The network for 'regulation of dna damage response signal transduction by p53 class mediator' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of dna damage response signal transduction by p53 class mediator

Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.

NameDescriptionProbabilityFunc Analog Organism
gscgoosecoid0.129
eaf2ELL associated factor 20.074
prmt1protein arginine methyltransferase 10.041
pax3apaired box gene 3a0.035
nhp2NHP2 ribonucleoprotein homolog (yeast)0.025
ppp4caprotein phosphatase 4 (formerly X), catalytic subunit a0.024
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.024
nkd1naked cuticle homolog 1 (Drosophila)0.023
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.021
npm4nucleophosmin/nucleoplasmin, 40.021
hmga1ahigh mobility group AT-hook 1a0.021
actn4actinin, alpha 40.020
twist1btwist1b0.020
dlx3bdistal-less homeobox gene 3b0.019
pcdh18bprotocadherin 18b0.019
mecomMDS1 and EVI1 complex locus0.018
rp2retinitis pigmentosa 2 (X-linked recessive)0.018
wlswntless homolog (Drosophila)0.018
ogt.1O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 10.018
prrc1proline-rich coiled-coil 10.018
etf1eukaryotic translation termination factor 10.017
sema3aasemaphorin 3aa0.017
hand2heart and neural crest derivatives expressed transcript 20.017
snrpb2small nuclear ribonucleoprotein polypeptide B20.017
tbx6T-box gene 60.017
ctssb.1cathepsin S, b.10.016
snrpasmall nuclear ribonucleoprotein polypeptide A0.016
pomgnt1protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase0.016
bms1lBMS1-like, ribosome assembly protein (yeast)0.016
foxa3forkhead box A30.016
npm1nucleophosmin 10.015
nola1nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs)0.015
inka1ainduced in neural crest by AP2, 1a0.015
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.015
mychmyelocytomatosis oncogene homolog0.015
ripply2ripply20.015
myod1myogenic differentiation 10.015
zgc:77052zgc:770520.015
psme3proteasome activator subunit 30.015
fzd7bfrizzled homolog 7b0.015
hmgb2ahigh-mobility group box 2a0.014
c20orf20c20orf20 homolog (H. sapiens)0.014
ddx39bDEAD (Asp-Glu-Ala-Asp) box polypeptide 39b0.014
tcea1transcription elongation factor A (SII), 10.014
rbm17RNA binding motif protein 170.014
admpanti-dorsalizing morphogenic protein0.014
ripply1ripply10.013
dnajc5gaDnaJ (Hsp40) homolog, subfamily C, member 5 gamma a0.013
znf703zinc finger protein 7030.013
ccng1cyclin G10.013
glmnaglomulin, FKBP associated protein a0.013
hsp47heat shock protein 470.013
thoc3THO complex 30.013
tia1lcytotoxic granule-associated RNA binding protein 1, like0.013
ccz1CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)0.013
pcnaproliferating cell nuclear antigen0.012
casp8caspase 8, apoptosis-related cysteine peptidase0.012
ppatphosphoribosyl pyrophosphate amidotransferase0.012
strapserine/threonine kinase receptor associated protein0.012
prpf38aPRP38 pre-mRNA processing factor 38 (yeast) domain containing A0.012
zfand5azinc finger, AN1-type domain 5a0.012
mmgt1membrane magnesium transporter 10.012
elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.012
fzd2frizzled homolog 20.012
mapk14amitogen-activated protein kinase 14a0.012
foxd3forkhead box D30.012
cdh1cadherin 1, epithelial0.012
api5apoptosis inhibitor 50.012
miosmissing oocyte, meiosis regulator, homolog (Drosophila)0.011
tsc22d2TSC22 domain family 2 and TSC22 domain family, member 20.011
hugHuG0.011
pfdn2prefoldin subunit 20.011
hapln1ahyaluronan and proteoglycan link protein 1a0.011
dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.011
ptgesprostaglandin E synthase0.011
h3f3aH3 histone, family 3A0.011
tmem2transmembrane protein 20.011
LOC555279hypothetical LOC5552790.011
bnip3lbBCL2/adenovirus E1B interacting protein 3-like b0.011
celf1cugbp, Elav-like family member 10.011
LOC560606novel protein similar to human and mouse leishmanolysin-like (metallopeptidase M8 family) (LMLN)0.011
snrnp27small nuclear ribonucleoprotein 27 (U4/U6.U5)0.011
ppil2peptidylprolyl isomerase (cyclophilin)-like 20.011
scrt1ascratch homolog 1, zinc finger protein a (Drosophila)0.011
dlx6adistal-less homeobox gene 6a0.011
ddx39aaDEAD (Asp-Glu-Ala-Asp) box polypeptide 39Aa0.011
ssbSjogren syndrome antigen B (autoantigen La)0.011
prmt5protein arginine methyltransferase 50.011
crestincrestin0.011
fcer1glFc receptor, IgE, high affinity I, gamma polypeptide like0.011
usp3ubiquitin specific peptidase 30.011
cwf19l1CWF19-like 1, cell cycle control0.010
jag1bjagged 1b0.010
rangap1Ran GTPase activating protein 10.010
st3gal5ST3 beta-galactoside alpha-2,3-sialyltransferase 50.010
ftsj1FtsJ homolog 1 (E. coli)0.010
foxc1bforkhead box C1b0.010
eif1beukaryotic translation initiation factor 1B0.010
zgc:55741zgc:557410.010
hnrnpa0heterogeneous nuclear ribonucleoprotein A00.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TP53tumor protein p530.317
HIPK2homeodomain interacting protein kinase 20.228
EP300E1A binding protein p3000.224
CDC5LCDC5 cell division cycle 5-like (S. pombe)0.204
NBNnibrin0.143
RB1retinoblastoma 10.106
BCAS2breast carcinoma amplified sequence 20.102
MYH7Bmyosin, heavy chain 7B, cardiac muscle, beta0.064
HIC2hypermethylated in cancer 20.057
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.053
UBR1ubiquitin protein ligase E3 component n-recognin 10.051
RAD18RAD18 homolog (S. cerevisiae)0.048
BCL2L11BCL2-like 11 (apoptosis facilitator)0.045
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.041
UBR3ubiquitin protein ligase E3 component n-recognin 3 (putative)0.030
SF3A1splicing factor 3a, subunit 1, 120kDa0.030
H3F3CH3 histone, family 3C0.029
MSNmoesin0.028
RIN1Ras and Rab interactor 10.026
KAT2BK(lysine) acetyltransferase 2B0.025
RBBP8retinoblastoma binding protein 80.024
CHEK2CHK2 checkpoint homolog (S. pombe)0.024
SF3A2splicing factor 3a, subunit 2, 66kDa0.024
HNRNPMheterogeneous nuclear ribonucleoprotein M0.020
MDM2Mdm2 p53 binding protein homolog (mouse)0.019
DAXXdeath-domain associated protein0.019
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.019
GATA2GATA binding protein 20.018
PSMC6proteasome (prosome, macropain) 26S subunit, ATPase, 60.018
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.016
NCOA3nuclear receptor coactivator 30.015
DDX5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.015
EGR1early growth response 10.014
TGIF1TGFB-induced factor homeobox 10.014
HNRNPH1heterogeneous nuclear ribonucleoprotein H1 (H)0.014
CREBBPCREB binding protein0.014
PSMD12proteasome (prosome, macropain) 26S subunit, non-ATPase, 120.014
CCND1cyclin D10.014
UHRF2ubiquitin-like with PHD and ring finger domains 20.014
FANCD2Fanconi anemia, complementation group D20.014
ENO1enolase 1, (alpha)0.014
DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.014
RUNX1runt-related transcription factor 10.014
KDM1Alysine (K)-specific demethylase 1A0.014
RBM4RNA binding motif protein 40.013
PRPF8PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)0.013
CXCR4chemokine (C-X-C motif) receptor 40.013
SF1splicing factor 10.013
MYCNv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.013
GAPDHglyceraldehyde-3-phosphate dehydrogenase0.013
AHRaryl hydrocarbon receptor0.012
NCOA2nuclear receptor coactivator 20.012
CHEK1CHK1 checkpoint homolog (S. pombe)0.012
DYRK1Bdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B0.012
BRCA1breast cancer 1, early onset0.012
PPM1Dprotein phosphatase, Mg2+/Mn2+ dependent, 1D0.011
CUX1cut-like homeobox 10.010
MDM4Mdm4 p53 binding protein homolog (mouse)0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.040
Mdm4transformed mouse 3T3 cell double minute 40.028
Nbnnibrin0.016
Brca1breast cancer 10.012
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism