The network for 'regulation of cell killing' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of cell killing

Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism.

NameDescriptionProbabilityFunc Analog Organism
polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.231
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.132
trim25tripartite motif-containing 250.077
LOC566020Gig2-like protein DreO0.077
scarb1scavenger receptor class B, member 10.073
lrrc33leucine rich repeat containing 330.063
yrkYes-related kinase0.062
LOC100535854ubiquitin carboxyl-terminal hydrolase CYLD-like0.058
hbbe1.1hemoglobin beta embryonic-1.10.056
casp8caspase 8, apoptosis-related cysteine peptidase0.052
npy4rneuropeptide Y receptor Y40.052
fcho2FCH domain only 20.048
stat1asignal transduction and activation of transcription 1a0.045
fasFas (TNF receptor superfamily, member 6)0.040
tfap2etranscription factor AP-2 epsilon0.038
ppp2r5eaprotein phosphatase 2, regulatory subunit B', epsilon isoform a0.036
grnagranulin a0.035
pax7bpaired box gene 7b0.034
sqstm1sequestosome 10.034
stat1bsignal transducer and activator of transcription 1b0.032
ifnphi1interferon phi 10.032
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.032
apaf1apoptotic protease activating factor 10.029
etnk1ethanolamine kinase 10.029
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.029
asah1bN-acylsphingosine amidohydrolase (acid ceramidase) 1b0.028
defbl3defensin, beta-like 30.028
g6pdglucose-6-phosphate dehydrogenase0.028
ugt5c2UDP glucuronosyltransferase 5 family, polypeptide C20.028
irf11interferon regulatory factor 110.027
pkzprotein kinase containing Z-DNA binding domains0.027
spns2spinster homolog 2 (Drosophila)0.026
mcl1amyeloid cell leukemia sequence 1a0.026
c1qbcomplement component 1, q subcomponent, B chain0.025
impdh1binosine 5'-phosphate dehydrogenase 1b0.025
cxcr3.2chemokine (C-X-C motif) receptor 3.20.025
LOC792676similar to N-myc-interactor (Nmi) (N-myc and STAT interactor)0.025
prkar1aaprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a0.025
pygmbphosphorylase, glycogen (muscle) b0.025
arl4aaADP-ribosylation factor-like 4aa0.025
styk1serine/threonine/tyrosine kinase 10.024
mst1rbmacrophage stimulating 1 receptor (c-met-related tyrosine kinase), b0.024
cflarCASP8 and FADD-like apoptosis regulator0.024
fcer1glFc receptor, IgE, high affinity I, gamma polypeptide like0.023
gsk3bglycogen synthase kinase 3 beta0.022
col5a3collagen, type V, alpha 30.022
c3ccomplement component c3c0.022
hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.021
ugt5a2UDP glucuronosyltransferase 5 family, polypeptide A20.021
psmb9aproteasome (prosome, macropain) subunit, beta type, 9a0.021
npy7rneuropeptide Y receptor Y70.021
cnnm2acyclin M2a0.021
wacaWW domain containing adaptor with coiled-coil a0.021
gna13aguanine nucleotide binding protein (G protein), alpha 13a0.021
sp8bsp8 transcription factor b0.021
mep1a.1meprin A, alpha.10.021
casp9caspase 9, apoptosis-related cysteine protease0.020
c1qccomplement component 1, q subcomponent, C chain0.020
ifi35interferon-induced protein 350.020
gadd45aagrowth arrest and DNA-damage-inducible, alpha, a0.020
nos2anitric oxide synthase 2a, inducible0.020
tlr4bbtoll-like receptor 4b, duplicate b0.020
gnsbglucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID), b0.020
isg15ISG15 ubiquitin-like modifier0.019
sdcbpsyndecan binding protein (syntenin)0.019
mxamyxovirus (influenza) resistance A0.019
itga2bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)0.019
nitr8novel immune-type receptor 80.019
gpr137bbG protein-coupled receptor 137bb0.019
slc9a1solute carrier family 9 (sodium/hydrogen exchanger), member 10.019
kpna3karyopherin (importin) alpha 30.019
itln1intelectin 10.019
c3bcomplement component c3b0.018
illr1immune-related, lectin-like receptor 10.018
LOC100005232Gig2-like protein DreD0.018
ip6k2inositol hexaphosphate kinase 20.018
pttg1ipbpituitary tumor-transforming 1 interacting protein b0.018
faddFas (tnfrsf6)-associated via death domain0.017
gbp1guanylate binding protein 10.017
atp2b4ATPase, Ca++ transporting, plasma membrane 40.017
il12bbinterleukin 12B, b0.017
csf1racolony stimulating factor 1 receptor, a0.017
irgq1immunity-related GTPase family, q10.017
nitr4anovel immune-type receptor 4a0.017
LOC100005454Gig2-like protein DreK0.017
fxr2fragile X mental retardation, autosomal homolog 20.017
lats1LATS, large tumor suppressor, homolog 1 (Drosophila)0.017
cd209CD209 molecule0.017
slc12a10.1solute carrier family 12 (sodium/potassium/chloride transporters), member 10.10.017
LOC567131calcitonin gene-related peptide type 1 receptor-like0.017
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HLA-Bmajor histocompatibility complex, class I, B0.975
HLA-Amajor histocompatibility complex, class I, A0.975
HLA-Cmajor histocompatibility complex, class I, C0.975
HLA-Gmajor histocompatibility complex, class I, G0.936
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.909
HLA-Emajor histocompatibility complex, class I, E0.870
HLA-Fmajor histocompatibility complex, class I, F0.838
KLRD1killer cell lectin-like receptor subfamily D, member 10.789
TAPBPTAP binding protein (tapasin)0.784
IL2RBinterleukin 2 receptor, beta0.739
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.649
CCL4chemokine (C-C motif) ligand 40.646
SH2D1ASH2 domain containing 1A0.629
SLAMF1signaling lymphocytic activation molecule family member 10.621
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.534
CD84CD84 molecule0.526
CCR5chemokine (C-C motif) receptor 50.515
CASP8caspase 8, apoptosis-related cysteine peptidase0.479
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.435
CCL5chemokine (C-C motif) ligand 50.394
IL8interleukin 80.372
CXCL9chemokine (C-X-C motif) ligand 90.362
IL1Binterleukin 1, beta0.265
PTPN1protein tyrosine phosphatase, non-receptor type 10.240
CCL8chemokine (C-C motif) ligand 80.226
NOSTRINnitric oxide synthase trafficker0.226
CCR1chemokine (C-C motif) receptor 10.179
IL6interleukin 6 (interferon, beta 2)0.170
GBAglucosidase, beta, acid0.155
MAPK1mitogen-activated protein kinase 10.145
CD2CD2 molecule0.143
IFNGinterferon, gamma0.139
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.122
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.118
CCR7chemokine (C-C motif) receptor 70.110
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.107
KLRC3killer cell lectin-like receptor subfamily C, member 30.080
BIDBH3 interacting domain death agonist0.080
CCL2chemokine (C-C motif) ligand 20.078
CCL20chemokine (C-C motif) ligand 200.077
CCL13chemokine (C-C motif) ligand 130.077
ICAM1intercellular adhesion molecule 10.077
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.076
RAB14RAB14, member RAS oncogene family0.075
PILRApaired immunoglobin-like type 2 receptor alpha0.075
KLRK1killer cell lectin-like receptor subfamily K, member 10.072
ITM2Bintegral membrane protein 2B0.071
CCL7chemokine (C-C motif) ligand 70.070
VAMP4vesicle-associated membrane protein 40.062
DPP4dipeptidyl-peptidase 40.061
CCR2chemokine (C-C motif) receptor 20.061
PTPN6protein tyrosine phosphatase, non-receptor type 60.060
SIGLEC7sialic acid binding Ig-like lectin 70.060
CXCL2chemokine (C-X-C motif) ligand 20.059
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.059
GZMKgranzyme K (granzyme 3; tryptase II)0.058
PVRL4poliovirus receptor-related 40.057
CCL22chemokine (C-C motif) ligand 220.054
IL18RAPinterleukin 18 receptor accessory protein0.053
KLRC2killer cell lectin-like receptor subfamily C, member 20.053
CXCL3chemokine (C-X-C motif) ligand 30.052
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.051
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.049
CXCR6chemokine (C-X-C motif) receptor 60.045
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.044
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.042
NKG7natural killer cell group 7 sequence0.041
PSMB8proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)0.041
TNFRSF12Atumor necrosis factor receptor superfamily, member 12A0.038
HK3hexokinase 3 (white cell)0.037
PVRL2poliovirus receptor-related 2 (herpesvirus entry mediator B)0.037
CD48CD48 molecule0.036
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.035
INSRinsulin receptor0.035
TNFtumor necrosis factor0.035
CAV1caveolin 1, caveolae protein, 22kDa0.034
CCR4chemokine (C-C motif) receptor 40.034
CD8ACD8a molecule0.032
CD163CD163 molecule0.031
CLEC10AC-type lectin domain family 10, member A0.031
CD3GCD3g molecule, gamma (CD3-TCR complex)0.031
GPR171G protein-coupled receptor 1710.031
IDEinsulin-degrading enzyme0.031
ITKIL2-inducible T-cell kinase0.031
KLRB1killer cell lectin-like receptor subfamily B, member 10.029
XCL2chemokine (C motif) ligand 20.029
GPR65G protein-coupled receptor 650.028
IFI35interferon-induced protein 350.028
CCL11chemokine (C-C motif) ligand 110.027
PVRL1poliovirus receptor-related 1 (herpesvirus entry mediator C)0.027
FCN1ficolin (collagen/fibrinogen domain containing) 10.027
SKAP1src kinase associated phosphoprotein 10.027
CXCL5chemokine (C-X-C motif) ligand 50.026
CSF2RAcolony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)0.026
TJP1tight junction protein 1 (zona occludens 1)0.025
IL7Rinterleukin 7 receptor0.024
NLRP3NLR family, pyrin domain containing 30.024
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
H2-K1histocompatibility 2, K1, K region0.998
H2-D1histocompatibility 2, D region locus 10.926
B2mbeta-2 microglobulin0.905
H2-Q7histocompatibility 2, Q region locus 70.889
FaslFas ligand (TNF superfamily, member 6)0.886
TapbpTAP binding protein0.871
Klrc1killer cell lectin-like receptor subfamily C, member 10.849
Klra9killer cell lectin-like receptor subfamily A, member 90.823
Slamf1signaling lymphocytic activation molecule family member 10.812
FynFyn proto-oncogene0.758
Ncr1natural cytotoxicity triggering receptor 10.711
Klrk1killer cell lectin-like receptor subfamily K, member 10.652
Gzmkgranzyme K0.593
Klrb1ckiller cell lectin-like receptor subfamily B member 1C0.590
Pnp2purine-nucleoside phosphorylase 20.542
Klrd1killer cell lectin-like receptor, subfamily D, member 10.527
Xcl1chemokine (C motif) ligand 10.525
Latlinker for activation of T cells0.521
Gzmagranzyme A0.475
Cd247CD247 antigen0.450
Il2rginterleukin 2 receptor, gamma chain0.395
Ccr9chemokine (C-C motif) receptor 90.380
Gzmbgranzyme B0.346
Tnfaip3tumor necrosis factor, alpha-induced protein 30.327
Casp8caspase 80.323
Lcklymphocyte protein tyrosine kinase0.314
H2-Q8histocompatibility 2, Q region locus 80.314
Il18rapinterleukin 18 receptor accessory protein0.310
Ctswcathepsin W0.301
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.290
Icosinducible T-cell co-stimulator0.280
Arrb1arrestin, beta 10.276
ItkIL2-inducible T-cell kinase0.269
Ciitaclass II transactivator0.264
Il2rbinterleukin 2 receptor, beta chain0.228
Ccl5chemokine (C-C motif) ligand 50.205
Klrb1akiller cell lectin-like receptor subfamily B member 1A0.199
Ctsbcathepsin B0.198
Map3k8mitogen-activated protein kinase kinase kinase 80.169
Ms4a1membrane-spanning 4-domains, subfamily A, member 10.154
Il2rainterleukin 2 receptor, alpha chain0.148
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.141
H2-Q5histocompatibility 2, Q region locus 50.132
Sh2d2aSH2 domain protein 2A0.125
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.123
Il7rinterleukin 7 receptor0.120
Cd244CD244 natural killer cell receptor 2B40.116
H2-Q6histocompatibility 2, Q region locus 60.113
Itga4integrin alpha 40.110
Cxcl9chemokine (C-X-C motif) ligand 90.108
Il18r1interleukin 18 receptor 10.108
Il2interleukin 20.108
Slamf7SLAM family member 70.103
Slamf8SLAM family member 80.099
Gbp7guanylate binding protein 70.099
Cd160CD160 antigen0.099
Il12binterleukin 12b0.098
Ctla4cytotoxic T-lymphocyte-associated protein 40.098
Stat1signal transducer and activator of transcription 10.097
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.097
Itgaxintegrin alpha X0.096
Gpr33G protein-coupled receptor 330.094
Cxcl2chemokine (C-X-C motif) ligand 20.091
Cxcl1chemokine (C-X-C motif) ligand 10.090
Ifnginterferon gamma0.090
Cd84CD84 antigen0.086
Mmp13matrix metallopeptidase 130.085
Gbp2guanylate binding protein 20.085
Cxcl10chemokine (C-X-C motif) ligand 100.083
Klrg1killer cell lectin-like receptor subfamily G, member 10.082
Nkg7natural killer cell group 7 sequence0.081
Il6interleukin 60.079
H2-Eb1histocompatibility 2, class II antigen E beta0.079
Ccr3chemokine (C-C motif) receptor 30.077
Glrp1glutamine repeat protein 10.075
Cd86CD86 antigen0.074
Il1rninterleukin 1 receptor antagonist0.072
Il4rainterleukin 4 receptor, alpha0.071
Klra8killer cell lectin-like receptor, subfamily A, member 80.071
Pyhin1pyrin and HIN domain family, member 10.071
Irg1immunoresponsive gene 10.071
Cd180CD180 antigen0.069
Dnase1l3deoxyribonuclease 1-like 30.068
Ccl4chemokine (C-C motif) ligand 40.067
Klra3killer cell lectin-like receptor, subfamily A, member 30.067
Ubdubiquitin D0.067
Cd7CD7 antigen0.066
Klra2killer cell lectin-like receptor, subfamily A, member 20.063
AW112010expressed sequence AW1120100.063
Nfkbienuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.063
Cxcr3chemokine (C-X-C motif) receptor 30.062
Selpselectin, platelet0.061
C920025E04RikRIKEN cDNA C920025E04 gene0.061
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.060
Cxcr6chemokine (C-X-C motif) receptor 60.060
Cd96CD96 antigen0.059
Il23ainterleukin 23, alpha subunit p190.058
Klra6killer cell lectin-like receptor, subfamily A, member 60.057
Cd3dCD3 antigen, delta polypeptide0.056
Klrb1fkiller cell lectin-like receptor subfamily B member 1F0.056
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-EC2RT1 class Ib, locus EC20.983
Cxcl10chemokine (C-X-C motif) ligand 100.586
RT1-CE12RT1 class I, locus CE120.556
Klrd1killer cell lectin-like receptor, subfamily D, member 10.410
Gzmbgranzyme B0.408
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.287
Mmp12matrix metallopeptidase 120.238
Hsph1heat shock 105/110 protein 10.203
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.201
Gzmkgranzyme K0.192
Nkg7natural killer cell group 7 sequence0.189
Rt1.aaMHC class I RT1.Aa alpha-chain0.121
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.120
Neurl3neuralized homolog 3 (Drosophila)0.093
RT1-S3RT1 class Ib, locus S30.089
Mcpt8mast cell protease 80.086
Il2rbinterleukin 2 receptor, beta0.082
Sellselectin L0.080
Cd247Cd247 molecule0.076
Ccl5chemokine (C-C motif) ligand 50.074
Ccl4chemokine (C-C motif) ligand 40.073
Il7rinterleukin 7 receptor0.066
LOC100364500RT1 class I, locus CE11-like0.062
Il1binterleukin 1 beta0.059
Hspb1heat shock protein 10.058
Ccl2chemokine (C-C motif) ligand 20.058
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.057
Atf3activating transcription factor 30.054
RT1-ClRT1 class Ib, locus Cl0.047
Ccr2chemokine (C-C motif) receptor 20.046
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.046
Igsf6immunoglobulin superfamily, member 60.043
Klra5killer cell lectin-like receptor, subfamily A, member 50.042
Ugt1a7cUDP glucuronosyltransferase 1 family, polypeptide A7C0.040
RT1-M3-1RT1 class Ib, locus M3, gene 10.038
RT1-N3RT1 class Ib, locus N30.038
Casp1caspase 10.036
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.036
Gimap4GTPase, IMAP family member 40.035
Prf1perforin 1 (pore forming protein)0.034
Ubbubiquitin B0.033
Ccl7chemokine (C-C motif) ligand 70.032
Cd2Cd2 molecule0.031
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.031
Tnftumor necrosis factor (TNF superfamily, member 2)0.031
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.031
Cd8aCD8a molecule0.030
Fut2fucosyltransferase 2 (secretor status included)0.029
Ccl3chemokine (C-C motif) ligand 30.029
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.028
Cd53Cd53 molecule0.028
Dnaja4DnaJ (Hsp40) homolog, subfamily A, member 40.027
Il6interleukin 60.026
Ear11eosinophil-associated, ribonuclease A family, member 110.024
Gzmagranzyme A0.024
Bcl2a1dB-cell leukemia/lymphoma 2 related protein A1d0.024
Xcl1chemokine (C motif) ligand 10.023
Ccr5chemokine (C-C motif) receptor 50.023
Cd14CD14 molecule0.022
Dcaf7DDB1 and CUL4 associated factor 70.022
LOC300024similar to Ly6-B antigen gene0.022
Oas1a2'-5' oligoadenylate synthetase 1A0.021
Gbp2guanylate binding protein 20.021
Fth1ferritin, heavy polypeptide 10.021
Cxcr4chemokine (C-X-C motif) receptor 40.020
RT1-BaRT1 class II, locus Ba0.020
Slc8a1solute carrier family 8 (sodium/calcium exchanger), member 10.020
Csf1colony stimulating factor 1 (macrophage)0.020
RGD1562844similar to serine (or cysteine) proteinase inhibitor, clade B, member 90.020
F2rl1coagulation factor II (thrombin) receptor-like 10.019
Irf1interferon regulatory factor 10.019
Klrb1akiller cell lectin-like receptor subfamily B, member 1A0.019
Tfectranscription factor EC0.019
Slfn2schlafen 20.019
Tlr7toll-like receptor 70.019
Zap70zeta-chain (TCR) associated protein kinase0.019
Plaurplasminogen activator, urokinase receptor0.019
RT1-CE16RT1 class I, locus CE160.018
Junbjun B proto-oncogene0.018
Mmp7matrix metallopeptidase 70.017
Clec9aC-type lectin domain family 9, member a0.015
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.014
Plcg2phospholipase C, gamma 20.014
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.014
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.014
Klrk1killer cell lectin-like receptor subfamily K, member 10.014
Lyz2lysozyme 20.014
Rhohras homolog gene family, member H0.014
Mapk3mitogen activated protein kinase 30.013
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.013
Irf2interferon regulatory factor 20.013
Seleselectin E0.012
Rgs1regulator of G-protein signaling 10.012
Ubdubiquitin D0.012
Golph3golgi phosphoprotein 3 (coat-protein)0.011
Itm2bintegral membrane protein 2B0.011
Cetn2centrin, EF-hand protein, 20.011
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism