The network for 'regulation of t cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of t cell differentiation

Any process that modulates the frequency, rate or extent of T cell differentiation.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
LCKlymphocyte-specific protein tyrosine kinase0.780
PTPN6protein tyrosine phosphatase, non-receptor type 60.779
IL4Rinterleukin 4 receptor0.740
B2Mbeta-2-microglobulin0.686
LATlinker for activation of T cells0.673
HLA-Amajor histocompatibility complex, class I, A0.552
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.525
HLA-Gmajor histocompatibility complex, class I, G0.512
EGFRepidermal growth factor receptor0.452
PLCG1phospholipase C, gamma 10.333
HLA-Fmajor histocompatibility complex, class I, F0.298
HLA-Emajor histocompatibility complex, class I, E0.296
CD80CD80 molecule0.275
HLA-Bmajor histocompatibility complex, class I, B0.269
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.231
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.196
HLA-DMBmajor histocompatibility complex, class II, DM beta0.195
HLA-Cmajor histocompatibility complex, class I, C0.184
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.179
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.172
CD247CD247 molecule0.159
PILRApaired immunoglobin-like type 2 receptor alpha0.143
BMPR1Abone morphogenetic protein receptor, type IA0.130
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.124
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.118
IL2RGinterleukin 2 receptor, gamma0.109
BIRC3baculoviral IAP repeat containing 30.100
PTPN1protein tyrosine phosphatase, non-receptor type 10.098
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.094
NCOR2nuclear receptor corepressor 20.086
TAPBPTAP binding protein (tapasin)0.080
GRAP2GRB2-related adaptor protein 20.059
TGIF1TGFB-induced factor homeobox 10.059
VAV1vav 1 guanine nucleotide exchange factor0.058
CD86CD86 molecule0.056
IL2RBinterleukin 2 receptor, beta0.055
CD22CD22 molecule0.055
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.054
TRAF1TNF receptor-associated factor 10.051
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.051
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.049
IL15RAinterleukin 15 receptor, alpha0.047
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.046
NCOA1nuclear receptor coactivator 10.046
LIN9lin-9 homolog (C. elegans)0.045
ICAM1intercellular adhesion molecule 10.045
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.045
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.042
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.040
JAK3Janus kinase 30.040
SKIv-ski sarcoma viral oncogene homolog (avian)0.039
CTBP1C-terminal binding protein 10.036
IL6Rinterleukin 6 receptor0.034
CXCR4chemokine (C-X-C motif) receptor 40.034
ITGALintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)0.033
PTPN22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.032
MAP4K1mitogen-activated protein kinase kinase kinase kinase 10.032
FSTL1follistatin-like 10.032
JAK1Janus kinase 10.031
PPARAperoxisome proliferator-activated receptor alpha0.030
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.029
CCND3cyclin D30.029
IL1R1interleukin 1 receptor, type I0.027
CCR7chemokine (C-C motif) receptor 70.026
SMAD7SMAD family member 70.026
EPORerythropoietin receptor0.025
TGFB1transforming growth factor, beta 10.024
BTN3A1butyrophilin, subfamily 3, member A10.024
HDAC9histone deacetylase 90.024
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.023
CDK6cyclin-dependent kinase 60.023
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.023
TANKTRAF family member-associated NFKB activator0.023
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.022
IL4interleukin 40.022
RXRAretinoid X receptor, alpha0.022
BTN3A3butyrophilin, subfamily 3, member A30.022
PDPK13-phosphoinositide dependent protein kinase-10.022
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.021
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.021
SHC1SHC (Src homology 2 domain containing) transforming protein 10.020
CSKc-src tyrosine kinase0.020
TNFAIP3tumor necrosis factor, alpha-induced protein 30.020
SOCS3suppressor of cytokine signaling 30.020
ESR1estrogen receptor 10.020
NOD2nucleotide-binding oligomerization domain containing 20.020
CCND1cyclin D10.020
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.020
MED25mediator complex subunit 250.019
EP300E1A binding protein p3000.019
PMLpromyelocytic leukemia0.019
SNX9sorting nexin 90.018
CSF2RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.018
PSMB9proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)0.018
DHX8DEAH (Asp-Glu-Ala-His) box polypeptide 80.018
HCKhemopoietic cell kinase0.017
IKZF3IKAROS family zinc finger 3 (Aiolos)0.017
SH3BP2SH3-domain binding protein 20.017
NR4A3nuclear receptor subfamily 4, group A, member 30.017
CD40CD40 molecule, TNF receptor superfamily member 50.016
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Jak2Janus kinase 20.997
Stat3signal transducer and activator of transcription 30.996
Foxp3forkhead box P30.991
Apcadenomatosis polyposis coli0.984
Tnftumor necrosis factor0.977
Ptpn11protein tyrosine phosphatase, non-receptor type 110.973
Egfrepidermal growth factor receptor0.969
Arandrogen receptor0.958
Fgfr2fibroblast growth factor receptor 20.953
Socs3suppressor of cytokine signaling 30.951
FynFyn proto-oncogene0.935
Ptenphosphatase and tensin homolog0.926
Il2rginterleukin 2 receptor, gamma chain0.878
Map3k14mitogen-activated protein kinase kinase kinase 140.871
RybpRING1 and YY1 binding protein0.858
Stat6signal transducer and activator of transcription 60.853
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)0.849
Kitkit oncogene0.846
Ifnginterferon gamma0.846
Inpp5dinositol polyphosphate-5-phosphatase D0.845
Icosinducible T-cell co-stimulator0.832
Runx1runt related transcription factor 10.831
Lcklymphocyte protein tyrosine kinase0.829
Stat5asignal transducer and activator of transcription 5A0.819
Nf1neurofibromatosis 10.809
Stat5bsignal transducer and activator of transcription 5B0.780
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.774
Gli3GLI-Kruppel family member GLI30.773
Cd80CD80 antigen0.768
Rnf2ring finger protein 20.753
Trp53transformation related protein 530.743
Smad4MAD homolog 4 (Drosophila)0.743
Ikzf1IKAROS family zinc finger 10.728
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.723
Sox9SRY-box containing gene 90.710
Foxn1forkhead box N10.707
Il6stinterleukin 6 signal transducer0.707
FasFas (TNF receptor superfamily member 6)0.703
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.702
Grb2growth factor receptor bound protein 20.697
Tgfb2transforming growth factor, beta 20.694
Bcl2B-cell leukemia/lymphoma 20.686
Ptprcprotein tyrosine phosphatase, receptor type, C0.681
Leprleptin receptor0.678
Rxraretinoid X receptor alpha0.661
Lyz2lysozyme 20.655
Tnfaip3tumor necrosis factor, alpha-induced protein 30.648
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.642
Egr2early growth response 20.629
Cd247CD247 antigen0.619
Zeb1zinc finger E-box binding homeobox 10.572
Bmpr1abone morphogenetic protein receptor, type 1A0.567
Ctla2acytotoxic T lymphocyte-associated protein 2 alpha0.556
Irf8interferon regulatory factor 80.555
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.552
CblCasitas B-lineage lymphoma0.542
Esr1estrogen receptor 1 (alpha)0.539
Hhexhematopoietically expressed homeobox0.529
Il1r1interleukin 1 receptor, type I0.529
Il1binterleukin 1 beta0.525
Pgrprogesterone receptor0.494
Bcl3B-cell leukemia/lymphoma 30.483
Cd40CD40 antigen0.481
FosFBJ osteosarcoma oncogene0.447
Gata4GATA binding protein 40.446
Pnp2purine-nucleoside phosphorylase 20.445
Gli2GLI-Kruppel family member GLI20.444
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.442
Batfbasic leucine zipper transcription factor, ATF-like0.439
Rargretinoic acid receptor, gamma0.433
Nlrp3NLR family, pyrin domain containing 30.420
Cdkn1bcyclin-dependent kinase inhibitor 1B0.413
H2-Eb1histocompatibility 2, class II antigen E beta0.413
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.410
Il27rainterleukin 27 receptor, alpha0.403
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.396
Cd28CD28 antigen0.391
Trp63transformation related protein 630.383
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.377
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.365
Ctla2bcytotoxic T lymphocyte-associated protein 2 beta0.363
Tgfb1transforming growth factor, beta 10.361
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.360
Shhsonic hedgehog0.358
Nodalnodal0.345
Smad3MAD homolog 3 (Drosophila)0.343
Meox2mesenchyme homeobox 20.342
Ccl2chemokine (C-C motif) ligand 20.341
Rag2recombination activating gene 20.337
Kiss1KiSS-1 metastasis-suppressor0.336
Il2rbinterleukin 2 receptor, beta chain0.335
Sfpi1SFFV proviral integration 10.334
Atxn1ataxin 10.333
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.326
Cishcytokine inducible SH2-containing protein0.313
WasWiskott-Aldrich syndrome homolog (human)0.313
TcraT-cell receptor alpha chain0.310
Cd4CD4 antigen0.307
Hrhairless0.307
Sfnstratifin0.306
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-Db1RT1 class II, locus Db10.458
Cd3gCD3 molecule, gamma0.148
RT1-DaRT1 class II, locus Da0.144
Cd247Cd247 molecule0.121
TcrbT-cell receptor beta chain0.108
Spnsialophorin0.105
Cd74Cd74 molecule, major histocompatibility complex, class II invariant chain0.087
Il2rbinterleukin 2 receptor, beta0.070
RT1-BbRT1 class II, locus Bb0.052
RT1-BaRT1 class II, locus Ba0.049
Il1binterleukin 1 beta0.045
Anpepalanyl (membrane) aminopeptidase0.043
Cd2Cd2 molecule0.043
Cd37CD37 molecule0.043
Itgb7integrin, beta 70.036
Cxcr4chemokine (C-X-C motif) receptor 40.034
Cd5Cd5 molecule0.030
Gzmkgranzyme K0.030
Latlinker for activation of T cells0.026
LOC100364854similar to RIKEN cDNA A430107P09 gene-like0.022
Igh-6immunoglobulin heavy chain 60.021
Il1r1interleukin 1 receptor, type I0.021
Plac8placenta-specific 80.021
Il2rginterleukin 2 receptor, gamma0.018
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.018
Mybpc2myosin binding protein C, fast-type0.017
Mef2dmyocyte enhancer factor 2D0.016
Gimap4GTPase, IMAP family member 40.016
Sykspleen tyrosine kinase0.013
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.013
Cxcl10chemokine (C-X-C motif) ligand 100.012
Foxs1forkhead box S10.012
Neurl3neuralized homolog 3 (Drosophila)0.011
Atp6v0cATPase, H+ transporting, lysosomal V0 subunit C0.011
Bin2bridging integrator 20.011
Ccl5chemokine (C-C motif) ligand 50.010
Igsf6immunoglobulin superfamily, member 60.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism