The network for 'regulation of response to cytokine stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of response to cytokine stimulus

Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus.

NameDescriptionProbabilityFunc Analog Organism
pafah1b1aplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a0.369
nrp2bneuropilin 2b0.364
ush1cUsher syndrome 1C (autosomal recessive, severe)0.307
ift88intraflagellar transport 88 homolog0.304
cav1caveolin 10.265
robo2roundabout homolog 20.243
il6rinterleukin 6 receptor0.242
atf3activating transcription factor 30.238
copebcore promoter element binding protein0.227
stat3signal transduction and activation of transcription 30.222
mmp9matrix metalloproteinase 90.216
cacna1dacalcium channel, voltage-dependent, L type, alpha 1D subunit, a0.204
mapk3mitogen-activated protein kinase 30.146
junbjun B proto-oncogene0.134
socs3asuppressor of cytokine signaling 3a0.128
slit3slit (Drosophila) homolog 30.121
ctbp2lC-terminal binding protein 2, like0.119
grnagranulin a0.119
ptprsaprotein tyrosine phosphatase, receptor type, s, a0.117
pafah1b1bplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b0.112
slc17a8solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 80.107
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.094
hdac4histone deacetylase 40.088
vtg1vitellogenin 10.082
iclp1invariant chain-like protein 10.081
scn1bbsodium channel, voltage-gated, type I, beta b0.080
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.078
slit2slit (Drosophila) homolog 20.075
dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.074
dvl3dishevelled, dsh homolog 3 (Drosophila)0.074
tnfsf10l2tumor necrosis factor (ligand) superfamily, member 10 like 20.073
irf11interferon regulatory factor 110.072
c1qccomplement component 1, q subcomponent, C chain0.070
synj1synaptojanin 10.070
dubduboraya0.070
jak1Janus kinase 10.066
scn1basodium channel, voltage-gated, type I, beta a0.066
si:rp71-39b20.7si:rp71-39b20.70.065
mapk4mitogen-activated protein kinase 40.065
zgc:153997zgc:1539970.065
ripk2receptor-interacting serine-threonine kinase 20.064
bmpr1aabone morphogenetic protein receptor, type 1aa0.063
lims1LIM and senescent cell antigen-like domains 10.061
mapk15mitogen-activated protein kinase 150.060
gsnbgelsolin b0.059
gnb1aguanine nucleotide binding protein (G protein), beta polypeptide 1a0.058
cntn2contactin 20.057
msxamuscle segment homeobox A0.055
ippkinositol 1,3,4,5,6-pentakisphosphate 2-kinase0.054
LOC566020Gig2-like protein DreO0.054
rc3rabconnectin 30.053
stat1bsignal transducer and activator of transcription 1b0.053
ntn2netrin 20.052
col7a1lcollagen type VII alpha 1-like0.051
caspacaspase a0.051
nrg2aneuregulin 2a0.050
cx30.3connexin 30.30.050
axin1axin 10.050
zgc:63721zgc:637210.050
frylfurry homolog-like (Drosophila)0.050
ptger2aprostaglandin E receptor 2a (subtype EP2)0.049
kdm5clysine (K)-specific demethylase 5C0.049
il6stinterleukin 6 signal transducer0.049
pabpc1bpoly A binding protein, cytoplasmic 1 b0.049
pcsk5aproprotein convertase subtilisin/kexin type 5a0.048
ptenaphosphatase and tensin homolog A0.048
stc1lstanniocalcin 1, like0.048
appaamyloid beta (A4) precursor protein a0.047
smg7Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)0.047
igf1rbinsulin-like growth factor 1b receptor0.047
pcdh15aprotocadherin 15a0.047
mcl1amyeloid cell leukemia sequence 1a0.046
emx3empty spiracles homeobox 30.046
slc6a8solute carrier family 6 (neurotransmitter transporter, creatine), member 80.046
atp2b4ATPase, Ca++ transporting, plasma membrane 40.045
s100sS100 calcium binding protein S0.045
card9caspase recruitment domain family, member 90.043
dip2cDIP2 disco-interacting protein 2 homolog C (Drosophila)0.043
alcamaactivated leukocyte cell adhesion molecule a0.043
sh3gl1bSH3-domain GRB2-like 1b0.043
LOC559616calcium-binding protein 1-like0.042
card14caspase recruitment domain family, member 140.041
plekhh1pleckstrin homology domain containing, family H (with MyTH4 domain) member 10.041
cluap1clusterin associated protein 10.041
mapk8bmitogen-activated protein kinase 8b0.041
ppp2r5eaprotein phosphatase 2, regulatory subunit B', epsilon isoform a0.040
mapk12mitogen-activated protein kinase 120.040
tnfaip8l2atumor necrosis factor, alpha-induced protein 8, like 2a0.040
pdcd2programmed cell death 20.040
kal1bKallmann syndrome 1b sequence0.040
si:dkey-76b14.4si:dkey-76b14.40.040
aox3aldehyde oxidase 30.039
ildr1bimmunoglobulin-like domain containing receptor 1b0.039
robo4roundabout homolog 40.038
gmfgglia maturation factor, gamma0.038
scinlbscinderin like b0.038
nfe2l2nuclear factor (erythroid-derived 2)-like 20.038
zgc:64051zgc:640510.038
duoxdual oxidase0.037
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.037
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
IRAK1interleukin-1 receptor-associated kinase 10.889
IRAK2interleukin-1 receptor-associated kinase 20.642
LCKlymphocyte-specific protein tyrosine kinase0.568
IL1R1interleukin 1 receptor, type I0.558
C1QAcomplement component 1, q subcomponent, A chain0.536
MYD88myeloid differentiation primary response gene (88)0.507
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.476
ZNF43zinc finger protein 430.469
TRAF6TNF receptor-associated factor 60.445
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.440
GRB2growth factor receptor-bound protein 20.357
CCR5chemokine (C-C motif) receptor 50.278
PMLpromyelocytic leukemia0.258
HCKhemopoietic cell kinase0.252
DTX3Ldeltex 3-like (Drosophila)0.246
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.200
ZNF253zinc finger protein 2530.185
ZNF273zinc finger protein 2730.180
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.171
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.159
SOCS3suppressor of cytokine signaling 30.153
ZNF675zinc finger protein 6750.152
SYKspleen tyrosine kinase0.152
JAK2Janus kinase 20.151
GHRgrowth hormone receptor0.119
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.112
GAS6growth arrest-specific 60.100
TMEM173transmembrane protein 1730.098
FASFas (TNF receptor superfamily, member 6)0.093
SPRR2Asmall proline-rich protein 2A0.092
CCL4chemokine (C-C motif) ligand 40.091
CXCL9chemokine (C-X-C motif) ligand 90.089
ZNF708zinc finger protein 7080.088
SH3KBP1SH3-domain kinase binding protein 10.087
CASP8caspase 8, apoptosis-related cysteine peptidase0.081
RNF31ring finger protein 310.081
C1QCcomplement component 1, q subcomponent, C chain0.080
RXRAretinoid X receptor, alpha0.078
C19orf50chromosome 19 open reading frame 500.075
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.073
ZNF91zinc finger protein 910.073
RARAretinoic acid receptor, alpha0.071
NCOR2nuclear receptor corepressor 20.070
DAXXdeath-domain associated protein0.065
UBASH3Bubiquitin associated and SH3 domain containing B0.060
PLCG1phospholipase C, gamma 10.060
ZNF93zinc finger protein 930.060
ZNF117zinc finger protein 1170.059
AXLAXL receptor tyrosine kinase0.057
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.057
PTPRBprotein tyrosine phosphatase, receptor type, B0.053
TNFAIP3tumor necrosis factor, alpha-induced protein 30.052
RUNX1runt-related transcription factor 10.051
IRAK4interleukin-1 receptor-associated kinase 40.049
IRF7interferon regulatory factor 70.049
ICAM1intercellular adhesion molecule 10.047
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.046
TLR4toll-like receptor 40.045
MAP3K3mitogen-activated protein kinase kinase kinase 30.045
STAT4signal transducer and activator of transcription 40.044
IL1RAPinterleukin 1 receptor accessory protein0.044
APOC1apolipoprotein C-I0.044
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.044
ZNF680zinc finger protein 6800.044
MAP2K5mitogen-activated protein kinase kinase 50.043
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.043
C1QBcomplement component 1, q subcomponent, B chain0.043
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.042
ZNF430zinc finger protein 4300.042
IDEinsulin-degrading enzyme0.042
ZNF85zinc finger protein 850.041
CYLDcylindromatosis (turban tumor syndrome)0.041
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.040
ZNF107zinc finger protein 1070.040
NLRC4NLR family, CARD domain containing 40.039
PELI3pellino homolog 3 (Drosophila)0.039
CXCL10chemokine (C-X-C motif) ligand 100.038
ZNF254zinc finger protein 2540.038
LATlinker for activation of T cells0.038
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.037
NCK1NCK adaptor protein 10.037
HPhaptoglobin0.036
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.036
PTPN11protein tyrosine phosphatase, non-receptor type 110.036
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.036
MAP3K2mitogen-activated protein kinase kinase kinase 20.035
CAV2caveolin 20.035
ATN1atrophin 10.035
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.034
SQSTM1sequestosome 10.033
CREBBPCREB binding protein0.032
CD14CD14 molecule0.032
FZD1frizzled homolog 1 (Drosophila)0.032
CCL7chemokine (C-C motif) ligand 70.032
CCR7chemokine (C-C motif) receptor 70.031
CASP10caspase 10, apoptosis-related cysteine peptidase0.031
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.031
ESR1estrogen receptor 10.031
LIMD1LIM domains containing 10.030
RIPK2receptor-interacting serine-threonine kinase 20.030
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Myd88myeloid differentiation primary response gene 880.855
Tlr4toll-like receptor 40.465
Casp8caspase 80.392
Irak4interleukin-1 receptor-associated kinase 40.319
Il1r1interleukin 1 receptor, type I0.295
H2-Aahistocompatibility 2, class II antigen A, alpha0.295
Stat3signal transducer and activator of transcription 30.263
Casp4caspase 4, apoptosis-related cysteine peptidase0.256
FynFyn proto-oncogene0.246
Map3k8mitogen-activated protein kinase kinase kinase 80.237
Robo1roundabout homolog 1 (Drosophila)0.209
Cd44CD44 antigen0.205
Traf6TNF receptor-associated factor 60.202
Robo2roundabout homolog 2 (Drosophila)0.178
Stat2signal transducer and activator of transcription 20.146
Ccr2chemokine (C-C motif) receptor 20.135
Stat1signal transducer and activator of transcription 10.116
Map3k3mitogen-activated protein kinase kinase kinase 30.111
Socs3suppressor of cytokine signaling 30.107
Nlrp3NLR family, pyrin domain containing 30.103
Sfnstratifin0.102
Il6interleukin 60.100
Casp1caspase 10.098
Tnfaip3tumor necrosis factor, alpha-induced protein 30.095
Jak2Janus kinase 20.086
Ndel1nuclear distribution gene E-like homolog 1 (A. nidulans)0.074
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.071
Slit3slit homolog 3 (Drosophila)0.070
H2-Eb1histocompatibility 2, class II antigen E beta0.069
H2-DMahistocompatibility 2, class II, locus DMa0.068
Unc93b1unc-93 homolog B1 (C. elegans)0.067
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.065
Lyz2lysozyme 20.064
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.064
Mdm2transformed mouse 3T3 cell double minute 20.063
Jak1Janus kinase 10.058
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.058
Cav1caveolin 1, caveolae protein0.058
Klrk1killer cell lectin-like receptor subfamily K, member 10.052
Gbp5guanylate binding protein 50.050
Aim2absent in melanoma 20.048
H2-Ab1histocompatibility 2, class II antigen A, beta 10.048
Dock2dedicator of cyto-kinesis 20.046
Ccl2chemokine (C-C motif) ligand 20.046
SharpinSHANK-associated RH domain interacting protein0.042
Ikbkbinhibitor of kappaB kinase beta0.042
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.041
Irak1interleukin-1 receptor-associated kinase 10.040
FasFas (TNF receptor superfamily member 6)0.039
Rnf31ring finger protein 310.038
Tyro3TYRO3 protein tyrosine kinase 30.036
Traf3TNF receptor-associated factor 30.035
Il6stinterleukin 6 signal transducer0.035
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.033
Dhx58DEXH (Asp-Glu-X-His) box polypeptide 580.031
Il2rbinterleukin 2 receptor, beta chain0.031
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.030
Pag1phosphoprotein associated with glycosphingolipid microdomains 10.030
Csf1colony stimulating factor 1 (macrophage)0.029
Mx1myxovirus (influenza virus) resistance 10.029
Apoeapolipoprotein E0.028
Ifnar1interferon (alpha and beta) receptor 10.028
Il4rainterleukin 4 receptor, alpha0.028
Rsad2radical S-adenosyl methionine domain containing 20.026
Il1binterleukin 1 beta0.026
Stat6signal transducer and activator of transcription 60.025
Rassf5Ras association (RalGDS/AF-6) domain family member 50.025
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.025
Il1rl1interleukin 1 receptor-like 10.024
H2-Q6histocompatibility 2, Q region locus 60.024
Trp63transformation related protein 630.024
Ticam1toll-like receptor adaptor molecule 10.023
Il17rainterleukin 17 receptor A0.023
Cyldcylindromatosis (turban tumor syndrome)0.023
Cd247CD247 antigen0.023
Adam8a disintegrin and metallopeptidase domain 80.023
Batfbasic leucine zipper transcription factor, ATF-like0.022
Il18r1interleukin 18 receptor 10.022
Cd86CD86 antigen0.022
Ifngr1interferon gamma receptor 10.021
Gzmbgranzyme B0.021
Nde1nuclear distribution gene E homolog 1 (A nidulans)0.021
Slit2slit homolog 2 (Drosophila)0.021
Tgfb1transforming growth factor, beta 10.020
Spp1secreted phosphoprotein 10.020
Parp10poly (ADP-ribose) polymerase family, member 100.020
Icam1intercellular adhesion molecule 10.020
Ptrfpolymerase I and transcript release factor0.020
Mertkc-mer proto-oncogene tyrosine kinase0.020
Trp53transformation related protein 530.020
Tlr2toll-like receptor 20.019
Lifleukemia inhibitory factor0.019
Bcl3B-cell leukemia/lymphoma 30.019
Tolliptoll interacting protein0.019
Ppargperoxisome proliferator activated receptor gamma0.018
Ikbkginhibitor of kappaB kinase gamma0.018
Serpina3gserine (or cysteine) peptidase inhibitor, clade A, member 3G0.018
Eya2eyes absent 2 homolog (Drosophila)0.018
1810019J16RikRIKEN cDNA 1810019J16 gene0.018
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.018
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism