The network for 'morphogenesis of an epithelium' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

morphogenesis of an epithelium

The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.

NameDescriptionProbabilityFunc Analog Organism
hnf1baHNF1 homeobox Ba0.996
notch1anotch homolog 1a0.994
tbx1T-box 10.988
sulf1sulfatase 10.987
foxa2forkhead box A20.987
cdh1cadherin 1, epithelial0.984
six3bsine oculis homeobox homolog 3b0.978
kdrlkinase insert domain receptor like0.978
shhasonic hedgehog a0.976
tp53tumor protein p530.972
dlx2adistal-less homeobox gene 2a0.967
mdkamidkine-related growth factor0.959
jag1bjagged 1b0.958
gli2aGLI-Kruppel family member GLI2a0.958
bmp2bbone morphogenetic protein 2b0.956
crabp2acellular retinoic acid binding protein 2, a0.952
ndr2nodal-related 20.952
six4bsine oculis homeobox homolog 4b0.951
ttnatitin a0.949
otpborthopedia homolog b0.941
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.933
foxn4forkhead box N40.932
pax8paired box gene 80.932
flhfloating head0.930
foxc1aforkhead box C1a0.928
lmx1b.1LIM homeobox transcription factor 1, beta 10.909
dlx5adistal-less homeobox gene 5a0.909
fgf3fibroblast growth factor 30.909
traf4atnf receptor-associated factor 4a0.908
etv5bets variant 5b0.902
col15a1bcollagen, type XV, alpha 1b0.901
notch3notch homolog 30.901
epb41l5erythrocyte membrane protein band 4.1 like 50.901
wnt11wingless-type MMTV integration site family, member 110.897
ift88intraflagellar transport 88 homolog0.896
arl13bADP-ribosylation factor-like 13b0.892
foxd3forkhead box D30.887
fgfr4fibroblast growth factor receptor 40.885
tbx20T-box 200.884
pkd2polycystic kidney disease 20.883
fgf8afibroblast growth factor 8 a0.877
shhbsonic hedgehog b0.875
hhexhematopoietically expressed homeobox0.871
plcg1phospholipase C, gamma 10.869
nrp2bneuropilin 2b0.859
lamb1alaminin, beta 1a0.846
tfap2atranscription factor AP-2 alpha0.845
irx4biroquois homeobox protein 4b0.840
efnb2aephrin B2a0.840
rargaretinoic acid receptor gamma a0.840
jag2jagged 20.840
hey2hairy/enhancer-of-split related with YRPW motif 20.837
gpr126G protein-coupled receptor 1260.835
wnt11rwingless-type MMTV integration site family, member 11, related0.831
sox9aSRY-box containing gene 9a0.828
pou3f3bPOU class 3 homeobox 3b0.827
lcp1lymphocyte cytosolic plastin 10.827
fzd10frizzled homolog 100.820
foxi1forkhead box I10.818
tgfb2transforming growth factor, beta 20.816
sox32SRY-box containing gene 320.816
osr2odd-skipped related 2 (Drosophila)0.816
slit3slit (Drosophila) homolog 30.815
egr2bearly growth response 2b0.810
tmem2transmembrane protein 20.808
gata5GATA-binding protein 50.802
gata3GATA-binding protein 30.799
tbx16T-box gene 160.797
wlswntless homolog (Drosophila)0.794
hapln1ahyaluronan and proteoglycan link protein 1a0.787
tp63tumor protein p630.786
fgfr2fibroblast growth factor receptor 20.784
pitx3paired-like homeodomain transcription factor 30.784
tpm4tropomyosin 40.783
hlx1H2.0-like homeo box 1 (Drosophila)0.775
mychmyelocytomatosis oncogene homolog0.770
hand2heart and neural crest derivatives expressed transcript 20.770
hhiphedgehog interacting protein0.765
pcdh18bprotocadherin 18b0.761
acvr1lactivin A receptor, type I like0.759
hoxa13bhomeo box A13b0.756
eya1eyes absent homolog 10.755
sox19aSRY-box containing gene 19a0.746
fli1afriend leukemia integration 1a0.745
fgf10afibroblast growth factor 10a0.739
fgfr3fibroblast growth factor receptor 30.739
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.738
col2a1acollagen type II, alpha-1a0.735
dlx4bdistal-less homeobox gene 4b0.733
oepone-eyed pinhead0.731
fzd7bfrizzled homolog 7b0.729
gata2aGATA-binding protein 2a0.723
lfnglunatic fringe homolog0.717
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Ras85DRas oncogene at 85D1.000
Rac1CG2248 gene product from transcript CG2248-RA1.000
Rho1CG8416 gene product from transcript CG8416-RB0.998
E(spl)Enhancer of split0.997
fz2frizzled 20.996
Cdc42CG12530 gene product from transcript CG12530-RA0.995
aPKCatypical protein kinase C0.993
EgfrEpidermal growth factor receptor0.991
VangVan Gogh0.990
Nrx-IVNeurexin IV0.983
argosCG4531 gene product from transcript CG4531-RA0.982
rheaCG6831 gene product from transcript CG6831-RA0.970
DadDaughters against dpp0.965
G-oalpha47AG protein oalpha 47A0.962
stumpsCG31317 gene product from transcript CG31317-RC0.962
par-1CG8201 gene product from transcript CG8201-RA0.962
JraJun-related antigen0.956
BicDBicaudal D0.952
ovoCG6824 gene product from transcript CG6824-RE0.951
p120ctnAdherens junction protein p1200.950
Sra-1specifically Rac1-associated protein 10.948
Wnt4Wnt oncogene analog 40.946
EcREcdysone receptor0.936
MadMothers against dpp0.936
E2f2E2F transcription factor 20.935
lolalongitudinals lacking0.934
McrMacroglobulin complement-related0.930
cicubitus interruptus0.929
stanstarry night0.922
cindrCIN85 and CD2AP orthologue0.913
aopanterior open0.896
Pi3K92ECG4141 gene product from transcript CG4141-RB0.890
CycACyclin A0.882
Applbeta amyloid protein precursor-like0.879
rawCG12437 gene product from transcript CG12437-RB0.871
HLHm5E(spl) region transcript m50.866
vvlventral veins lacking0.862
Src42ASrc oncogene at 42A0.860
gbbglass bottom boat0.856
RalaRas-related protein0.850
Akt1CG4006 gene product from transcript CG4006-RA0.849
PknProtein kinase related to protein kinase N0.847
LanB2Laminin B20.847
mewmultiple edematous wings0.821
emcextra macrochaetae0.819
Sema-1bCG6446 gene product from transcript CG6446-RA0.813
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor1.000
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.999
FN1fibronectin 10.994
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.986
FGFR2fibroblast growth factor receptor 20.976
NOTCH1notch 10.975
JAG1jagged 10.968
ESR1estrogen receptor 10.964
RHOAras homolog gene family, member A0.963
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.961
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.936
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.924
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.916
THBS1thrombospondin 10.892
COL1A1collagen, type I, alpha 10.884
TP53tumor protein p530.879
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.839
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.838
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.827
CREBBPCREB binding protein0.825
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.804
SMAD2SMAD family member 20.803
NCOR2nuclear receptor corepressor 20.772
BBS10Bardet-Biedl syndrome 100.754
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.753
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.752
SP1Sp1 transcription factor0.744
SMAD3SMAD family member 30.741
TP63tumor protein p630.735
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.704
NOTCH3notch 30.700
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.689
CTGFconnective tissue growth factor0.686
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.686
NCOR1nuclear receptor corepressor 10.652
BMP1bone morphogenetic protein 10.650
DVL3dishevelled, dsh homolog 3 (Drosophila)0.645
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.640
VEGFAvascular endothelial growth factor A0.637
EGR1early growth response 10.629
PTPN1protein tyrosine phosphatase, non-receptor type 10.621
CASP9caspase 9, apoptosis-related cysteine peptidase0.616
ARPC4actin related protein 2/3 complex, subunit 4, 20kDa0.614
EP300E1A binding protein p3000.592
COL1A2collagen, type I, alpha 20.583
FGF1fibroblast growth factor 1 (acidic)0.571
TIMP3TIMP metallopeptidase inhibitor 30.566
METmet proto-oncogene (hepatocyte growth factor receptor)0.565
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.564
FHL2four and a half LIM domains 20.561
COL4A1collagen, type IV, alpha 10.560
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.547
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.545
EPS8epidermal growth factor receptor pathway substrate 80.542
PRKCZprotein kinase C, zeta0.541
FLNAfilamin A, alpha0.538
SMAD7SMAD family member 70.534
GSK3Bglycogen synthase kinase 3 beta0.531
SMAD4SMAD family member 40.509
SIN3ASIN3 homolog A, transcription regulator (yeast)0.507
KRT17keratin 170.507
COL5A1collagen, type V, alpha 10.472
COL3A1collagen, type III, alpha 10.468
BMP7bone morphogenetic protein 70.468
ARHGAP1Rho GTPase activating protein 10.463
RARAretinoic acid receptor, alpha0.461
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.461
RXRAretinoid X receptor, alpha0.458
ITGB4integrin, beta 40.453
KLK10kallikrein-related peptidase 100.448
ERBB2IPerbb2 interacting protein0.444
KCNJ4potassium inwardly-rectifying channel, subfamily J, member 40.442
ACTR3ARP3 actin-related protein 3 homolog (yeast)0.428
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.416
SMURF2SMAD specific E3 ubiquitin protein ligase 20.413
PTK2PTK2 protein tyrosine kinase 20.410
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.400
APCadenomatous polyposis coli0.396
AXIN1axin 10.394
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.388
PBX1pre-B-cell leukemia homeobox 10.376
RASA1RAS p21 protein activator (GTPase activating protein) 10.375
SOCS3suppressor of cytokine signaling 30.370
COL2A1collagen, type II, alpha 10.366
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.360
SQSTM1sequestosome 10.352
FOXF2forkhead box F20.350
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.345
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.341
EPAS1endothelial PAS domain protein 10.318
GATA4GATA binding protein 40.307
TGFB1transforming growth factor, beta 10.305
FGFR1fibroblast growth factor receptor 10.303
TRIP6thyroid hormone receptor interactor 60.300
FNBP1Lformin binding protein 1-like0.292
SIRT1sirtuin 10.292
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Col12a1collagen, type XII, alpha 10.425
Prrx1paired related homeobox 10.340
Nek9NIMA (never in mitosis gene a)- related kinase 90.326
Fgfr2fibroblast growth factor receptor 20.174
Golph3golgi phosphoprotein 3 (coat-protein)0.171
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.159
Arntaryl hydrocarbon receptor nuclear translocator0.155
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.134
Creb1cAMP responsive element binding protein 10.132
Syt4synaptotagmin IV0.117
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.110
Unc5bunc-5 homolog B (C. elegans)0.100
Lamc1laminin, gamma 10.096
Lims1LIM and senescent cell antigen-like domains 10.094
Tacr1tachykinin receptor 10.093
Dchs1dachsous 1 (Drosophila)0.091
Itpr2inositol 1,4,5-triphosphate receptor, type 20.089
Kitv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.089
Myh9myosin, heavy chain 9, non-muscle0.085
Ednrbendothelin receptor type B0.081
Mllt4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.080
Dab2disabled homolog 2 (Drosophila)0.080
Jak1Janus kinase 10.078
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.077
Bdkrb2bradykinin receptor B20.077
Foxe3forkhead box E30.077
Stat5bsignal transducer and activator of transcription 5B0.077
Ptpn12protein tyrosine phosphatase, non-receptor type 120.073
Pou3f2POU class 3 homeobox 20.072
Dcaf17DDB1 and CUL4 associated factor 170.068
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.068
Bcl2B-cell CLL/lymphoma 20.067
Calcrlcalcitonin receptor-like0.065
Il1r1interleukin 1 receptor, type I0.063
Lig3ligase III, DNA, ATP-dependent0.063
Tcf4transcription factor 40.062
Nfianuclear factor I/A0.058
Grm7glutamate receptor, metabotropic 70.058
Shox2short stature homeobox 20.056
Dlg1discs, large homolog 1 (Drosophila)0.056
Itgb1integrin, beta 10.055
Irs1insulin receptor substrate 10.055
Gata6GATA binding protein 60.054
Pak2p21 protein (Cdc42/Rac)-activated kinase 20.052
Ascl1achaete-scute complex homolog 1 (Drosophila)0.049
Igfbp5insulin-like growth factor binding protein 50.049
Flt1FMS-related tyrosine kinase 10.049
Tnctenascin C0.049
Pfn1profilin 10.048
Igfbp3insulin-like growth factor binding protein 30.048
Ube2d4ubiquitin-conjugating enzyme E2D 40.047
Npr3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)0.047
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.047
Rab3il1RAB3A interacting protein (rabin3)-like 10.047
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.047
Fgfr1Fibroblast growth factor receptor 10.046
Prkar2aprotein kinase, cAMP dependent regulatory, type II alpha0.045
Nos3nitric oxide synthase 3, endothelial cell0.045
Gpc1glypican 10.044
Cpa3carboxypeptidase A3, mast cell0.044
Tcf12transcription factor 120.044
Csnk1g1casein kinase 1, gamma 10.044
Slc30a2solute carrier family 30 (zinc transporter), member 20.043
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.043
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.043
Trhr2thyrotropin releasing hormone receptor 20.043
Tgfbr2transforming growth factor, beta receptor II0.042
Casp3caspase 30.042
Mycsmyc-like oncogene, s-myc protein0.042
Taok1TAO kinase 10.041
Nab1Ngfi-A binding protein 10.041
Crtapcartilage associated protein0.041
Capn6calpain 60.041
Baiap2BAI1-associated protein 20.040
Ptger4prostaglandin E receptor 4 (subtype EP4)0.040
Cpxm2carboxypeptidase X (M14 family), member 20.040
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.039
Lphn2latrophilin 20.039
Scarf2scavenger receptor class F, member 20.038
Actbactin, beta0.038
Fat2FAT tumor suppressor homolog 2 (Drosophila)0.038
Synrgsynergin, gamma0.037
Ddr1discoidin domain receptor tyrosine kinase 10.036
Timp2TIMP metallopeptidase inhibitor 20.036
Cd80Cd80 molecule0.036
Aebp1AE binding protein 10.036
Cgaglycoprotein hormones, alpha polypeptide0.036
Htr65-hydroxytryptamine (serotonin) receptor 60.036
Bmp7bone morphogenetic protein 70.034
Il1rl1interleukin 1 receptor-like 10.034
Tgfbr3transforming growth factor, beta receptor III0.034
Atp1b1ATPase, Na+/K+ transporting, beta 1 polypeptide0.033
Mcammelanoma cell adhesion molecule0.033
B2mbeta-2 microglobulin0.032
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism