluble, 40.029
RAP2BRAP2B, member of RAS oncogene family0.028
MUC13mucin 13, cell surface associated0.024
NOS1APnitric oxide synthase 1 (neuronal) adaptor protein0.023
RNF5ring finger protein 50.018
GFI1Bgrowth factor independent 1B transcription repressor0.018
IL1RAPL1interleukin 1 receptor accessory protein-like 10.018
RYR2ryanodine receptor 2 (cardiac)0.016
PLEKHA6pleckstrin homology domain containing, family A member 60.015
USP19ubiquitin specific peptidase 190.014
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.011
CLCA1chloride channel accessory 10.010
NF2neurofibromin 2 (merlin)0.010
LPAR2lysophosphatidic acid receptor 20.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Slc34a1solute carrier family 34 (sodium phosphate), member 10.033
Trpv1transient receptor potential cation channel, subfamily V, member 10.023
Rnf208ring finger protein 2080.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Slc9a1solute carrier family 9 (sodium/hydrogen exchanger), member 10.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism