The network for 'endodermal cell fate specification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endodermal cell fate specification

The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.

NameDescriptionProbabilityFunc Analog Organism
flhfloating head0.984
bmp4bone morphogenetic protein 40.898
tbx1T-box 10.865
fn1fibronectin 10.852
bmp2bbone morphogenetic protein 2b0.838
pax2apaired box gene 2a0.835
tbx16T-box gene 160.821
fgf3fibroblast growth factor 30.800
foxi1forkhead box I10.792
her7hairy and enhancer of split related-70.770
hnf1baHNF1 homeobox Ba0.745
ventventral expressed homeobox0.744
shhasonic hedgehog a0.743
jag2jagged 20.724
wnt5bwingless-type MMTV integration site family, member 5b0.704
pcdh8protocadherin 80.698
dusp6dual specificity phosphatase 60.680
ndr2nodal-related 20.677
fgf17fibroblast growth factor 170.652
fgf8afibroblast growth factor 8 a0.625
ndr1nodal-related 10.563
vedventrally expressed dharma/bozozok antagonist0.527
hand2heart and neural crest derivatives expressed transcript 20.505
cdh2cadherin 2, neuronal0.491
emx3empty spiracles homeobox 30.473
dkk1bdickkopf 1b0.408
notch1anotch homolog 1a0.406
lhx1aLIM homeobox 1a0.373
gbx2gastrulation brain homeo box 20.371
oepone-eyed pinhead0.369
ntlano tail a0.353
eya1eyes absent homolog 10.351
myod1myogenic differentiation 10.350
snai1asnail homolog 1a (Drosophila)0.334
cdx4caudal type homeo box transcription factor 40.299
spry4sprouty (Drosophila) homolog 40.298
osr2odd-skipped related 2 (Drosophila)0.292
foxd5forkhead box D50.273
foxd3forkhead box D30.271
btg2B-cell translocation gene 20.263
pdgfaaplatelet-derived growth factor alpha a0.260
foxh1forkhead box H10.260
foxg1aforkhead box G1a0.256
fgfr4fibroblast growth factor receptor 40.248
efnb2aephrin B2a0.245
six3asine oculis homeobox homolog 3a0.240
gata3GATA-binding protein 30.226
cdh1cadherin 1, epithelial0.224
mespamesoderm posterior a0.223
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.210
wif1wnt inhibitory factor 10.208
fzd5frizzled homolog 50.194
six4bsine oculis homeobox homolog 4b0.193
sox9aSRY-box containing gene 9a0.176
jag1bjagged 1b0.169
evx1even-skipped homeobox 10.164
her1hairy-related 10.161
notch1bnotch homolog 1b0.159
tp63tumor protein p630.156
admpanti-dorsalizing morphogenic protein0.144
notch2notch homolog 20.143
has2hyaluronan synthase 20.139
sox32SRY-box containing gene 320.132
foxa1forkhead box A10.132
hoxa2bhomeo box A2b0.132
tbx2bT-box 2b0.131
fgfr1afibroblast growth factor receptor 1a0.129
fgf10afibroblast growth factor 10a0.128
tbx20T-box 200.126
fzd8bfrizzled homolog 8b0.123
rarabretinoic acid receptor, alpha b0.122
mmp2matrix metalloproteinase 20.122
fzd10frizzled homolog 100.122
her5hairy-related 50.121
gli1GLI-Kruppel family member 10.120
pitx2paired-like homeodomain transcription factor 20.117
nanos3nanos homolog 30.117
gli2aGLI-Kruppel family member GLI2a0.116
ephb4beph receptor B4b0.116
ascl1aachaete-scute complex-like 1a (Drosophila)0.115
irx1biroquois homeobox protein 1, b0.115
runx2brunt-related transcription factor 2b0.114
fli1afriend leukemia integration 1a0.112
zp2.2zona pellucida glycoprotein 2.20.110
aldh1a2aldehyde dehydrogenase 1 family, member A20.109
bonbonnie and clyde0.108
eomesaeomesodermin homolog a0.107
pou3f3bPOU class 3 homeobox 3b0.107
sox19bSRY-box containing gene 19b0.106
otx1aorthodenticle homolog 1a0.105
hmx4H6 family homeobox 40.104
wnt11wingless-type MMTV integration site family, member 110.103
sox1aSRY-box containing gene 1a0.103
chrna2acholinergic receptor, nicotinic, alpha polypeptide 2a (neuronal)0.102
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SP1Sp1 transcription factor1.000
SMAD7SMAD family member 70.999
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.999
BMP2bone morphogenetic protein 20.999
PAX3paired box 30.998
POU3F2POU class 3 homeobox 20.996
FYNFYN oncogene related to SRC, FGR, YES0.994
BMPR1Abone morphogenetic protein receptor, type IA0.994
FOXD3forkhead box D30.985
DVL3dishevelled, dsh homolog 3 (Drosophila)0.982
SMAD2SMAD family member 20.972
DVL1dishevelled, dsh homolog 1 (Drosophila)0.972
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.971
SMAD4SMAD family member 40.963
SOX10SRY (sex determining region Y)-box 100.962
SOX2SRY (sex determining region Y)-box 20.924
SMAD1SMAD family member 10.917
CSNK1Ecasein kinase 1, epsilon0.874
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.863
LCKlymphocyte-specific protein tyrosine kinase0.862
SMAD3SMAD family member 30.846
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.811
TAB3TGF-beta activated kinase 1/MAP3K7 binding protein 30.764
BMP7bone morphogenetic protein 70.753
CTNNBIP1catenin, beta interacting protein 10.740
JAG1jagged 10.722
NEDD4neural precursor cell expressed, developmentally down-regulated 40.692
WWP2WW domain containing E3 ubiquitin protein ligase 20.688
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.646
AXIN1axin 10.602
MAPK8mitogen-activated protein kinase 80.583
SMAD5SMAD family member 50.558
SYKspleen tyrosine kinase0.504
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.502
PLCG1phospholipase C, gamma 10.496
RANBP2RAN binding protein 20.492
FSTL1follistatin-like 10.441
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.433
CTNND1catenin (cadherin-associated protein), delta 10.409
GDF5growth differentiation factor 50.407
SNIP1Smad nuclear interacting protein 10.405
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.401
WT1Wilms tumor 10.384
NOTCH3notch 30.366
APCadenomatous polyposis coli0.366
LRP6low density lipoprotein receptor-related protein 60.360
FGF1fibroblast growth factor 1 (acidic)0.359
SOX21SRY (sex determining region Y)-box 210.336
MEOX2mesenchyme homeobox 20.263
ZNF512Bzinc finger protein 512B0.260
SMURF2SMAD specific E3 ubiquitin protein ligase 20.259
FGF2fibroblast growth factor 2 (basic)0.249
HCKhemopoietic cell kinase0.219
SOX11SRY (sex determining region Y)-box 110.210
FGFR2fibroblast growth factor receptor 20.205
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.204
TRAF6TNF receptor-associated factor 60.200
LRRK2leucine-rich repeat kinase 20.179
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.176
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.175
SLC9A3R2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.167
SALL2sal-like 2 (Drosophila)0.158
CEP164centrosomal protein 164kDa0.153
MAML1mastermind-like 1 (Drosophila)0.152
NOVA2neuro-oncological ventral antigen 20.151
BBS10Bardet-Biedl syndrome 100.151
SMAD6SMAD family member 60.149
HCFC1host cell factor C1 (VP16-accessory protein)0.146
ZFYVE9zinc finger, FYVE domain containing 90.145
GAS7growth arrest-specific 70.142
FOXG1forkhead box G10.136
CLTCclathrin, heavy chain (Hc)0.136
SOX9SRY (sex determining region Y)-box 90.131
SPRR2Asmall proline-rich protein 2A0.128
NOSTRINnitric oxide synthase trafficker0.125
GTPBP5GTP binding protein 5 (putative)0.115
CDH3cadherin 3, type 1, P-cadherin (placental)0.114
KLF5Kruppel-like factor 5 (intestinal)0.106
MDFIMyoD family inhibitor0.101
HNF1AHNF1 homeobox A0.100
CADM4cell adhesion molecule 40.100
POU3F3POU class 3 homeobox 30.098
NEDD9neural precursor cell expressed, developmentally down-regulated 90.098
SMAD9SMAD family member 90.097
FBXL15F-box and leucine-rich repeat protein 150.096
OTPorthopedia homeobox0.095
FRS2fibroblast growth factor receptor substrate 20.090
MYBv-myb myeloblastosis viral oncogene homolog (avian)0.090
BMP4bone morphogenetic protein 40.089
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.087
NR0B1nuclear receptor subfamily 0, group B, member 10.086
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.084
KLHL12kelch-like 12 (Drosophila)0.083
SKIv-ski sarcoma viral oncogene homolog (avian)0.082
PHLDA1pleckstrin homology-like domain, family A, member 10.082
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.081
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.081
TAB1TGF-beta activated kinase 1/MAP3K7 binding protein 10.079
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Fgfr2fibroblast growth factor receptor 21.000
Vangl2vang-like 2 (van gogh, Drosophila)1.000
Pitx2paired-like homeodomain transcription factor 21.000
Fgf8fibroblast growth factor 81.000
Foxc1forkhead box C11.000
Otx2orthodenticle homolog 2 (Drosophila)1.000
Gli3GLI-Kruppel family member GLI31.000
Pax3paired box gene 31.000
Hand1heart and neural crest derivatives expressed transcript 11.000
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)1.000
Bmp4bone morphogenetic protein 41.000
Hand2heart and neural crest derivatives expressed transcript 21.000
Sox2SRY-box containing gene 21.000
Foxc2forkhead box C21.000
Six1sine oculis-related homeobox 1 homolog (Drosophila)1.000
Tcfap2atranscription factor AP-2, alpha0.999
Eya1eyes absent 1 homolog (Drosophila)0.999
Jag1jagged 10.999
Tbx1T-box 10.999
Ctnnb1catenin (cadherin associated protein), beta 10.999
Chd7chromodomain helicase DNA binding protein 70.999
Dlx5distal-less homeobox 50.999
Pax2paired box gene 20.999
Tbx3T-box 30.998
Pitx1paired-like homeodomain transcription factor 10.998
Sox9SRY-box containing gene 90.997
Dvl2dishevelled 2, dsh homolog (Drosophila)0.997
Gbx2gastrulation brain homeobox 20.997
Prrx1paired related homeobox 10.997
Foxg1forkhead box G10.996
Sall4sal-like 4 (Drosophila)0.994
Lrp6low density lipoprotein receptor-related protein 60.992
Hoxa1homeobox A10.992
Sox11SRY-box containing gene 110.989
Gata4GATA binding protein 40.989
Zeb1zinc finger E-box binding homeobox 10.988
Msx1homeobox, msh-like 10.987
Hes1hairy and enhancer of split 1 (Drosophila)0.986
Wnt3awingless-related MMTV integration site 3A0.985
Isl1ISL1 transcription factor, LIM/homeodomain0.983
Alx4aristaless-like homeobox 40.977
Ptpn11protein tyrosine phosphatase, non-receptor type 110.977
Smosmoothened homolog (Drosophila)0.976
Efnb2ephrin B20.976
Apcadenomatosis polyposis coli0.972
Fgf10fibroblast growth factor 100.969
Fgfr1fibroblast growth factor receptor 10.967
Fgfr3fibroblast growth factor receptor 30.960
Runx2runt related transcription factor 20.960
Msx2homeobox, msh-like 20.959
Pou5f1POU domain, class 5, transcription factor 10.953
Meox2mesenchyme homeobox 20.950
Ednraendothelin receptor type A0.944
Ror2receptor tyrosine kinase-like orphan receptor 20.941
Map3k7mitogen-activated protein kinase kinase kinase 70.941
Tgfb2transforming growth factor, beta 20.941
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.907
Ptch1patched homolog 10.905
Pax6paired box gene 60.894
Gata3GATA binding protein 30.868
Retret proto-oncogene0.861
Acvr1activin A receptor, type 10.859
Smad6MAD homolog 6 (Drosophila)0.849
Vangl1vang-like 1 (van gogh, Drosophila)0.841
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.838
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.836
Hoxa13homeobox A130.821
Zic3zinc finger protein of the cerebellum 30.806
Smad1MAD homolog 1 (Drosophila)0.796
Nf1neurofibromatosis 10.791
Dvl3dishevelled 3, dsh homolog (Drosophila)0.789
Pax1paired box gene 10.781
Dll4delta-like 4 (Drosophila)0.774
Rspo2R-spondin 2 homolog (Xenopus laevis)0.765
Emx1empty spiracles homolog 1 (Drosophila)0.765
Rargretinoic acid receptor, gamma0.763
Bmp7bone morphogenetic protein 70.762
Fgf3fibroblast growth factor 30.760
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.759
Hoxd13homeobox D130.758
En1engrailed 10.757
Gscgoosecoid homeobox0.750
Bmpr1abone morphogenetic protein receptor, type 1A0.743
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.741
Otx1orthodenticle homolog 1 (Drosophila)0.720
Lmx1aLIM homeobox transcription factor 1 alpha0.720
Lef1lymphoid enhancer binding factor 10.720
Cd247CD247 antigen0.720
Wnt1wingless-related MMTV integration site 10.698
Hesx1homeobox gene expressed in ES cells0.675
TcraT-cell receptor alpha chain0.663
Foxn1forkhead box N10.663
Psen1presenilin 10.663
Prrx2paired related homeobox 20.659
Ptk2PTK2 protein tyrosine kinase 20.654
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism