The network for 'lamellipodium assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

lamellipodium assembly

Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.

NameDescriptionProbabilityFunc Analog Organism
cdc42cell division cycle 420.328
igfbp3insulin-like growth factor binding protein 30.223
robo1roundabout homolog 10.155
gab1GRB2-associated binding protein 10.120
wacaWW domain containing adaptor with coiled-coil a0.113
wnt4awingless-type MMTV integration site family, member 4a0.103
dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.103
ythdf1YTH domain family, member 10.101
gsnagelsolin a0.100
sncbsynuclein, beta0.095
nrp2bneuropilin 2b0.094
arhgdiaRho GDP dissociation inhibitor (GDI) alpha0.093
mitfamicrophthalmia-associated transcription factor a0.086
rhoabras homolog gene family, member Ab0.083
ptprfbprotein tyrosine phosphatase, receptor type, f, b0.081
dvl2dishevelled, dsh homolog 2 (Drosophila)0.080
dag1dystroglycan 10.080
gfi1.1growth factor independent 1.10.075
fzd7afrizzled homolog 7a0.075
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.073
sept8aseptin 8a0.071
ap1g1adaptor-related protein complex 1, gamma 1 subunit0.070
stmstarmaker0.069
cotl1coactosin-like 1 (Dictyostelium)0.067
zgc:91930zgc:919300.067
me2malic enzyme 2, NAD(+)-dependent, mitochondrial0.066
acta1aactin, alpha 1a, skeletal muscle0.065
cdc42ep1CDC42 effector protein (Rho GTPase binding) 10.063
stac3SH3 and cysteine rich domain 30.062
lta4hleukotriene A4 hydrolase0.060
atp6v1alATPase, H+ transporting, lysosomal V1 subunit A, like0.058
aldoabaldolase a, fructose-bisphosphate, b0.058
dip2cDIP2 disco-interacting protein 2 homolog C (Drosophila)0.057
p4ha2procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 20.056
rcn1reticulocalbin 1, EF-hand calcium binding domain0.055
xirp1xin actin-binding repeat containing 10.055
lhx2bLIM homeobox 2b0.054
oepone-eyed pinhead0.053
spry4sprouty (Drosophila) homolog 40.052
zgc:66286zgc:662860.052
gapdhsglyceraldehyde-3-phosphate dehydrogenase, spermatogenic0.052
gsk3bglycogen synthase kinase 3 beta0.051
map2k6mitogen-activated protein kinase kinase 60.051
ndel1anudE nuclear distribution gene E homolog like 1 (A. nidulans) A0.051
bactin1bactin10.050
gng3guanine nucleotide binding protein (G protein), gamma 30.049
spry2sprouty homolog 20.049
hk1hexokinase 10.048
cnn2calponin 20.048
ppm1aaprotein phosphatase, Mg2+/Mn2+ dependent, 1Aa0.048
kif7kinesin family member 70.048
copebcore promoter element binding protein0.048
cyt1type I cytokeratin, enveloping layer0.048
cacnb1calcium channel, voltage-dependent, beta 1 subunit0.048
dzip1DAZ interacting protein 10.045
ergic2ERGIC and golgi 20.045
im:7154036im:71540360.045
mknk2bMAP kinase-interacting serine/threonine kinase 2b0.045
flot1bflotillin 1b0.045
cdh2cadherin 2, neuronal0.045
zgc:113625zgc:1136250.044
arpc5bactin related protein 2/3 complex, subunit 5B0.044
myl9lmyosin, light polypeptide 9, like0.043
msxbmuscle segment homeobox B0.043
ube2i2ubiquitin-conjugating enzyme E2I20.042
vdac3voltage-dependent anion channel 30.042
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.042
snd1staphylococcal nuclease domain containing 10.041
ahcyl1S-adenosylhomocysteine hydrolase-like 10.041
ift46intraflagellar transport protein 460.041
tcea1transcription elongation factor A (SII), 10.041
taf1TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor0.041
wdr1WD repeat domain 10.040
acsbg2acyl-CoA synthetase bubblegum family member 20.040
fgfr3fibroblast growth factor receptor 30.040
zgc:195154zgc:1951540.040
id:ibd2050id:ibd20500.039
skianuclear oncoprotein skia0.039
ap2m1aadaptor-related protein complex 2, mu 1 subunit, a0.039
smyhc1slow myosin heavy chain 10.038
ephb4beph receptor B4b0.038
tbx2bT-box 2b0.038
rc3rabconnectin 30.038
cdk8cyclin-dependent kinase 80.038
bnip3lbBCL2/adenovirus E1B interacting protein 3-like b0.038
wnt10awingless-type MMTV integration site family, member 10a0.037
nsfaN-ethylmaleimide-sensitive factor a0.037
actr3ARP3 actin-related protein 3 homolog (yeast)0.037
ctnnb1catenin (cadherin-associated protein), beta 10.037
ywhag13-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 10.037
map4k5mitogen-activated protein kinase kinase kinase kinase 50.037
ppp2r2dprotein phosphatase 2, regulatory subunit B, delta isoform0.036
midnmidnolin0.036
irx3airoquois homeobox protein 3a0.036
axin1axin 10.035
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.035
tp63tumor protein p630.035
mycbp2MYC binding protein 20.035
aldoaaaldolase a, fructose-bisphosphate, a0.035
ulk2unc-51-like kinase 2 (C. elegans)0.034
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
cdc-42Protein CDC-420.517
mig-2Protein MIG-20.301
unc-96Protein UNC-960.181
hmp-1Protein HMP-10.175
unc-32Protein UNC-320.168
C06G3.6Protein C06G3.60.161
ina-1Protein INA-10.143
lmn-1Protein LMN-10.118
goa-1Protein GOA-10.118
sax-3Protein SAX-30.113
CELE_T04H1.2Protein T04H1.20.101
unc-73Protein UNC-730.100
C52B9.4Protein C52B9.40.094
etr-1Protein ETR-10.093
cam-1Protein CAM-10.093
arx-1Protein ARX-10.093
ced-10Protein CED-100.092
vps-32.1Protein VPS-32.10.092
unc-16Protein UNC-160.089
unc-9Protein UNC-90.083
pkn-1Protein PKN-10.080
clh-5Protein CLH-50.080
unc-104Protein UNC-1040.079
unc-36Protein UNC-360.078
gsp-1Protein GSP-10.070
air-2Protein AIR-20.065
sel-12Protein SEL-120.061
unc-108Protein UNC-1080.058
pph-4.1Protein PPH-4.10.058
rgs-7Protein RGS-70.058
lir-1Protein LIR-10.056
F38A5.1Protein F38A5.10.055
CELE_B0238.10Protein B0238.100.055
syg-1Protein SYG-10.054
EEED8.10Protein EEED8.100.053
rig-4Protein RIG-40.043
memb-1Protein MEMB-10.043
K10C3.4Protein K10C3.40.041
tag-175Protein TAG-1750.041
Y77E11A.1Protein Y77E11A.10.041
cpna-5Protein CPNA-50.041
pqn-55Protein PQN-550.041
gmeb-1Protein GMEB-10.040
tba-1Protein TBA-10.039
unc-60Protein UNC-600.039
C24A3.2Protein C24A3.20.036
acs-17Protein ACS-170.035
mab-5Protein MAB-50.035
hid-1Protein HID-10.035
abl-1Protein ABL-10.035
C11E4.6Protein C11E4.60.034
cdf-1Protein CDF-10.034
sem-5Protein SEM-50.034
snf-1Protein SNF-10.034
C34F6.10Protein C34F6.100.033
gex-3Protein GEX-30.032
hlh-30Protein HLH-300.032
emb-9Protein EMB-90.032
F21A10.2Protein F21A10.20.032
C11H1.3Protein C11H1.30.032
C18A3.4Protein C18A3.40.031
glit-1Protein GLIT-10.031
pat-3Protein PAT-30.031
C06G1.5Protein C06G1.50.031
unc-68Protein UNC-680.030
ykt-6Protein YKT-60.030
rsbp-1Protein RSBP-10.028
tag-241Protein TAG-2410.028
C46C11.1Protein C46C11.10.028
atg-11Protein ATG-110.028
ost-1Protein OST-10.028
T04F8.6Protein T04F8.60.028
dpm-1Protein DPM-10.028
nhr-49Protein NHR-490.027
sorb-1Protein SORB-10.027
cst-1Protein CST-10.027
twk-31Protein TWK-310.027
D2013.6Protein D2013.60.027
C18E9.2Protein C18E9.20.026
scpl-2Protein SCPL-20.026
T19A6.1Protein T19A6.10.026
T03G6.3Protein T03G6.30.025
swan-2Protein SWAN-20.025
xnp-1Protein XNP-10.025
W06A7.2Protein W06A7.20.025
tat-5Protein TAT-50.024
F41H10.3Protein F41H10.30.024
sad-1Protein SAD-10.024
sor-1Protein SOR-10.024
ehs-1Protein EHS-10.024
F54E4.3Protein F54E4.30.023
R151.8Protein R151.80.023
C52E12.4Protein C52E12.40.023
K04G7.1Protein K04G7.10.022
unc-50Protein UNC-500.022
mig-38Protein MIG-380.022
cdh-4Protein CDH-40.022
smgl-1Protein SMGL-10.022
C41H7.5Protein C41H7.50.022
F22D3.2Protein F22D3.20.022
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Rac1CG2248 gene product from transcript CG2248-RA0.522
mbcmyoblast city0.515
HemHEM-protein0.513
Rho1CG8416 gene product from transcript CG8416-RB0.504
EphrinCG1862 gene product from transcript CG1862-RA0.416
Sra-1specifically Rac1-associated protein 10.384
roboroundabout0.372
cpbcapping protein beta0.343
dadaughterless0.326
chicchickadee0.325
Arp66BActin-related protein 66B0.313
enaenabled0.309
Vrp1Verprolin 10.283
Rac2CG8556 gene product from transcript CG8556-RA0.184
par-1CG8201 gene product from transcript CG8201-RA0.181
S6kRPS6-p70-protein kinase0.158
Sop2Suppressor of profilin 20.151
Arp14DActin-related protein 14D0.119
RanBPMRan-binding protein M0.089
DlicDynein light intermediate chain0.088
AblAbl tyrosine kinase0.079
Arc-p34CG10954 gene product from transcript CG10954-RA0.077
MrtfMyocardin-related transcription factor0.073
ctaconcertina0.068
Pak3CG14895 gene product from transcript CG14895-RA0.066
numbCG3779 gene product from transcript CG3779-RB0.057
Src64BSrc oncogene at 64B0.054
bazbazooka0.053
l(2)k16918lethal (2) k169180.052
wbwing blister0.051
twitwist0.050
Dcr-1Dicer-10.049
Myo31DFMyosin 31DF0.048
AbiAbelson interacting protein0.047
twftwinfilin0.045
zfh1Zn finger homeodomain 10.044
BicDBicaudal D0.043
Rpn6Proteasome p44.5 subunit0.041
RalaRas-related protein0.040
midmidline0.040
matsmob as tumor suppressor0.040
lqfRliquid facets-Related0.038
commcommissureless0.037
simsingle-minded0.036
DscamDown syndrome cell adhesion molecule0.035
CG17082CG17082 gene product from transcript CG17082-RD0.033
konkon-tiki0.032
bskbasket0.032
flrflare0.032
cpacapping protein alpha0.032
ChcClathrin heavy chain0.031
IlkIntegrin linked kinase0.031
Six4CG3871 gene product from transcript CG3871-RA0.030
FucT6alpha1,6-fucosyltransferase0.030
CG14869CG14869 gene product from transcript CG14869-RB0.030
taitaiman0.029
slislit0.029
14-3-3zetaCG17870 gene product from transcript CG17870-RB0.028
kuzkuzbanian0.028
pllpelle0.028
pod1CG4532 gene product from transcript CG4532-RF0.028
RhoGEF2CG9635 gene product from transcript CG9635-RF0.027
otkoff-track0.027
LamCLamin C0.027
Gyc76CGuanylyl cyclase at 76C0.026
trioCG18214 gene product from transcript CG18214-RA0.026
p120ctnAdherens junction protein p1200.026
Wnt5Wnt oncogene analog 50.025
exbaextra bases0.025
RhoGAPp190CG32555 gene product from transcript CG32555-RB0.024
CortactinCG3637 gene product from transcript CG3637-RA0.024
msnmisshapen0.024
RhoGAP93BCG3421 gene product from transcript CG3421-RA0.024
CG3563CG3563 gene product from transcript CG3563-RA0.023
hkbhuckebein0.023
laceCG4162 gene product from transcript CG4162-RA0.023
btlbreathless0.023
ininturned0.023
Pros25Proteasome 25kD subunit0.022
Cdc42CG12530 gene product from transcript CG12530-RA0.022
tuptailup0.022
binbiniou0.021
lealeak0.020
Arf51FADP ribosylation factor 51F0.020
Pkc98EProtein C kinase 98E0.020
HSPC300CG30173 gene product from transcript CG30173-RA0.020
fzfrizzled0.019
Lim3CG10699 gene product from transcript CG10699-RB0.019
blowblown fuse0.019
Stat92ESignal-transducer and activator of transcription protein at 92E0.018
rolsrolling pebbles0.018
CG11791CG11791 gene product from transcript CG11791-RB0.018
hdhumpty dumpty0.017
zipzipper0.017
beta-Specbeta Spectrin0.016
spospook0.016
kelkelch0.015
kniknirps0.015
PakPAK-kinase0.015
TlToll0.015
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.990
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.982
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.916
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.865
ILKintegrin-linked kinase0.844
BAIAP2BAI1-associated protein 20.648
GRB7growth factor receptor-bound protein 70.637
ZNF746zinc finger protein 7460.618
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.377
GAS7growth arrest-specific 70.323
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.323
PRKCZprotein kinase C, zeta0.303
VAV1vav 1 guanine nucleotide exchange factor0.265
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.226
SPTAN1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)0.210
NCKAP1NCK-associated protein 10.202
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.196
JUPjunction plakoglobin0.171
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.170
ARPC3actin related protein 2/3 complex, subunit 3, 21kDa0.169
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.166
DVL3dishevelled, dsh homolog 3 (Drosophila)0.163
ARPC1Bactin related protein 2/3 complex, subunit 1B, 41kDa0.156
SH3GL3SH3-domain GRB2-like 30.119
SHC1SHC (Src homology 2 domain containing) transforming protein 10.117
TWF2twinfilin, actin-binding protein, homolog 2 (Drosophila)0.116
PLCG1phospholipase C, gamma 10.110
LRRK2leucine-rich repeat kinase 20.109
CAP1CAP, adenylate cyclase-associated protein 1 (yeast)0.098
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.098
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 10.097
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.096
CD2APCD2-associated protein0.089
ATN1atrophin 10.086
MAPK8mitogen-activated protein kinase 80.084
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.083
CAPZBcapping protein (actin filament) muscle Z-line, beta0.081
LIMS1LIM and senescent cell antigen-like domains 10.074
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.070
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.060
NUMBnumb homolog (Drosophila)0.060
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.059
EPS8epidermal growth factor receptor pathway substrate 80.054
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.051
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.050
ACTR2ARP2 actin-related protein 2 homolog (yeast)0.046
SORBS3sorbin and SH3 domain containing 30.045
DVL1dishevelled, dsh homolog 1 (Drosophila)0.044
PFN1profilin 10.043
LDOC1leucine zipper, down-regulated in cancer 10.043
HCKhemopoietic cell kinase0.042
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.042
PFDN1prefoldin subunit 10.039
LLGL1lethal giant larvae homolog 1 (Drosophila)0.037
EFNA5ephrin-A50.037
ABI2abl-interactor 20.037
ARPC5actin related protein 2/3 complex, subunit 5, 16kDa0.036
EFNA1ephrin-A10.036
PACSIN1protein kinase C and casein kinase substrate in neurons 10.034
DOCK1dedicator of cytokinesis 10.034
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.033
TRIP6thyroid hormone receptor interactor 60.032
WASF1WAS protein family, member 10.031
CDC42EP3CDC42 effector protein (Rho GTPase binding) 30.031
RAC2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)0.031
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.030
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.029
GRB10growth factor receptor-bound protein 100.029
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.029
TRIP10thyroid hormone receptor interactor 100.027
FYBFYN binding protein0.027
CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b0.026
FASLGFas ligand (TNF superfamily, member 6)0.025
PRKCIprotein kinase C, iota0.025
WASLWiskott-Aldrich syndrome-like0.025
DSG2desmoglein 20.024
NCKIPSDNCK interacting protein with SH3 domain0.024
TCF4transcription factor 40.024
FAT1FAT tumor suppressor homolog 1 (Drosophila)0.023
KITLGKIT ligand0.023
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.023
PKP3plakophilin 30.023
SH2D1ASH2 domain containing 1A0.022
DEF6differentially expressed in FDCP 6 homolog (mouse)0.022
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.022
LRP6low density lipoprotein receptor-related protein 60.022
CTNND1catenin (cadherin-associated protein), delta 10.022
LLGL2lethal giant larvae homolog 2 (Drosophila)0.022
NPTNneuroplastin0.021
FERMT2fermitin family member 20.021
FZD1frizzled homolog 1 (Drosophila)0.020
CHRDchordin0.020
ZNF71zinc finger protein 710.020
IRS1insulin receptor substrate 10.019
PARVAparvin, alpha0.019
PTK6PTK6 protein tyrosine kinase 60.019
SNAI1snail homolog 1 (Drosophila)0.019
RICTORRPTOR independent companion of MTOR, complex 20.018
MOBKL1BMOB1, Mps One Binder kinase activator-like 1B (yeast)0.018
COTL1coactosin-like 1 (Dictyostelium)0.018
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism