The network for 'gene silencing by mirna' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

gene silencing by mirna

Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression.

NameDescriptionProbabilityFunc Analog Organism
aplnraapelin receptor a0.304
LOC570775protein argonaute-1-like0.204
hnrnpabheterogeneous nuclear ribonucleoprotein A/B0.055
dzip1DAZ interacting protein 10.048
bonbonnie and clyde0.036
ptgesprostaglandin E synthase0.036
ints6integrator complex subunit 60.035
eif2c4eukaryotic translation initiation factor 2C, 40.035
sh3bp5SH3-domain binding protein 5 (BTK-associated)0.033
hnrnpuheterogeneous nuclear ribonucleoprotein U0.033
acvr1bactivin A receptor, type IB0.031
slc9a3.2solute carrier family 9 (sodium/hydrogen exchanger), member 3.20.026
satb2SATB homeobox 20.025
ubr5ubiquitin protein ligase E3 component n-recognin 50.025
srsf2serine/arginine-rich splicing factor 20.025
ewsr1bEwing sarcoma breakpoint region 1b0.024
cdk7cyclin-dependent kinase 70.023
hnrnpmheterogeneous nuclear ribonucleoprotein M0.022
hnrnpa0heterogeneous nuclear ribonucleoprotein A00.020
slit1bslit homolog 1b (Drosophila)0.019
raver1ribonucleoprotein, PTB-binding 10.019
opa1optic atrophy 1 (human)0.018
ewsr1aEwing sarcoma breakpoint region 1a0.018
her15.2hairy and enhancer of split-related 15.20.018
lppr3blipid phosphate phosphatase-related protein type 3b0.017
ssr4signal sequence receptor, delta0.017
egfl7EGF-like-domain, multiple 70.016
nadl1.1neural adhesion molecule L1.10.016
mapk3mitogen-activated protein kinase 30.016
extl3exostoses (multiple)-like 30.016
ctr9Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.015
fkbp10FK506 binding protein 100.015
khdrbs1aKH domain containing, RNA binding, signal transduction associated 1a0.015
setaSET translocation (myeloid leukemia-associated) A0.015
rbmxRNA binding motif protein, X-linked0.015
ppp1cblprotein phosphatase 1, catalytic subunit, beta isoform, like0.014
srsf11serine/arginine-rich splicing factor 110.014
LOC555504novel protocadherin protein0.014
rpn2ribophorin II0.014
restRE1-silencing transcription factor0.013
cdk8cyclin-dependent kinase 80.013
pou5f1POU domain, class 5, transcription factor 10.013
LOC555163myelin protein zero-like protein 1-like0.013
mtmr8myotubularin related protein 80.013
mapk1mitogen-activated protein kinase 10.012
hnrnpl2heterogeneous nuclear ribonucleoprotein L20.012
ints2integrator complex subunit 20.012
ef1aelongation factor 1-alpha0.012
figfc-fos induced growth factor0.012
xrn25'-3' exoribonuclease 20.011
rbpjarecombination signal binding protein for immunoglobulin kappa J region a0.011
rbm22RNA binding motif protein 220.011
celf1cugbp, Elav-like family member 10.011
ccnhcyclin H0.011
acvr1lactivin A receptor, type I like0.011
gro1groucho 10.011
k23k23 gene0.011
prkd1protein kinase D10.011
ppibpeptidylprolyl isomerase B (cyclophilin B)0.011
smarce1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 10.011
sfrs3bsplicing factor, arginine/serine-rich 3b0.010
LOC100535786transcription elongation regulator 1-like0.010
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.010
LOC100535549cytoplasmic polyadenylation element-binding protein 4-like0.010
badBCL2-antagonist of cell death0.010
ubr3ubiquitin protein ligase E3 component n-recognin 30.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
rsp-8Protein RSP-80.012
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
pashapartner of drosha0.621
lidlittle imaginal discs0.575
Vps16AVacuolar protein sorting 16A0.492
Ge-1CG6181 gene product from transcript CG6181-RA0.457
sxcsuper sex combs0.399
droshaCG8730 gene product from transcript CG8730-RA0.368
Nipped-ACG33554 gene product from transcript CG33554-RE0.311
CG9772CG9772 gene product from transcript CG9772-RB0.269
tho2CG31671 gene product from transcript CG31671-RA0.250
swshort wing0.226
Rm62CG10279 gene product from transcript CG10279-RD0.202
DlicDynein light intermediate chain0.156
Tao-1CG14217 gene product from transcript CG14217-RF0.149
Aos1CG12276 gene product from transcript CG12276-RA0.147
Usp7ubiquitin-specific protease 70.125
fl(2)dfemale lethal d0.119
Patr-1Protein associated with topo II related - 10.109
drddrop dead0.100
Nipped-BCG17704 gene product from transcript CG17704-RI0.087
CG8443CG8443 gene product from transcript CG8443-RA0.082
Hel25EHelicase at 25E0.079
SmoxSmad on X0.071
MAN1CG3167 gene product from transcript CG3167-RA0.069
alpha-AdaptinCG4260 gene product from transcript CG4260-RA0.065
Ube3aUbiquitin protein ligase E3A0.063
Snr1Snf5-related 10.060
CG34415CG34415 gene product from transcript CG34415-RC0.060
PargPoly(ADP-ribose) glycohydrolase0.055
Cbp80cap binding protein 800.053
Aac11CG6582 gene product from transcript CG6582-RA0.048
king-tubbyking tubby0.047
e(y)3enhancer of yellow 30.047
CTCFCG8591 gene product from transcript CG8591-RA0.045
l(1)G0289lethal (1) G02890.045
CtBPC-terminal Binding Protein0.043
RYBPRing and YY1 Binding Protein0.039
Rat1CG10354 gene product from transcript CG10354-RA0.038
Hrb98DEHeterogeneous nuclear ribonucleoprotein at 98DE0.037
Ars2CG7843 gene product from transcript CG7843-RA0.036
Hr4CG16902 gene product from transcript CG16902-RC0.032
Vap-33-1CG5014 gene product from transcript CG5014-RB0.031
mubmushroom-body expressed0.030
Lk6CG17342 gene product from transcript CG17342-RA0.030
CG4747CG4747 gene product from transcript CG4747-RB0.030
zpgzero population growth0.029
Ptp61FProtein tyrosine phosphatase 61F0.029
kirrekin of irre0.028
eastenhanced adult sensory threshold0.028
U2ACG1406 gene product from transcript CG1406-RA0.027
Vps26Vacuolar protein sorting 260.027
larkCG8597 gene product from transcript CG8597-RD0.027
CG34350CG34350 gene product from transcript CG34350-RA0.026
CG3773CG3773 gene product from transcript CG3773-RA0.025
Tango6Transport and Golgi organization 60.025
ash1absent, small, or homeotic discs 10.025
faxfailed axon connections0.025
nocteno circadian temperature entrainment0.024
CG10107CG10107 gene product from transcript CG10107-RA0.023
TER94CG2331 gene product from transcript CG2331-RA0.022
CG15440CG15440 gene product from transcript CG15440-RA0.022
CG42260CG42260 gene product from transcript CG42260-RB0.022
CG9821CG9821 gene product from transcript CG9821-RB0.021
PcafCG4107 gene product from transcript CG4107-RA0.021
CG10289CG10289 gene product from transcript CG10289-RA0.020
Eip75BEcdysone-induced protein 75B0.020
CoproxCoproporphyrinogen oxidase0.020
Mlp84BMuscle LIM protein at 84B0.019
Ulp1CG12359 gene product from transcript CG12359-RA0.019
Hr51Hormone receptor 510.019
CG2875CG2875 gene product from transcript CG2875-RB0.018
Sry-betaSerendipity beta0.018
Nf-YANuclear factor Y-box A0.018
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
DICER1dicer 1, ribonuclease type III1.000
EIF2C2eukaryotic translation initiation factor 2C, 21.000
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 21.000
TNRC6Atrinucleotide repeat containing 6A1.000
EIF2C1eukaryotic translation initiation factor 2C, 11.000
TNRC6Btrinucleotide repeat containing 6B0.994
EIF2C3eukaryotic translation initiation factor 2C, 30.978
EIF2C4eukaryotic translation initiation factor 2C, 40.920
WWP2WW domain containing E3 ubiquitin protein ligase 20.891
IPO8importin 80.774
TNRC6Ctrinucleotide repeat containing 6C0.646
DGCR8DiGeorge syndrome critical region gene 80.620
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.595
PABPC1poly(A) binding protein, cytoplasmic 10.414
PAX3paired box 30.367
DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.357
LIN28Blin-28 homolog B (C. elegans)0.353
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.343
HNRNPA2B1heterogeneous nuclear ribonucleoprotein A2/B10.343
SF1splicing factor 10.304
STAT1signal transducer and activator of transcription 1, 91kDa0.299
DCP1ADCP1 decapping enzyme homolog A (S. cerevisiae)0.247
KLF6Kruppel-like factor 60.242
HIPK3homeodomain interacting protein kinase 30.202
FOXD3forkhead box D30.199
DROSHAdrosha, ribonuclease type III0.187
C17orf85chromosome 17 open reading frame 850.177
HNRNPMheterogeneous nuclear ribonucleoprotein M0.169
ZC3HAV1zinc finger CCCH-type, antiviral 10.163
DHX9DEAH (Asp-Glu-Ala-His) box polypeptide 90.157
ACTN1actinin, alpha 10.146
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.126
TRIM71tripartite motif containing 710.123
IER2immediate early response 20.110
CEBPDCCAAT/enhancer binding protein (C/EBP), delta0.109
POGZpogo transposable element with ZNF domain0.107
PAN3PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)0.099
PARP9poly (ADP-ribose) polymerase family, member 90.091
TRRAPtransformation/transcription domain-associated protein0.084
HCFC1host cell factor C1 (VP16-accessory protein)0.080
G3BP1GTPase activating protein (SH3 domain) binding protein 10.077
U2AF2U2 small nuclear RNA auxiliary factor 20.076
FUSfused in sarcoma0.075
YY1YY1 transcription factor0.075
C20orf20chromosome 20 open reading frame 200.074
SP1Sp1 transcription factor0.074
UPF1UPF1 regulator of nonsense transcripts homolog (yeast)0.073
PARP12poly (ADP-ribose) polymerase family, member 120.073
TRIM25tripartite motif containing 250.072
RUVBL1RuvB-like 1 (E. coli)0.068
DTX3Ldeltex 3-like (Drosophila)0.062
FTSJD2FtsJ methyltransferase domain containing 20.061
DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.059
CYLDcylindromatosis (turban tumor syndrome)0.058
DMAP1DNA methyltransferase 1 associated protein 10.056
JUNDjun D proto-oncogene0.055
DAZLdeleted in azoospermia-like0.055
FOSFBJ murine osteosarcoma viral oncogene homolog0.053
TARDBPTAR DNA binding protein0.051
MOV10Mov10, Moloney leukemia virus 10, homolog (mouse)0.051
VASPvasodilator-stimulated phosphoprotein0.050
EGR1early growth response 10.049
JUNBjun B proto-oncogene0.048
ESR1estrogen receptor 10.048
SOX2SRY (sex determining region Y)-box 20.048
PARNpoly(A)-specific ribonuclease (deadenylation nuclease)0.046
HOXA9homeobox A90.045
PPP1R16Aprotein phosphatase 1, regulatory (inhibitor) subunit 16A0.044
SOX10SRY (sex determining region Y)-box 100.039
DHX58DEXH (Asp-Glu-X-His) box polypeptide 580.036
LATS1LATS, large tumor suppressor, homolog 1 (Drosophila)0.034
SAMD9sterile alpha motif domain containing 90.034
HNRNPUL1heterogeneous nuclear ribonucleoprotein U-like 10.033
IFIT5interferon-induced protein with tetratricopeptide repeats 50.033
DPCDdeleted in primary ciliary dyskinesia homolog (mouse)0.031
IFI44interferon-induced protein 440.031
OAS32'-5'-oligoadenylate synthetase 3, 100kDa0.031
FLNBfilamin B, beta0.030
GCN1L1GCN1 general control of amino-acid synthesis 1-like 1 (yeast)0.029
PARP14poly (ADP-ribose) polymerase family, member 140.029
SCRIBscribbled homolog (Drosophila)0.028
STAT2signal transducer and activator of transcription 2, 113kDa0.028
SNAI1snail homolog 1 (Drosophila)0.027
CMPK2cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial0.027
INO80INO80 homolog (S. cerevisiae)0.026
MOCS3molybdenum cofactor synthesis 30.025
MGEA5meningioma expressed antigen 5 (hyaluronidase)0.025
ISG15ISG15 ubiquitin-like modifier0.025
DDX5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.024
NFAT5nuclear factor of activated T-cells 5, tonicity-responsive0.024
EPSTI1epithelial stromal interaction 1 (breast)0.024
SAMD9Lsterile alpha motif domain containing 9-like0.023
SAFB2scaffold attachment factor B20.022
NCOA3nuclear receptor coactivator 30.022
PPP1R15Aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.021
VPS72vacuolar protein sorting 72 homolog (S. cerevisiae)0.021
DUSP1dual specificity phosphatase 10.021
MX1myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)0.021
SRRM2serine/arginine repetitive matrix 20.021
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Eif2c2eukaryotic translation initiation factor 2C, 21.000
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.998
Brd4bromodomain containing 40.986
Trraptransformation/transcription domain-associated protein0.983
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.979
Tnrc6ctrinucleotide repeat containing 6C0.976
Tnrc6btrinucleotide repeat containing 6b0.968
Bptfbromodomain PHD finger transcription factor0.963
Eif2c1eukaryotic translation initiation factor 2C, 10.961
Ddx6DEAD (Asp-Glu-Ala-Asp) box polypeptide 60.957
Mll3myeloid/lymphoid or mixed-lineage leukemia 30.946
Mll1myeloid/lymphoid or mixed-lineage leukemia 10.944
NanogNanog homeobox0.935
Akap9A kinase (PRKA) anchor protein (yotiao) 90.899
Trim32tripartite motif-containing 320.827
JunbJun-B oncogene0.787
Tcfcp2l1transcription factor CP2-like 10.776
Safbscaffold attachment factor B0.686
Trim25tripartite motif-containing 250.671
Smad4MAD homolog 4 (Drosophila)0.648
FosFBJ osteosarcoma oncogene0.620
Chd4chromodomain helicase DNA binding protein 40.612
Hsf2heat shock factor 20.610
Phf21aPHD finger protein 21A0.577
Lin28blin-28 homolog B (C. elegans)0.536
Btg2B-cell translocation gene 2, anti-proliferative0.472
Dusp1dual specificity phosphatase 10.414
Ash1lash1 (absent, small, or homeotic)-like (Drosophila)0.382
Nfkbiznuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.375
Uba2ubiquitin-like modifier activating enzyme 20.373
Dmap1DNA methyltransferase 1-associated protein 10.360
Ehmt1euchromatic histone methyltransferase 10.360
Nr4a1nuclear receptor subfamily 4, group A, member 10.347
Lin28alin-28 homolog A (C. elegans)0.347
Arid1aAT rich interactive domain 1A (SWI-like)0.339
Sh3gl2SH3-domain GRB2-like 20.334
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.316
Bach1BTB and CNC homology 10.311
Dhx30DEAH (Asp-Glu-Ala-His) box polypeptide 300.310
Cul7cullin 70.299
Ddx17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.288
Mcl1myeloid cell leukemia sequence 10.281
Trim71tripartite motif-containing 710.263
Stat2signal transducer and activator of transcription 20.256
Tnrc6atrinucleotide repeat containing 6a0.234
Btg1B-cell translocation gene 1, anti-proliferative0.209
Trim21tripartite motif-containing 210.209
Dag1dystroglycan 10.209
Atrataxia telangiectasia and Rad3 related0.201
Nr0b1nuclear receptor subfamily 0, group B, member 10.181
Safb2scaffold attachment factor B20.178
Zbtb20zinc finger and BTB domain containing 200.177
Droshadrosha, ribonuclease type III0.175
BC006779cDNA sequence BC0067790.167
Ifit1interferon-induced protein with tetratricopeptide repeats 10.163
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.162
Pabpc1poly(A) binding protein, cytoplasmic 10.160
Pcbp2poly(rC) binding protein 20.157
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.151
Pum1pumilio 1 (Drosophila)0.149
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.149
Wdr77WD repeat domain 770.147
Ptmaprothymosin alpha0.146
Unc93b1unc-93 homolog B1 (C. elegans)0.145
Rc3h1RING CCCH (C3H) domains 10.144
Wnk1WNK lysine deficient protein kinase 10.141
Gatad2bGATA zinc finger domain containing 2B0.137
Tgfbr2transforming growth factor, beta receptor II0.136
Rtp4receptor transporter protein 40.130
Csrnp1cysteine-serine-rich nuclear protein 10.130
Fam193bfamily with sequence similarity 193, member B0.129
Egr1early growth response 10.128
Mx2myxovirus (influenza virus) resistance 20.123
Npc1Niemann Pick type C10.120
Srsf9serine/arginine-rich splicing factor 90.120
Ier2immediate early response 20.119
Rxraretinoid X receptor alpha0.118
Plxna1plexin A10.112
Samd9lsterile alpha motif domain containing 9-like0.112
Gon4lgon-4-like (C.elegans)0.111
Mbtd1mbt domain containing 10.108
Mov10Moloney leukemia virus 100.108
Mcm3apminichromosome maintenance deficient 3 (S. cerevisiae) associated protein0.106
Nf1neurofibromatosis 10.104
Gigyf1GRB10 interacting GYF protein 10.101
JunJun oncogene0.098
Dync1i1dynein cytoplasmic 1 intermediate chain 10.098
Cpsf1cleavage and polyadenylation specific factor 10.096
Ubn2ubinuclein 20.096
Irf9interferon regulatory factor 90.094
Mycmyelocytomatosis oncogene0.094
Plekha5pleckstrin homology domain containing, family A member 50.089
Oasl22'-5' oligoadenylate synthetase-like 20.088
CrebbpCREB binding protein0.085
Parp12poly (ADP-ribose) polymerase family, member 120.085
Stat3signal transducer and activator of transcription 30.080
Nfycnuclear transcription factor-Y gamma0.080
Zfp462zinc finger protein 4620.080
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Gng10guanine nucleotide binding protein (G protein), gamma 100.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism