The network for 'immunoglobulin production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

immunoglobulin production

The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

NameDescriptionProbabilityFunc Analog Organism
nod1nucleotide-binding oligomerization domain containing 10.238
LOC557072caspase recruitment domain-containing protein 11-like0.180
mybl2myeloblastosis oncogene-like 20.107
mcm5MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)0.102
nap1l1nucleosome assembly protein 1, like 10.090
chtf18CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)0.067
msh2mutS homolog 2 (E. coli)0.065
msh6mutS homolog 6 (E. coli)0.064
grnagranulin a0.063
tlr3toll-like receptor 30.059
atad5aATPase family, AAA domain containing 5a0.054
pds5bPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.051
dusp6dual specificity phosphatase 60.036
c1qccomplement component 1, q subcomponent, C chain0.033
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.032
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.031
ext1bexostoses (multiple) 1b0.030
LOC100000934hypothetical protein LOC1000009340.030
tlr9toll-like receptor 90.030
crb2acrumbs homolog 2a0.029
mbtps1membrane-bound transcription factor protease, site 10.028
mycamyelocytomatosis oncogene a0.027
efna2ephrin A20.027
ptger4bprostaglandin E receptor 4 (subtype EP4) b0.027
mcm4MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae)0.027
pola1polymerase (DNA directed), alpha 10.026
mtmr8myotubularin related protein 80.025
lrrc33leucine rich repeat containing 330.025
zfrzinc finger RNA binding protein0.024
khdrbs1bKH domain containing, RNA binding, signal transduction associated 1b0.023
terttelomerase reverse transcriptase0.023
cx43connexin 430.023
brip1BRCA1 interacting protein C-terminal helicase 10.022
grn1granulin 10.022
phf16PHD finger protein 160.022
tbx21T-box 210.022
pole2polymerase (DNA directed), epsilon 20.021
pola2polymerase (DNA directed), alpha 20.021
nitr5novel immune-type receptor 5 and immune-type receptor 5-like0.021
setdb1aSET domain, bifurcated 1a0.021
stc1lstanniocalcin 1, like0.021
c1qbcomplement component 1, q subcomponent, B chain0.021
lipclipase, hepatic0.021
sox19aSRY-box containing gene 19a0.021
ahr2aryl hydrocarbon receptor 20.020
dnttdeoxynucleotidyltransferase, terminal0.020
hirip3HIRA interacting protein 30.020
flot1bflotillin 1b0.020
olig4oligodendrocyte transcription factor 40.020
lgals2alectin, galactoside-binding, soluble, 2a0.020
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.020
cd40lgCD40 ligand0.020
kiss1KiSS-1 metastasis-suppressor0.020
aldh18a1aldehyde dehydrogenase 18 family, member A10.020
casrlcalcium-sensing receptor, like0.019
glud1aglutamate dehydrogenase 1a0.019
igfbp1binsulin-like growth factor binding protein 1b0.019
pold2polymerase (DNA directed), delta 2, regulatory subunit0.019
irak4interleukin-1 receptor-associated kinase 40.019
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)0.019
tfebtranscription factor EB0.019
senp6aSUMO1/sentrin specific peptidase 6a0.018
ptp4a3protein tyrosine phosphatase type IVA, member 30.018
pold1polymerase (DNA directed), delta 1, catalytic subunit0.018
pcsk9proprotein convertase subtilisin/kexin type 90.018
LOC566020Gig2-like protein DreO0.018
foxp3aforkhead box P3a0.018
rorcaRAR-related orphan receptor C a0.018
ighmimmunoglobulin heavy constant mu and immunoglobulin heavy constant mu0.018
lgr8.2hypothetical LOC5668880.018
ezh2enhancer of zeste homolog 2 (Drosophila)0.018
hspa9heat shock protein 90.018
npatnuclear protein, ataxia-telangiectasia locus0.018
rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.018
cyp2aa2y cytochrome P450, family 2, subfamily AA, polypeptide 20.017
tgm2btransglutaminase 2b0.017
rnasenribonuclease type III, nuclear0.017
ifnphi1interferon phi 10.017
hmgb1bhigh-mobility group box 1b0.017
acp5bacid phosphatase 5b, tartrate resistant0.017
il8interleukin 80.017
med24mediator complex subunit 240.017
ighzimmunoglobulin heavy constant zeta0.017
chek2CHK2 checkpoint homolog (S. pombe)0.017
restRE1-silencing transcription factor0.017
atp2b4ATPase, Ca++ transporting, plasma membrane 40.017
gga1golgi associated, gamma adaptin ear containing, ARF binding protein 10.016
tnfrsf18tumor necrosis factor receptor superfamily, member 180.016
defbl3defensin, beta-like 30.016
pth1aparathyroid hormone 1a0.016
ercc2excision repair cross-complementing rodent repair deficiency, complementation group 20.016
slc2a1asolute carrier family 2 (facilitated glucose transporter), member 1a0.016
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BRCA1breast cancer 1, early onset0.331
MLH1mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)0.258
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.150
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.142
SYKspleen tyrosine kinase0.091
APLFaprataxin and PNKP like factor0.076
RAD50RAD50 homolog (S. cerevisiae)0.065
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.064
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.057
IL4Rinterleukin 4 receptor0.054
MSH2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)0.044
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.042
MSH6mutS homolog 6 (E. coli)0.042
HLA-DRB5major histocompatibility complex, class II, DR beta 50.034
HLA-DMBmajor histocompatibility complex, class II, DM beta0.033
GRAP2GRB2-related adaptor protein 20.030
BRIP1BRCA1 interacting protein C-terminal helicase 10.028
TNFRSF13Btumor necrosis factor receptor superfamily, member 13B0.027
LAPTM5lysosomal protein transmembrane 50.024
ZNF830zinc finger protein 8300.021
XRCC4X-ray repair complementing defective repair in Chinese hamster cells 40.021
TRAF1TNF receptor-associated factor 10.021
IL2RGinterleukin 2 receptor, gamma0.021
RNF11ring finger protein 110.019
FANCD2Fanconi anemia, complementation group D20.019
TAL1T-cell acute lymphocytic leukemia 10.017
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.015
PTPN6protein tyrosine phosphatase, non-receptor type 60.015
CD40CD40 molecule, TNF receptor superfamily member 50.014
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.013
MSH3mutS homolog 3 (E. coli)0.013
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.012
HLA-DPB1major histocompatibility complex, class II, DP beta 10.012
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.011
PMS1PMS1 postmeiotic segregation increased 1 (S. cerevisiae)0.011
HLA-DRB4major histocompatibility complex, class II, DR beta 40.011
PMS2PMS2 postmeiotic segregation increased 2 (S. cerevisiae)0.011
TRAF3TNF receptor-associated factor 30.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ifnginterferon gamma0.993
Cd40CD40 antigen0.950
Cd28CD28 antigen0.948
Atmataxia telangiectasia mutated homolog (human)0.937
Il4interleukin 40.930
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.902
Ighimmunoglobulin heavy chain complex0.887
Stat3signal transducer and activator of transcription 30.870
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.861
FasFas (TNF receptor superfamily member 6)0.842
Rag2recombination activating gene 20.838
Socs1suppressor of cytokine signaling 10.817
Foxp3forkhead box P30.814
Ccl2chemokine (C-C motif) ligand 20.812
Il10interleukin 100.811
Pou5f1POU domain, class 5, transcription factor 10.796
Stat6signal transducer and activator of transcription 60.788
Traf2TNF receptor-associated factor 20.752
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.732
Lyz2lysozyme 20.709
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.672
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.645
Latlinker for activation of T cells0.632
Sox2SRY-box containing gene 20.603
Cd19CD19 antigen0.596
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.572
Il4rainterleukin 4 receptor, alpha0.569
Stat5bsignal transducer and activator of transcription 5B0.557
Batfbasic leucine zipper transcription factor, ATF-like0.542
Casp4caspase 4, apoptosis-related cysteine peptidase0.495
Ccr1chemokine (C-C motif) receptor 10.482
Ccr7chemokine (C-C motif) receptor 70.440
FynFyn proto-oncogene0.432
Tnfaip3tumor necrosis factor, alpha-induced protein 30.373
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.371
Irf9interferon regulatory factor 90.360
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.338
Pdcd1programmed cell death 10.337
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.336
Il1r1interleukin 1 receptor, type I0.335
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.329
Msr1macrophage scavenger receptor 10.319
TcraT-cell receptor alpha chain0.299
S1pr2sphingosine-1-phosphate receptor 20.289
NanogNanog homeobox0.287
Il6interleukin 60.274
Il1binterleukin 1 beta0.263
C3ar1complement component 3a receptor 10.262
Casp1caspase 10.259
Myd88myeloid differentiation primary response gene 880.258
Otx2orthodenticle homolog 2 (Drosophila)0.248
Ccl22chemokine (C-C motif) ligand 220.240
Il10rainterleukin 10 receptor, alpha0.237
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.231
Aireautoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)0.223
Ccl12chemokine (C-C motif) ligand 120.222
Il2rginterleukin 2 receptor, gamma chain0.220
Il6stinterleukin 6 signal transducer0.218
Prf1perforin 1 (pore forming protein)0.218
Ptgs2prostaglandin-endoperoxide synthase 20.211
Ctsscathepsin S0.199
Cbfa2t3core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)0.198
Birc3baculoviral IAP repeat-containing 30.193
Ctla4cytotoxic T-lymphocyte-associated protein 40.189
Dll4delta-like 4 (Drosophila)0.184
FaslFas ligand (TNF superfamily, member 6)0.183
Nckap1lNCK associated protein 1 like0.183
Ltblymphotoxin B0.181
Brca2breast cancer 20.179
Socs3suppressor of cytokine signaling 30.173
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.173
Lag3lymphocyte-activation gene 30.172
Stat5asignal transducer and activator of transcription 5A0.171
Pitx1paired-like homeodomain transcription factor 10.171
Il2interleukin 20.171
Gpr132G protein-coupled receptor 1320.170
Rc3h1RING CCCH (C3H) domains 10.170
Wt1Wilms tumor 1 homolog0.167
Sall4sal-like 4 (Drosophila)0.165
Irf4interferon regulatory factor 40.164
Cd14CD14 antigen0.163
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.159
Sall3sal-like 3 (Drosophila)0.158
H2-Aahistocompatibility 2, class II antigen A, alpha0.155
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.151
Mdm2transformed mouse 3T3 cell double minute 20.151
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.151
Selpselectin, platelet0.150
Ccl8chemokine (C-C motif) ligand 80.149
Batf3basic leucine zipper transcription factor, ATF-like 30.146
Tcf3transcription factor 30.145
Rag1recombination activating gene 10.144
Fcgr2bFc receptor, IgG, low affinity IIb0.141
Cd40lgCD40 ligand0.139
Rargretinoic acid receptor, gamma0.137
Map3k7mitogen-activated protein kinase kinase kinase 70.137
Tbx3T-box 30.129
Tal1T-cell acute lymphocytic leukemia 10.128
PycardPYD and CARD domain containing0.126
Ch25hcholesterol 25-hydroxylase0.125
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism