The network for 'developmental programmed cell death' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

developmental programmed cell death

The activation of endogenous cellular processes that result in the death of a cell as part of its development.

NameDescriptionProbabilityFunc Analog Organism
pax8paired box gene 80.846
eng2aengrailed 2a0.828
tp73tumor protein p730.701
ptf1apancreas specific transcription factor, 1a0.547
ascl1aachaete-scute complex-like 1a (Drosophila)0.481
baxabcl2-associated X protein, a0.427
flhfloating head0.425
jag2jagged 20.382
wnt1wingless-type MMTV integration site family, member 10.347
otx5orthodenticle homolog 50.342
nr2e3nuclear receptor subfamily 2, group E, member 30.331
vsx2visual system homeobox 20.311
sox10SRY-box containing gene 100.281
hoxd11ahomeo box D11a0.233
slc15a2solute carrier family 15 (H+/peptide transporter), member 20.226
evx1even-skipped homeobox 10.219
nkx2.2aNK2 transcription factor related 2a0.211
pax2bpaired box gene 2b0.205
bmp4bone morphogenetic protein 40.202
pax5paired box gene 50.195
lhx2bLIM homeobox 2b0.178
lmx1b.1LIM homeobox transcription factor 1, beta 10.171
coblcordon-bleu homolog (mouse)0.167
wnt7bbwingless-type MMTV integration site family, member 7Bb0.167
neurog1neurogenin 10.153
egr2bearly growth response 2b0.147
atoh7atonal homolog 70.146
tfe3btranscription factor binding to IGHM enhancer 3b0.145
sox9bSRY-box containing gene 9b0.141
wnt8bwingless-type MMTV integration site family, member 8b0.140
neurod4neurogenic differentiation 40.135
fgfr1afibroblast growth factor receptor 1a0.133
eng1aengrailed 1a0.130
trpm7transient receptor potential cation channel, subfamily M, member 70.125
irx3biroquois homeobox protein 3b0.123
mmp9matrix metalloproteinase 90.122
nkx2.3NK2 transcription factor related 30.119
hhiphedgehog interacting protein0.118
cdkn1acyclin-dependent kinase inhibitor 1A0.117
cmybtranscription factor cmyb0.117
fgf8bfibroblast growth factor 8 b0.116
notch3notch homolog 30.115
ccdc151coiled-coil domain containing 1510.113
fgf3fibroblast growth factor 30.110
pou3f3bPOU class 3 homeobox 3b0.109
sfrp5secreted frizzled-related protein 50.109
tbx2bT-box 2b0.109
lrrc6leucine rich repeat containing 60.108
eya1eyes absent homolog 10.107
foxi1forkhead box I10.105
notch1anotch homolog 1a0.105
rx1retinal homeobox gene 10.104
aldh1a2aldehyde dehydrogenase 1 family, member A20.103
rx2retinal homeobox gene 20.100
fgf22fibroblast growth factor 220.100
pdlim2PDZ and LIM domain 2 (mystique)0.097
hoxc5ahomeo box C5a0.097
gata3GATA-binding protein 30.097
chpfchondroitin polymerizing factor0.095
phox2apaired-like homeobox 2a0.094
lhx5LIM homeobox 50.093
per2period homolog 2 (Drosophila)0.092
oc90otoconin 900.092
osr2odd-skipped related 2 (Drosophila)0.090
prdm16PR domain containing 160.089
hoxa5ahomeo box A5a0.089
prox1prospero-related homeobox gene 10.089
crb1crumbs homolog 1 (Drosophila)0.086
fgf10afibroblast growth factor 10a0.084
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.082
rorcaRAR-related orphan receptor C a0.081
gadd45aagrowth arrest and DNA-damage-inducible, alpha, a0.078
exorhextra-ocular rhodopsin0.078
tmem2transmembrane protein 20.077
hnf4ahepatocyte nuclear factor 4, alpha0.076
sbf1SET binding factor 10.075
vwa2von Willebrand factor A domain containing 20.075
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.075
mitfamicrophthalmia-associated transcription factor a0.074
pou3f3aPOU class 3 homeobox 3a0.074
pax6apaired box gene 6a0.073
pcsk5aproprotein convertase subtilisin/kexin type 5a0.073
cyp19a1acytochrome P450, family 19, subfamily A, polypeptide 1a0.071
uba1ubiquitin-like modifier activating enzyme 10.070
crb2acrumbs homolog 2a0.069
nr5a2nuclear receptor subfamily 5, group A, member 20.068
hoxc11ahomeo box C11a0.068
vsx1visual system homeobox 1 homolog, chx10-like0.068
wt1awilms tumor 1a0.067
dll4delta-like 4 (Drosophila)0.067
mab21l2mab-21-like 20.067
gdnfglial cell derived neurotrophic factor0.067
foxe1forkhead box E1 (thyroid transcription factor 2)0.066
ihhaIndian hedgehog homolog a0.064
cdh6cadherin 60.064
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Dcp-1Death caspase-10.980
fkhfork head0.891
Atg18Autophagy-specific gene 180.877
cicubitus interruptus0.859
EcREcdysone receptor0.839
Tak1TGF-beta activated kinase 10.827
Atg9Autophagy-specific gene 90.819
Pi3K59FPhosphotidylinositol 3 kinase 59F0.812
Atg1Autophagy-specific gene 10.768
Eip93FCG18389 gene product from transcript CG18389-RB0.751
Atg8aAutophagy-specific gene 8a0.735
trptransient receptor potential0.702
Pi3K92ECG4141 gene product from transcript CG4141-RB0.660
debcldeath executioner Bcl-2 homologue0.655
ninaEneither inactivation nor afterpotential E0.618
NcNedd2-like caspase0.610
JraJun-related antigen0.589
CG11347CG11347 gene product from transcript CG11347-RE0.565
rapretina aberrant in pattern0.484
RfabgRetinoid- and fatty acid-binding glycoprotein0.483
Eip74EFEcdysone-induced protein 74EF0.472
smi35Asmell impaired 35A0.460
PebProtein ejaculatory bulb0.452
TorTarget of rapamycin0.449
ovoCG6824 gene product from transcript CG6824-RE0.426
RagACG11968 gene product from transcript CG11968-RA0.408
Sox14Sox box protein 140.403
Src42ASrc oncogene at 42A0.399
locolocomotion defects0.397
inaDinactivation no afterpotential D0.352
ik2IkappaB kinase-like 20.346
opaodd paired0.340
eIF-4aEukaryotic initiation factor 4a0.337
PEKpancreatic eIF-2alpha kinase0.303
LysBLysozyme B0.297
Cad99CCG31009 gene product from transcript CG31009-RB0.297
EgfrEpidermal growth factor receptor0.296
edlETS-domain lacking0.269
Rac1CG2248 gene product from transcript CG2248-RA0.267
CecA1Cecropin A10.263
B52CG10851 gene product from transcript CG10851-RB0.263
Atg7Autophagy-specific gene 70.258
Trf2TATA box binding protein-related factor 20.249
Hsc70-4Heat shock protein cognate 40.246
SodSuperoxide dismutase0.242
fz2frizzled 20.236
BG4CG12297 gene product from transcript CG12297-RA0.233
Abd-BAbdominal B0.229
ParpPoly-(ADP-ribose) polymerase0.225
RASSF8CG5053 gene product from transcript CG5053-RA0.225
Rh6Rhodopsin 60.223
bchsblue cheese0.218
CG14540CG14540 gene product from transcript CG14540-RA0.216
CG34168CG34168 gene product from transcript CG34168-RA0.213
CecA2Cecropin A20.213
cathDCG1548 gene product from transcript CG1548-RA0.204
Myo10Aunconventional myosin class XV0.197
LysCLysozyme C0.195
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CASP8caspase 8, apoptosis-related cysteine peptidase0.947
E2F4E2F transcription factor 4, p107/p130-binding0.944
RB1retinoblastoma 10.943
BTRCbeta-transducin repeat containing0.906
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.895
CHEK2CHK2 checkpoint homolog (S. pombe)0.887
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.874
BCL2B-cell CLL/lymphoma 20.813
FGFR1fibroblast growth factor receptor 10.798
RXRAretinoid X receptor, alpha0.733
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.724
C2orf65chromosome 2 open reading frame 650.719
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.700
NLRC4NLR family, CARD domain containing 40.682
BADBCL2-associated agonist of cell death0.677
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.659
IL1R1interleukin 1 receptor, type I0.640
BCL2L1BCL2-like 10.618
TBX5T-box 50.586
BAK1BCL2-antagonist/killer 10.583
NOTCH1notch 10.555
FBXW11F-box and WD repeat domain containing 110.485
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.480
RUNX1runt-related transcription factor 10.478
STK3serine/threonine kinase 30.398
GFI1Bgrowth factor independent 1B transcription repressor0.380
CASP4caspase 4, apoptosis-related cysteine peptidase0.350
BAXBCL2-associated X protein0.349
FBXO7F-box protein 70.340
JAG1jagged 10.337
NOTCH3notch 30.313
RARAretinoic acid receptor, alpha0.306
APCadenomatous polyposis coli0.294
PPP2R5Aprotein phosphatase 2, regulatory subunit B', alpha0.293
KITLGKIT ligand0.291
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.269
TFDP1transcription factor Dp-10.259
PKP4plakophilin 40.258
RYBPRING1 and YY1 binding protein0.253
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.247
CDK6cyclin-dependent kinase 60.241
RBL2retinoblastoma-like 2 (p130)0.227
NKX2-1NK2 homeobox 10.220
NGFnerve growth factor (beta polypeptide)0.217
MDM4Mdm4 p53 binding protein homolog (mouse)0.210
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.209
LIN9lin-9 homolog (C. elegans)0.206
CTGFconnective tissue growth factor0.204
CDK2cyclin-dependent kinase 20.202
WHSC1L1Wolf-Hirschhorn syndrome candidate 1-like 10.202
IL1RAPinterleukin 1 receptor accessory protein0.199
NR4A1nuclear receptor subfamily 4, group A, member 10.196
TFDP2transcription factor Dp-2 (E2F dimerization partner 2)0.195
TRIP6thyroid hormone receptor interactor 60.195
BIDBH3 interacting domain death agonist0.190
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.185
BCL2L11BCL2-like 11 (apoptosis facilitator)0.177
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.168
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.167
UHRF2ubiquitin-like with PHD and ring finger domains 20.162
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.157
CCNE1cyclin E10.148
PHLPP1PH domain and leucine rich repeat protein phosphatase 10.147
E2F2E2F transcription factor 20.142
MDM2Mdm2 p53 binding protein homolog (mouse)0.140
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.138
BECN1beclin 1, autophagy related0.137
IL1RNinterleukin 1 receptor antagonist0.135
STRN3striatin, calmodulin binding protein 30.135
BIKBCL2-interacting killer (apoptosis-inducing)0.134
CCT8chaperonin containing TCP1, subunit 8 (theta)0.134
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.132
HRhairless homolog (mouse)0.132
MED25mediator complex subunit 250.130
TP53BP2tumor protein p53 binding protein, 20.128
CASP10caspase 10, apoptosis-related cysteine peptidase0.118
HNF1AHNF1 homeobox A0.116
AMOTL2angiomotin like 20.115
AHRaryl hydrocarbon receptor0.113
E2F6E2F transcription factor 60.113
ZFYVE9zinc finger, FYVE domain containing 90.112
CCND1cyclin D10.112
CUX1cut-like homeobox 10.110
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.108
MAPK8mitogen-activated protein kinase 80.106
PARK2parkinson protein 2, E3 ubiquitin protein ligase (parkin)0.106
GSK3Bglycogen synthase kinase 3 beta0.105
BBC3BCL2 binding component 30.101
LIN54lin-54 homolog (C. elegans)0.095
MAPK1mitogen-activated protein kinase 10.092
BANPBTG3 associated nuclear protein0.092
MAGEA2melanoma antigen family A, 20.091
PARP1poly (ADP-ribose) polymerase 10.091
BCL2A1BCL2-related protein A10.089
AMBRA1autophagy/beclin-1 regulator 10.087
EP300E1A binding protein p3000.087
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.085
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif, 10.085
FKBP8FK506 binding protein 8, 38kDa0.085
RIPK2receptor-interacting serine-threonine kinase 20.084
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog0.994
Gli3GLI-Kruppel family member GLI30.991
Wnt3awingless-related MMTV integration site 3A0.988
Pax8paired box gene 80.972
Pax2paired box gene 20.951
Trp53transformation related protein 530.946
Otx2orthodenticle homolog 2 (Drosophila)0.903
Fgfr2fibroblast growth factor receptor 20.891
Zeb1zinc finger E-box binding homeobox 10.872
Pax3paired box gene 30.835
Bcl2B-cell leukemia/lymphoma 20.826
Pitx2paired-like homeodomain transcription factor 20.816
Ptenphosphatase and tensin homolog0.806
Msx1homeobox, msh-like 10.791
Prrx1paired related homeobox 10.785
Fgf8fibroblast growth factor 80.784
Gli2GLI-Kruppel family member GLI20.748
Ascl1achaete-scute complex homolog 1 (Drosophila)0.746
Vegfavascular endothelial growth factor A0.718
Lef1lymphoid enhancer binding factor 10.676
Emx1empty spiracles homolog 1 (Drosophila)0.665
Rb1retinoblastoma 10.651
Pax6paired box gene 60.649
Nkx1-2NK1 transcription factor related, locus 2 (Drosophila)0.629
Tbx3T-box 30.620
Hand2heart and neural crest derivatives expressed transcript 20.603
Gata6GATA binding protein 60.597
Pax9paired box gene 90.582
Dll1delta-like 1 (Drosophila)0.566
Foxg1forkhead box G10.544
Notch2Notch gene homolog 2 (Drosophila)0.528
Foxc1forkhead box C10.527
Tbx2T-box 20.523
Lmx1aLIM homeobox transcription factor 1 alpha0.515
Kitkit oncogene0.492
Fgfr1fibroblast growth factor receptor 10.483
Psen1presenilin 10.474
Bdnfbrain derived neurotrophic factor0.472
En1engrailed 10.468
Tcf3transcription factor 30.467
Gata4GATA binding protein 40.445
Dlx5distal-less homeobox 50.442
Hoxc6homeobox C60.429
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.429
Ighimmunoglobulin heavy chain complex0.419
Hes1hairy and enhancer of split 1 (Drosophila)0.406
Ntf3neurotrophin 30.403
Ctnnb1catenin (cadherin associated protein), beta 10.382
Msx2homeobox, msh-like 20.377
Nkx2-3NK2 transcription factor related, locus 3 (Drosophila)0.374
Ror2receptor tyrosine kinase-like orphan receptor 20.373
Hoxd13homeobox D130.369
Hoxd11homeobox D110.368
Fzd8frizzled homolog 8 (Drosophila)0.367
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.357
Hoxd3homeobox D30.355
Gdnfglial cell line derived neurotrophic factor0.353
Ptf1apancreas specific transcription factor, 1a0.351
Insm1insulinoma-associated 10.349
Cd40CD40 antigen0.346
Phexphosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)0.343
Pdx1pancreatic and duodenal homeobox 10.341
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.334
Hoxa2homeobox A20.330
Lhx5LIM homeobox protein 50.327
Hoxa1homeobox A10.325
Vax1ventral anterior homeobox containing gene 10.325
Sox7SRY-box containing gene 70.321
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.304
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.303
Fgf15fibroblast growth factor 150.303
Sox2SRY-box containing gene 20.297
Hoxa13homeobox A130.295
Nr5a1nuclear receptor subfamily 5, group A, member 10.285
Adra2badrenergic receptor, alpha 2b0.282
Prrx2paired related homeobox 20.279
Eya1eyes absent 1 homolog (Drosophila)0.278
Wt1Wilms tumor 1 homolog0.278
Cdkn2acyclin-dependent kinase inhibitor 2A0.277
Tcf15transcription factor 150.267
UncxUNC homeobox0.260
Pthlhparathyroid hormone-like peptide0.240
Ptprbprotein tyrosine phosphatase, receptor type, B0.239
Efna2ephrin A20.237
Lhx1LIM homeobox protein 10.232
Neurog2neurogenin 20.228
Wnt1wingless-related MMTV integration site 10.227
Myod1myogenic differentiation 10.223
Tgfb2transforming growth factor, beta 20.222
Apaf1apoptotic peptidase activating factor 10.220
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.218
Retret proto-oncogene0.216
Alx4aristaless-like homeobox 40.213
Clcnkachloride channel Ka0.211
Gja3gap junction protein, alpha 30.210
Nkx6-1NK6 homeobox 10.209
Lama5laminin, alpha 50.207
Emx2empty spiracles homolog 2 (Drosophila)0.202
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.016
Slc29a2solute carrier family 29 (nucleoside transporters), member 20.016
Ptprcprotein tyrosine phosphatase, receptor type, C0.016
Rnase1ribonuclease, RNase A family, 1 (pancreatic)0.014
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.014
Casp2caspase 20.013
Nrasneuroblastoma ras oncogene0.013
Bcl2B-cell CLL/lymphoma 20.013
Gja5gap junction protein, alpha 50.012
Psmc5proteasome (prosome, macropain) 26S subunit, ATPase, 50.012
Ptpn18protein tyrosine phosphatase, non-receptor type 180.012
Casp8caspase 80.012
Tspotranslocator protein0.012
Nlgn3neuroligin 30.011
NrarpNotch-regulated ankyrin repeat protein0.011
Foxe1forkhead box E1 (thyroid transcription factor 2)0.011
Adaradenosine deaminase, RNA-specific0.011
Crybb1crystallin, beta B10.011
Skap2src kinase associated phosphoprotein 20.011
Metmet proto-oncogene0.011
Parp14poly (ADP-ribose) polymerase family, member 140.011
Dhfrdihydrofolate reductase0.011
Itgb7integrin, beta 70.011
A3galt2alpha 1,3-galactosyltransferase 20.011
Olr837olfactory receptor 8370.010
Dchs1dachsous 1 (Drosophila)0.010
Cybbcytochrome b-245, beta polypeptide0.010
Ctsccathepsin C0.010
Zp1zona pellucida glycoprotein 1 (sperm receptor)0.010
Hes5hairy and enhancer of split 5 (Drosophila)0.010
Ralgdsral guanine nucleotide dissociation stimulator0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism