The network for 'locus ceruleus development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

locus ceruleus development

The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.

NameDescriptionProbabilityFunc Analog Organism
phox2apaired-like homeobox 2a0.926
fgf10afibroblast growth factor 10a0.853
bmp2bbone morphogenetic protein 2b0.817
nadl1.1neural adhesion molecule L1.10.481
il17rdinterleukin 17 receptor D0.442
phox2bpaired-like homeobox 2b0.424
hoxd4ahomeo box D4a0.384
pax2apaired box gene 2a0.293
tbx1T-box 10.276
ascl1aachaete-scute complex-like 1a (Drosophila)0.276
fgfr1afibroblast growth factor receptor 1a0.253
fras1Fraser syndrome 10.222
gpr126G protein-coupled receptor 1260.169
pea3ETS-domain transcription factor pea30.168
hmx3homeo box (H6 family) 30.151
atoh1aatonal homolog 1a0.148
neurog1neurogenin 10.141
pax9paired box gene 90.136
prrx1bpaired related homeobox 1b0.120
dlx5adistal-less homeobox gene 5a0.118
bmp4bone morphogenetic protein 40.116
foxi1forkhead box I10.110
bmp2abone morphogenetic protein 2a0.110
prdm1aPR domain containing 1a, with ZNF domain0.104
shhasonic hedgehog a0.101
entpd3ectonucleoside triphosphate diphosphohydrolase 30.090
eya1eyes absent homolog 10.090
lhx6LIM homeobox 60.090
dlx6adistal-less homeobox gene 6a0.086
insm1ainsulinoma-associated 1a0.086
cdh6cadherin 60.081
map2k4amitogen-activated protein kinase kinase 4a0.080
fgf18afibroblast growth factor 18a0.075
fgf17fibroblast growth factor 170.074
aldh1a3aldehyde dehydrogenase 1 family, member A30.074
p2rx2purinergic receptor P2X, ligand-gated ion channel, 20.073
stmn2bstathmin-like 2b0.071
wnt1wingless-type MMTV integration site family, member 10.071
spry1sprouty homolog 1 (Drosophila)0.068
loxl2blysyl oxidase-like 2b0.067
elavl3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.066
igfbp3insulin-like growth factor binding protein 30.065
gnao1aguanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a0.060
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.057
barx1BarH-like homeobox 10.055
gfra2glial cell line derived neurotrophic factor family receptor alpha 20.053
eng2bengrailed 2b0.053
lmx1b.1LIM homeobox transcription factor 1, beta 10.051
klf4Kruppel-like factor 40.050
cxcr4bchemokine (C-X-C motif), receptor 4b0.050
hoxa13bhomeo box A13b0.049
cntn2contactin 20.047
hand2heart and neural crest derivatives expressed transcript 20.047
fgf3fibroblast growth factor 30.046
fgf4fibroblast growth factor 40.046
dlx4bdistal-less homeobox gene 4b0.046
irx2airoquois homeobox protein 2, a0.043
hoxd11ahomeo box D11a0.042
wnt2wingless-type MMTV integration site family member 20.042
nadl1.2neural adhesion molecule L1.20.042
hmx2H6 family homeobox 20.042
plxnb2bplexin b2b0.041
gfra1bgdnf family receptor alpha 1b0.039
wnt4awingless-type MMTV integration site family, member 4a0.038
tgfb2transforming growth factor, beta 20.038
otx1borthodenticle homolog 1b0.038
tcf7transcription factor 7 (T-cell specific, HMG-box)0.036
gpd2glycerol-3-phosphate dehydrogenase 2 (mitochondrial)0.035
dlx2bdistal-less homeobox gene 2b0.035
olfm1aolfactomedin 1a0.033
six2asine oculis-related homeobox 2a0.033
wnt8bwingless-type MMTV integration site family, member 8b0.031
vcanbversican b0.029
fgf13bfibroblast growth factor 13b0.028
eng1aengrailed 1a0.028
sst1.1somatostatin 1, tandem duplicate 10.028
nipblbnovel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila)0.027
trpa1btransient receptor potential cation channel, subfamily A, member 1b0.027
tcf21transcription factor 210.026
og9xOG9 homeobox gene0.026
col14a1collagen, type XIV, alpha 10.026
hint2histidine triad nucleotide binding protein 20.025
pink1PTEN induced putative kinase 10.024
spry4sprouty (Drosophila) homolog 40.024
lbx1aladybird homeobox 1a0.023
smoxspermine oxidase0.023
eomesaeomesodermin homolog a0.023
irx5biroquois homeobox protein 5b0.022
gle1GLE1 RNA export mediator homolog (yeast)0.022
grhl2bgrainyhead-like 2b (Drosophila)0.022
crabp2acellular retinoic acid binding protein 2, a0.022
lmx1b.2LIM homeobox transcription factor 1, beta 20.022
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Tbx1T-box 11.000
Eya1eyes absent 1 homolog (Drosophila)1.000
Pax3paired box gene 31.000
Foxc1forkhead box C11.000
Six1sine oculis-related homeobox 1 homolog (Drosophila)1.000
Msx1homeobox, msh-like 11.000
Gli3GLI-Kruppel family member GLI31.000
Hand2heart and neural crest derivatives expressed transcript 21.000
Tcfap2atranscription factor AP-2, alpha0.999
Sox9SRY-box containing gene 90.999
Dlx5distal-less homeobox 50.999
Bmp4bone morphogenetic protein 40.999
Fgfr2fibroblast growth factor receptor 20.999
Foxc2forkhead box C20.999
Isl1ISL1 transcription factor, LIM/homeodomain0.998
Gbx2gastrulation brain homeobox 20.996
Tgfb2transforming growth factor, beta 20.996
Rargretinoic acid receptor, gamma0.996
Pax2paired box gene 20.995
Hoxa1homeobox A10.994
Otx2orthodenticle homolog 2 (Drosophila)0.994
Ednraendothelin receptor type A0.993
Smosmoothened homolog (Drosophila)0.993
Bmp7bone morphogenetic protein 70.991
Foxg1forkhead box G10.988
Pitx2paired-like homeodomain transcription factor 20.986
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.978
Hand1heart and neural crest derivatives expressed transcript 10.978
Fgfr1fibroblast growth factor receptor 10.971
Gscgoosecoid homeobox0.960
Fgf10fibroblast growth factor 100.957
Gli2GLI-Kruppel family member GLI20.924
Msx2homeobox, msh-like 20.903
Zeb1zinc finger E-box binding homeobox 10.899
Rarbretinoic acid receptor, beta0.847
Rspo2R-spondin 2 homolog (Xenopus laevis)0.842
Fgf8fibroblast growth factor 80.808
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.785
Jag1jagged 10.751
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.749
Ntf3neurotrophin 30.748
Ror2receptor tyrosine kinase-like orphan receptor 20.730
Chd7chromodomain helicase DNA binding protein 70.715
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.704
Acvr1activin A receptor, type 10.685
Hoxa3homeobox A30.659
Retret proto-oncogene0.605
Hoxa2homeobox A20.600
Runx2runt related transcription factor 20.597
Alx4aristaless-like homeobox 40.556
Pax9paired box gene 90.553
Pax6paired box gene 60.530
Bmp2bone morphogenetic protein 20.502
Fgfr3fibroblast growth factor receptor 30.462
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.417
Vangl2vang-like 2 (van gogh, Drosophila)0.384
Vegfavascular endothelial growth factor A0.369
Pbx1pre B-cell leukemia transcription factor 10.362
Tgfbr2transforming growth factor, beta receptor II0.354
Tbx15T-box 150.352
Dlx6distal-less homeobox 60.289
Sox11SRY-box containing gene 110.272
Mesp1mesoderm posterior 10.264
Dlx2distal-less homeobox 20.257
Ptpn11protein tyrosine phosphatase, non-receptor type 110.252
Sox2SRY-box containing gene 20.250
Rararetinoic acid receptor, alpha0.231
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.214
Hmx3H6 homeobox 30.207
Lmx1aLIM homeobox transcription factor 1 alpha0.200
Alx1ALX homeobox 10.191
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.183
Efnb2ephrin B20.183
Ece1endothelin converting enzyme 10.173
En1engrailed 10.171
Otx1orthodenticle homolog 1 (Drosophila)0.169
Lmx1bLIM homeobox transcription factor 1 beta0.161
Nrg1neuregulin 10.153
Twist2twist homolog 2 (Drosophila)0.150
Meox2mesenchyme homeobox 20.132
Col2a1collagen, type II, alpha 10.116
Hoxd3homeobox D30.111
Pitx1paired-like homeodomain transcription factor 10.105
Alx3aristaless-like homeobox 30.103
Gata4GATA binding protein 40.103
Mn1meningioma 10.103
Gdnfglial cell line derived neurotrophic factor0.094
Ascl1achaete-scute complex homolog 1 (Drosophila)0.094
Lhx1LIM homeobox protein 10.093
Nkx3-2NK3 homeobox 20.087
Bdnfbrain derived neurotrophic factor0.087
Fgf3fibroblast growth factor 30.086
Wt1Wilms tumor 1 homolog0.084
Ctnnb1catenin (cadherin associated protein), beta 10.084
Hoxb1homeobox B10.074
Lrp6low density lipoprotein receptor-related protein 60.072
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.072
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism