The network for 'negative regulation of tor signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of tor signaling

Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.

NameDescriptionProbabilityFunc Analog Organism
ocrloculocerebrorenal syndrome of Lowe0.435
prickle2prickle-like 2 (Drosophila)0.288
tm9sf2transmembrane 9 superfamily member 20.198
cry2bcryptochrome 2b0.176
cdc14aaCDC14 cell division cycle 14 homolog A, a0.144
nf1aneurofibromin 1a0.142
trpc4apatransient receptor potential cation channel, subfamily C, member 4 associated protein a0.132
arntl1aaryl hydrocarbon receptor nuclear translocator-like 1a0.129
homezhomeodomain leucine zipper gene0.125
acvr1bactivin A receptor, type IB0.102
lppLIM domain containing preferred translocation partner in lipoma0.100
zfyve28zinc finger, FYVE domain containing 280.087
rnf40ring finger protein 400.086
mark3MAP/microtubule affinity-regulating kinase 30.082
tfe3btranscription factor binding to IGHM enhancer 3b0.080
clock3clock homolog 3 (mouse)0.078
vcanaversican a0.077
faslgFas ligand (TNF superfamily, member 6)0.076
sbf1SET binding factor 10.076
casc3cancer susceptibility candidate 30.075
itga3bintegrin, alpha 3b0.066
c11orf2c11orf2 homolog (H. sapiens)0.062
brd2abromodomain-containing 2a0.061
mstnamyostatin a0.060
sec24cSEC24 family, member C (S. cerevisiae)0.058
trpm7transient receptor potential cation channel, subfamily M, member 70.058
atrxalpha thalassemia/mental retardation syndrome X-linked homolog (human)0.056
mical2bmicrotubule associated monoxygenase, calponin and LIM domain containing 2b0.053
per3period homolog 3 (Drosophila)0.050
zdhhc8bzinc finger, DHHC-type containing 8b0.049
shmt2serine hydroxymethyltransferase 2 (mitochondrial)0.049
sart3squamous cell carcinoma antigen recognised by T cells 30.049
pou2f1aPOU class 2 homeobox 1a0.047
pld1aphospholipase D1a0.047
trim13tripartite motif-containing 130.046
insrainsulin receptor a0.045
arap3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 30.044
etfaelectron-transfer-flavoprotein, alpha polypeptide0.043
klhl11kelch-like 11 (Drosophila)0.042
slu7SLU7 splicing factor homolog (S. cerevisiae)0.042
gon4lgon-4-like (C.elegans)0.040
cry4cryptochrome 40.039
clasp2cytoplasmic linker associated protein 20.038
arntl2aryl hydrocarbon receptor nuclear translocator-like 20.036
gyltl1bglycosyltransferase-like 1b0.035
zmynd19zinc finger, MYND domain containing 190.033
insrbinsulin receptor b0.033
tfe3atranscription factor binding to IGHM enhancer 3a0.033
rmnd5brequired for meiotic nuclear division 5 homolog B (S. cerevisiae)0.032
sheSrc homology 2 domain containing E0.031
aldh2baldehyde dehydrogenase 2b0.031
agbl5ATP/GTP binding protein-like 50.031
fut10fucosyltransferase 100.029
igf2binsulin-like growth factor 2b0.029
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.029
sec23ipSEC23 interacting protein0.029
znf148zinc finger protein 1480.029
cdc16cell division cycle 16 homolog (S. cerevisiae)0.028
sox9bSRY-box containing gene 9b0.028
sirt1sirtuin (silent mating type information regulation 2 homolog) 10.027
stat3signal transduction and activation of transcription 30.027
tmem170atransmembrane protein 170A0.026
arfgap2ADP-ribosylation factor GTPase activating protein 20.026
usp25ubiquitin specific protease 250.026
ero1lERO1-like (S. cerevisiae)0.025
ggnbp2gametogenetin binding protein 20.025
hcsthematopoietic cell signal transducer0.025
hic1lhypermethylated in cancer 1 like0.025
klhl18kelch-like 18 (Drosophila)0.025
rxrbaretinoid x receptor, beta a0.025
znf711zinc finger protein 7110.024
ankrd13cankyrin repeat domain 13C0.024
npeppsaminopeptidase puromycin sensitive0.024
fcho2FCH domain only 20.024
dixdc1bDIX domain containing 1b0.024
ccnt2acyclin T2a0.024
LOC559090PWWP domain-containing protein 2A-like0.024
esamaendothelial cell adhesion molecule a0.024
pafah1b1aplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a0.024
ptprkprotein tyrosine phosphatase, receptor type, K0.024
brapBRCA1 associated protein0.023
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)0.023
dusp4dual specificity phosphatase 40.023
snai2snail homolog 2 (Drosophila)0.023
cited2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.023
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Akt1CG4006 gene product from transcript CG4006-RA0.112
MntCG13316 gene product from transcript CG13316-RD0.077
S6kRPS6-p70-protein kinase0.061
CG8155CG8155 gene product from transcript CG8155-RA0.057
CycGCyclin G0.043
PtenCG5671 gene product from transcript CG5671-RB0.040
ImpL2Ecdysone-inducible gene L20.029
Tsc1CG6147 gene product from transcript CG6147-RA0.025
slikSterile20-like kinase0.022
HLH106Helix loop helix protein 1060.020
InRInsulin-like receptor0.020
dcodiscs overgrown0.019
MadMothers against dpp0.016
mubmushroom-body expressed0.015
ThorCG8846 gene product from transcript CG8846-RA0.015
Lk6CG17342 gene product from transcript CG17342-RA0.014
Atg18Autophagy-specific gene 180.012
Vap-33-1CG5014 gene product from transcript CG5014-RB0.011
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MTORmechanistic target of rapamycin (serine/threonine kinase)0.936
FBXW11F-box and WD repeat domain containing 110.914
BTRCbeta-transducin repeat containing0.804
RPTORregulatory associated protein of MTOR, complex 10.735
SKP1S-phase kinase-associated protein 10.667
TSC2tuberous sclerosis 20.548
CDC34cell division cycle 34 homolog (S. cerevisiae)0.300
RICTORRPTOR independent companion of MTOR, complex 20.289
PRKAB2protein kinase, AMP-activated, beta 2 non-catalytic subunit0.259
TSC1tuberous sclerosis 10.202
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 20.152
PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.146
UBE2Bubiquitin-conjugating enzyme E2B (RAD6 homolog)0.132
TFRCtransferrin receptor (p90, CD71)0.109
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.077
CLOCKclock homolog (mouse)0.075
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.070
YAP1Yes-associated protein 10.061
DEPTORDEP domain containing MTOR-interacting protein0.058
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.053
FBXW2F-box and WD repeat domain containing 20.044
TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)0.040
PTPN23protein tyrosine phosphatase, non-receptor type 230.038
WEE1WEE1 homolog (S. pombe)0.030
APCadenomatous polyposis coli0.028
MAPK6mitogen-activated protein kinase 60.026
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.023
DAPK1death-associated protein kinase 10.022
PRKAG1protein kinase, AMP-activated, gamma 1 non-catalytic subunit0.019
AXIN1axin 10.018
ACACAacetyl-CoA carboxylase alpha0.018
PRKAG2protein kinase, AMP-activated, gamma 2 non-catalytic subunit0.017
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.017
PREX1phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 10.015
AHRaryl hydrocarbon receptor0.014
FBXW7F-box and WD repeat domain containing 70.014
FOXO3forkhead box O30.014
VEGFAvascular endothelial growth factor A0.013
MAPKAP1mitogen-activated protein kinase associated protein 10.012
UBR1ubiquitin protein ligase E3 component n-recognin 10.012
KAT2BK(lysine) acetyltransferase 2B0.012
CDC25Acell division cycle 25 homolog A (S. pombe)0.012
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.011
AKT1v-akt murine thymoma viral oncogene homolog 10.011
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.011
HDAC4histone deacetylase 40.011
PDCD6IPprogrammed cell death 6 interacting protein0.010
PRKAA1protein kinase, AMP-activated, alpha 1 catalytic subunit0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Apcadenomatosis polyposis coli0.948
Ctnnb1catenin (cadherin associated protein), beta 10.936
Nf2neurofibromatosis 20.865
Trp53transformation related protein 530.844
Ptenphosphatase and tensin homolog0.760
Tsc1tuberous sclerosis 10.632
Clockcircadian locomotor output cycles kaput0.578
Hif1ahypoxia inducible factor 1, alpha subunit0.504
Nr3c1nuclear receptor subfamily 3, group C, member 10.476
Vhlvon Hippel-Lindau tumor suppressor0.469
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.436
Ahraryl-hydrocarbon receptor0.375
Tsc2tuberous sclerosis 20.340
Mapk14mitogen-activated protein kinase 140.313
Rb1retinoblastoma 10.270
Cry1cryptochrome 1 (photolyase-like)0.190
Axin1axin 10.162
Cdkn1bcyclin-dependent kinase inhibitor 1B0.153
Otporthopedia homolog (Drosophila)0.147
Egln1EGL nine homolog 1 (C. elegans)0.146
Leprleptin receptor0.133
Sim1single-minded homolog 1 (Drosophila)0.125
Phc1polyhomeotic-like 1 (Drosophila)0.116
Mdm2transformed mouse 3T3 cell double minute 20.083
Nf1neurofibromatosis 10.067
Rint1RAD50 interactor 10.066
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.061
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.056
Fnip1folliculin interacting protein 10.056
BrafBraf transforming gene0.053
Per2period homolog 2 (Drosophila)0.049
Insrinsulin receptor0.046
Hprthypoxanthine guanine phosphoribosyl transferase0.046
Phc2polyhomeotic-like 2 (Drosophila)0.046
Irs2insulin receptor substrate 20.042
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.042
Arntaryl hydrocarbon receptor nuclear translocator0.040
Npas2neuronal PAS domain protein 20.039
Prkag1protein kinase, AMP-activated, gamma 1 non-catalytic subunit0.039
Egln3EGL nine homolog 3 (C. elegans)0.038
Psen1presenilin 10.037
Xpaxeroderma pigmentosum, complementation group A0.036
Arnt2aryl hydrocarbon receptor nuclear translocator 20.034
Prkab1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.033
Foxa2forkhead box A20.031
Raf1v-raf-leukemia viral oncogene 10.029
Kiss1KiSS-1 metastasis-suppressor0.028
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.026
Ghrgrowth hormone receptor0.026
Cry2cryptochrome 2 (photolyase-like)0.025
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.022
Adam17a disintegrin and metallopeptidase domain 170.022
Fbxo11F-box protein 110.022
Tbk1TANK-binding kinase 10.021
Ep300E1A binding protein p3000.021
Atf2activating transcription factor 20.021
Foxo3forkhead box O30.020
E2f1E2F transcription factor 10.020
Arandrogen receptor0.018
Efnb2ephrin B20.018
Per1period homolog 1 (Drosophila)0.018
Foxo1forkhead box O10.017
Sumo1SMT3 suppressor of mif two 3 homolog 1 (yeast)0.017
Nfe2l2nuclear factor, erythroid derived 2, like 20.016
Reps1RalBP1 associated Eps domain containing protein0.016
Npc1Niemann Pick type C10.016
Msh2mutS homolog 2 (E. coli)0.014
Ppargperoxisome proliferator activated receptor gamma0.014
Cops2COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana)0.014
Tsga10testis specific 100.014
Rdh10retinol dehydrogenase 10 (all-trans)0.014
Dlg1discs, large homolog 1 (Drosophila)0.014
Fbxl20F-box and leucine-rich repeat protein 200.014
Hbb-b1hemoglobin, beta adult major chain0.014
Stk11serine/threonine kinase 110.013
Ghgrowth hormone0.013
Esr2estrogen receptor 2 (beta)0.013
Siah1bseven in absentia 1B0.012
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.012
Skp1aS-phase kinase-associated protein 1A0.012
Morc3microrchidia 30.012
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.011
Ulk1Unc-51 like kinase 1 (C. elegans)0.011
Ank1ankyrin 1, erythroid0.011
Bmi1Bmi1 polycomb ring finger oncogene0.011
Akt1thymoma viral proto-oncogene 10.011
Carm1coactivator-associated arginine methyltransferase 10.011
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.011
Arntlaryl hydrocarbon receptor nuclear translocator-like0.011
Casp4caspase 4, apoptosis-related cysteine peptidase0.011
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.010
Wasf1WASP family 10.010
Sos1son of sevenless homolog 1 (Drosophila)0.010
Smad3MAD homolog 3 (Drosophila)0.010
Ptpn11protein tyrosine phosphatase, non-receptor type 110.010
Rhot1ras homolog gene family, member T10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ireb2iron responsive element binding protein 20.081
Git1G protein-coupled receptor kinase interacting ArfGAP 10.042
Smek2SMEK homolog 2, suppressor of mek1 (Dictyostelium)0.040
Usp9xubiquitin specific peptidase 9, X-linked0.036
Errfi1ERBB receptor feedback inhibitor 10.031
Rock2Rho-associated coiled-coil containing protein kinase 20.029
Carm1coactivator-associated arginine methyltransferase 10.026
Atp6v0a1ATPase, H+ transporting, lysosomal V0 subunit A10.025
Ppardperoxisome proliferator-activated receptor delta0.023
Zfp260zinc finger protein 2600.020
Pkn2protein kinase N20.020
Atxn2lataxin 2-like0.019
Hnrpdlheterogeneous nuclear ribonucleoprotein D-like0.016
Adrm1adhesion regulating molecule 10.015
Supt5hsuppressor of Ty 5 homolog (S. cerevisiae)0.014
Cherpcalcium homeostasis endoplasmic reticulum protein0.014
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.014
Ptpn12protein tyrosine phosphatase, non-receptor type 120.013
Raf1v-raf-leukemia viral oncogene 10.013
Znf598zinc finger protein 5980.013
Scaf1SR-related CTD-associated factor 10.013
RGD1564560similar to RCK0.013
Tsc22d3TSC22 domain family, member 30.013
Bat3HLA-B-associated transcript 30.012
Sgk1serum/glucocorticoid regulated kinase 10.012
Trmt1TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae)0.012
Jak2Janus kinase 20.012
Med25mediator complex subunit 250.012
Tbcetubulin folding cofactor E0.012
Slc27a1solute carrier family 27 (fatty acid transporter), member 10.011
Myo9amyosin IXA0.011
Orc4lorigin recognition complex, subunit 4-like (yeast)0.011
Pcnxl3pecanex-like 3 (Drosophila)0.011
Pelp1proline, glutamate and leucine rich protein 10.011
Kcnn1potassium intermediate/small conductance calcium-activated channel, subfamily N, member 10.011
Nup88nucleoporin 880.010
Sf1splicing factor 10.010
Ciz1CDKN1A interacting zinc finger protein 10.010
RGD1307161similar to 0610010K06Rik protein0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism