The network for 'apical protein localization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

apical protein localization

Any process in which a protein is transported to, or maintained in, apical regions of the cell.

NameDescriptionProbabilityFunc Analog Organism
crb2acrumbs homolog 2a1.000
epb41l5erythrocyte membrane protein band 4.1 like 50.972
crb2bcrumbs homolog 2b0.799
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.738
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)0.687
ift88intraflagellar transport 88 homolog0.619
crb3acrumbs homolog 3a0.594
prkciprotein kinase C, iota0.593
grk7aG-protein-coupled receptor kinase 7a0.577
crb1crumbs homolog 1 (Drosophila)0.488
crb3bcrumbs homolog 3b0.392
rp2retinitis pigmentosa 2 (X-linked recessive)0.214
pde6cphosphodiesterase 6C, cGMP-specific, cone, alpha prime0.209
kif17kinesin family member 170.192
pafah1b1bplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b0.188
guca1cguanylate cyclase activator 1C0.179
arr3barrestin 3b, retinal (X-arrestin)0.147
pafah1b1aplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a0.135
grk1bG protein-coupled receptor kinase 1 b0.116
dctn1adynactin 1a0.108
dync1h1dynein, cytoplasmic 1, heavy chain 10.105
s1pr2sphingosine-1-phosphate receptor 20.102
lrp2low density lipoprotein-related protein 20.078
cacnb2bcalcium channel, voltage-dependent, beta 2b0.069
stilTAL1 (SCL) interrupting locus0.061
ripk2receptor-interacting serine-threonine kinase 20.044
cplx4acomplexin 4a0.043
tnfrsfatumor necrosis factor receptor superfamily, member a0.033
fzd7bfrizzled homolog 7b0.032
slc24a5solute carrier family 24, member 50.028
gc3guanylyl cyclase 30.028
LOC100000934hypothetical protein LOC1000009340.027
crxcone-rod homeobox0.024
mpp5bmembrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5b)0.021
lama1laminin, alpha 10.020
fcho2FCH domain only 20.016
stat3signal transduction and activation of transcription 30.016
mibmind bomb0.015
phexphosphate regulating gene with homologues to endopeptidases on the X chromosome0.015
skianuclear oncoprotein skia0.015
sagbS-antigen; retina and pineal gland (arrestin) b0.015
gna12guanine nucleotide binding protein (G protein) alpha 120.015
ankrd12ankyrin repeat domain 120.015
npeppsaminopeptidase puromycin sensitive0.014
rc3rabconnectin 30.014
cxxc1CXXC finger 1 (PHD domain)0.013
grhl2bgrainyhead-like 2b (Drosophila)0.013
ube4bubiquitination factor E4B, UFD2 homolog (S. cerevisiae)0.013
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.013
pard6gbpar-6 partitioning defective 6 homolog gamma B (C. elegans)0.012
akt2v-akt murine thymoma viral oncogene homolog 20.012
lrrc4.1leucine rich repeat containing 4.10.012
pitpnbphosphotidylinositol transfer protein, beta0.012
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.012
b3gnt7UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 70.012
fn1fibronectin 10.012
casp3acaspase 3, apoptosis-related cysteine protease a0.011
rykreceptor-like tyrosine kinase0.011
npc1Niemann-Pick disease, type C10.011
egln3egl nine homolog 3 (C. elegans)0.011
smad3aMAD homolog 3a (Drosophila)0.011
cacna1icalcium channel, voltage-dependent, T type, alpha 1I subunit0.010
eno1enolase 1, (alpha)0.010
opn1sw2opsin 1 (cone pigments), short-wave-sensitive 20.010
gnl2guanine nucleotide binding protein-like 2 (nucleolar)0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
aopanterior open0.215
RalaRas-related protein0.045
DlicDynein light intermediate chain0.021
lkb1CG9374 gene product from transcript CG9374-RJ0.018
kibrakibra ortholog0.014
Rab11Rab-protein 110.013
Cdc42CG12530 gene product from transcript CG12530-RA0.013
trioCG18214 gene product from transcript CG18214-RA0.013
PatjCG12021 gene product from transcript CG12021-RC0.011
Sop2Suppressor of profilin 20.011
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Dvl2dishevelled 2, dsh homolog (Drosophila)0.898
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.599
Ltblymphotoxin B0.438
Map3k14mitogen-activated protein kinase kinase kinase 140.402
Dvl3dishevelled 3, dsh homolog (Drosophila)0.259
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.176
Tnftumor necrosis factor0.136
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.122
Dlg1discs, large homolog 1 (Drosophila)0.092
Myo6myosin VI0.083
Tsc2tuberous sclerosis 20.075
Ndel1nuclear distribution gene E-like homolog 1 (A. nidulans)0.071
Ifnginterferon gamma0.069
Scn5asodium channel, voltage-gated, type V, alpha0.064
Tbx5T-box 50.063
Il7interleukin 70.061
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.054
Psen1presenilin 10.049
Ltalymphotoxin A0.042
Wdr1WD repeat domain 10.041
Dlg3discs, large homolog 3 (Drosophila)0.039
Tbx3T-box 30.037
Tsc1tuberous sclerosis 10.036
Ptk7PTK7 protein tyrosine kinase 70.036
Dlg4discs, large homolog 4 (Drosophila)0.035
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.031
Efnb2ephrin B20.030
Cxcl13chemokine (C-X-C motif) ligand 130.029
Clstn1calsyntenin 10.029
Apcadenomatosis polyposis coli0.028
Cxcr5chemokine (C-X-C motif) receptor 50.027
Toxthymocyte selection-associated high mobility group box0.026
Arcactivity regulated cytoskeletal-associated protein0.024
Inainternexin neuronal intermediate filament protein, alpha0.021
Ptprqprotein tyrosine phosphatase, receptor type, Q0.020
Nrcamneuron-glia-CAM-related cell adhesion molecule0.020
Rac1RAS-related C3 botulinum substrate 10.019
9430031J16RikRIKEN cDNA 9430031J16 gene0.018
Itgb1integrin beta 1 (fibronectin receptor beta)0.017
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.017
Vangl2vang-like 2 (van gogh, Drosophila)0.017
Prkar1aprotein kinase, cAMP dependent regulatory, type I, alpha0.016
Nde1nuclear distribution gene E homolog 1 (A nidulans)0.016
Ttc7tetratricopeptide repeat domain 70.016
Vamp2vesicle-associated membrane protein 20.015
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.014
Rock2Rho-associated coiled-coil containing protein kinase 20.014
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.013
Gata3GATA binding protein 30.013
Notonotochord homolog (Xenopus laevis)0.013
Actn1actinin, alpha 10.012
Caskcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.012
Spna2spectrin alpha 20.012
Klc2kinesin light chain 20.012
Grm1glutamate receptor, metabotropic 10.011
Dnm1dynamin 10.011
Tjp1tight junction protein 10.011
Wwtr1WW domain containing transcription regulator 10.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism