The network for 'retinoic acid receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

retinoic acid receptor signaling pathway

The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands.

NameDescriptionProbabilityFunc Analog Organism
rxraaretinoid X receptor, alpha a0.891
ppargperoxisome proliferator activated receptor gamma0.802
raraaretinoic acid receptor, alpha a0.770
crabp2acellular retinoic acid binding protein 2, a0.646
etv5bets variant 5b0.603
fabp2fatty acid binding protein 2, intestinal0.572
gata5GATA-binding protein 50.433
gli2aGLI-Kruppel family member GLI2a0.348
rxrgaretinoid x receptor, gamma a0.315
cdx4caudal type homeo box transcription factor 40.218
pou1f1POU domain, class 1, transcription factor 10.192
hoxb1bhomeo box B1b0.187
aldh1a2aldehyde dehydrogenase 1 family, member A20.187
nr1d2bnuclear receptor subfamily 1, group D, member 2b0.183
fabp11afatty acid binding protein 11a0.172
kctd15apotassium channel tetramerisation domain containing 15a0.169
tm4sf4transmembrane 4 L six family member 40.163
dctdopachrome tautomerase0.155
nrp2bneuropilin 2b0.154
rxrbaretinoid x receptor, beta a0.150
mtpmicrosomal triglyceride transfer protein0.136
fgfr2fibroblast growth factor receptor 20.127
axin2axin 2 (conductin, axil)0.115
trpv6transient receptor potential cation channel, subfamily V, member 60.109
lfnglunatic fringe homolog0.107
tgif1TGFB-induced factor homeobox 10.092
sox11aSRY-box containing gene 11a0.084
rarabretinoic acid receptor, alpha b0.083
pvrl1apoliovirus receptor-related 1a0.080
ptbp2polypyrimidine tract binding protein 20.079
nr2f5nuclear receptor subfamily 2, group F, member 50.078
fzd7afrizzled homolog 7a0.076
esr2bestrogen receptor 2b0.074
tcf12transcription factor 120.073
tead3aTEA domain family member 3 a0.071
fabp1b.1fatty acid binding protein 1b, tandem duplicate 10.069
rdh10aretinol dehydrogenase 10a0.069
fabp3fatty acid binding protein 3, muscle and heart0.069
rxrabretinoid x receptor, alpha b0.068
meis2.1myeloid ecotropic viral integration site 2.10.067
rxrgbretinoid X receptor, gamma b0.067
sox9aSRY-box containing gene 9a0.067
myh11amyosin, heavy polypeptide 11, smooth muscle a0.064
tp53tumor protein p530.063
prdm5PR domain containing 50.063
gng13aguanine nucleotide binding protein (G protein), gamma 13a0.061
dhrs3adehydrogenase/reductase (SDR family) member 3a0.061
fzd7bfrizzled homolog 7b0.059
znf703zinc finger protein 7030.059
sox17SRY-box containing gene 170.059
aqp1a.1aquaporin 1a, tandem duplicate 10.059
hdac4histone deacetylase 40.059
ncor2nuclear receptor co-repressor 20.058
gamtguanidinoacetate N-methyltransferase0.058
ntn1anetrin 1a0.058
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.056
ldb1aLIM-domain binding factor 1a0.055
rassf1Ras association (RalGDS/AF-6) domain family 10.052
sox19aSRY-box containing gene 19a0.052
nr1i2nuclear receptor subfamily 1, group I, member 20.052
ryr3ryanodine receptor 30.052
caprin1acell cycle associated protein 1a0.051
fgf8afibroblast growth factor 8 a0.051
sema3aasemaphorin 3aa0.050
fstafollistatin a0.049
pcdh18bprotocadherin 18b0.049
mab21l2mab-21-like 20.049
cnot6CCR4-NOT transcription complex, subunit 60.046
nr1d2anuclear receptor subfamily 1, group D, member 2a0.045
cacnb2bcalcium channel, voltage-dependent, beta 2b0.044
tfr1btransferrin receptor 1b0.044
robo4roundabout homolog 40.043
efnb3bephrin B3b0.042
pbx1apre-B-cell leukemia transcription factor 1a0.042
jam3bjunctional adhesion molecule 3b0.040
s100a1S100 calcium binding protein A10.040
prtgaprotogenin homolog a (Gallus gallus)0.039
rorabRAR-related orphan receptor A, paralog b0.039
aldh2aaldehyde dehydrogenase 2 family (mitochondrial)a0.038
nrip1bnuclear receptor interacting protein 1b0.038
pax3apaired box gene 3a0.037
per2period homolog 2 (Drosophila)0.036
id1inhibitor of DNA binding 10.035
irx3biroquois homeobox protein 3b0.035
fstl1afollistatin-like 1a0.035
pdzd7aPDZ domain containing 7a0.035
id2ainhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a0.035
jag1ajagged 1a0.034
sf1splicing factor 10.034
cgaglycoprotein hormones, alpha polypeptide0.034
fzd8afrizzled homolog 8a0.033
smarcd3bSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3b0.032
nme4non-metastatic cells 4, protein expressed in0.032
nr5a2nuclear receptor subfamily 5, group A, member 20.032
efemp2EGF-containing fibulin-like extracellular matrix protein 20.031
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RARAretinoic acid receptor, alpha0.988
ESR1estrogen receptor 10.834
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)0.785
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.672
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.572
NCOA1nuclear receptor coactivator 10.455
RXRAretinoid X receptor, alpha0.438
MED1mediator complex subunit 10.282
NCOR2nuclear receptor corepressor 20.209
AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)0.127
HNF4Ahepatocyte nuclear factor 4, alpha0.073
CREBBPCREB binding protein0.071
MED25mediator complex subunit 250.069
NR0B2nuclear receptor subfamily 0, group B, member 20.060
BAP1BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)0.048
PDIA3protein disulfide isomerase family A, member 30.047
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.034
PPARGperoxisome proliferator-activated receptor gamma0.034
SMPD1sphingomyelin phosphodiesterase 1, acid lysosomal0.031
SPOPspeckle-type POZ protein0.028
IKIK cytokine, down-regulator of HLA II0.028
ESRRGestrogen-related receptor gamma0.026
NRIP1nuclear receptor interacting protein 10.020
NCOA3nuclear receptor coactivator 30.019
LGALS8lectin, galactoside-binding, soluble, 80.019
NCOA6nuclear receptor coactivator 60.016
PPP5Cprotein phosphatase 5, catalytic subunit0.016
RXRBretinoid X receptor, beta0.015
ITGB1BP2integrin beta 1 binding protein (melusin) 20.015
CNOT8CCR4-NOT transcription complex, subunit 80.014
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.013
TRRAPtransformation/transcription domain-associated protein0.012
KLHL24kelch-like 24 (Drosophila)0.012
MYLK2myosin light chain kinase 20.012
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.852
Tbx3T-box 30.828
Pitx2paired-like homeodomain transcription factor 20.735
Rxraretinoid X receptor alpha0.690
Rargretinoic acid receptor, gamma0.545
Otx2orthodenticle homolog 2 (Drosophila)0.518
Pitx1paired-like homeodomain transcription factor 10.496
Pbx1pre B-cell leukemia transcription factor 10.362
Ascl1achaete-scute complex homolog 1 (Drosophila)0.355
Rararetinoic acid receptor, alpha0.333
Foxg1forkhead box G10.304
Pax2paired box gene 20.300
Cdx2caudal type homeobox 20.223
Pax3paired box gene 30.201
Ghrgrowth hormone receptor0.185
Neurod1neurogenic differentiation 10.179
Cyp26a1cytochrome P450, family 26, subfamily a, polypeptide 10.166
Shhsonic hedgehog0.166
Pou4f2POU domain, class 4, transcription factor 20.155
Hoxa9homeobox A90.150
Foxc2forkhead box C20.126
Runx1t1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.124
Nr2f2nuclear receptor subfamily 2, group F, member 20.110
Gscgoosecoid homeobox0.102
Tbx5T-box 50.097
Lhx3LIM homeobox protein 30.085
Nr5a1nuclear receptor subfamily 5, group A, member 10.080
Neurod4neurogenic differentiation 40.079
Sox11SRY-box containing gene 110.078
Btbd17BTB (POZ) domain containing 170.074
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.069
Nr2f1nuclear receptor subfamily 2, group F, member 10.067
Gdf11growth differentiation factor 110.065
Tcfap2atranscription factor AP-2, alpha0.063
Emx1empty spiracles homolog 1 (Drosophila)0.061
Leprleptin receptor0.059
Hoxd3homeobox D30.054
Hoxa13homeobox A130.053
Rnf2ring finger protein 20.052
Myf5myogenic factor 50.051
Prox1prospero-related homeobox 10.051
Pbx3pre B-cell leukemia transcription factor 30.050
Gja5gap junction protein, alpha 50.047
Mesp1mesoderm posterior 10.047
Notch2Notch gene homolog 2 (Drosophila)0.047
Efna2ephrin A20.047
Hand2heart and neural crest derivatives expressed transcript 20.045
Pax8paired box gene 80.045
Scn5asodium channel, voltage-gated, type V, alpha0.044
Hoxa2homeobox A20.044
Igf1insulin-like growth factor 10.044
Lifleukemia inhibitory factor0.042
Fgf8fibroblast growth factor 80.040
Dll4delta-like 4 (Drosophila)0.039
Kdm2blysine (K)-specific demethylase 2B0.038
Sox2SRY-box containing gene 20.037
Tlx3T-cell leukemia, homeobox 30.036
Hoxa5homeobox A50.035
Ror2receptor tyrosine kinase-like orphan receptor 20.035
Isl1ISL1 transcription factor, LIM/homeodomain0.035
Ebf2early B-cell factor 20.034
Rarbretinoic acid receptor, beta0.034
Pax6paired box gene 60.034
Hoxb4homeobox B40.033
Il10interleukin 100.031
Snai1snail homolog 1 (Drosophila)0.031
Chd7chromodomain helicase DNA binding protein 70.031
Ptf1apancreas specific transcription factor, 1a0.030
Neurog2neurogenin 20.029
Gata4GATA binding protein 40.029
Bdnfbrain derived neurotrophic factor0.029
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.028
MecomMDS1 and EVI1 complex locus0.028
Dlx1distal-less homeobox 10.027
Lhx1LIM homeobox protein 10.027
Smad6MAD homolog 6 (Drosophila)0.027
DbpD site albumin promoter binding protein0.026
Thrathyroid hormone receptor alpha0.025
Lef1lymphoid enhancer binding factor 10.025
Insm1insulinoma-associated 10.025
Gli3GLI-Kruppel family member GLI30.024
Pou3f3POU domain, class 3, transcription factor 30.024
Cbfa2t3core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)0.024
Gata5GATA binding protein 50.024
Hand1heart and neural crest derivatives expressed transcript 10.023
Tcf3transcription factor 30.023
Sox4SRY-box containing gene 40.023
Zic3zinc finger protein of the cerebellum 30.022
Prdm16PR domain containing 160.022
Vdrvitamin D receptor0.022
Ncor1nuclear receptor co-repressor 10.022
Nhlh1nescient helix loop helix 10.022
Hoxa3homeobox A30.022
Lhcgrluteinizing hormone/choriogonadotropin receptor0.021
Foxc1forkhead box C10.021
Crb2crumbs homolog 2 (Drosophila)0.020
Shox2short stature homeobox 20.020
Col13a1collagen, type XIII, alpha 10.020
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
DbpD site of albumin promoter (albumin D-box) binding protein0.623
Pdia4protein disulfide isomerase family A, member 40.416
Tgfbr2transforming growth factor, beta receptor II0.382
Nfibnuclear factor I/B0.244
Rararetinoic acid receptor, alpha0.162
Sec61a1Sec61 alpha 1 subunit (S. cerevisiae)0.110
Slco2a1solute carrier organic anion transporter family, member 2a10.099
Gstm2glutathione S-transferase mu 20.080
Stat6signal transducer and activator of transcription 60.080
Nfianuclear factor I/A0.079
Pdia3protein disulfide isomerase family A, member 30.075
Rxraretinoid X receptor alpha0.075
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.072
Enpepglutamyl aminopeptidase0.058
Tcf3transcription factor 30.050
Rxrgretinoid X receptor gamma0.050
Agtr1aangiotensin II receptor, type 1a0.050
Znf532zinc finger protein 5320.048
Nr2f6nuclear receptor subfamily 2, group F, member 60.044
Il10rainterleukin 10 receptor, alpha0.043
Hsp90b1heat shock protein 90, beta, member 10.042
Epn1Epsin 10.041
Tcf4transcription factor 40.040
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.038
Efnb1ephrin B10.038
Hspa5heat shock protein 50.038
Nfat5nuclear factor of activated T-cells 50.038
Zfp362zinc finger protein 3620.037
Vipr1vasoactive intestinal peptide receptor 10.037
Il1r1interleukin 1 receptor, type I0.036
Sorbs3sorbin and SH3 domain containing 30.035
Ppt2palmitoyl-protein thioesterase 20.032
Ddr1discoidin domain receptor tyrosine kinase 10.032
Nup153nucleoporin 1530.031
Sdc3syndecan 30.031
Mpzmyelin protein zero0.029
Tgfbr3transforming growth factor, beta receptor III0.029
Brd3bromodomain containing 30.027
Akt2v-akt murine thymoma viral oncogene homolog 20.025
Foxo1forkhead box O10.024
Cyp27a1cytochrome P450, family 27, subfamily a, polypeptide 10.024
Fgd4FYVE, RhoGEF and PH domain containing 40.024
Cyb5r1cytochrome b5 reductase 10.023
Slc25a10solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 100.023
Map3k11mitogen-activated protein kinase kinase kinase 110.023
Sardhsarcosine dehydrogenase0.022
Hyou1hypoxia up-regulated 10.020
Ergv-ets erythroblastosis virus E26 oncogene homolog (avian)0.020
Gulogulonolactone (L-) oxidase0.019
Nficnuclear factor I/C0.018
Zfp469zinc finger protein 4690.018
Nr1d2nuclear receptor subfamily 1, group D, member 20.018
Pip4k2bphosphatidylinositol-5-phosphate 4-kinase, type II, beta0.018
Timp3TIMP metallopeptidase inhibitor 30.018
Falzfetal Alzheimer antigen0.017
Hsf4heat shock transcription factor 40.017
LOC287004Mg1 protein0.017
Slco2b1solute carrier organic anion transporter family, member 2b10.016
Neu2sialidase 2 (cytosolic sialidase)0.015
Map3k3mitogen activated protein kinase kinase kinase 30.015
Zbtb4zinc finger and BTB domain containing 40.015
Lgals9lectin, galactoside-binding, soluble, 90.015
Igfbp5insulin-like growth factor binding protein 50.015
Syngr2synaptogyrin 20.015
Cdc2l6cell division cycle 2-like 6 (CDK8-like)0.014
Chrnecholinergic receptor, nicotinic, epsilon0.014
Pde4dphosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)0.014
Srebf1sterol regulatory element binding transcription factor 10.014
Il15interleukin 150.014
Cald1caldesmon 10.013
Runx1t1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.013
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.013
Sult1e1sulfotransferase family 1E, estrogen-preferring, member 10.013
Taf6TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor0.013
Col8a1collagen, type VIII, alpha 10.013
Dhfrdihydrofolate reductase0.012
Bcl2B-cell CLL/lymphoma 20.012
Masp1mannan-binding lectin serine peptidase 10.012
Bmpr2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.012
Spata24spermatogenesis associated 240.011
Acacbacetyl-Coenzyme A carboxylase beta0.011
Tfebtranscription factor EB0.011
Rnase1ribonuclease, RNase A family, 1 (pancreatic)0.011
C1qtnf2C1q and tumor necrosis factor related protein 20.011
Mef2dmyocyte enhancer factor 2D0.011
Rfc1replication factor C (activator 1) 10.011
Pde4aphosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)0.011
Cysltr2cysteinyl leukotriene receptor 20.011
Tattyrosine aminotransferase0.010
Sod3superoxide dismutase 3, extracellular0.010
Acot2acyl-CoA thioesterase 20.010
Tefthyrotrophic embryonic factor0.010
Pdia6protein disulfide isomerase family A, member 60.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism