The network for 'hydrogen peroxide metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

hydrogen peroxide metabolic process

The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.

NameDescriptionProbabilityFunc Analog Organism
prdx2peroxiredoxin 20.966
sod2superoxide dismutase 2, mitochondrial0.741
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.654
prdx3peroxiredoxin 30.648
ahcyS-adenosylhomocysteine hydrolase0.637
esdesterase D/formylglutathione hydrolase0.626
atp5gATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9)0.599
park7parkinson disease (autosomal recessive, early onset) 70.579
aldh7a1aldehyde dehydrogenase 7 family, member A10.543
trpv6transient receptor potential cation channel, subfamily V, member 60.454
gstp1glutathione S-transferase pi0.451
sod1superoxide dismutase 1, soluble0.387
ivdisovaleryl Coenzyme A dehydrogenase0.385
nme2b.1non-metastatic cells 2b.1, protein (NM23B) expressed in0.339
cbr1lcarbonyl reductase 1-like0.232
gpiaglucose phosphate isomerase a0.228
gpx4bglutathione peroxidase 4b0.215
decr12,4-dienoyl CoA reductase 1, mitochondrial0.204
ndufb10NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 100.203
mdh1amalate dehydrogenase 1a, NAD (soluble)0.201
cyp3c1cytochrome P450, family 3, subfamily c, polypeptide 10.191
acadmacyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain0.170
got2bglutamic-oxaloacetic transaminase 2b, mitochondrial (aspartate aminotransferase 2)0.169
chchd10coiled-coil-helix-coiled-coil-helix domain containing 100.165
myh11amyosin, heavy polypeptide 11, smooth muscle a0.160
coro1acoronin, actin binding protein, 1A0.160
ndufa9NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 90.159
etfaelectron-transfer-flavoprotein, alpha polypeptide0.158
adh5alcohol dehydrogenase 50.149
ripk2receptor-interacting serine-threonine kinase 20.142
brp44brain protein 440.142
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.132
mifmacrophage migration inhibitory factor0.123
got2aglutamic-oxaloacetic transaminase 2a, mitochondrial (aspartate aminotransferase 2)0.123
ldhbalactate dehydrogenase Ba0.122
mibp2muscle-specific beta 1 integrin binding protein 20.116
acat1acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)0.114
atp5hATP synthase, H+ transporting, mitochondrial F0 complex, subunit d0.114
manfmesencephalic astrocyte-derived neurotrophic factor0.113
hsd3b7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase0.112
dnpepaspartyl aminopeptidase0.105
cacnb2acalcium channel, voltage-dependent, beta 2a0.103
vwfvon Willebrand factor0.102
lgals9l1lectin, galactoside-binding, soluble, 9 (galectin 9)-like 10.096
ppargperoxisome proliferator activated receptor gamma0.094
nlgn4bneuroligin 4b0.094
rnf128aring finger protein 128a0.093
mmp13amatrix metalloproteinase 13a0.093
blvrbbiliverdin reductase B (flavin reductase (NADPH))0.091
mt2metallothionein 20.090
ctsbacathepsin B, a0.088
slc4a1asolute carrier family 4, anion exchanger, member 1a0.087
suclg1succinate-CoA ligase, GDP-forming, alpha subunit0.086
ctszcathepsin Z0.081
sdhasuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)0.079
ndufb6NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 60.079
epas1bendothelial PAS domain protein 1b0.075
ndufv1NADH dehydrogenase (ubiquinone) flavoprotein 10.075
slc25a25asolute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a0.074
gapdhglyceraldehyde-3-phosphate dehydrogenase0.074
hadhahydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase, alpha subunit0.074
vdravitamin D receptor a0.072
acadlacyl-Coenzyme A dehydrogenase, long chain0.069
insrbinsulin receptor b0.069
ssr4signal sequence receptor, delta0.069
lcp1lymphocyte cytosolic plastin 10.069
ppibpeptidylprolyl isomerase B (cyclophilin B)0.067
aldh6a1aldehyde dehydrogenase 6 family, member A10.066
fabp6fatty acid binding protein 6, ileal (gastrotropin)0.066
pafah1b1bplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b0.065
hspa5heat shock protein 50.065
mmp9matrix metalloproteinase 90.064
pgdphosphogluconate hydrogenase0.064
htr1aa5-hydroxytryptamine (serotonin) receptor 1A a0.064
ndufs7NADH dehydrogenase (ubiquinone) Fe-S protein 7, (NADH-coenzyme Q reductase)0.063
ndufa8NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 80.063
eif2s1eukaryotic translation initiation factor 2, subunit 1 alpha0.061
ca2carbonic anhydrase II0.060
dlstdihydrolipoamide S-succinyltransferase0.059
pikfyvephosphoinositide kinase, FYVE finger containing0.059
atp5c1ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 10.057
acox1acyl-Coenzyme A oxidase 1, palmitoyl0.057
ptpn6protein tyrosine phosphatase, non-receptor type 60.056
idh1isocitrate dehydrogenase 1 (NADP+), soluble0.055
pdha1apyruvate dehydrogenase (lipoamide) alpha 1a0.054
pdip5protein disulfide isomerase-related protein (provisional)0.052
scp2sterol carrier protein 20.052
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Sod2Superoxide dismutase 2 (Mn)0.086
SodSuperoxide dismutase0.047
Mekk1CG7717 gene product from transcript CG7717-RB0.032
Trxr-1Thioredoxin reductase-10.028
PHGPxCG12013 gene product from transcript CG12013-RC0.027
Prosalpha1Proteasome alpha1 subunit0.023
Prx2540-1Peroxiredoxin 25400.016
CG2862CG2862 gene product from transcript CG2862-RA0.016
Prx2540-2Peroxiredoxin 25400.012
AnnXAnnexin X0.011
CG6429CG6429 gene product from transcript CG6429-RA0.011
CG4390CG4390 gene product from transcript CG4390-RB0.011
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HBA2hemoglobin, alpha 20.998
HBBhemoglobin, beta0.996
SOD1superoxide dismutase 1, soluble0.933
HBG2hemoglobin, gamma G0.932
APOEapolipoprotein E0.801
NCF2neutrophil cytosolic factor 20.751
NCF4neutrophil cytosolic factor 4, 40kDa0.735
PRDX4peroxiredoxin 40.567
PARK7Parkinson disease (autosomal recessive, early onset) 70.308
PRKCGprotein kinase C, gamma0.300
IGF1Rinsulin-like growth factor 1 receptor0.261
TIMP2TIMP metallopeptidase inhibitor 20.215
PRKCDprotein kinase C, delta0.213
GPX4glutathione peroxidase 4 (phospholipid hydroperoxidase)0.132
CAV1caveolin 1, caveolae protein, 22kDa0.116
PRDX1peroxiredoxin 10.110
EGFRepidermal growth factor receptor0.103
DUSP23dual specificity phosphatase 230.092
HBE1hemoglobin, epsilon 10.086
HBDhemoglobin, delta0.083
PRDX6peroxiredoxin 60.077
MMP12matrix metallopeptidase 12 (macrophage elastase)0.072
PRDX3peroxiredoxin 30.069
GLRXglutaredoxin (thioltransferase)0.068
IRS1insulin receptor substrate 10.065
DAD1defender against cell death 10.064
VDAC1voltage-dependent anion channel 10.058
APOA2apolipoprotein A-II0.056
MDH1malate dehydrogenase 1, NAD (soluble)0.056
PDIA6protein disulfide isomerase family A, member 60.054
OAZ1ornithine decarboxylase antizyme 10.050
HSPA8heat shock 70kDa protein 80.048
APOC3apolipoprotein C-III0.046
SLC4A1solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)0.046
MMP3matrix metallopeptidase 3 (stromelysin 1, progelatinase)0.044
NCF1neutrophil cytosolic factor 10.040
JAK1Janus kinase 10.040
THBS2thrombospondin 20.037
PARK2parkinson protein 2, E3 ubiquitin protein ligase (parkin)0.037
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.036
HSD17B4hydroxysteroid (17-beta) dehydrogenase 40.035
TGFB1transforming growth factor, beta 10.035
PRDX2peroxiredoxin 20.035
LCATlecithin-cholesterol acyltransferase0.034
ENO1enolase 1, (alpha)0.033
MMP1matrix metallopeptidase 1 (interstitial collagenase)0.032
PGAM1phosphoglycerate mutase 1 (brain)0.031
SNCAIPsynuclein, alpha interacting protein0.031
APOA1apolipoprotein A-I0.029
TBXA2Rthromboxane A2 receptor0.029
PTPN11protein tyrosine phosphatase, non-receptor type 110.029
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.029
CYBAcytochrome b-245, alpha polypeptide0.028
CXCL5chemokine (C-X-C motif) ligand 50.027
NOXO1NADPH oxidase organizer 10.027
HBQ1hemoglobin, theta 10.026
PRKCAprotein kinase C, alpha0.025
MMP10matrix metallopeptidase 10 (stromelysin 2)0.024
HBZhemoglobin, zeta0.024
FRS2fibroblast growth factor receptor substrate 20.023
TXNDC5thioredoxin domain containing 5 (endoplasmic reticulum)0.020
PF4platelet factor 40.020
WT1Wilms tumor 10.020
EHHADHenoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase0.020
LRRK2leucine-rich repeat kinase 20.019
TRIM9tripartite motif containing 90.019
HADHhydroxyacyl-CoA dehydrogenase0.019
GRB10growth factor receptor-bound protein 100.019
PEBP1phosphatidylethanolamine binding protein 10.018
FIS1fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)0.018
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.017
IRS2insulin receptor substrate 20.017
TNFRSF10Ctumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain0.017
SSBP1single-stranded DNA binding protein 10.016
S100A9S100 calcium binding protein A90.016
PPA1pyrophosphatase (inorganic) 10.016
GSPT1G1 to S phase transition 10.016
MMP13matrix metallopeptidase 13 (collagenase 3)0.016
ALAS2aminolevulinate, delta-, synthase 20.016
HSPD1heat shock 60kDa protein 1 (chaperonin)0.015
LDHBlactate dehydrogenase B0.015
ITGA2integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)0.014
CAMPcathelicidin antimicrobial peptide0.014
LBPlipopolysaccharide binding protein0.014
MEP1Ameprin A, alpha (PABA peptide hydrolase)0.014
COL4A1collagen, type IV, alpha 10.014
GYPBglycophorin B (MNS blood group)0.014
GAB1GRB2-associated binding protein 10.014
STAT5Bsignal transducer and activator of transcription 5B0.013
PRDX5peroxiredoxin 50.013
FGAfibrinogen alpha chain0.013
PPBPpro-platelet basic protein (chemokine (C-X-C motif) ligand 7)0.013
SPP1secreted phosphoprotein 10.013
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.012
PTPN5protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)0.012
TRIP10thyroid hormone receptor interactor 100.012
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Hbb-b1hemoglobin, beta adult major chain0.558
Duox2dual oxidase 20.121
Tshrthyroid stimulating hormone receptor0.094
Thrathyroid hormone receptor alpha0.088
Pax8paired box gene 80.080
Ghrgrowth hormone receptor0.075
Ptpn11protein tyrosine phosphatase, non-receptor type 110.064
Uqcrbubiquinol-cytochrome c reductase binding protein0.050
Thrbthyroid hormone receptor beta0.047
Foxc1forkhead box C10.046
Leprleptin receptor0.038
Romo1reactive oxygen species modulator 10.037
Gcshglycine cleavage system protein H (aminomethyl carrier)0.034
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.034
Cav1caveolin 1, caveolae protein0.032
Ahspalpha hemoglobin stabilizing protein0.032
Tpothyroid peroxidase0.032
Ctsgcathepsin G0.029
Hsd3b7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 70.029
Mmp2matrix metallopeptidase 20.028
Runx2runt related transcription factor 20.027
Pgk1phosphoglycerate kinase 10.027
Lmnalamin A0.024
Fam96afamily with sequence similarity 96, member A0.022
Idh1isocitrate dehydrogenase 1 (NADP+), soluble0.020
Ndufab1NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 10.019
Ppargperoxisome proliferator activated receptor gamma0.019
Ndufb6NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 60.018
Dbidiazepam binding inhibitor0.018
Slc10a6solute carrier family 10 (sodium/bile acid cotransporter family), member 60.018
C5ar1complement component 5a receptor 10.018
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.018
Cyb5cytochrome b-50.017
Loxlysyl oxidase0.016
Col1a1collagen, type I, alpha 10.016
Lrp1low density lipoprotein receptor-related protein 10.016
Ins2insulin II0.015
Fbn1fibrillin 10.015
Prdx1peroxiredoxin 10.015
Aifm1apoptosis-inducing factor, mitochondrion-associated 10.015
Irs1insulin receptor substrate 10.015
Esr1estrogen receptor 1 (alpha)0.015
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.015
Psma5proteasome (prosome, macropain) subunit, alpha type 50.015
Hgdhomogentisate 1, 2-dioxygenase0.015
Gpx1glutathione peroxidase 10.015
Mrpl13mitochondrial ribosomal protein L130.014
Tmed10transmembrane emp24-like trafficking protein 10 (yeast)0.014
Nos3nitric oxide synthase 3, endothelial cell0.014
Mtx2metaxin 20.013
Ndufv2NADH dehydrogenase (ubiquinone) flavoprotein 20.013
Hint1histidine triad nucleotide binding protein 10.013
Ces3acarboxylesterase 3A0.013
Sik3SIK family kinase 30.013
Lrp2low density lipoprotein receptor-related protein 20.013
Apoeapolipoprotein E0.013
Apoa1bpapolipoprotein A-I binding protein0.012
Mmp10matrix metallopeptidase 100.012
Scp2sterol carrier protein 2, liver0.012
Vav2vav 2 oncogene0.012
Krt32keratin 320.011
Slc7a2solute carrier family 7 (cationic amino acid transporter, y+ system), member 20.011
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.011
Kcne1potassium voltage-gated channel, Isk-related subfamily, member 10.011
Habp2hyaluronic acid binding protein 20.011
Krt81keratin 810.011
Hpd4-hydroxyphenylpyruvic acid dioxygenase0.011
Abcg8ATP-binding cassette, sub-family G (WHITE), member 80.011
Nr1i3nuclear receptor subfamily 1, group I, member 30.011
Cyp2d34cytochrome P450, family 2, subfamily d, polypeptide 340.011
Qdprquinoid dihydropteridine reductase0.011
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.011
Inhbcinhibin beta-C0.010
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.010
Nr1h4nuclear receptor subfamily 1, group H, member 40.010
Aco1aconitase 10.010
Cyp2d9cytochrome P450, family 2, subfamily d, polypeptide 90.010
Tattyrosine aminotransferase0.010
Sod2superoxide dismutase 2, mitochondrial0.010
Timm23translocase of inner mitochondrial membrane 23 homolog (yeast)0.010
Aurkcaurora kinase C0.010
Socs5suppressor of cytokine signaling 50.010
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hbbhemoglobin, beta1.000
LOC100134871beta globin minor gene1.000
Alas2aminolevulinate, delta-, synthase 20.999
LOC287167globin, alpha0.998
Hba-a2hemoglobin alpha, adult chain 20.998
Hbb-b1hemoglobin, beta adult major chain0.947
Uqcrc2ubiquinol cytochrome c reductase core protein 20.364
Pdhbpyruvate dehydrogenase (lipoamide) beta0.330
Mmp13matrix metallopeptidase 130.102
Dlatdihydrolipoamide S-acetyltransferase0.100
Rnf213ring finger protein 2130.067
Ndufv2NADH dehydrogenase (ubiquinone) flavoprotein 20.061
Bpnt13'(2'), 5'-bisphosphate nucleotidase 10.054
Sod2superoxide dismutase 2, mitochondrial0.049
Atp5hATP synthase, H+ transporting, mitochondrial F0 complex, subunit d0.044
Ghitmgrowth hormone inducible transmembrane protein0.038
Ccng1cyclin G10.038
Chchd2coiled-coil-helix-coiled-coil-helix domain containing 20.033
Rsad2radical S-adenosyl methionine domain containing 20.029
Carhsp1calcium regulated heat stable protein 10.028
Me1malic enzyme 1, NADP(+)-dependent, cytosolic0.025
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.024
Lgals5lectin, galactose binding, soluble 50.022
Ddx58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.021
Atp5f1ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B10.020
Slc25a5solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 50.020
Socs3suppressor of cytokine signaling 30.019
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.019
Gja5gap junction protein, alpha 50.017
Uqcrfs1ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 10.017
Alox15arachidonate 15-lipoxygenase0.017
Ube2bubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae)0.016
Mgst2microsomal glutathione S-transferase 20.016
Ly6allymphocyte antigen 6 complex, locus A-like0.016
LOC619574hypothetical protein LOC6195740.015
Skp1S-phase kinase-associated protein 10.015
Psma3proteasome (prosome, macropain) subunit, alpha type 30.014
Vkorc1vitamin K epoxide reductase complex, subunit 10.013
Sod1superoxide dismutase 1, soluble0.013
Bcl2l1Bcl2-like 10.012
Nploc4nuclear protein localization 4 homolog (S. cerevisiae)0.012
Aqp5aquaporin 50.011
Hspd1heat shock protein 1 (chaperonin)0.011
Gclcglutamate-cysteine ligase, catalytic subunit0.011
Cox8acytochrome c oxidase subunit VIIIa0.011
Srxn1sulfiredoxin 1 homolog (S. cerevisiae)0.011
Gpx1glutathione peroxidase 10.011
Cyb5acytochrome b5 type A (microsomal)0.011
Vamp8vesicle-associated membrane protein 80.010
Slc39a14solute carrier family 39 (zinc transporter), member 140.010
LOC100362108poly (ADP-ribose) polymerase family, member 100.010
Oaz1ornithine decarboxylase antizyme 10.010
Adaradenosine deaminase, RNA-specific0.010
Qdprquinoid dihydropteridine reductase0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
YJR085Chypothetical protein0.027
YLR264C-Ahypothetical protein0.015
YOL038C-Ahypothetical protein0.014
YPR157Whypothetical protein0.014
YDL086Whypothetical protein0.014
YLR162Whypothetical protein0.014
YBL029C-Ahypothetical protein0.013
YLR042Chypothetical protein0.012
YNR014Whypothetical protein0.012
YAR068Whypothetical protein0.012
YBR013Chypothetical protein0.011
YIR035Chypothetical protein0.011
YOL013W-Ahypothetical protein0.011
YJL181Whypothetical protein0.010
YPL067Chypothetical protein0.010
YKR075Chypothetical protein0.010