The network for 'appendage morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

appendage morphogenesis

The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch.

NameDescriptionProbabilityFunc Analog Organism
bmp4bone morphogenetic protein 40.996
hoxa9ahomeo box A9a0.994
fgf8afibroblast growth factor 8 a0.989
hoxc6ahomeo box C6a0.988
hoxb5ahomeo box B5a0.988
hoxb5bhomeo box B5b0.986
hnf1baHNF1 homeobox Ba0.982
sox9aSRY-box containing gene 9a0.979
hoxb3ahomeo box B3a0.970
hoxd11ahomeo box D11a0.967
shhasonic hedgehog a0.963
eve1even-skipped-like10.959
hoxc4ahomeo box C4a0.957
fras1Fraser syndrome 10.956
gbx2gastrulation brain homeo box 20.948
eya1eyes absent homolog 10.948
hoxc8ahomeo box C8a0.943
hoxb1bhomeo box B1b0.940
prdm1aPR domain containing 1a, with ZNF domain0.937
hoxa11bhomeo box A11b0.929
hoxa13bhomeo box A13b0.922
gscgoosecoid0.920
cdx4caudal type homeo box transcription factor 40.918
frem2aFras1 related extracellular matrix protein 2a0.907
gli1GLI-Kruppel family member 10.903
chdchordin0.901
hoxd10ahomeo box D10a0.899
hoxb6bhomeo box B6b0.898
bmp2bbone morphogenetic protein 2b0.895
frem1aFras1 related extracellular matrix 1a0.887
hoxa9bhomeo box A9b0.886
lef1lymphocyte enhancer binding factor 10.877
mibmind bomb0.864
wnt5bwingless-type MMTV integration site family, member 5b0.851
twist3twist30.834
fn1fibronectin 10.824
fgf10afibroblast growth factor 10a0.808
hoxc9ahomeo box C9a0.798
twist1btwist1b0.798
bmp1abone morphogenetic protein 1a0.783
hoxa5ahomeo box A5a0.779
hoxd4ahomeo box D4a0.775
dlx5adistal-less homeobox gene 5a0.775
hoxa4ahomeo box A4a0.774
pcsk5bproprotein convertase subtilisin/kexin type 5b0.770
vcanbversican b0.769
msxdmuscle segment homeobox D0.759
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.753
hoxd9ahomeo box D9a0.742
jag2jagged 20.732
crabp2acellular retinoic acid binding protein 2, a0.713
ptch1patched 10.695
pax2apaired box gene 2a0.692
hmx4H6 family homeobox 40.688
furinafurin (paired basic amino acid cleaving enzyme) a0.686
six4bsine oculis homeobox homolog 4b0.679
tbx1T-box 10.676
atoh1aatonal homolog 1a0.674
bmp2abone morphogenetic protein 2a0.673
runx2brunt-related transcription factor 2b0.669
bocbrother of CDO0.668
col2a1acollagen type II, alpha-1a0.647
fgf3fibroblast growth factor 30.626
tp63tumor protein p630.623
meis3myeloid ecotropic viral integration site 30.613
wnt4awingless-type MMTV integration site family, member 4a0.600
fgf24fibroblast growth factor 240.590
msxbmuscle segment homeobox B0.584
hoxb2ahomeo box B2a0.574
hoxb4ahomeo box B4a0.561
ntlano tail a0.558
pax8paired box gene 80.554
gdf6agrowth differentiation factor 6a0.553
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.550
hoxb8ahomeo box B8a0.547
evx1even-skipped homeobox 10.540
hoxc1ahomeo box C1a0.536
col1a1acollagen, type I, alpha 1a0.528
tbx16T-box gene 160.526
hoxd13ahomeo box D13a0.525
hoxb6ahomeo box B6a0.518
wnt3awingless-type MMTV integration site family, member 3A0.512
flhfloating head0.512
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.506
hand2heart and neural crest derivatives expressed transcript 20.500
snai1asnail homolog 1a (Drosophila)0.488
prrx1apaired related homeobox 1a0.472
ihhaIndian hedgehog homolog a0.472
foxa2forkhead box A20.465
dlx4adistal-less homeobox gene 4a0.453
fgf4fibroblast growth factor 40.447
pou5f1POU domain, class 5, transcription factor 10.444
dlx3bdistal-less homeobox gene 3b0.438
rarabretinoic acid receptor, alpha b0.437
hoxa3ahomeo box A3a0.436
ndr2nodal-related 20.430
spawsouthpaw0.425
pitx3paired-like homeodomain transcription factor 30.425
itga3bintegrin, alpha 3b0.411
wnt2bbwingless-type MMTV integration site family, member 2Bb0.409
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Ras85DRas oncogene at 85D1.000
Rho1CG8416 gene product from transcript CG8416-RB0.999
araaraucan0.998
EgfrEpidermal growth factor receptor0.996
zipzipper0.994
tkvthickveins0.993
fzfrizzled0.993
fjfour-jointed0.993
kuzkuzbanian0.992
fz2frizzled 20.991
MoeMoesin0.987
edechinoid0.986
SerSerrate0.985
armarmadillo0.985
dsdachsous0.984
mewmultiple edematous wings0.979
ctcut0.974
howheld out wings0.973
CG32372CG32372 gene product from transcript CG32372-RA0.972
eyaeyes absent0.969
fngfringe0.968
ifinflated0.967
PknProtein kinase related to protein kinase N0.962
gbbglass bottom boat0.959
DllDistal-less0.959
dallydivision abnormally delayed0.957
chicchickadee0.957
cicubitus interruptus0.956
vgvestigial0.955
argosCG4531 gene product from transcript CG4531-RA0.954
tshteashirt0.953
smosmoothened0.953
ash2absent, small, or homeotic discs 20.953
RYBPRing and YY1 Binding Protein0.952
nkdnaked cuticle0.948
JIL-1CG6297 gene product from transcript CG6297-RA0.947
pucpuckered0.946
mysmyospheroid0.946
Akt1CG4006 gene product from transcript CG4006-RA0.944
G-oalpha47AG protein oalpha 47A0.938
Mkp3Mitogen-activated protein kinase phosphatase 30.938
Rac1CG2248 gene product from transcript CG2248-RA0.938
NNotch0.936
knknot0.936
WnkCG7177 gene product from transcript CG7177-RA0.936
cswcorkscrew0.936
PclPolycomblike0.936
sqzsqueeze0.935
UbxUltrabithorax0.935
hthhomothorax0.928
hhhedgehog0.928
alaristaless0.926
vvlventral veins lacking0.925
mammastermind0.922
spispitz0.922
sglsugarless0.921
nubnubbin0.921
shgshotgun0.918
TolloCG6890 gene product from transcript CG6890-RA0.916
hipkhomeodomain interacting protein kinase0.916
dvedefective proventriculus0.912
dshdishevelled0.912
LanB1CG7123 gene product from transcript CG7123-RA0.911
inscinscuteable0.910
Su(z)12CG8013 gene product from transcript CG8013-RA0.906
Act5CActin 5C0.904
rlrolled0.903
osoutstretched0.902
Bre1CG10542 gene product from transcript CG10542-RA0.899
Fmr1CG6203 gene product from transcript CG6203-RC0.898
SmrSmrter0.890
RhoGEF2CG9635 gene product from transcript CG9635-RF0.889
mirrmirror0.881
coscosta0.877
dppdecapentaplegic0.868
Cul-3Cullin-30.868
dandistal antenna0.867
fkhfork head0.866
bibifid0.866
emcextra macrochaetae0.860
ptcpatched0.856
BxBeadex0.853
VangVan Gogh0.844
Sp1CG1343 gene product from transcript CG1343-RB0.843
osaCG7467 gene product from transcript CG7467-RD0.839
apapterous0.837
wgwingless0.832
lolalongitudinals lacking0.829
ftfat0.826
ssspineless0.824
sbbscribbler0.823
pnrpannier0.822
Doc2Dorsocross20.819
kelkelch0.810
KrKruppel0.808
sogshort gastrulation0.806
hephhephaestus0.804
ttvtout-velu0.803
lqfliquid facets0.794
Lim3CG10699 gene product from transcript CG10699-RB0.791
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ZNF43zinc finger protein 430.989
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.898
ZNF253zinc finger protein 2530.807
ZNF273zinc finger protein 2730.764
JAG1jagged 10.534
BMP2bone morphogenetic protein 20.510
SKIv-ski sarcoma viral oncogene homolog (avian)0.448
MEIS1Meis homeobox 10.433
PSEN1presenilin 10.408
SMAD3SMAD family member 30.395
FKBP1AFK506 binding protein 1A, 12kDa0.381
NOTCH3notch 30.362
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.360
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.358
SOX2SRY (sex determining region Y)-box 20.347
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.335
SKILSKI-like oncogene0.333
ZFYVE9zinc finger, FYVE domain containing 90.307
ZNF675zinc finger protein 6750.293
SMAD4SMAD family member 40.291
HDAC2histone deacetylase 20.287
FGF1fibroblast growth factor 1 (acidic)0.277
SUFUsuppressor of fused homolog (Drosophila)0.276
ZNF117zinc finger protein 1170.274
TGFB1transforming growth factor, beta 10.250
NOTCH1notch 10.248
CREBBPCREB binding protein0.240
BMP1bone morphogenetic protein 10.234
ZNF708zinc finger protein 7080.230
SMAD2SMAD family member 20.229
ZNF430zinc finger protein 4300.224
BMP7bone morphogenetic protein 70.222
MMP14matrix metallopeptidase 14 (membrane-inserted)0.214
SIN3ASIN3 homolog A, transcription regulator (yeast)0.211
MDFIMyoD family inhibitor0.203
FHL2four and a half LIM domains 20.189
ZNF91zinc finger protein 910.188
ARandrogen receptor0.175
ZNF93zinc finger protein 930.170
YY1YY1 transcription factor0.165
ARRB1arrestin, beta 10.165
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.165
ZNF680zinc finger protein 6800.155
ELL2elongation factor, RNA polymerase II, 20.152
ZNF85zinc finger protein 850.131
HOXA10homeobox A100.129
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.124
TGFBR1transforming growth factor, beta receptor 10.124
BMPR1Abone morphogenetic protein receptor, type IA0.117
SETD8SET domain containing (lysine methyltransferase) 80.114
FGFR2fibroblast growth factor receptor 20.109
ZNF254zinc finger protein 2540.108
RXRAretinoid X receptor, alpha0.100
BMP4bone morphogenetic protein 40.094
FGF18fibroblast growth factor 180.093
HDAC1histone deacetylase 10.089
COL1A2collagen, type I, alpha 20.089
BCL2L1BCL2-like 10.089
HOXA11homeobox A110.087
MEIS2Meis homeobox 20.085
HOXD9homeobox D90.084
PMLpromyelocytic leukemia0.082
ATN1atrophin 10.080
TRIP6thyroid hormone receptor interactor 60.079
MLLT1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10.076
WNT1wingless-type MMTV integration site family, member 10.075
BCAMbasal cell adhesion molecule (Lutheran blood group)0.075
LRP6low density lipoprotein receptor-related protein 60.074
RARAretinoic acid receptor, alpha0.072
PSEN2presenilin 2 (Alzheimer disease 4)0.072
HOXD13homeobox D130.071
HOXD11homeobox D110.065
SMAD6SMAD family member 60.062
GATA4GATA binding protein 40.060
HOXB5homeobox B50.059
ACVR1activin A receptor, type I0.059
RBBP4retinoblastoma binding protein 40.057
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.056
HOXC6homeobox C60.056
FOXF2forkhead box F20.055
COL7A1collagen, type VII, alpha 10.055
COL2A1collagen, type II, alpha 10.054
LBX1ladybird homeobox 10.051
DLX4distal-less homeobox 40.050
NGFRnerve growth factor receptor0.046
FGFR1fibroblast growth factor receptor 10.045
TGFB3transforming growth factor, beta 30.044
PRRX2paired related homeobox 20.042
TLE1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)0.042
JAG2jagged 20.041
TJP1tight junction protein 1 (zona occludens 1)0.041
FGF3fibroblast growth factor 30.041
HOXD10homeobox D100.041
WNT3Awingless-type MMTV integration site family, member 3A0.039
FSTL1follistatin-like 10.039
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.039
THBS1thrombospondin 10.038
FGFR3fibroblast growth factor receptor 30.037
STK36serine/threonine kinase 360.037
HMGA2high mobility group AT-hook 20.036
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Gli3GLI-Kruppel family member GLI31.000
Shhsonic hedgehog1.000
Fgfr2fibroblast growth factor receptor 21.000
Pitx2paired-like homeodomain transcription factor 21.000
Pax6paired box gene 61.000
Foxc1forkhead box C11.000
Fgfr1fibroblast growth factor receptor 11.000
Pax3paired box gene 31.000
Otx2orthodenticle homolog 2 (Drosophila)1.000
Pax2paired box gene 21.000
Bmp4bone morphogenetic protein 41.000
Fgf8fibroblast growth factor 81.000
Msx1homeobox, msh-like 11.000
Hand1heart and neural crest derivatives expressed transcript 11.000
Bmp7bone morphogenetic protein 71.000
Six1sine oculis-related homeobox 1 homolog (Drosophila)1.000
Tbx1T-box 11.000
Eya1eyes absent 1 homolog (Drosophila)1.000
Foxc2forkhead box C21.000
Rargretinoic acid receptor, gamma1.000
Hand2heart and neural crest derivatives expressed transcript 21.000
Prrx2paired related homeobox 21.000
Tbx3T-box 31.000
Prrx1paired related homeobox 11.000
Tcfap2atranscription factor AP-2, alpha0.999
Dlx5distal-less homeobox 50.999
Gli2GLI-Kruppel family member GLI20.999
Tgfb2transforming growth factor, beta 20.999
Hoxd13homeobox D130.999
Sox2SRY-box containing gene 20.999
Pbx1pre B-cell leukemia transcription factor 10.999
Gbx2gastrulation brain homeobox 20.999
Ptenphosphatase and tensin homolog0.999
Ror2receptor tyrosine kinase-like orphan receptor 20.998
Hoxa11homeobox A110.998
Rararetinoic acid receptor, alpha0.998
Pitx1paired-like homeodomain transcription factor 10.998
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.998
Alx4aristaless-like homeobox 40.998
Msx2homeobox, msh-like 20.998
Fgf10fibroblast growth factor 100.997
Hoxa10homeobox A100.996
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.995
Pcsk5proprotein convertase subtilisin/kexin type 50.995
Smosmoothened homolog (Drosophila)0.995
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.995
Lhx1LIM homeobox protein 10.995
Hoxd11homeobox D110.994
Sox9SRY-box containing gene 90.994
Wnt3awingless-related MMTV integration site 3A0.994
Trp53transformation related protein 530.994
Chrdchordin0.993
Fgfr3fibroblast growth factor receptor 30.993
Tgfbr2transforming growth factor, beta receptor II0.992
Zeb1zinc finger E-box binding homeobox 10.991
Lmx1bLIM homeobox transcription factor 1 beta0.991
Gscgoosecoid homeobox0.991
Lef1lymphoid enhancer binding factor 10.989
Hoxa13homeobox A130.989
Vangl2vang-like 2 (van gogh, Drosophila)0.988
Col2a1collagen, type II, alpha 10.987
Hoxa1homeobox A10.987
Vegfavascular endothelial growth factor A0.986
Meox2mesenchyme homeobox 20.986
En1engrailed 10.985
Emx2empty spiracles homolog 2 (Drosophila)0.983
Pkd1polycystic kidney disease 1 homolog0.983
Otx1orthodenticle homolog 1 (Drosophila)0.981
Sfrp2secreted frizzled-related protein 20.981
Runx2runt related transcription factor 20.980
Sall4sal-like 4 (Drosophila)0.977
Foxh1forkhead box H10.977
Tbx15T-box 150.976
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.974
Wt1Wilms tumor 1 homolog0.973
Nognoggin0.971
Pax9paired box gene 90.970
Dkk1dickkopf homolog 1 (Xenopus laevis)0.970
Acvr1activin A receptor, type 10.969
Twist2twist homolog 2 (Drosophila)0.965
Wnt5awingless-related MMTV integration site 5A0.965
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.963
Nr5a1nuclear receptor subfamily 5, group A, member 10.963
Fbn1fibrillin 10.963
Jag1jagged 10.962
Rarbretinoic acid receptor, beta0.962
Notch2Notch gene homolog 2 (Drosophila)0.959
Hoxa9homeobox A90.959
Hoxa2homeobox A20.953
Twist1twist homolog 1 (Drosophila)0.952
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.952
Nodalnodal0.951
Bcl2B-cell leukemia/lymphoma 20.948
Hoxd9homeobox D90.943
Ptf1apancreas specific transcription factor, 1a0.943
Notch1Notch gene homolog 1 (Drosophila)0.942
Zic3zinc finger protein of the cerebellum 30.937
Fgf15fibroblast growth factor 150.934
Mks1Meckel syndrome, type 10.930
Ednraendothelin receptor type A0.929
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Lef1lymphoid enhancer binding factor 10.287
Fmodfibromodulin0.233
Serpine2serine (or cysteine) peptidase inhibitor, clade E, member 20.201
Mmp13matrix metallopeptidase 130.193
Prrx1paired related homeobox 10.182
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.178
Elnelastin0.165
Nkd1naked cuticle homolog 1 (Drosophila)0.157
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.135
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.122
Galgalanin prepropeptide0.118
Olfml2bolfactomedin-like 2B0.116
Myh3myosin, heavy chain 3, skeletal muscle, embryonic0.105
C1qtnf5C1q and tumor necrosis factor related protein 50.102
Scarf2scavenger receptor class F, member 20.097
Col3a1collagen, type III, alpha 10.094
Acvr1activin A receptor, type I0.090
Mmp9matrix metallopeptidase 90.089
Dchs1dachsous 1 (Drosophila)0.087
Shox2short stature homeobox 20.087
Lamc1laminin, gamma 10.082
Tcf12transcription factor 120.081
Timp3TIMP metallopeptidase inhibitor 30.077
Igfbp5insulin-like growth factor binding protein 50.076
Fgf7fibroblast growth factor 70.076
Ubtfupstream binding transcription factor, RNA polymerase I0.073
Srpxsushi-repeat-containing protein, X-linked0.073
Unc5bunc-5 homolog B (C. elegans)0.071
Sod3superoxide dismutase 3, extracellular0.070
Slc9a1solute carrier family 9 (sodium/hydrogen exchanger), member 10.069
Nek9NIMA (never in mitosis gene a)- related kinase 90.069
Figfc-fos induced growth factor0.068
Gcm1glial cells missing homolog 1 (Drosophila)0.068
Fgfr1Fibroblast growth factor receptor 10.068
Bst1bone marrow stromal cell antigen 10.066
Nrg1neuregulin 10.065
Icosinducible T-cell co-stimulator0.063
Cyp21a1cytochrome P450, family 21, subfamily a, polypeptide 10.063
Bgnbiglycan0.062
Prrx2paired related homeobox 20.062
Ptprsprotein tyrosine phosphatase, receptor type, S0.062
Capn6calpain 60.061
Arsbarylsulfatase B0.060
Ctrcchymotrypsin C (caldecrin)0.058
Glg1golgi apparatus protein 10.057
Bmp1bone morphogenetic protein 10.056
Lamb2laminin, beta 20.056
Chadchondroadherin0.056
Phexphosphate regulating endopeptidase homolog, X-linked0.055
Lect1leukocyte cell derived chemotaxin 10.055
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.055
Pax8paired box 80.054
Col12a1collagen, type XII, alpha 10.054
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.054
Snrpd2small nuclear ribonucleoprotein D2 polypeptide0.054
Irs1insulin receptor substrate 10.054
Fzd2frizzled homolog 2 (Drosophila)0.052
Galr2galanin receptor 20.051
Ugt1a7cUDP glucuronosyltransferase 1 family, polypeptide A7C0.050
Mmp23matrix metallopeptidase 230.050
Ccl11chemokine (C-C motif) ligand 110.049
Mcpt2mast cell protease 20.049
Mogmyelin oligodendrocyte glycoprotein0.049
Scn5asodium channel, voltage-gated, type V, alpha subunit0.049
Jak1Janus kinase 10.048
Cox6b2cytochrome c oxidase subunit VIb polypeptide 20.048
Mpripmyosin phosphatase Rho interacting protein0.048
MefvMediterranean fever0.048
Appamyloid beta (A4) precursor protein0.047
Col5a2collagen, type V, alpha 20.047
Pld1phospholipase D10.047
Igf2rinsulin-like growth factor 2 receptor0.046
Expiextracellular proteinase inhibitor0.046
Il8rbinterleukin 8 receptor, beta0.046
Ccna1cyclin A10.046
Mybphmyosin binding protein H0.045
Trem2triggering receptor expressed on myeloid cells 20.044
Pcnxl3pecanex-like 3 (Drosophila)0.044
Ptpn14protein tyrosine phosphatase, non-receptor type 140.043
Mmp2matrix metallopeptidase 20.043
Hrnbp3hexaribonucleotide binding protein 30.043
Htr2a5-hydroxytryptamine (serotonin) receptor 2A0.043
Bnc1basonuclin 10.042
Bmp4bone morphogenetic protein 40.042
Tgfb2transforming growth factor, beta 20.042
Col5a1collagen, type V, alpha 10.042
Tacr1tachykinin receptor 10.042
Col1a2collagen, type I, alpha 20.042
Eef2eukaryotic translation elongation factor 20.041
Hdac1lhistone deacetylase 1-like0.041
Ccdc3coiled-coil domain containing 30.041
MrgprfMAS-related GPR, member F0.041
Csf3colony stimulating factor 3 (granulocyte)0.040
Dact1dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)0.040
Chd4chromodomain helicase DNA binding protein 40.040
Myh9myosin, heavy chain 9, non-muscle0.039
Slc34a2solute carrier family 34 (sodium phosphate), member 20.039
Gpc1glypican 10.039
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.039
Cxcl2chemokine (C-X-C motif) ligand 20.039
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism