The network for 'collagen biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

collagen biosynthetic process

The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).

NameDescriptionProbabilityFunc Analog Organism
col1a1acollagen, type I, alpha 1a0.987
col5a1procollagen, type V, alpha 10.929
col1a2collagen, type I, alpha 20.893
sparcsecreted acidic cysteine rich glycoprotein0.680
plod2procollagen-lysine, 2-oxoglutarate 5-dioxygenase 20.466
hapln1ahyaluronan and proteoglycan link protein 1a0.422
bmp2bbone morphogenetic protein 2b0.418
foxj1aforkhead box J1a0.334
plod1aprocollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a0.279
col2a1acollagen type II, alpha-1a0.202
tcf7transcription factor 7 (T-cell specific, HMG-box)0.200
tcf12transcription factor 120.184
il6stinterleukin 6 signal transducer0.178
col11a1acollagen, type XI, alpha 1a0.174
zgc:85866zgc:858660.168
fbn2bfibrillin 2b0.162
chsy1chondroitin sulfate synthase 10.161
cav1caveolin 10.154
gata5GATA-binding protein 50.142
osr1odd-skipped related 1 (Drosophila)0.141
dlx5adistal-less homeobox gene 5a0.139
ctgfconnective tissue growth factor0.137
col10a1collagen, type X, alpha 10.134
postnperiostin, osteoblast specific factor0.126
jag1bjagged 1b0.090
col11a1bcollagen type XI alpha-1b and collagen, type XI, alpha 1b0.088
col27a1acollagen, type XXVII, alpha 1a0.087
tpm4tropomyosin 40.082
bmp1abone morphogenetic protein 1a0.082
LOC565459tight junction protein ZO-1-like0.078
igf2binsulin-like growth factor 2b0.077
duoxdual oxidase0.076
arl13bADP-ribosylation factor-like 13b0.067
matn4matrilin 40.061
col1a1bcollagen, type I, alpha 1b0.061
zgc:63947zgc:639470.060
agr2anterior gradient homolog 2 (Xenopus laevis)0.059
cebpaCCAAT/enhancer binding protein (C/EBP), alpha0.058
col5a2lcollagen, type V, alpha 2-like0.056
sepw1selenoprotein W, 10.056
pthlhparathyroid hormone-like hormone0.054
frzbfrizzled-related protein0.053
foxa3forkhead box A30.052
LOC100334210growth/differentiation factor 5-like0.050
mtpmicrosomal triglyceride transfer protein0.048
ahr2aryl hydrocarbon receptor 20.048
spry4sprouty (Drosophila) homolog 40.047
si:ch211-173b8.2si:ch211-173b8.20.045
cftrcystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)0.045
junjun proto-oncogene0.043
sdprbserum deprivation response b0.043
prdm1aPR domain containing 1a, with ZNF domain0.042
fgf10afibroblast growth factor 10a0.041
tgfb2transforming growth factor, beta 20.041
map1lc3amicrotubule-associated protein 1 light chain 3 alpha0.040
plod3procollagen-lysine, 2-oxoglutarate 5-dioxygenase 30.039
col6a2collagen, type VI, alpha 20.039
trpv6transient receptor potential cation channel, subfamily V, member 60.039
myh11amyosin, heavy polypeptide 11, smooth muscle a0.038
vcanbversican b0.038
serpinb1serpin peptidase inhibitor, clade B (ovalbumin), member 10.038
fgf20afibroblast growth factor 20a0.037
twist2twist20.037
pmp22bperipheral myelin protein 22b0.036
vgll4lvestigial like 4 like0.035
tppp3tubulin polymerization-promoting protein family member 30.034
LOC569128hypothetical protein LOC5691280.034
hsp47heat shock protein 470.033
si:dkey-151c10.1si:dkey-151c10.10.033
wnt11rwingless-type MMTV integration site family, member 11, related0.033
col6a3collagen, type VI, alpha 30.033
zgc:56419zgc:564190.032
pfkfb4l6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4, like0.031
dcndecorin0.031
col27a1bcollagen, type XXVII, alpha 1b0.030
wu:fv91b12wu:fv91b120.030
bmpr2bbone morphogenetic protein receptor, type II b (serine/threonine kinase)0.029
itgb1bintegrin, beta 1b0.029
fxyd1FXYD domain containing ion transport regulator 1 (phospholemman)0.029
surf4lsurfeit gene 4, like0.028
rnasel1ribonuclease like 10.028
zgc:171553zgc:1715530.027
zgc:111821zgc:1118210.027
notch2notch homolog 20.027
cebpdCCAAT/enhancer binding protein (C/EBP), delta0.027
si:dkey-76k16.7si:dkey-76k16.70.027
cpa5carboxypeptidase A50.027
chpfchondroitin polymerizing factor0.026
wif1wnt inhibitory factor 10.026
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.026
csnk1a1casein kinase 1, alpha 10.026
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.026
papss2b3'-phosphoadenosine 5'-phosphosulfate synthase 2b0.025
gata6GATA-binding protein 60.025
cdx1bcaudal type homeobox 1 b0.025
ptprebprotein tyrosine phosphatase, receptor type, E, b0.025
sox9aSRY-box containing gene 9a0.024
bhlhe41basic helix-loop-helix family, member e410.024
aqp1a.1aquaporin 1a, tandem duplicate 10.024
zgc:92411zgc:924110.024
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.716
COL1A2collagen, type I, alpha 20.644
COL4A1collagen, type IV, alpha 10.595
FSTL1follistatin-like 10.370
COL4A2collagen, type IV, alpha 20.301
BMPR1Abone morphogenetic protein receptor, type IA0.253
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.226
DDR2discoidin domain receptor tyrosine kinase 20.222
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.128
COL1A1collagen, type I, alpha 10.121
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.099
ENGendoglin0.094
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.093
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.084
COL6A1collagen, type VI, alpha 10.077
PKD1polycystic kidney disease 1 (autosomal dominant)0.066
PXDNperoxidasin homolog (Drosophila)0.062
FN1fibronectin 10.054
MXRA5matrix-remodelling associated 50.053
LOXlysyl oxidase0.048
THBS1thrombospondin 10.042
COL3A1collagen, type III, alpha 10.041
CYR61cysteine-rich, angiogenic inducer, 610.041
POSTNperiostin, osteoblast specific factor0.036
ALBalbumin0.028
BGNbiglycan0.028
LTBP2latent transforming growth factor beta binding protein 20.028
TGFB3transforming growth factor, beta 30.028
COL6A2collagen, type VI, alpha 20.027
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.026
TMBIM6transmembrane BAX inhibitor motif containing 60.026
ELNelastin0.024
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.022
CAV1caveolin 1, caveolae protein, 22kDa0.022
TECPR1tectonin beta-propeller repeat containing 10.020
CANXcalnexin0.019
S100BS100 calcium binding protein B0.019
ADAM12ADAM metallopeptidase domain 120.018
IL6Rinterleukin 6 receptor0.018
IGFBP3insulin-like growth factor binding protein 30.018
MMP11matrix metallopeptidase 11 (stromelysin 3)0.017
COL5A2collagen, type V, alpha 20.017
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.017
PCOLCEprocollagen C-endopeptidase enhancer0.016
THY1Thy-1 cell surface antigen0.014
CAV2caveolin 20.014
IL6interleukin 6 (interferon, beta 2)0.014
NRP1neuropilin 10.014
LAMB1laminin, beta 10.013
HSPG2heparan sulfate proteoglycan 20.013
CD248CD248 molecule, endosialin0.013
LAMC1laminin, gamma 1 (formerly LAMB2)0.013
WISP1WNT1 inducible signaling pathway protein 10.012
MFAP2microfibrillar-associated protein 20.012
FGF18fibroblast growth factor 180.012
COL6A3collagen, type VI, alpha 30.012
SULF1sulfatase 10.011
F3coagulation factor III (thromboplastin, tissue factor)0.011
PLXDC1plexin domain containing 10.011
TMED10transmembrane emp24-like trafficking protein 10 (yeast)0.011
FBN1fibrillin 10.010
NID2nidogen 2 (osteonidogen)0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog0.978
Lepleptin0.897
Ptf1apancreas specific transcription factor, 1a0.516
Gli3GLI-Kruppel family member GLI30.513
Pax6paired box gene 60.506
Nhlh1nescient helix loop helix 10.486
Ascl1achaete-scute complex homolog 1 (Drosophila)0.454
Pdx1pancreatic and duodenal homeobox 10.386
Zeb1zinc finger E-box binding homeobox 10.356
Hand2heart and neural crest derivatives expressed transcript 20.336
Otx2orthodenticle homolog 2 (Drosophila)0.293
Ptenphosphatase and tensin homolog0.290
Neurog2neurogenin 20.242
Il6stinterleukin 6 signal transducer0.230
Onecut1one cut domain, family member 10.225
Neurod1neurogenic differentiation 10.188
Bgnbiglycan0.181
Nos3nitric oxide synthase 3, endothelial cell0.174
Pax3paired box gene 30.166
Gata1GATA binding protein 10.162
Tlr4toll-like receptor 40.158
Irx1Iroquois related homeobox 1 (Drosophila)0.153
Neurod4neurogenic differentiation 40.144
Pitx2paired-like homeodomain transcription factor 20.138
Sox9SRY-box containing gene 90.133
En1engrailed 10.123
Pkd1polycystic kidney disease 1 homolog0.122
Ptgs2prostaglandin-endoperoxide synthase 20.121
Gata4GATA binding protein 40.115
Tgfb2transforming growth factor, beta 20.104
Pax7paired box gene 70.102
Nkx3-2NK3 homeobox 20.098
Gli2GLI-Kruppel family member GLI20.093
Hand1heart and neural crest derivatives expressed transcript 10.089
Csf1colony stimulating factor 1 (macrophage)0.088
Nos2nitric oxide synthase 2, inducible0.087
Foxf1aforkhead box F1a0.086
Foxc2forkhead box C20.085
Ror2receptor tyrosine kinase-like orphan receptor 20.084
Il1r1interleukin 1 receptor, type I0.084
Nkx6-1NK6 homeobox 10.083
Plin1perilipin 10.083
Amhr2anti-Mullerian hormone type 2 receptor0.078
Hoxa11homeobox A110.073
Hic1hypermethylated in cancer 10.072
Apoeapolipoprotein E0.066
Cyr61cysteine rich protein 610.066
Foxd2forkhead box D20.066
Fgfr2fibroblast growth factor receptor 20.065
Tgfb1i1transforming growth factor beta 1 induced transcript 10.064
Col6a1collagen, type VI, alpha 10.064
Tcfap2atranscription factor AP-2, alpha0.063
Cav1caveolin 1, caveolae protein0.062
Engendoglin0.061
Fkbp10FK506 binding protein 100.061
Snai1snail homolog 1 (Drosophila)0.060
Mmp9matrix metallopeptidase 90.060
Sim2single-minded homolog 2 (Drosophila)0.057
Fgf15fibroblast growth factor 150.055
Fbn1fibrillin 10.054
Itgb3integrin beta 30.054
Gja1gap junction protein, alpha 10.053
Foxc1forkhead box C10.053
Lhx5LIM homeobox protein 50.052
Notch2Notch gene homolog 2 (Drosophila)0.052
Fstl1follistatin-like 10.052
Loxl1lysyl oxidase-like 10.051
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.050
Wfikkn2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.049
Plgplasminogen0.049
F2coagulation factor II0.048
Ccl2chemokine (C-C motif) ligand 20.047
Leprleptin receptor0.047
Isl1ISL1 transcription factor, LIM/homeodomain0.047
Kdelr3KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 30.046
Prozprotein Z, vitamin K-dependent plasma glycoprotein0.045
Runx2runt related transcription factor 20.043
Col1a1collagen, type I, alpha 10.043
Hoxb1homeobox B10.042
Pou4f2POU domain, class 4, transcription factor 20.041
Cbfa2t3core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)0.041
Vegfavascular endothelial growth factor A0.039
Thbs1thrombospondin 10.037
Tal1T-cell acute lymphocytic leukemia 10.037
Irx5Iroquois related homeobox 5 (Drosophila)0.036
Gscgoosecoid homeobox0.036
Col2a1collagen, type II, alpha 10.035
Pcolceprocollagen C-endopeptidase enhancer protein0.035
Esr1estrogen receptor 1 (alpha)0.034
Itih1inter-alpha trypsin inhibitor, heavy chain 10.034
Tgfbr2transforming growth factor, beta receptor II0.034
Tlx3T-cell leukemia, homeobox 30.034
Hspg2perlecan (heparan sulfate proteoglycan 2)0.032
Crb2crumbs homolog 2 (Drosophila)0.032
Cdca3cell division cycle associated 30.032
MecomMDS1 and EVI1 complex locus0.031
Sox11SRY-box containing gene 110.031
Bmp4bone morphogenetic protein 40.031
Stat3signal transducer and activator of transcription 30.029
Gpr50G-protein-coupled receptor 500.028
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism