The network for 'regulation of cell shape' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of cell shape

Any process that modulates the surface configuration of a cell.

NameDescriptionProbabilityFunc Analog Organism
itgb1b.2integrin, beta 1b.20.882
fgfr1afibroblast growth factor receptor 1a0.877
tie1endothelium-specific receptor tyrosine kinase 10.796
aldocbaldolase C, fructose-bisphosphate, b0.635
gna12guanine nucleotide binding protein (G protein) alpha 120.626
arpc5aactin related protein 2/3 complex, subunit 5A0.571
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.529
pitx3paired-like homeodomain transcription factor 30.466
coblcordon-bleu homolog (mouse)0.435
flot2aflotillin 2a0.415
tjp1tight junction protein 1 (zona occludens 1)0.403
gng5guanine nucleotide binding protein (G protein), gamma 50.375
myl9lmyosin, light polypeptide 9, like0.374
arpc5bactin related protein 2/3 complex, subunit 5B0.374
itgavintegrin, alpha V0.374
pacsin3protein kinase C and casein kinase substrate in neurons 30.373
vwfvon Willebrand factor0.372
gng7guanine nucleotide binding protein (G protein), gamma 70.358
itgb3bintegrin beta 3b0.354
rc3rabconnectin 30.351
fzd7bfrizzled homolog 7b0.345
pak1p21/Cdc42/Rac1-activated kinase 10.343
il7rinterleukin 7 receptor0.340
zeb1zinc finger E-box binding homeobox 10.337
notch3notch homolog 30.326
ptprbprotein tyrosine phosphatase, receptor type, b0.322
hmx2H6 family homeobox 20.320
mmp9matrix metalloproteinase 90.313
msnamoesin a0.304
pvalb8parvalbumin 80.300
tie2endothelium-specific receptor tyrosine kinase 20.300
emilin1aelastin microfibril interfacer 1a0.290
atp2b1aATPase, Ca++ transporting, plasma membrane 1a0.290
cdh5cadherin 50.289
nhsl1aNHS-like 1a0.280
jak1Janus kinase 10.273
hs6st2heparan sulfate 6-O-sulfotransferase 20.270
mfn2mitofusin 20.266
plxnb2aplexin b2a0.255
tgfb3transforming growth factor, beta 30.248
unc5bunc-5 homolog B (C. elegans)0.246
mpllmyeloproliferative leukemia virus oncogene, like0.236
grinaglutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)0.233
srsf4serine/arginine-rich splicing factor 40.229
gsnagelsolin a0.226
egr1early growth response 10.226
gadd45abgrowth arrest and DNA-damage-inducible, alpha, b0.214
ctnnacatenin (cadherin-associated protein), alpha0.213
znrf1zinc and ring finger 10.209
arhgdiaRho GDP dissociation inhibitor (GDI) alpha0.202
vegfaavascular endothelial growth factor Aa0.194
trpv4transient receptor potential cation channel, subfamily V, member 40.192
appbamyloid beta (A4) precursor protein b0.191
krt8keratin 80.188
cacna1dacalcium channel, voltage-dependent, L type, alpha 1D subunit, a0.186
dag1dystroglycan 10.186
lmo4aLIM domain only 4a0.185
jam3bjunctional adhesion molecule 3b0.184
gna13aguanine nucleotide binding protein (G protein), alpha 13a0.183
LOC100331639hypothetical protein LOC1003316390.183
btg1B-cell translocation gene 10.182
arpc4actin related protein 2/3 complex, subunit 40.175
cyt1type I cytokeratin, enveloping layer0.173
stau1staufen, RNA binding protein, homolog 1 (Drosophila)0.173
rykreceptor-like tyrosine kinase0.172
cnihcornichon homolog (Drosophila)0.171
ptbp1apolypyrimidine tract binding protein 1a0.168
stmn1bstathmin 1b0.168
eif5aeukaryotic translation initiation factor 5A0.167
gng2guanine nucleotide binding protein (G protein), gamma 20.162
golga7golgi autoantigen, golgin subfamily a, 70.161
fam76bfamily with sequence similarity 76, member B0.158
atp1a1a.4ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide0.157
LOC100151531zinc finger protein Gfi-1b-like0.156
atp6v1alATPase, H+ transporting, lysosomal V1 subunit A, like0.155
scinlascinderin like a0.155
ryr3ryanodine receptor 30.155
tal1T-cell acute lymphocytic leukemia 10.154
slit2slit (Drosophila) homolog 20.153
ube2aubiquitin-conjugating enzyme E2A (RAD6 homolog)0.152
fmnl2aformin-like 2a0.152
llgl2lethal giant larvae homolog 2 (Drosophila)0.151
casz1castor zinc finger 10.148
mapk12mitogen-activated protein kinase 120.148
syt11asynaptotagmin XIa0.148
calm1acalmodulin 1a0.148
itgb1bintegrin, beta 1b0.147
wt1bwilms tumor 1b0.147
rbm24aRNA binding motif protein 24a0.146
itgb1aintegrin, beta 1a0.145
atat1alpha tubulin acetyltransferase 10.145
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
crt-1Protein CRT-10.124
bar-1Protein BAR-10.089
C11E4.6Protein C11E4.60.062
sorb-1Protein SORB-10.053
K07C5.6Protein K07C5.60.047
plc-1Protein PLC-10.043
CELE_T05E11.3Protein T05E11.30.039
thoc-2Protein THOC-20.035
abl-1Protein ABL-10.032
eea-1Protein EEA-10.027
let-60Protein LET-600.027
mep-1Protein MEP-10.025
etr-1Protein ETR-10.022
egl-8Protein EGL-80.021
pac-1Protein PAC-10.021
xpo-1Protein XPO-10.021
pat-3Protein PAT-30.020
gsp-1Protein GSP-10.019
ten-1Protein TEN-10.019
trr-1Protein TRR-10.019
CELE_Y44A6D.2Protein Y44A6D.20.019
pig-1Protein PIG-10.018
spt-5Protein SPT-50.017
pry-1Protein PRY-10.016
lir-1Protein LIR-10.016
zyg-9Protein ZYG-90.016
F54D12.4Protein F54D12.40.015
sem-5Protein SEM-50.015
C49H3.6Protein C49H3.60.014
hmp-1Protein HMP-10.014
ccr-4Protein CCR-40.014
tlk-1Protein TLK-10.014
clk-2Protein CLK-20.012
rpm-1Protein RPM-10.012
gdi-1Protein GDI-10.012
unc-60Protein UNC-600.012
R11A8.7Protein R11A8.70.011
cas-1Protein CAS-10.011
unc-112Protein UNC-1120.011
F21A10.2Protein F21A10.20.011
B0511.12Protein B0511.120.011
lag-1Protein LAG-10.010
F54C9.9Protein F54C9.90.010
fln-2Protein FLN-20.010
tag-241Protein TAG-2410.010
ptc-1Protein PTC-10.010
tag-232Protein TAG-2320.010
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Rho1CG8416 gene product from transcript CG8416-RB0.994
Ras85DRas oncogene at 85D0.889
Rac1CG2248 gene product from transcript CG2248-RA0.846
AbiAbelson interacting protein0.825
mbcmyoblast city0.806
par-1CG8201 gene product from transcript CG8201-RA0.751
l(2)gllethal (2) giant larvae0.740
Arp14DActin-related protein 14D0.739
Rab5Rab-protein 50.657
JraJun-related antigen0.653
KhcKinesin heavy chain0.630
Rac2CG8556 gene product from transcript CG8556-RA0.614
PvrPDGF- and VEGF-receptor related0.581
Cip4CG15015 gene product from transcript CG15015-RA0.579
mspsmini spindles0.528
Src64BSrc oncogene at 64B0.454
RalaRas-related protein0.387
AblAbl tyrosine kinase0.383
aPKCatypical protein kinase C0.360
Nrx-IVNeurexin IV0.360
alpha-Catalpha Catenin0.345
CtBPC-terminal Binding Protein0.343
WASpCG1520 gene product from transcript CG1520-RA0.317
drkdownstream of receptor kinase0.316
Cdc42CG12530 gene product from transcript CG12530-RA0.304
Myo31DFMyosin 31DF0.302
pod1CG4532 gene product from transcript CG4532-RF0.292
bip2CG2009 gene product from transcript CG2009-RA0.236
cpacapping protein alpha0.235
CG10641CG10641 gene product from transcript CG10641-RA0.229
His3:CG33863CG33863 gene product from transcript CG33863-RA0.219
lunaCG33473 gene product from transcript CG33473-RB0.213
Src42ASrc oncogene at 42A0.208
Sra-1specifically Rac1-associated protein 10.200
Arc-p34CG10954 gene product from transcript CG10954-RA0.189
LamCLamin C0.176
Mpk2CG5475 gene product from transcript CG5475-RB0.168
Arf51FADP ribosylation factor 51F0.164
DadDaughters against dpp0.156
FBX011FBX011 ortholog0.150
Rab2Rab-protein 20.145
sqhspaghetti squash0.143
ctpcut up0.139
Rab7Rab-protein 70.138
Rip11Rab11 interacting protein0.137
blotbloated tubules0.136
Arf79FADP ribosylation factor 79F0.135
Wnt5Wnt oncogene analog 50.134
Mp20Muscle protein 200.133
X11LCG5675 gene product from transcript CG5675-RB0.132
MrtfMyocardin-related transcription factor0.130
zfh1Zn finger homeodomain 10.129
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.992
GRB2growth factor receptor-bound protein 20.988
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.943
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.917
EGFRepidermal growth factor receptor0.856
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.802
RHOAras homolog gene family, member A0.740
PLCG1phospholipase C, gamma 10.705
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.681
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.639
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.565
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.502
TNK2tyrosine kinase, non-receptor, 20.426
BCAR1breast cancer anti-estrogen resistance 10.378
BAIAP2BAI1-associated protein 20.376
ARHGEF11Rho guanine nucleotide exchange factor (GEF) 110.318
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.295
FLNAfilamin A, alpha0.278
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.276
VAV1vav 1 guanine nucleotide exchange factor0.273
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.267
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.266
ARHGAP1Rho GTPase activating protein 10.259
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.255
FN1fibronectin 10.253
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.250
ILKintegrin-linked kinase0.244
FYNFYN oncogene related to SRC, FGR, YES0.244
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.234
AKT1v-akt murine thymoma viral oncogene homolog 10.226
SPTAN1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)0.223
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.222
NCK1NCK adaptor protein 10.203
RASA1RAS p21 protein activator (GTPase activating protein) 10.202
GRB7growth factor receptor-bound protein 70.196
SH3KBP1SH3-domain kinase binding protein 10.177
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.176
LATlinker for activation of T cells0.175
EPS8epidermal growth factor receptor pathway substrate 80.172
GAS7growth arrest-specific 70.167
NRP1neuropilin 10.155
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.135
PRKCZprotein kinase C, zeta0.126
SHC1SHC (Src homology 2 domain containing) transforming protein 10.122
FMR1fragile X mental retardation 10.119
TOM1L1target of myb1 (chicken)-like 10.119
WIPF1WAS/WASL interacting protein family, member 10.112
CDK9cyclin-dependent kinase 90.111
CCR5chemokine (C-C motif) receptor 50.108
PGK1phosphoglycerate kinase 10.105
PKM2pyruvate kinase, muscle0.105
SEMA4Asema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A0.102
ACTN1actinin, alpha 10.101
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.097
NCKAP1NCK-associated protein 10.088
FGF1fibroblast growth factor 1 (acidic)0.087
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.086
PTPN6protein tyrosine phosphatase, non-receptor type 60.083
LCKlymphocyte-specific protein tyrosine kinase0.082
SOS1son of sevenless homolog 1 (Drosophila)0.081
ARRB1arrestin, beta 10.081
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.081
PTPN13protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)0.076
AFF4AF4/FMR2 family, member 40.076
ITGB5integrin, beta 50.069
ITKIL2-inducible T-cell kinase0.065
FLNBfilamin B, beta0.065
ADAM19ADAM metallopeptidase domain 190.064
HCKhemopoietic cell kinase0.064
ARPC3actin related protein 2/3 complex, subunit 3, 21kDa0.063
LARP7La ribonucleoprotein domain family, member 70.062
GAB1GRB2-associated binding protein 10.062
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.061
ARPC1Bactin related protein 2/3 complex, subunit 1B, 41kDa0.060
MAP3K5mitogen-activated protein kinase kinase kinase 50.060
CDH5cadherin 5, type 2 (vascular endothelium)0.059
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.058
UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)0.058
HSPB1heat shock 27kDa protein 10.057
ARRB2arrestin, beta 20.056
MYL12Bmyosin, light chain 12B, regulatory0.055
SYKspleen tyrosine kinase0.055
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.055
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.054
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.054
SH3BP2SH3-domain binding protein 20.053
PFN1profilin 10.052
CAV1caveolin 1, caveolae protein, 22kDa0.052
GOLGA2golgin A20.051
SORBS2sorbin and SH3 domain containing 20.048
MAP4K1mitogen-activated protein kinase kinase kinase kinase 10.047
ABI1abl-interactor 10.047
SORBS1sorbin and SH3 domain containing 10.046
MAPK14mitogen-activated protein kinase 140.044
SH3RF1SH3 domain containing ring finger 10.044
SPTBspectrin, beta, erythrocytic0.044
HEXIM1hexamethylene bis-acetamide inducible 10.043
F11RF11 receptor0.043
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tgfb1transforming growth factor, beta 10.962
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.883
Nos3nitric oxide synthase 3, endothelial cell0.847
Csf1colony stimulating factor 1 (macrophage)0.692
Akt1thymoma viral proto-oncogene 10.645
Ilkintegrin linked kinase0.638
Itgb1integrin beta 1 (fibronectin receptor beta)0.572
Abi1abl-interactor 10.570
Itga3integrin alpha 30.560
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.475
Vav1vav 1 oncogene0.456
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.439
Prkceprotein kinase C, epsilon0.431
Grb2growth factor receptor bound protein 20.390
Wdr1WD repeat domain 10.372
Ptprcprotein tyrosine phosphatase, receptor type, C0.368
SrcRous sarcoma oncogene0.365
Enahenabled homolog (Drosophila)0.348
Ctnnd1catenin (cadherin associated protein), delta 10.342
Vdrvitamin D receptor0.330
BlnkB-cell linker0.328
Socs1suppressor of cytokine signaling 10.317
Wipf1WAS/WASL interacting protein family, member 10.316
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform0.306
Stat3signal transducer and activator of transcription 30.293
Inpp5dinositol polyphosphate-5-phosphatase D0.291
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.284
Ptk2PTK2 protein tyrosine kinase 20.280
Ccl2chemokine (C-C motif) ligand 20.278
Bcar1breast cancer anti-estrogen resistance 10.268
Hexahexosaminidase A0.257
Vaspvasodilator-stimulated phosphoprotein0.254
Ccr2chemokine (C-C motif) receptor 20.250
Ptpn6protein tyrosine phosphatase, non-receptor type 60.241
Egfrepidermal growth factor receptor0.239
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.234
Fgfr1fibroblast growth factor receptor 10.232
Ank1ankyrin 1, erythroid0.230
Flt4FMS-like tyrosine kinase 40.229
Smad4MAD homolog 4 (Drosophila)0.227
FynFyn proto-oncogene0.225
Cnn2calponin 20.221
Slc9a3r2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.218
Lyz2lysozyme 20.212
Plcg2phospholipase C, gamma 20.208
Apcadenomatosis polyposis coli0.206
Hcls1hematopoietic cell specific Lyn substrate 10.203
Tnftumor necrosis factor0.191
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.184
Phc2polyhomeotic-like 2 (Drosophila)0.181
Lama5laminin, alpha 50.179
Leprleptin receptor0.178
Il2rbinterleukin 2 receptor, beta chain0.177
Plxnb1plexin B10.171
Laptm5lysosomal-associated protein transmembrane 50.171
Icam1intercellular adhesion molecule 10.168
Mmp9matrix metallopeptidase 90.166
Itgaxintegrin alpha X0.159
Lmnalamin A0.159
Ephb2Eph receptor B20.158
Sept9septin 90.157
Dlg4discs, large homolog 4 (Drosophila)0.148
Gnb2guanine nucleotide binding protein (G protein), beta 20.146
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.146
Hif1ahypoxia inducible factor 1, alpha subunit0.145
Vegfavascular endothelial growth factor A0.144
Iqgap1IQ motif containing GTPase activating protein 10.143
Ptpreprotein tyrosine phosphatase, receptor type, E0.142
Itgb3integrin beta 30.142
Hmha1histocompatibility (minor) HA-10.141
Efnb2ephrin B20.141
WasWiskott-Aldrich syndrome homolog (human)0.140
Cd2apCD2-associated protein0.140
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.140
Mvpmajor vault protein0.139
Sdc3syndecan 30.131
Arpc4actin related protein 2/3 complex, subunit 40.129
Gja1gap junction protein, alpha 10.129
Fmnl1formin-like 10.129
Ric8resistance to inhibitors of cholinesterase 8 homolog (C. elegans)0.124
Sdcbpsyndecan binding protein0.123
Spna2spectrin alpha 20.120
Ptprsprotein tyrosine phosphatase, receptor type, S0.118
Tubb4tubulin, beta 40.116
Rac1RAS-related C3 botulinum substrate 10.116
Ncf1neutrophil cytosolic factor 10.115
Hspg2perlecan (heparan sulfate proteoglycan 2)0.115
Cltcclathrin, heavy polypeptide (Hc)0.114
Lgals3lectin, galactose binding, soluble 30.112
Nrcamneuron-glia-CAM-related cell adhesion molecule0.111
Hckhemopoietic cell kinase0.111
Wdr26WD repeat domain 260.111
Kif5bkinesin family member 5B0.109
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.108
Nr3c1nuclear receptor subfamily 3, group C, member 10.105
Trp53transformation related protein 530.102
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Timm13translocase of inner mitochondrial membrane 13 homolog (yeast)0.017
Stoml2stomatin (Epb7.2)-like 20.013
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
YMR124Whypothetical protein0.011