The network for 'central nervous system development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

central nervous system development

The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.

NameDescriptionProbabilityFunc Analog Organism
sox2SRY-box containing gene 21.000
eya1eyes absent homolog 11.000
shhasonic hedgehog a1.000
gata3GATA-binding protein 31.000
gli2aGLI-Kruppel family member GLI2a0.999
fgf3fibroblast growth factor 30.999
olig2oligodendrocyte lineage transcription factor 20.999
lhx1aLIM homeobox 1a0.998
ascl1aachaete-scute complex-like 1a (Drosophila)0.998
tbx1T-box 10.998
egr2bearly growth response 2b0.997
otpborthopedia homolog b0.997
vdravitamin D receptor a0.996
six4bsine oculis homeobox homolog 4b0.996
sox1aSRY-box containing gene 1a0.996
shhbsonic hedgehog b0.995
pax2apaired box gene 2a0.995
tal1T-cell acute lymphocytic leukemia 10.995
bmp2bbone morphogenetic protein 2b0.994
gbx2gastrulation brain homeo box 20.994
sox19aSRY-box containing gene 19a0.993
otx1borthodenticle homolog 1b0.993
lef1lymphocyte enhancer binding factor 10.993
ndr2nodal-related 20.992
foxd3forkhead box D30.992
her15.1hairy and enhancer of split-related 15.10.991
aldh1a2aldehyde dehydrogenase 1 family, member A20.991
hand2heart and neural crest derivatives expressed transcript 20.990
epha4aeph receptor A4a0.989
epb41l5erythrocyte membrane protein band 4.1 like 50.989
lhx5LIM homeobox 50.989
spry4sprouty (Drosophila) homolog 40.987
bdnfbrain-derived neurotrophic factor0.986
pax6apaired box gene 6a0.985
ncam1bneural cell adhesion molecule 1b0.985
meis2.1myeloid ecotropic viral integration site 2.10.985
barhl2BarH-like 20.984
sox3SRY-box containing gene 30.982
pitx2paired-like homeodomain transcription factor 20.982
rx3retinal homeobox gene 30.981
hoxa3ahomeo box A3a0.980
six3bsine oculis homeobox homolog 3b0.979
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.978
otx2orthodenticle homolog 20.978
smosmoothened homolog (Drosophila)0.975
robo2roundabout homolog 20.974
meis3myeloid ecotropic viral integration site 30.973
fabp7afatty acid binding protein 7, brain, a0.973
robo3roundabout homolog 30.972
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.972
hdac1histone deacetylase 10.971
pax3apaired box gene 3a0.971
nr2f1anuclear receptor subfamily 2, group F, member 1a0.968
pax8paired box gene 80.968
hnf1baHNF1 homeobox Ba0.968
hoxc4ahomeo box C4a0.966
barhl1.1BarH-like 1.10.965
dlx5adistal-less homeobox gene 5a0.964
rx2retinal homeobox gene 20.964
zic4zic family member 40.964
hoxb5bhomeo box B5b0.960
wnt1wingless-type MMTV integration site family, member 10.959
nr2e1nuclear receptor subfamily 2, group E, member 10.959
six1bsine oculis homeobox homolog 1b0.958
wnt8bwingless-type MMTV integration site family, member 8b0.958
gdnfglial cell derived neurotrophic factor0.956
tbx16T-box gene 160.955
arxaristaless related homeobox0.954
neo1neogenin 10.953
mbpmyelin basic protein0.952
hmx3homeo box (H6 family) 30.952
epb4.1l4erythrocyte protein band 4.1-like 40.950
fezf2FEZ family zinc finger 20.948
pax7apaired box gene 7a0.947
foxa3forkhead box A30.947
hhiphedgehog interacting protein0.947
fzd7afrizzled homolog 7a0.946
tp53tumor protein p530.945
atoh1aatonal homolog 1a0.945
cxcr4bchemokine (C-X-C motif), receptor 4b0.944
dlx3bdistal-less homeobox gene 3b0.944
jag2jagged 20.944
vcanaversican a0.943
her5hairy-related 50.939
ptenbphosphatase and tensin homolog B (mutated in multiple advanced cancers 1)0.939
wnt2bbwingless-type MMTV integration site family, member 2Bb0.937
nr2f2nuclear receptor subfamily 2, group F, member 20.936
pou3f1POU class 3 homeobox 10.931
irx3airoquois homeobox protein 3a0.931
fzd8afrizzled homolog 8a0.929
sall4sal-like 4 (Drosophila)0.928
tbx20T-box 200.924
dbx1adeveloping brain homeobox 1a0.923
robo1roundabout homolog 10.922
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
cicubitus interruptus0.998
EgfrEpidermal growth factor receptor0.996
Ten-aTenascin accessory0.986
trioCG18214 gene product from transcript CG18214-RA0.977
Rac1CG2248 gene product from transcript CG2248-RA0.976
slmbsupernumerary limbs0.972
argosCG4531 gene product from transcript CG4531-RA0.971
DscamDown syndrome cell adhesion molecule0.970
PtpmegCG1228 gene product from transcript CG1228-RD0.966
CycACyclin A0.962
Sema-1aCG18405 gene product from transcript CG18405-RD0.957
Fas2Fasciclin 20.956
Ras85DRas oncogene at 85D0.955
E(spl)Enhancer of split0.951
opaodd paired0.926
vvlventral veins lacking0.925
Src42ASrc oncogene at 42A0.922
Fmr1CG6203 gene product from transcript CG6203-RC0.906
pashapartner of drosha0.894
mbcmyoblast city0.882
snssticks and stones0.877
grimCG4345 gene product from transcript CG4345-RA0.875
Top2Topoisomerase 20.874
PhmPeptidylglycine-alpha-hydroxylating monooxygenase0.868
InRInsulin-like receptor0.864
TBPHCG10327 gene product from transcript CG10327-RC0.860
Nedd4CG42279 gene product from transcript CG42279-RJ0.848
Ced-12CG5336 gene product from transcript CG5336-RA0.844
par-1CG8201 gene product from transcript CG8201-RA0.842
norpAno receptor potential A0.842
slp1sloppy paired 10.840
Tm1Tropomyosin 10.832
MadMothers against dpp0.831
Syx1ASyntaxin 1A0.824
bowlbrother of odd with entrails limited0.808
robo3CG5423 gene product from transcript CG5423-RA0.804
CG2865CG2865 gene product from transcript CG2865-RA0.800
stanstarry night0.762
HLHm7E(spl) region transcript m70.760
snostrawberry notch0.759
EcREcdysone receptor0.756
Sema-2aCG4700 gene product from transcript CG4700-RC0.744
Su(H)Suppressor of Hairless0.741
ph-ppolyhomeotic proximal0.736
HGTXCG13475 gene product from transcript CG13475-RB0.734
nonAno on or off transient A0.729
sleslender lobes0.723
amosabsent MD neurons and olfactory sensilla0.722
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor0.998
TP53tumor protein p530.997
ESR1estrogen receptor 10.993
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.978
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.973
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.956
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.945
MDM2Mdm2 p53 binding protein homolog (mouse)0.943
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.936
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.913
ATXN1ataxin 10.887
NCOR1nuclear receptor corepressor 10.886
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.855
METmet proto-oncogene (hepatocyte growth factor receptor)0.838
FGFR2fibroblast growth factor receptor 20.818
DAXXdeath-domain associated protein0.806
SIN3ASIN3 homolog A, transcription regulator (yeast)0.787
APCadenomatous polyposis coli0.712
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.669
CREBBPCREB binding protein0.653
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.652
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.616
ARandrogen receptor0.608
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.600
PKM2pyruvate kinase, muscle0.590
HDAC1histone deacetylase 10.586
MYOD1myogenic differentiation 10.585
EP300E1A binding protein p3000.567
TAL1T-cell acute lymphocytic leukemia 10.562
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.552
DRD2dopamine receptor D20.545
ACTBactin, beta0.525
RXRAretinoid X receptor, alpha0.521
CASP3caspase 3, apoptosis-related cysteine peptidase0.513
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.508
S100BS100 calcium binding protein B0.497
FGFR1fibroblast growth factor receptor 10.488
TP73tumor protein p730.476
NCOR2nuclear receptor corepressor 20.463
PDX1pancreatic and duodenal homeobox 10.458
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.453
ITSN1intersectin 1 (SH3 domain protein)0.450
NR4A1nuclear receptor subfamily 4, group A, member 10.444
SP1Sp1 transcription factor0.438
MAP3K5mitogen-activated protein kinase kinase kinase 50.433
POU3F2POU class 3 homeobox 20.419
NOTCH1notch 10.418
FGF1fibroblast growth factor 1 (acidic)0.414
FYNFYN oncogene related to SRC, FGR, YES0.414
CRHR1corticotropin releasing hormone receptor 10.409
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.400
PPARAperoxisome proliferator-activated receptor alpha0.392
SORBS3sorbin and SH3 domain containing 30.382
MPDZmultiple PDZ domain protein0.372
SKIv-ski sarcoma viral oncogene homolog (avian)0.363
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.359
LBX1ladybird homeobox 10.357
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.353
RBFOX1RNA binding protein, fox-1 homolog (C. elegans) 10.345
EGR1early growth response 10.344
HCFC1host cell factor C1 (VP16-accessory protein)0.335
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.328
NCOA2nuclear receptor coactivator 20.327
PBX1pre-B-cell leukemia homeobox 10.325
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.325
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.317
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.308
SFRP1secreted frizzled-related protein 10.307
BCL2L1BCL2-like 10.304
RUNX1runt-related transcription factor 10.304
ZNF43zinc finger protein 430.300
FGF3fibroblast growth factor 30.297
NTRK3neurotrophic tyrosine kinase, receptor, type 30.295
EPAS1endothelial PAS domain protein 10.293
ARID1AAT rich interactive domain 1A (SWI-like)0.293
WNT1wingless-type MMTV integration site family, member 10.292
JAG1jagged 10.288
PEX14peroxisomal biogenesis factor 140.287
FLNAfilamin A, alpha0.282
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.281
SHC1SHC (Src homology 2 domain containing) transforming protein 10.281
CASP9caspase 9, apoptosis-related cysteine peptidase0.278
RBBP4retinoblastoma binding protein 40.277
SMAD3SMAD family member 30.272
PKD2polycystic kidney disease 2 (autosomal dominant)0.271
SC4MOLsterol-C4-methyl oxidase-like0.268
GSK3Bglycogen synthase kinase 3 beta0.264
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.261
SOX1SRY (sex determining region Y)-box 10.257
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.257
NCOA1nuclear receptor coactivator 10.255
IGF1Rinsulin-like growth factor 1 receptor0.254
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.252
XIAPX-linked inhibitor of apoptosis0.249
SMAD2SMAD family member 20.247
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.247
APPamyloid beta (A4) precursor protein0.246
VEGFAvascular endothelial growth factor A0.243
PDIA3protein disulfide isomerase family A, member 30.241
PFN1profilin 10.238
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Grm7glutamate receptor, metabotropic 70.655
Anxa2annexin A20.621
Drd1adopamine receptor D1A0.605
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.604
Fgfr2fibroblast growth factor receptor 20.593
Gad2glutamate decarboxylase 20.587
Sirpasignal-regulatory protein alpha0.584
Nrcamneuronal cell adhesion molecule0.516
Notch3Notch homolog 3 (Drosophila)0.515
Kcnj15potassium inwardly-rectifying channel, subfamily J, member 150.510
Rims1regulating synaptic membrane exocytosis 10.479
S100a10S100 calcium binding protein A100.466
Gria4glutamate receptor, ionotrophic, AMPA 40.465
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 10.463
Ahraryl hydrocarbon receptor0.456
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.442
Egr1early growth response 10.441
Grik1glutamate receptor, ionotropic, kainate 10.441
Kcnj9potassium inwardly-rectifying channel, subfamily J, member 90.438
Adrb1adrenergic, beta-1-, receptor0.434
Lgals3lectin, galactoside-binding, soluble, 30.431
Cd4Cd4 molecule0.430
Pnlippancreatic lipase0.421
Chrna7cholinergic receptor, nicotinic, alpha 70.421
Nrxn1neurexin 10.418
Robo1roundabout homolog 1 (Drosophila)0.416
Id3inhibitor of DNA binding 30.407
Atxn1ataxin 10.403
Ptafrplatelet-activating factor receptor0.403
Eporerythropoietin receptor0.401
Itgamintegrin, alpha M0.401
Slc14a2solute carrier family 14 (urea transporter), member 20.400
Mapre1microtubule-associated protein, RP/EB family, member 10.399
Gabrb3gamma-aminobutyric acid (GABA) A receptor, beta 30.397
Hoxa2homeo box A20.396
Chrna9cholinergic receptor, nicotinic, alpha 90.393
Ntrk1neurotrophic tyrosine kinase, receptor, type 10.387
Arnt2aryl hydrocarbon receptor nuclear translocator 20.384
Nr4a2nuclear receptor subfamily 4, group A, member 20.381
Ednrbendothelin receptor type B0.379
Syt4synaptotagmin IV0.379
Galr3galanin receptor 30.377
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.372
Marcksmyristoylated alanine rich protein kinase C substrate0.369
Kcnt1potassium channel, subfamily T, member 10.362
Crxcone-rod homeobox0.361
Arpc1bactin related protein 2/3 complex, subunit 1B0.356
Cckbrcholecystokinin B receptor0.355
Add3adducin 3 (gamma)0.347
Adra2cadrenergic, alpha-2C-, receptor0.346
Drd2dopamine receptor D20.346
Slc32a1solute carrier family 32 (GABA vesicular transporter), member 10.343
Dlg4discs, large homolog 4 (Drosophila)0.336
Calcrlcalcitonin receptor-like0.335
Sprr1alsmall proline-rich protein 1A-like0.335
Cgaglycoprotein hormones, alpha polypeptide0.329
Slco2b1solute carrier organic anion transporter family, member 2b10.328
Dlgap3discs, large (Drosophila) homolog-associated protein 30.328
Sdc3syndecan 30.327
Neurod1neurogenic differentiation 10.326
Hoxa1homeo box A10.325
Gabra3gamma-aminobutyric acid (GABA) A receptor, alpha 30.324
Cntn2contactin 2 (axonal)0.322
Celsr3cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)0.318
LOC246267resection-induced TPI (rs11)0.318
Slc1a1solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 10.317
Lzts1leucine zipper, putative tumor suppressor 10.317
Cntn3contactin 3 (plasmacytoma associated)0.315
Cntfrciliary neurotrophic factor receptor0.311
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.305
Myt1lmyelin transcription factor 1-like0.304
St18suppression of tumorigenicity 180.304
Slc1a2solute carrier family 1 (glial high affinity glutamate transporter), member 20.303
Camk4calcium/calmodulin-dependent protein kinase IV0.301
Gabra1gamma-aminobutyric acid (GABA) A receptor, alpha 10.301
Slc22a7solute carrier family 22 (organic anion transporter), member 70.301
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.300
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.297
CebpeCCAAT/enhancer binding protein (C/EBP), epsilon0.293
Slc6a1solute carrier family 6 (neurotransmitter transporter, GABA), member 10.292
Hapln1hyaluronan and proteoglycan link protein 10.289
Ptprsprotein tyrosine phosphatase, receptor type, S0.288
Gas7growth arrest specific 70.287
Tac1tachykinin 10.286
Ube2d4ubiquitin-conjugating enzyme E2D 40.286
Hcn1hyperpolarization-activated cyclic nucleotide-gated potassium channel 10.286
Ageradvanced glycosylation end product-specific receptor0.282
Krtap1-5keratin associated protein 1-50.282
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.282
Rhoaras homolog gene family, member A0.280
Ompolfactory marker protein0.275
Mogmyelin oligodendrocyte glycoprotein0.274
Nkx2-1NK2 homeobox 10.274
Mc5rmelanocortin 5 receptor0.274
Nrg2neuregulin 20.270
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism